{"id":"https://openalex.org/W2997597802","doi":"https://doi.org/10.25083/rbl/24.6/1000.1007","title":"Internal Validation of the Methods for Determination of Water-Soluble Vitamins from Frozen Fruits by HPLC-HRMS","display_name":"Internal Validation of the Methods for Determination of Water-Soluble Vitamins from Frozen Fruits by HPLC-HRMS","publication_year":2019,"publication_date":"2019-12-24","ids":{"openalex":"https://openalex.org/W2997597802","doi":"https://doi.org/10.25083/rbl/24.6/1000.1007","mag":"2997597802"},"language":"en","primary_location":{"id":"doi:10.25083/rbl/24.6/1000.1007","doi":"https://doi.org/10.25083/rbl/24.6/1000.1007","is_oa":true,"landing_page_url":"https://doi.org/10.25083/rbl/24.6/1000.1007","pdf_url":"https://doi.org/10.25083/rbl/24.6/1000.1007","source":{"id":"https://openalex.org/S39127591","display_name":"ROMANIAN BIOTECHNOLOGICAL LETTERS","issn_l":"1224-5984","issn":["1224-5984","2248-3942"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310314624","host_organization_name":"University of Bucharest","host_organization_lineage":["https://openalex.org/P4310314624"],"host_organization_lineage_names":["University of Bucharest"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian Biotechnological Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.25083/rbl/24.6/1000.1007","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030647443","display_name":"ADRIAN CONSTANTIN AS\u0102NIC\u0102","orcid":"https://orcid.org/0000-0002-3043-1499","observed_orcids":["https://orcid.org/0000-0002-3043-1499"]},"institutions":[{"id":"https://openalex.org/I2801529014","display_name":"University of Agronomic Sciences and Veterinary Medicine of Bucharest","ror":"https://ror.org/04rssyw40","country_code":"RO","type":"education","lineage":["https://openalex.org/I2801529014"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"ADRIAN CONSTANTIN AS\u0102NIC\u0102","raw_affiliation_strings":["University of Agronomic Sciences and Veterinary Medicine of Bucharest, Faculty of Horticulture, 59 Marasti Blvd, District 1, 011464, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Agronomic Sciences and Veterinary Medicine of Bucharest, Faculty of Horticulture, 59 Marasti Blvd, District 1, 011464, Bucharest, Romania","institution_ids":["https://openalex.org/I2801529014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044400862","display_name":"Lumini\u021ba Catan\u0103","orcid":"https://orcid.org/0000-0002-4093-6693","observed_orcids":["https://orcid.org/0000-0002-4093-6693"]},"institutions":[{"id":"https://openalex.org/I4210109653","display_name":"National Research & Development Institute for Food Bioresources \u2012 IBA Bucharest","ror":"https://ror.org/01q2zc414","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210109653"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"LUMINI\u021aA CATAN\u0102","raw_affiliation_strings":["National Research and Development Institute for Food Bioresources -IBA Bucharest, 6 Dinu Vintila Street, 021102, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research and Development Institute for Food Bioresources -IBA Bucharest, 6 Dinu Vintila Street, 021102, Bucharest, Romania","institution_ids":["https://openalex.org/I4210109653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031698388","display_name":"Monica Catana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109653","display_name":"National Research & Development Institute for Food Bioresources \u2012 IBA Bucharest","ror":"https://ror.org/01q2zc414","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210109653"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"MONICA CATAN\u0102","raw_affiliation_strings":["National Research and Development Institute for Food Bioresources -IBA Bucharest, 6 Dinu Vintila Street, 021102, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research and Development Institute for Food Bioresources -IBA Bucharest, 6 Dinu Vintila Street, 021102, Bucharest, Romania","institution_ids":["https://openalex.org/I4210109653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005885885","display_name":"Anda-Gratiela Burnete","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109653","display_name":"National Research & Development Institute for Food Bioresources \u2012 IBA