{"id":"https://openalex.org/W2997550312","doi":"https://doi.org/10.1096/fj.201901901r","title":"Maternal regulation of SATB2 in osteo\u2010progeniters impairs skeletal development in offspring","display_name":"Maternal regulation of SATB2 in osteo\u2010progeniters impairs skeletal development in offspring","publication_year":2019,"publication_date":"2019-12-23","ids":{"openalex":"https://openalex.org/W2997550312","doi":"https://doi.org/10.1096/fj.201901901r","mag":"2997550312","pmid":"https://pubmed.ncbi.nlm.nih.gov/31908011"},"language":"en","primary_location":{"id":"doi:10.1096/fj.201901901r","doi":"https://doi.org/10.1096/fj.201901901r","is_oa":true,"landing_page_url":"https://doi.org/10.1096/fj.201901901r","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.201901901R","source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.201901901R","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000727397","display_name":"Jin\u2010Ran Chen","orcid":"https://orcid.org/0000-0001-6984-5878","observed_orcids":["https://orcid.org/0000-0001-6984-5878"]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jin\u2010Ran Chen","raw_affiliation_strings":["Arkansas Children's Nutrition Center, Little Rock, AR, USA","Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, Little Rock, AR, USA","institution_ids":["https://openalex.org/I4210146069"]},{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101585008","display_name":"Haijun Zhao","orcid":"https://orcid.org/0000-0002-4031-8895","observed_orcids":["https://orcid.org/0000-0002-4031-8895"]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haijun Zhao","raw_affiliation_strings":["Arkansas Children's Nutrition Center, Little Rock, AR, USA","Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, Little Rock, AR, USA","institution_ids":["https://openalex.org/I4210146069"]},{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015737319","display_name":"Oxana P. Lazarenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oxana P. Lazarenko","raw_affiliation_strings":["Arkansas Children's Nutrition Center, Little Rock, AR, USA","Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, Little Rock, AR, USA","institution_ids":["https://openalex.org/I4210146069"]},{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064881126","display_name":"Michael L. Blackburn","orcid":"https://orcid.org/0000-0002-4126-3750","observed_orcids":["https://orcid.org/0000-0002-4126-3750"]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Blackburn","raw_affiliation_strings":["Arkansas Children's Nutrition Center, Little Rock, AR, USA","Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, Little Rock, AR, USA","institution_ids":["https://openalex.org/I4210146069"]},{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035081477","display_name":"Kartik Shankar","orcid":"https://orcid.org/0000-0002-7964-9026","observed_orcids":["https://orcid.org/0000-0002-7964-9026"]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kartik Shankar","raw_affiliation_strings":["Arkansas Children's Nutrition Center, Little Rock, AR, USA","Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, Little Rock, AR, USA","institution_ids":["https://openalex.org/I4210146069"]},{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000727397"],"corresponding_institution_ids":["https://openalex.org/I4210146069","https://openalex.org/I79620101"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":{"value":3740,"currency":"USD","value_usd":3740},"fwci":1.8155,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.84726403,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"34","issue":"2","first_page":"2511","last_page":"2523"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.49540001153945923,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.49540001153945923,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.4440999925136566,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maternal-obesity","display_name":"maternal obesity","score":0.9160000085830688},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8289999961853027},{"id":"https://openalex.org/keywords/satb2","display_name":"SATB2","score":0.8069999814033508},{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.9390000104904175},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.800000011920929},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/fetal-skeletal-development","display_name":"fetal bone development","score":0.7590000033378601},{"id":"https://openalex.org/keywords/trabecular-bone-mass","display_name":"trabecular bone mass","score":0.8410000205039978},{"id":"https://openalex.org/keywords/polycomb-repressive-complex","display_name":"polycomb repressive complex","score":0.6299999952316284},{"id":"https://openalex.org/keywords/developmental-programming","display_name":"developmental programming","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.7308505773544312},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6810808181762695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.620717465877533},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5839579701423645},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5768988728523254},{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.5492768287658691},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.514621376991272},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.4810360074043274},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4712196886539459},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37676867842674255},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16447925567626953},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.1528213620185852},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1365737020969391},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1304161250591278},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.12363305687904358},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.05938330292701721}],"mesh":[{"descriptor_ui":"D000079262","descriptor_name":"Pregnancy in Obesity","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D000079262","descriptor_name":"Pregnancy in Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000079262","descriptor_name":"Pregnancy in Obesity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D036961","descriptor_name":"Matrix