{"id":"https://openalex.org/W2997723919","doi":"https://doi.org/10.1016/j.expneurol.2019.113161","title":"Zn2+ entry through the mitochondrial calcium uniporter is a critical contributor to mitochondrial dysfunction and neurodegeneration","display_name":"Zn2+ entry through the mitochondrial calcium uniporter is a critical contributor to mitochondrial dysfunction and neurodegeneration","publication_year":2019,"publication_date":"2019-12-24","ids":{"openalex":"https://openalex.org/W2997723919","doi":"https://doi.org/10.1016/j.expneurol.2019.113161","mag":"2997723919","pmid":"https://pubmed.ncbi.nlm.nih.gov/31881218","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6957126"},"language":"en","primary_location":{"id":"doi:10.1016/j.expneurol.2019.113161","doi":"https://doi.org/10.1016/j.expneurol.2019.113161","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.expneurol.2019.113161","pdf_url":null,"source":{"id":"https://openalex.org/S165592611","display_name":"Experimental Neurology","issn_l":"0014-4886","issn":["0014-4886","1090-2430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6957126","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039149981","display_name":"Sunggoan Ji","orcid":"https://orcid.org/0000-0003-1308-2474","observed_orcids":["https://orcid.org/0000-0003-1308-2474"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sung G. Ji","raw_affiliation_strings":["Department of Anatomy & Neurobiology, University of California, Irvine, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy & Neurobiology, University of California, Irvine, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048315457","display_name":"Yuliya V. Medvedeva","orcid":"https://orcid.org/0009-0000-0730-0936","observed_orcids":["https://orcid.org/0009-0000-0730-0936"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuliya V. Medvedeva","raw_affiliation_strings":["Department of Neurology, University of California, Irvine, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of California, Irvine, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043030783","display_name":"John H. Weiss","orcid":"https://orcid.org/0000-0001-9323-7813","observed_orcids":["https://orcid.org/0000-0001-9323-7813"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John H. Weiss","raw_affiliation_strings":["Department of Anatomy & Neurobiology, University of California, Irvine, United States of America; Department of Neurology, University of California, Irvine, United States of America. Electronic address: jweiss@uci.edu","Department of Anatomy & Neurobiology, University of California, Irvine, United States of America","Department of Neurology, University of California, Irvine, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-9323-7813","affiliations":[{"raw_affiliation_string":"Department of Anatomy & Neurobiology, University of California, Irvine, United States of America; Department of Neurology, University of California, Irvine, United States of America. Electronic address: jweiss@uci.edu","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Anatomy & Neurobiology, University of California, Irvine, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Neurology, University of California, Irvine, United States of America","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043030783"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":3150,"currency":"USD","value_usd":3150},"apc_paid":null,"fwci":2.344,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.90285374,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"325","issue":null,"first_page":"113161","last_page":"113161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.5820000171661377},{"id":"https://openalex.org/keywords/mitochondrial-calcium-uniporter","display_name":"mitochondrial calcium uniporter","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7829999923706055},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8510000109672546},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.8080000281333923},{"id":"https://openalex.org/keywords/oxygen-glucose-deprivation","display_name":"oxygen-glucose deprivation","score":0.6480000019073486},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.6660000085830688},{"id":"https://openalex.org/keywords/ca1-pyramidal-neurons","display_name":"CA1 pyramidal neurons","score":0.8040000200271606},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.859000027179718},{"id":"https://openalex.org/keywords/mitochondrial-membrane-depolarization","display_name":"mitochondrial depolarization","score":0.8190000057220459},{"id":"https://openalex.org/keywords/mitochondrial-swelling","display_name":"mitochondrial swelling","score":0.7459999918937683},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.7200000286102295},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C35341161","wikidata":"https://www.wikidata.org/wiki/Q289992","display_name":"Uniporter","level":4,"score":0.8811817169189453},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.7830280661582947},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5355498790740967},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5283154845237732},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4806862771511078},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3620991110801697},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2676791548728943},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23814299702644348},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17603519558906555},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1283722221851349},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.07770085334777832},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.06448227167129517},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016291","descriptor_name":"Dizocilpine