{"id":"https://openalex.org/W2997706904","doi":null,"title":"Non-contrast imaging characteristics of papillary renal cell carcinoma: implications for diagnosis and subtyping.","display_name":"Non-contrast imaging characteristics of papillary renal cell carcinoma: implications for diagnosis and subtyping.","publication_year":2019,"publication_date":"2019-10-01","ids":{"openalex":"https://openalex.org/W2997706904","mag":"2997706904","pmid":"https://pubmed.ncbi.nlm.nih.gov/31629440"},"language":"en","primary_location":{"id":"pmid:31629440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31629440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Canadian journal of urology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064070676","display_name":"Anand V. Badri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anand V Badri","raw_affiliation_strings":["Division of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000457743","display_name":"Nikhil Waingankar","orcid":"https://orcid.org/0000-0003-4703-0074","observed_orcids":["https://orcid.org/0000-0003-4703-0074"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nikhil Waingankar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005858850","display_name":"Kristin W. Edwards","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristin Edwards","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091629756","display_name":"Alexander Kutikov","orcid":"https://orcid.org/0000-0003-1525-6247","observed_orcids":["https://orcid.org/0000-0003-1525-6247"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Kutikov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109210290","display_name":"Rosaleen B. Parsons","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosaleen B Parsons","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002111756","display_name":"David Y. Chen","orcid":"https://orcid.org/0000-0002-3681-6576","observed_orcids":["https://orcid.org/0000-0002-3681-6576","https://orcid.org/0009-0007-5537-9096"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Y Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080057051","display_name":"Marc C. Smaldone","orcid":"https://orcid.org/0000-0003-4160-0005","observed_orcids":["https://orcid.org/0000-0003-4160-0005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc C Smaldone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065101092","display_name":"Rosalia Viterbo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosalia Viterbo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075320625","display_name":"Richard Evan Greenberg","orcid":"https://orcid.org/0000-0002-8609-1307","observed_orcids":["https://orcid.org/0000-0002-8609-1307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard E Greenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5043554307","display_name":"Robert G. Uzzo","orcid":"https://orcid.org/0000-0003-2398-6530","observed_orcids":["https://orcid.org/0000-0003-2398-6530"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert G Uzzo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6714,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.68661118,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"26","issue":"5","first_page":"9916","last_page":"9921"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/papillary-renal-cell-carcinoma","display_name":"papillary renal cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/non-contrast-ct","display_name":"non-contrast CT","score":0.6909999847412109},{"id":"https://openalex.org/keywords/tumor-subtypes","display_name":"tumor subtypes","score":0.5040000081062317},{"id":"https://openalex.org/keywords/low-attenuation","display_name":"low attenuation","score":0.36899998784065247},{"id":"https://openalex.org/keywords/renal-tumor-diagnosis","display_name":"renal tumor diagnosis","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.924012303352356},{"id":"https://openalex.org/C2776531350","wikidata":"https://www.wikidata.org/wiki/Q16877679","display_name":"Papillary renal cell carcinomas","level":3,"score":0.6571007966995239},{"id":"https://openalex.org/C187954543","wikidata":"https://www.wikidata.org/wiki/Q1501273","display_name":"Hounsfield