{"id":"https://openalex.org/W2997699064","doi":null,"title":"A Randomized, Double-blind, Placebo-controlled, Parallel Study Evaluating the Efficacy of Bacillus subtilis MB40 to Reduce Abdominal Discomfort, Gas, and Bloating.","display_name":"A Randomized, Double-blind, Placebo-controlled, Parallel Study Evaluating the Efficacy of Bacillus subtilis MB40 to Reduce Abdominal Discomfort, Gas, and Bloating.","publication_year":2021,"publication_date":"2021-06-01","ids":{"openalex":"https://openalex.org/W2997699064","mag":"2997699064","pmid":"https://pubmed.ncbi.nlm.nih.gov/31719214"},"language":"en","primary_location":{"id":"pmid:31719214","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31719214","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alternative therapies in health and medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002300998","display_name":"Christopher Penet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Penet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Richard Kramer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Kramer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Robert Little","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Little","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033972889","display_name":"Jessica L. Spears","orcid":"https://orcid.org/0000-0002-7603-3509","observed_orcids":["https://orcid.org/0000-0002-7603-3509"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica L Spears","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Julia Parker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia Parker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Janaki K Iyer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janaki K Iyer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076559050","display_name":"Najla Guthrie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Najla Guthrie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5052687197","display_name":"Malkanthi Evans","orcid":"https://orcid.org/0000-0003-0832-677X","observed_orcids":["https://orcid.org/0000-0003-0832-677X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Malkanthi Evans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1145,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.72997082,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"27","issue":"S1","first_page":"146","last_page":"157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.3037000000476837,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.8640000224113464},{"id":"https://openalex.org/keywords/bloating","display_name":"bloating","score":0.9810000061988831},{"id":"https://openalex.org/keywords/abdominal-discomfort","display_name":"abdominal discomfort","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gas","display_name":"gases","score":0.7609999775886536},{"id":"https://openalex.org/keywords/dyspepsia","display_name":"dyspepsia","score":0.7639999985694885},{"id":"https://openalex.org/keywords/probiotic-supplementation","display_name":"probiotic supplementation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7009999752044678},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.7509999871253967},{"id":"https://openalex.org/keywords/gastrointestinal-symptoms","display_name":"gastrointestinal symptoms","score":0.5809999704360962},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.5709999799728394},{"id":"https://openalex.org/keywords/bowel-habits","display_name":"bowel habits","score":0.49000000953674316},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.6650000214576721},{"id":"https://openalex.org/keywords/healthy-adults","display_name":"healthy adults","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C2776956441","wikidata":"https://www.wikidata.org/wiki/Q4927059","display_name":"Bloating","level":3,"score":0.9702352285385132},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8194561004638672},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7917665243148804},{"id":"https://openalex.org/C2780955771","wikidata":"https://www.wikidata.org/wiki/Q183425","display_name":"Abdominal pain","level":2,"score":0.5859341025352478},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.5768581032752991},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5059654116630554},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49992966651916504},{"id":"https://openalex.org/C202061045","wikidata":"https://www.wikidata.org/wiki/Q7200267","display_name":"Placebo-controlled