Maleate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.expneurol.2019.113161","doi":"https://doi.org/10.1016/j.expneurol.2019.113161","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.expneurol.2019.113161","pdf_url":null,"source":{"id":"https://openalex.org/S165592611","display_name":"Experimental Neurology","issn_l":"0014-4886","issn":["0014-4886","1090-2430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Neurology","raw_type":"journal-article"},{"id":"pmid:31881218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31881218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental neurology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6957126","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6957126","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Exp Neurol","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt4qp3736m","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/4qp3736m","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7d42h92k","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7d42h92k","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Experimental Neurology, vol 325","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6957126","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6957126","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Exp Neurol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G197872212","display_name":"Mitochondrial Zn2+ accumulation in ischemic neuronal injury","funder_award_id":"16PRE29560003","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G5898468737","display_name":"Mitochondrial Zn2+ accumulation and the induction of ischemic neurodegeneration","funder_award_id":"R56NS100494","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7546727507","display_name":"Mitochondrial Zn2+ in ischemic neurodegeneration: In vivo tests of principle studies in a rat cardiac arrest model","funder_award_id":"R21NS096987","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8527422560","display_name":"Intramitochondrial Zn2+ accumulation and the induction of ischemic neurodegeneration","funder_award_id":"17GRNT33410181","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W157666778","https://openalex.org/W204294393","https://openalex.org/W1173363010","https://openalex.org/W1520819787","https://openalex.org/W1527191847","https://openalex.org/W1549264432","https://openalex.org/W1581055808","https://openalex.org/W1922083656","https://openalex.org/W1963709297","https://openalex.org/W1972176624","https://openalex.org/W1973113581","https://openalex.org/W1985584861","https://openalex.org/W1990557260","https://openalex.org/W1991647860","https://openalex.org/W1992177920","https://openalex.org/W2002480100","https://openalex.org/W2004007082","https://openalex.org/W2005641666","https://openalex.org/W2012887938","https://openalex.org/W2020622209","https://openalex.org/W2022940264","https://openalex.org/W2025392991","https://openalex.org/W2027064502","https://openalex.org/W2028452582","https://openalex.org/W2029107363","https://openalex.org/W2030560422","https://openalex.org/W2035213438","https://openalex.org/W2038443140","https://openalex.org/W2040150290","https://openalex.org/W2041254498","https://openalex.org/W2042274919","https://openalex.org/W2042550512","https://openalex.org/W2046423382","https://openalex.org/W2054119742","https://openalex.org/W2054566340","https://openalex.org/W2055473238","https://openalex.org/W2057520074","https://openalex.org/W2057726768","https://openalex.org/W2063336891","https://openalex.org/W2070085673","https://openalex.org/W2070802660","https://openalex.org/W2071213192","https://openalex.org/W2073160869","https://openalex.org/W2075876062","https://openalex.org/W2077122729","https://openalex.org/W2081115605","https://openalex.org/W2082469108","https://openalex.org/W2085273994","https://openalex.org/W2101826917","https://openalex.org/W2105202319","https://openalex.org/W2112696881","https://openalex.org/W2119983609","https://openalex.org/W2127394252","https://openalex.org/W2129426814","https://openalex.org/W2131437696","https://openalex.org/W2133569747","https://openalex.org/W2133739669","https://openalex.org/W2137530842","https://openalex.org/W2138861499","https://openalex.org/W2139748951","https://openalex.org/W2149684302","https://openalex.org/W2154231092","https://openalex.org/W2157179113","https://openalex.org/W2171521731","https://openalex.org/W2189144032","https://openalex.org/W2557537936","https://openalex.org/W2560262478","https://openalex.org/W2791453970","https://openalex.org/W2794437033","https://openalex.org/W2802598948","https://openalex.org/W2946874008","https://openalex.org/W4322703187"],"related_works":["https://openalex.org/W2070085673","https://openalex.org/W3045858610","https://openalex.org/W2063336891","https://openalex.org/W2794437033","https://openalex.org/W2587826581","https://openalex.org/W1520819787","https://openalex.org/W2078797635","https://openalex.org/W6908132514","https://openalex.org/W2027064502","https://openalex.org/W2980831385"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-01-10T00:00:00"}