Bucharest","ror":"https://ror.org/01q2zc414","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210109653"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"ANDA GRA\u021aIELA BURNETE","raw_affiliation_strings":["National Research and Development Institute for Food Bioresources -IBA Bucharest, 6 Dinu Vintila Street, 021102, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research and Development Institute for Food Bioresources -IBA Bucharest, 6 Dinu Vintila Street, 021102, Bucharest, Romania","institution_ids":["https://openalex.org/I4210109653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056649755","display_name":"Monica Alexandra Lazar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109653","display_name":"National Research & Development Institute for Food Bioresources \u2012 IBA Bucharest","ror":"https://ror.org/01q2zc414","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210109653"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"MONICA ALEXANDRA LAZ\u0102R","raw_affiliation_strings":["National R&D Institute for Food Bioresources IBA Bucharest , 6 Dinu Vintil\u0103 Street , District 2 , 021102 , Bucharest , Romania","National Research and Development Institute for Food Bioresources -IBA Bucharest, 6 Dinu Vintila Street, 021102, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National R&D Institute for Food Bioresources IBA Bucharest , 6 Dinu Vintil\u0103 Street , District 2 , 021102 , Bucharest , Romania","institution_ids":["https://openalex.org/I4210109653"]},{"raw_affiliation_string":"National Research and Development Institute for Food Bioresources -IBA Bucharest, 6 Dinu Vintila Street, 021102, Bucharest, Romania","institution_ids":["https://openalex.org/I4210109653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024489548","display_name":"Nastasia Belc","orcid":"https://orcid.org/0000-0002-8732-4539","observed_orcids":["https://orcid.org/0000-0002-8732-4539"]},"institutions":[{"id":"https://openalex.org/I4210109653","display_name":"National Research & Development Institute for Food Bioresources \u2012 IBA Bucharest","ror":"https://ror.org/01q2zc414","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210109653"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"NASTASIA BELC","raw_affiliation_strings":["National Research and Development Institute for Food Bioresources -IBA Bucharest , 6 Dinu Vintila Street , 021102 , Bucharest , Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research and Development Institute for Food Bioresources -IBA Bucharest , 6 Dinu Vintila Street , 021102 , Bucharest , Romania","institution_ids":["https://openalex.org/I4210109653"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075568482","display_name":"A. Mart\u00ednez Sanmart\u00edn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123090","display_name":"Centro Tecnol\u00f3gico Nacional de la Conserva y Alimentaci\u00f3n","ror":"https://ror.org/034dp0092","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210123090"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"ANGEL MART\u00cdNEZ SANMARTIN","raw_affiliation_strings":["Centro Tecnol\u00f3gico Nacional de la Conserva y Alimentaci\u00f3n, Calle Concordia s/n. 30500. Molina de Segura Murcia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Tecnol\u00f3gico Nacional de la Conserva y Alimentaci\u00f3n, Calle Concordia s/n. 30500. Molina de Segura Murcia, Spain","institution_ids":["https://openalex.org/I4210123090"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1586,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.46368715,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"24","issue":"6","first_page":"1000","last_page":"1007"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14127","display_name":"Food Nutrient Composition and Product Development","score":0.6797000169754028,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14127","display_name":"Food Nutrient Composition and Product Development","score":0.6797000169754028,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.19120000302791595,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11423","display_name":"Pesticide Residue Analysis and Safety","score":0.05400000140070915,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/water-soluble-vitamins","display_name":"water-soluble vitamins","score":0.9990000128746033},{"id":"https://openalex.org/keywords/frozen-fruit","display_name":"frozen