{"id":"https://openalex.org/W2997807953","doi":"https://doi.org/10.1016/j.jns.2019.10.1409","title":"The Roche HD natural history study \u2013 An external comparator by design","display_name":"The Roche HD natural history study \u2013 An external comparator by design","publication_year":2019,"publication_date":"2019-10-01","ids":{"openalex":"https://openalex.org/W2997807953","doi":"https://doi.org/10.1016/j.jns.2019.10.1409","mag":"2997807953"},"language":"en","primary_location":{"id":"doi:10.1016/j.jns.2019.10.1409","doi":"https://doi.org/10.1016/j.jns.2019.10.1409","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jns.2019.10.1409","pdf_url":"http://www.jns-journal.com/article/S0022510X19318830/pdf","source":{"id":"https://openalex.org/S169054600","display_name":"Journal of the Neurological Sciences","issn_l":"0022-510X","issn":["0022-510X","1878-5883"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Neurological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jns-journal.com/article/S0022510X19318830/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027340010","display_name":"Gregory J. Hooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113058","display_name":"Roche (United Kingdom)","ror":"https://ror.org/024tgbv41","country_code":"GB","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4210113058"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G. Hooper","raw_affiliation_strings":["Roche Products Ltd, Neuroscience-Huntington's Disease, Welwyn Garden City, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Products Ltd, Neuroscience-Huntington's Disease, Welwyn Garden City, United Kingdom","institution_ids":["https://openalex.org/I4210113058"]}]},{"author_position":"middle","author":{"id":null,"display_name":"G. Palermo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"G. Palermo","raw_affiliation_strings":["F. Hoffmann-La Roche Ltd., Product Development, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Hoffmann-La Roche Ltd., Product Development, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059938202","display_name":"F. Hlavac","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"F. Hlavac","raw_affiliation_strings":["F. Hoffmann-La Roche Ltd, Product Development Global, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Hoffmann-La Roche Ltd, Product Development Global, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072981968","display_name":"C. Finnegan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Finnegan","raw_affiliation_strings":["Almac Group, Almac Clinical Technologies LLC, Souderton, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Almac Group, Almac Clinical Technologies LLC, Souderton, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037371947","display_name":"Elsbeth Frick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"E. Frick","raw_affiliation_strings":["F. Hoffmann-La Roche Ltd., PD Clinical Operations, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Hoffmann-La Roche Ltd., PD Clinical Operations, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005910368","display_name":"Lauren M. Boak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"L. Boak","raw_affiliation_strings":["F. Hoffmann-La Roche Ltd., Product Development Neuroscience, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Hoffmann-La Roche Ltd., Product Development Neuroscience, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068308578","display_name":"Rachelle Smith Doody","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]},{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"R. Doody","raw_affiliation_strings":["F. Hoffmann-La Roche Ltd and Genentech Inc., Neurodegeneration, South San Francisco- USA, and Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Hoffmann-La Roche Ltd and Genentech Inc., Neurodegeneration, South San Francisco- USA, and Basel, Switzerland","institution_ids":["https://openalex.org/I118019719","https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008618034","display_name":"Scott Schobel","orcid":"https://orcid.org/0000-0001-6182-1943","observed_orcids":["https://orcid.org/0000-0001-6182-1943"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"S. Schobel","raw_affiliation_strings":["F. Hoffmann-La Roche Ltd., Product Development Neuroscience, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Hoffmann-La Roche Ltd., Product Development Neuroscience, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062884561","display_name":"Blair R. Leavitt","orcid":"https://orcid.org/0000-0002-4532-766X","observed_orcids":["https://orcid.org/0000-0002-4532-766X"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"B. Leavitt","raw_affiliation_strings":["Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3250,"currency":"USD","value_usd":3250},"apc_paid":null,"fwci":0.1194,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44314685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"405","issue":null,"first_page":"312","last_page":"312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/natural-history-disease","display_name":"natural history (disease)","score":0.6510000228881836},{"id":"https://openalex.org/keywords/mutant-huntingtin","display_name":"mutant huntingtin","score":0.9200000166893005},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.953000009059906},{"id":"https://openalex.org/keywords/open-label-extension","display_name":"open-label extension","score":0.8180000185966492},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.6970000267028809},{"id":"https://openalex.org/keywords/unified-huntington-s-disease-rating-scale","display_name":"Unified Huntington's Disease Rating Scale","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cag-repeat-length","display_name":"CAG repeat length","score":0.7509999871253967},{"id":"https://openalex.org/keywords/longitudinal-cohort","display_name":"longitudinal cohort","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C163276114","wikidata":"https://www.wikidata.org/wiki/Q484591","display_name":"Natural history","level":2,"score":0.6917814612388611},{"id":"https://openalex.org/C2778279407","wikidata":"https://www.wikidata.org/wiki/Q6980711","display_name":"Natural history study","level":3,"score":0.68248051404953},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6657321453094482},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5722293257713318},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.537118673324585},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5304683446884155},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5276516675949097},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4888550639152527},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43253594636917114},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.42685651779174805},{"id":"https://openalex.org/C83849319","wikidata":"https://www.wikidata.org/wiki/Q7295720","display_name":"Rating scale","level":2,"score":0.4183202385902405},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.26563653349876404},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13624542951583862},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09118914604187012},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jns.2019.10.1409","doi":"https://doi.org/10.1016/j.jns.2019.10.1409","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jns.2019.10.1409","pdf_url":"http://www.jns-journal.com/article/S0022510X19318830/pdf","source":{"id":"https://openalex.org/S169054600","display_name":"Journal of the Neurological Sciences","issn_l":"0022-510X","issn":["0022-510X","1878-5883"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Neurological Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jns.2019.10.1409","doi":"https://doi.org/10.1016/j.jns.2019.10.1409","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jns.2019.10.1409","pdf_url":"http://www.jns-journal.com/article/S0022510X19318830/pdf","source":{"id":"https://openalex.org/S169054600","display_name":"Journal of the Neurological Sciences","issn_l":"0022-510X","issn":["0022-510X","1878-5883"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Neurological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/study-protocol","display_name":"Study Protocol"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2997807953.pdf","grobid_xml":"https://content.openalex.org/works/W2997807953.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7019807759","https://openalex.org/W2891882745","https://openalex.org/W3112958994","https://openalex.org/W7222987490","https://openalex.org/W2027482612","https://openalex.org/W4402374505","https://openalex.org/W2020117714","https://openalex.org/W7164209697","https://openalex.org/W7223091298","https://openalex.org/W607166518"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-01-10T00:00:00"}