study","level":5,"score":0.4747767150402069},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.45654961466789246},{"id":"https://openalex.org/C108797546","wikidata":"https://www.wikidata.org/wiki/Q204015","display_name":"Defecation","level":2,"score":0.4222142696380615},{"id":"https://openalex.org/C2991744798","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blind","level":4,"score":0.257437527179718},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015746","descriptor_name":"Abdominal Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:31719214","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31719214","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alternative therapies in health and medicine","raw_type":"Journal Article"},{"id":"mag:2997699064","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31719214","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4407044989","https://openalex.org/W4307033705","https://openalex.org/W4416040747","https://openalex.org/W2550234422","https://openalex.org/W4414658404","https://openalex.org/W7123450038","https://openalex.org/W76664558","https://openalex.org/W4385406732","https://openalex.org/W1994832668","https://openalex.org/W4322763870"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Bloating":[1,97],"is":[2],"a":[3,13,34,77,91,100,108,169,296,306],"common":[4],"yet":[5],"poorly":[6],"managed":[7],"complaint":[8],"among":[9],"healthy":[10,47],"people,":[11],"with":[12,33,145,168,183,200,277],"complex":[14],"etiology":[15],"that":[16],"impacts":[17],"health":[18,301],"and":[19,29,44,96,107,146,152,156,179,191,204,219,282,319,325],"general":[20,300],"well-being.":[21],"The":[22],"study":[23],"intended":[24],"to":[25,61,115,230,287],"evaluate":[26],"the":[27,125,160,175,186,196,234,247,264,290],"efficacy":[28],"safety":[30],"of":[31,127,143,148,177,181,188,194,198,275,284,308],"supplementation":[32,255,304],"probiotic,":[35],"Bacillus":[36],"subtilis":[37],"MB40":[38,64,155,164,235,248,254,294,303],"(MB40),":[39],"on":[40,163],"bloating,":[41,149,185,281],"abdominal":[42,150,201,278],"discomfort,":[43,279],"gas":[45,153],"in":[46,134,138,174,233,246,271,299],"participants.":[48],"METHODS:":[49],"In":[50],"this":[51],"multi-center,":[52],"double-blind,":[53],"placebo-controlled,":[54],"parallel":[55],"trial,":[56],"100":[57],"participants":[58],"were":[59,118,130,225],"randomized":[60],"receive":[62],"either":[63],"at":[65,305],"5":[66,309],"\u00d7":[67,310],"109":[68,311],"colony":[69],"forming":[70],"units":[71],"(CFU;":[72],"n":[73],"=":[74,80,213,217,223,242],"50)":[75,81],"or":[76],"placebo":[78,157,173],"(n":[79],"once":[82],"daily":[83,139,313],"for":[84,314],"4-weeks.":[85],"Participants":[86],"completed":[87],"3":[88],"questionnaires":[89],"daily:":[90],"modified":[92,101],"Abdominal":[93],"Discomfort,":[94],"Gas,":[95],"(mADGB)":[98],"questionnaire,":[99],"Gastrointestinal":[102],"Symptoms":[103],"Rating":[104],"Scale":[105],"(mGSRS),":[106],"Bowel":[109],"Habits":[110],"Diary":[111],"(BHD).":[112],"Participants'":[113],"responses":[114],"each":[116],"question":[117],"combined":[119],"into":[120],"weekly":[121,136],"averages.":[122],"RESULTS:":[123],"At":[124,237],"end":[126],"4-weeks,":[128],"there":[129],"no":[131],"significant":[132,269],"differences":[133],"average":[135],"change":[137],"bloating":[140,260,272],"intensity,":[141,273],"number":[142,180,187,197,274],"days":[144,182,189,199,276],"duration":[147,192,283],"discomfort":[151,202],"between":[154],"groups.":[158],"However,":[159],"male":[161,265,291],"sub-group":[162,266,292],"achieved":[165],"clinical":[166],"thresholds":[167],"greater":[170],"decrease":[171],"over":[172],"intensity":[176],"(1.38)":[178],"(1.32)":[184,203],"(1.06)":[190],"(86-minutes)":[193],"gas,":[195,280,285],"diarrhea":[205],"symptom":[206],"score":[207],"(1.02).":[208],"Role":[209],"limitation":[210],"(physical;":[211],"P":[212],".026),":[214],"vitality":[215],"(P":[216,222,241],".034)":[218],"social":[220],"functioning":[221,240],".037)":[224],"significantly":[226,244,258],"improved":[227,245],"from":[228],"baseline":[229],"week":[231],"4":[232],"group.":[236],"2-weeks,":[238],"physical":[239],".017)":[243],"group":[249],"versus":[250],"placebo.":[251,288],"CONCLUSIONS:":[252],"Although":[253],"did":[256],"not":[257],"improve":[259],"across":[261],"all":[262,322],"populations,":[263],"demonstrated":[267],"clinically":[268],"reductions":[270],"compared":[286],"Additionally,":[289],"receiving":[293],"had":[295],"10%":[297],"improvement":[298],"score.":[302],"dose":[307],"CFU":[312],"4-weeks":[315],"was":[316],"also":[317],"safe":[318],"well-tolerated":[320],"as":[321],"biometric,":[323],"vital,":[324],"hematological":[326],"measures":[327],"remained":[328],"within":[329],"normal":[330],"laboratory":[331],"ranges":[332],"(Clinical":[333],"Trials":[334],"NCT02950012).":[335]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-01-10T00:00:00"}