{"id":"https://openalex.org/W2997629185","doi":"https://doi.org/10.1208/s12249-019-1585-7","title":"Role of Omega-3 Fatty Acids and Butter Oil in Targeting Delivery of Donepezil Hydrochloride Microemulsion to Brain via the Intranasal Route: a Comparative Study","display_name":"Role of Omega-3 Fatty Acids and Butter Oil in Targeting Delivery of Donepezil Hydrochloride Microemulsion to Brain via the Intranasal Route: a Comparative Study","publication_year":2020,"publication_date":"2020-01-03","ids":{"openalex":"https://openalex.org/W2997629185","doi":"https://doi.org/10.1208/s12249-019-1585-7","mag":"2997629185","pmid":"https://pubmed.ncbi.nlm.nih.gov/31900652"},"language":"en","primary_location":{"id":"doi:10.1208/s12249-019-1585-7","doi":"https://doi.org/10.1208/s12249-019-1585-7","is_oa":false,"landing_page_url":"https://doi.org/10.1208/s12249-019-1585-7","pdf_url":null,"source":{"id":"https://openalex.org/S1234972","display_name":"AAPS PharmSciTech","issn_l":"1530-9932","issn":["1530-9932"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AAPS PharmSciTech","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016791460","display_name":"Dignesh Khunt","orcid":"https://orcid.org/0000-0002-8850-7468","observed_orcids":["https://orcid.org/0000-0002-8850-7468"]},"institutions":[{"id":"https://openalex.org/I4210102411","display_name":"National Institute of Pharmaceutical Education and Research - Ahmedabad","ror":"https://ror.org/01dphnv87","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210102411"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Dignesh Khunt","raw_affiliation_strings":["Department of Pharmaceutics, NIPER-Ahmedabad, Palaj, Opp. Airforce station Headquarter, Gandhinagar, Gujarat, 382355, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, NIPER-Ahmedabad, Palaj, Opp. Airforce station Headquarter, Gandhinagar, Gujarat, 382355, India","institution_ids":["https://openalex.org/I4210102411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084331577","display_name":"Meenakshee Shrivas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102411","display_name":"National Institute of Pharmaceutical Education and Research - Ahmedabad","ror":"https://ror.org/01dphnv87","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210102411"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Meenakshee Shrivas","raw_affiliation_strings":["Department of Pharmaceutics, NIPER-Ahmedabad, Palaj, Opp. Airforce station Headquarter, Gandhinagar, Gujarat, 382355, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, NIPER-Ahmedabad, Palaj, Opp. Airforce station Headquarter, Gandhinagar, Gujarat, 382355, India","institution_ids":["https://openalex.org/I4210102411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069208272","display_name":"Suryanarayana Polaka","orcid":"https://orcid.org/0000-0001-7053-9392","observed_orcids":["https://orcid.org/0000-0001-7053-9392"]},"institutions":[{"id":"https://openalex.org/I4210102411","display_name":"National Institute of Pharmaceutical Education and Research - Ahmedabad","ror":"https://ror.org/01dphnv87","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210102411"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Suryanarayana Polaka","raw_affiliation_strings":["Department of Pharmaceutics, NIPER-Ahmedabad, Palaj, Opp. Airforce station Headquarter, Gandhinagar, Gujarat, 382355, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, NIPER-Ahmedabad, Palaj, Opp. Airforce station Headquarter, Gandhinagar, Gujarat, 382355, India","institution_ids":["https://openalex.org/I4210102411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041054709","display_name":"Piyush Gondaliya","orcid":"https://orcid.org/0000-0003-3590-5785","observed_orcids":["https://orcid.org/0000-0003-3590-5785"]},"institutions":[{"id":"https://openalex.org/I4210102411","display_name":"National Institute of Pharmaceutical Education and Research - Ahmedabad","ror":"https://ror.org/01dphnv87","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210102411"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Piyush Gondaliya","raw_affiliation_strings":["Department of Biotechnology, NIPER-Ahmedabad, Gandhinagar, Gujarat, 382355, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, NIPER-Ahmedabad, Gandhinagar, Gujarat, 382355, India","institution_ids":["https://openalex.org/I4210102411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090475312","display_name":"Manju Misra","orcid":"https://orcid.org/0000-0002-5907-4659","observed_orcids":["https://orcid.org/0000-0002-5907-4659"]},"institutions":[{"id":"https://openalex.org/I4210102411","display_name":"National Institute of Pharmaceutical Education and Research - Ahmedabad","ror":"https://ror.org/01dphnv87","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210102411"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Manju Misra","raw_affiliation_strings":["Department of Pharmaceutics, NIPER-Ahmedabad, Palaj, Opp. Airforce station Headquarter, Gandhinagar, Gujarat, 382355, India. mmisraniper@yahoo.com","Department of Pharmaceutics, NIPER-Ahmedabad, Palaj, Opp. Airforce station Headquarter, Gandhinagar, Gujarat, 382355, India"],"raw_orcid":"https://orcid.org/0000-0002-5907-4659","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, NIPER-Ahmedabad, Palaj, Opp. Airforce station Headquarter, Gandhinagar, Gujarat, 