scale","level":3,"score":0.6563055515289307},{"id":"https://openalex.org/C83852419","wikidata":"https://www.wikidata.org/wiki/Q2713292","display_name":"Subtyping","level":2,"score":0.558790922164917},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.526888370513916},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.48026227951049805},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4707995653152466},{"id":"https://openalex.org/C184652730","wikidata":"https://www.wikidata.org/wiki/Q2357982","display_name":"Attenuation","level":2,"score":0.46549686789512634},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.4597513675689697},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4421805739402771},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.43261295557022095},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2874407470226288},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.17304745316505432},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:31629440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31629440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Canadian journal of urology","raw_type":"Journal Article"},{"id":"mag:2997706904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31629440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2996796031","https://openalex.org/W2604246790","https://openalex.org/W2891661826","https://openalex.org/W2593550662","https://openalex.org/W2163748372","https://openalex.org/W2142567952","https://openalex.org/W4391196929","https://openalex.org/W2810248280","https://openalex.org/W2460173197","https://openalex.org/W3094000252"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Current":[1],"radiographic":[2],"guidelines":[3],"suggest":[4,257],"unenhanced":[5,85],"renal":[6,26],"lesions":[7],"<":[8,198,207,233],"20":[9,92,158,262],"Hounsfield":[10],"Units":[11],"(HU)":[12],"are":[13],"overwhelmingly":[14],"benign,":[15,84],"requiring":[16],"no":[17],"further":[18],"evaluation.":[19],"We":[20,47,94],"evaluate":[21],"our":[22,49],"experience":[23],"with":[24,31,40,56,100,118,132,175,222],"papillary":[25,67],"cell":[27],"carcinoma":[28],"(pRCC)":[29],"presenting":[30],"low":[32,101,154,240,259],"pre-contrast":[33,155,185,212,243],"attenuation":[34,39,87,102,108,156,186,241,260],"and":[35,103,109,138],"the":[36,96,105,250],"relationship":[37,106],"of":[38,98,145,218,226],"histologic":[41],"pRCC":[42,60,99,110,147,219],"subtype.":[43,254],"MATERIALS":[44],"AND":[45],"METHODS:":[46],"reviewed":[48],"institutional":[50],"kidney":[51],"cancer":[52],"database":[53],"for":[54],"patients":[55,117],"pT1":[57],"or":[58],"pT2":[59],"between":[61,107],"2003-2017.":[62],"Tumors":[63],"were":[64,75,121,173],"categorized":[65],"by":[66,69],"subtype":[68,111,220],"expert":[70],"uropathologists.":[71],"Preoperative":[72],"CT":[73,267],"images":[74],"analyzed":[76],"at":[77],"six":[78],"regional":[79],"tumor":[80,124],"locations.":[81],"Low,":[82],"presumably":[83],"median":[86],"was":[88,126,214],"defined":[89],"as":[90,162,271],"\u2264":[91],"HU.":[93],"calculated":[95],"frequency":[97],"assessed":[104],"using":[112,164],"logistic":[113],"regression.":[114],"RESULTS:":[115],"Sixty-one":[116],"evaluable":[119],"imaging":[120,268],"included.":[122],"Median":[123],"size":[125],"6":[127],"cm":[128],"(1.7":[129],"cm-15.3":[130],"cm)":[131],"39%":[133],"(n":[134,140,149,170],"=":[135,141,150,171,230],"24)":[136,172],"type-1":[137,188],"61%":[139],"37)":[142],"type-2.":[143],"Half":[144],"all":[146],"tumors":[148,181],"30)":[151],"exhibited":[152],"very":[153,239],"(<":[157,261],"HU),":[159],"risking":[160],"misdiagnosis":[161],"benign":[163],"current":[165],"guidelines.":[166],"Of":[167],"these,":[168],"80%":[169],"type-2":[174,180,228,253],"significant":[176],"biological":[177],"potential.":[178],"Overall,":[179],"demonstrated":[182],"a":[183,223,272],"lower":[184,211],"than":[187],"(median":[189],"HU:":[190,201],"19.8":[191],"(1.5-42.3)":[192],"versus":[193,203],"29.6":[194],"HU":[195,213],"(10-45.8),":[196],"p":[197,206,232],"0.01;":[199],"max":[200],"25.3":[202],"36.5":[204],"HU,":[205],"0.01).":[208,234],"After":[209],"adjustment,":[210],"an":[215],"independent":[216],"predictor":[217],"associated":[221],"5.5-fold":[224],"increase":[225],"being":[227],"(OR":[229],"5.47,":[231],"CONCLUSION:":[235],"pRCCs":[236],"may":[237],"exhibit":[238],"on":[242,265],"CT.":[244],"This":[245],"appears":[246],"more":[247,251],"common":[248],"among":[249],"aggressive":[252],"These":[255],"data":[256],"that":[258],"HU)":[263],"alone":[264],"non-contrast":[266],"is":[269],"insufficient":[270],"single":[273],"parameter":[274],"to":[275],"rule":[276],"out":[277],"malignancy.":[278]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-01-10T00:00:00"}