Attachment Region Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D041641","descriptor_name":"Musculoskeletal Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1096/fj.201901901r","doi":"https://doi.org/10.1096/fj.201901901r","is_oa":true,"landing_page_url":"https://doi.org/10.1096/fj.201901901r","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.201901901R","source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmid:31908011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31908011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1096/fj.201901901r","doi":"https://doi.org/10.1096/fj.201901901r","is_oa":true,"landing_page_url":"https://doi.org/10.1096/fj.201901901r","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.201901901R","source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1363709718","display_name":null,"funder_award_id":"6026-51000-01005S","funder_id":"https://openalex.org/F4320332605","funder_display_name":"Agricultural Research Service"},{"id":"https://openalex.org/G3511223801","display_name":null,"funder_award_id":"6026\u25a151000\u25a1010\u25a105S","funder_id":"https://openalex.org/F4320306114","funder_display_name":"U.S. Department of Agriculture"}],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320332605","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2997550312.pdf","grobid_xml":"https://content.openalex.org/works/W2997550312.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W85290381","https://openalex.org/W86264492","https://openalex.org/W989040778","https://openalex.org/W1144202826","https://openalex.org/W1553969934","https://openalex.org/W1555699174","https://openalex.org/W1815726862","https://openalex.org/W1976663122","https://openalex.org/W2015132841","https://openalex.org/W2018113993","https://openalex.org/W2030377420","https://openalex.org/W2031675290","https://openalex.org/W2040798120","https://openalex.org/W2045852033","https://openalex.org/W2050385053","https://openalex.org/W2052048413","https://openalex.org/W2068633908","https://openalex.org/W2083321610","https://openalex.org/W2089817928","https://openalex.org/W2095573967","https://openalex.org/W2106694682","https://openalex.org/W2112655992","https://openalex.org/W2122367477","https://openalex.org/W2123061802","https://openalex.org/W2140146894","https://openalex.org/W2141229724","https://openalex.org/W2143847855","https://openalex.org/W2157422767","https://openalex.org/W2160101394","https://openalex.org/W2160403269","https://openalex.org/W2160418500","https://openalex.org/W2167215996","https://openalex.org/W2168341804","https://openalex.org/W2280551993","https://openalex.org/W2523447198","https://openalex.org/W2530805564","https://openalex.org/W2582073651","https://openalex.org/W2584939126","https://openalex.org/W2605058663","https://openalex.org/W2732676223","https://openalex.org/W2754413322","https://openalex.org/W2807923763","https://openalex.org/W2883033946"],"related_works":["https://openalex.org/W2951203122","https://openalex.org/W2883033946","https://openalex.org/W852318413","https://openalex.org/W4292255371","https://openalex.org/W4254310471","https://openalex.org/W2095573967","https://openalex.org/W3175588548","https://openalex.org/W7100441331","https://openalex.org/W2523447198","https://openalex.org/W2491890558"],"abstract_inverted_index":{"Abstract":[0],"Nutritional":[1],"status":[2],"during":[3],"intrauterine":[4],"and/or":[5],"early":[6],"postnatal":[7],"life":[8],"has":[9],"substantial":[10],"influence":[11],"on":[12,47,126],"adult":[13],"offspring":[14],"health.":[15],"Along":[16],"these":[17],"lines,":[18],"there":[19],"is":[20],"a":[21,131],"growing":[22],"body":[23],"of":[24,44,76,85,97,110,124,129,140,239],"evidence":[25],"illustrating":[26],"that":[27,116,186,223],"high":[28],"fat":[29],"diet":[30],"(HFD)\u2010induced":[31],"maternal":[32,45,55,224],"obesity":[33,46,56,226],"can":[34],"regulate":[35],"fetal":[36,49,232],"bone":[37,199],"development.":[38],"Thus,":[39],"we":[40],"investigated":[41],"the":[42,98,105,127],"effects":[43],"both":[48],"skeletal":[50],"development":[51],"and":[52,144,155,174,180,189,196],"mechanisms":[53],"linking":[54],"to":[57,87],"osteoblast":[58,137],"differentiation":[59,84],"in":[60,142,153,176,194],"offspring.":[61],"Embryonic":[62],"osteogenic":[63],"calvarial":[64],"cells":[65,146,157,177],"(EOCCs)":[66],"were":[67,163,192],"isolated":[68],"from":[69,90,178,201,215],"fetuses":[70],"at":[71],"gestational":[72],"day":[73],"18.5":[74],"(E18.5)":[75],"HFD\u2010induced":[77,225],"obese":[78,92],"rat":[79],"dams.":[80,93],"We":[81,182],"observed":[82],"impaired":[83],"EOCCs":[86,143,154],"mature":[88],"osteoblasts":[89],"HFD":[91],"ChIP\u2010seq\u2010based":[94],"genome\u2010wide":[95],"localization":[96],"repressive":[99],"histone":[100,107],"mark":[101],"H3K27me3":[102,125],"(mediated":[103],"via":[104,242],"polycomb":[106],"methyltransferase,":[108],"enhancer":[109],"zeste":[111],"homologue":[112],"2":[113],"[Ezh2])":[114],"showed":[115],"this":[117],"phenotype":[118],"was":[119],"associated":[120,229],"with":[121,165,213,230],"increased":[122,147,193,197],"enrichment":[123],"gene":[128],"SATB2,":[130],"critical":[132],"transcription":[133],"factor":[134],"required":[135],"for":[136],"differentiation.":[138],"Knockdown":[139],"Ezh2":[141,151,204],"ST2":[145,156],"SATB2":[148,159,175,187,240],"expression;":[149],"while":[150],"overexpression":[152],"decreased":[158],"expression.":[160],"These":[161,220],"data":[162],"consistent":[164],"experimental":[166],"results":[167],"showing":[168],"strong":[169],"association":[170],"between":[171],"H3K27me3,":[172],"Ezh2,":[173],"rats":[179],"humans.":[181],"have":[183],"further":[184],"presented":[185],"mRNA":[188],"protein":[190],"expression":[191,241],"bones,":[195],"trabecular":[198],"mass":[200],"pre\u2010osteoblast":[202],"specific":[203],"deletion":[205],"(Ezh2":[206],"flox/flox":[207],"Osx\u2010Cre":[208],"+":[209,218],"cko)":[210],"mice":[211],"compared":[212],"those":[214],"control":[216,238],"Cre":[217],"mice.":[219],"findings":[221],"indicate":[222],"may":[227],"be":[228],"decreasing":[231],"pre\u2010osteoblastic":[233],"cell":[234],"differentiation,":[235],"under":[236],"epigenetic":[237],"Ezh2\u2010dependent":[243],"mechanisms.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-01-10T00:00:00"}