fruit","score":0.9359999895095825},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9559999704360962},{"id":"https://openalex.org/keywords/b-vitamins","display_name":"B vitamins","score":0.8849999904632568},{"id":"https://openalex.org/keywords/riboflavin","display_name":"riboflavin","score":0.7829999923706055},{"id":"https://openalex.org/keywords/pantothenic-acid","display_name":"pantothenic acid","score":0.9919999837875366},{"id":"https://openalex.org/keywords/vitamin-b6","display_name":"vitamin B6","score":1.0},{"id":"https://openalex.org/keywords/biotin","display_name":"biotin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/method-validation","display_name":"method validation","score":0.6690000295639038},{"id":"https://openalex.org/keywords/hplc-hrms","display_name":"HPLC-HRMS","score":0.8579999804496765},{"id":"https://openalex.org/keywords/aronia-melanocarpa","display_name":"Aronia melanocarpa","score":0.7350000143051147},{"id":"https://openalex.org/keywords/strawberry","display_name":"strawberry","score":0.8970000147819519},{"id":"https://openalex.org/keywords/vitamin-extraction","display_name":"vitamin extraction","score":0.5249999761581421},{"id":"https://openalex.org/keywords/internal-standard","display_name":"internal standard","score":0.43799999356269836},{"id":"https://openalex.org/keywords/food-analysis","display_name":"food analysis","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9216133952140808},{"id":"https://openalex.org/C2777379063","wikidata":"https://www.wikidata.org/wiki/Q161233","display_name":"Formic acid","level":2,"score":0.8754005432128906},{"id":"https://openalex.org/C2775986502","wikidata":"https://www.wikidata.org/wiki/Q420466","display_name":"Ammonium formate","level":3,"score":0.8432188034057617},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.8146442174911499},{"id":"https://openalex.org/C2780178953","wikidata":"https://www.wikidata.org/wiki/Q2001841","display_name":"Formate","level":3,"score":0.6191578507423401},{"id":"https://openalex.org/C40684141","wikidata":"https://www.wikidata.org/wiki/Q902061","display_name":"Electrospray ionization","level":3,"score":0.5338066220283508},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5336350202560425},{"id":"https://openalex.org/C2780548424","wikidata":"https://www.wikidata.org/wiki/Q412803","display_name":"Hippuric acid","level":3,"score":0.512755274772644},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.4921106696128845},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.45247992873191833},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.11698481440544128},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0780201256275177},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.25083/rbl/24.6/1000.1007","doi":"https://doi.org/10.25083/rbl/24.6/1000.1007","is_oa":true,"landing_page_url":"https://doi.org/10.25083/rbl/24.6/1000.1007","pdf_url":"https://doi.org/10.25083/rbl/24.6/1000.1007","source":{"id":"https://openalex.org/S39127591","display_name":"ROMANIAN BIOTECHNOLOGICAL LETTERS","issn_l":"1224-5984","issn":["1224-5984","2248-3942"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310314624","host_organization_name":"University of Bucharest","host_organization_lineage":["https://openalex.org/P4310314624"],"host_organization_lineage_names":["University of Bucharest"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian Biotechnological Letters","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.25083/rbl/24.6/1000.1007","doi":"https://doi.org/10.25083/rbl/24.6/1000.1007","is_oa":true,"landing_page_url":"https://doi.org/10.25083/rbl/24.6/1000.1007","pdf_url":"https://doi.org/10.25083/rbl/24.6/1000.1007","source":{"id":"https://openalex.org/S39127591","display_name":"ROMANIAN BIOTECHNOLOGICAL LETTERS","issn_l":"1224-5984","issn":["1224-5984","2248-3942"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310314624","host_organization_name":"University of Bucharest","host_organization_lineage":["https://openalex.org/P4310314624"],"host_organization_lineage_names":["University of Bucharest"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian Biotechnological Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6735000014305115,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4864199281","display_name":null,"funder_award_id":"PN- III -P1-1","funder_id":"https://openalex.org/F4320323983","funder_display_name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii"},{"id":"https://openalex.org/G788691142","display_name":null,"funder_award_id":"PN-III-P1-1.2-PCCDI","funder_id":"https://openalex.org/F4320323983","funder_display_name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii"}],"funders":[{"id":"https://openalex.org/F4320323983","display_name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","ror":"https://ror.org/01q7jq182"},{"id":"https://openalex.org/F4320336189","display_name":"Colegiul Consultativ pentru Cercetare-Dezvoltare \u015fi Inovare","ror":"https://ror.org/03mc0m715"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2997597802.pdf","grobid_xml":"https://content.openalex.org/works/W2997597802.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W171584737","https://openalex.org/W1986276463","https://openalex.org/W2005098299","https://openalex.org/W2030549846","https://openalex.org/W2082212045","https://openalex.org/W2083068652","https://openalex.org/W2149867743","https://openalex.org/W2168750598","https://openalex.org/W2312357129","https://openalex.org/W4301817314","https://openalex.org/W6960235643"],"related_works":["https://openalex.org/W7032896028","https://openalex.org/W2944797524","https://openalex.org/W2886691376","https://openalex.org/W7136044093","https://openalex.org/W7017979344","https://openalex.org/W2766270314","https://openalex.org/W4384938008","https://openalex.org/W3120213873","https://openalex.org/W4414376997","https://openalex.org/W6977268111"],"abstract_inverted_index":{"The":[0],"analytical":[1],"methods":[2,161,184],"were":[3,75,202],"developed":[4,199],"and":[5,10,19,48,71,111,129,139,171,180,200,224,240],"validated":[6,201],"for":[7,192,204],"separation,":[8],"detection":[9],"quantification":[11],"of":[12,35,50,96,206,210,250],"water-soluble":[13,193,207],"vitamins":[14,52,70,141,175,194,208],"(C,":[15],"B2,":[16],"B5,":[17],"B6":[18,242],"B7)":[20],"from":[21,260],"frozen":[22,197,211,226,252],"fruits":[23,215,253],"by":[24],"high":[25,31],"performance":[26],"liquid":[27],"chromatography":[28],"coupled":[29],"with":[30],"resolution":[32],"mass":[33],"spectrometry.Extraction":[34],"vitamin":[36,219,230,235,241,247],"C":[37,126,220],"was":[38,61,127,153,257],"achieved":[39,62],"in":[40,53,131,142,196],"0.1%":[41,54],"formic":[42,55,108,123],"acid":[43,56,73,109,124,150],"solution":[44,57],"at":[45,58],"room":[46],"temperature,":[47],"extraction":[49],"B-group":[51,140],"70\u00b0C.Extracts":[59],"purification":[60],"on":[63,77],"SPE":[64],"C18":[65,80],"cartridges,":[66],"500":[67],"mg/3":[68],"mL.Water-soluble":[69],"hippuric":[72],"(IS)":[74],"separated":[76],"a":[78,163,186],"reverse-phase":[79],"Hypersil":[81],"GOLD":[82],"aQ":[83],"150":[84],"x":[85],"2.1":[86],"mm,":[87],"3":[88],"\u03bcm":[89],"particle":[90],"size,":[91],"using":[92],"mobile":[93],"phases":[94],"consisting":[95],"995":[97,112],"mL":[98,102,107,113,117,122],"water":[99],"LC-MS,":[100,115],"5":[101,116],"2M":[103,118],"ammonium":[104,119],"formate,":[105,120],"1":[106,121],"(A)":[110],"metanol":[114],"(B).Vitamin":[125],"detected":[128,154],"quantified":[130],"the":[132,143,156,217,225,228,251],"Electrospray":[133,144],"Ionization":[134,145],"negative":[135],"ion":[136,147,159],"mode":[137,148],"(ESI-),":[138],"positive":[146],"(ESI+).Hippuric":[149],"(internal":[151],"standard)":[152],"both":[155],"ESI-and":[157],"ESI+":[158],"modes.The":[160],"have":[162,216],"good":[164,187],"sensitivity":[165],"(vitamin":[166],"C:":[167],"LOD":[168,177],"=":[169,173,178,182],"340.32\u03bcg/L":[170],"LOQ":[172,181],"1031.27\u03bcg/L;":[174],"B:":[176],"0.862-8.451\u03bcg/L":[179],"2.585-25.355\u03bcg/L).The":[183],"showed":[185],"precision,":[188],"RSD":[189],"<":[190],"10%":[191],"analysis":[195],"fruits.Methods":[198],"applied":[203],"determination":[205],"content":[209,221,232,237,243,249],"fruits.Frozen":[212],"Aronia":[213],"melanocarpa":[214],"highest":[218,229],"(39.785":[222],"mg/100g),":[223],"strawberries":[227],"B2":[231],"(1.735":[233],"mg/kg),":[234,245],"B5":[236],"(3.703":[238],"mg/kg)":[239],"(3.553":[244],"respectively.The":[246],"B7":[248],"taken":[254],"into":[255],"study":[256],"low,":[258],"ranging":[259],"0.375":[261],"to":[262],"0.615":[263],"mg/100g.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-01-10T00:00:00"}