382355, India. mmisraniper@yahoo.com","institution_ids":["https://openalex.org/I4210102411"]},{"raw_affiliation_string":"Department of Pharmaceutics, NIPER-Ahmedabad, Palaj, Opp. Airforce station Headquarter, Gandhinagar, Gujarat, 382355, India","institution_ids":["https://openalex.org/I4210102411"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016791460","https://openalex.org/A5041054709","https://openalex.org/A5069208272","https://openalex.org/A5084331577","https://openalex.org/A5090475312"],"corresponding_institution_ids":["https://openalex.org/I4210102411"],"apc_list":{"value":3260,"currency":"USD","value_usd":3260},"apc_paid":null,"fwci":3.0333,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.91742342,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"21","issue":"2","first_page":"45","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/donepezil-hydrochloride","display_name":"donepezil hydrochloride","score":0.9800000190734863},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.8489999771118164},{"id":"https://openalex.org/keywords/butter-oil","display_name":"butter oil","score":0.9259999990463257},{"id":"https://openalex.org/keywords/fish-oil","display_name":"fish oil","score":0.9950000047683716},{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.9010000228881836},{"id":"https://openalex.org/keywords/drug-delivery-to-the-brain","display_name":"brain drug delivery","score":0.7419999837875366},{"id":"https://openalex.org/keywords/microemulsions","display_name":"microemulsions","score":0.890999972820282},{"id":"https://openalex.org/keywords/nasal-permeability","display_name":"nasal permeability","score":0.8090000152587891},{"id":"https://openalex.org/keywords/brain-bioavailability","display_name":"brain bioavailability","score":0.7120000123977661},{"id":"https://openalex.org/keywords/globule-size","display_name":"globule size","score":0.7409999966621399},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7239999771118164},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9070000052452087}],"concepts":[{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.8323231935501099},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7216073870658875},{"id":"https://openalex.org/C190119865","wikidata":"https://www.wikidata.org/wiki/Q338019","display_name":"Microemulsion","level":3,"score":0.6916322112083435},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.6650718450546265},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5669307708740234},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.42297428846359253},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41944634914398193},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.2977645993232727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07770827412605286},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0769924521446228},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067048","descriptor_name":"Ghee","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077265","descriptor_name":"Donepezil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004655","descriptor_name":"Emulsions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015525","descriptor_name":"Fatty Acids, Omega-3","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1208/s12249-019-1585-7","doi":"https://doi.org/10.1208/s12249-019-1585-7","is_oa":false,"landing_page_url":"https://doi.org/10.1208/s12249-019-1585-7","pdf_url":null,"source":{"id":"https://openalex.org/S1234972","display_name":"AAPS PharmSciTech","issn_l":"1530-9932","issn":["1530-9932"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AAPS PharmSciTech","raw_type":"journal-article"},{"id":"pmid:31900652","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31900652","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AAPS PharmSciTech","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1149736171","https://openalex.org/W1515777772","https://openalex.org/W1518881239","https://openalex.org/W1608805670","https://openalex.org/W2028868188","https://openalex.org/W2044337739","https://openalex.org/W2049526451","https://openalex.org/W2061113234","https://openalex.org/W2062034516","https://openalex.org/W2067790699","https://openalex.org/W2106536537","https://openalex.org/W2124228085","https://openalex.org/W2346140805","https://openalex.org/W2381160200","https://openalex.org/W2462234872","https://openalex.org/W2583052788","https://openalex.org/W2584693724","https://openalex.org/W2613051711","https://openalex.org/W2776146933","https://openalex.org/W2784266022","https://openalex.org/W2883488123","https://openalex.org/W2890576426","https://openalex.org/W2903517662","https://openalex.org/W2904948652","https://openalex.org/W2913404400","https://openalex.org/W2922048127","https://openalex.org/W2938566593","https://openalex.org/W2942970434","https://openalex.org/W3116551730","https://openalex.org/W6633679168"],"related_works":["https://openalex.org/W2613051711","https://openalex.org/W3011603932","https://openalex.org/W3013637835","https://openalex.org/W2091322268","https://openalex.org/W2782024058","https://openalex.org/W2235679952","https://openalex.org/W7155392277","https://openalex.org/W2074931859","https://openalex.org/W4366163678","https://openalex.org/W7201838012"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-01-10T00:00:00"}