{"id":"https://openalex.org/W2997396405","doi":"https://doi.org/10.1002/bjs.11348","title":"Meta-analysis of \u03b1-blockade versus no blockade before adrenalectomy for phaeochromocytoma","display_name":"Meta-analysis of \u03b1-blockade versus no blockade before adrenalectomy for phaeochromocytoma","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W2997396405","doi":"https://doi.org/10.1002/bjs.11348","mag":"2997396405","pmid":"https://pubmed.ncbi.nlm.nih.gov/31903584"},"language":"en","primary_location":{"id":"doi:10.1002/bjs.11348","doi":"https://doi.org/10.1002/bjs.11348","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bjs.11348","pdf_url":"https://bjssjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bjs.11348","source":{"id":"https://openalex.org/S61740008","display_name":"British journal of surgery","issn_l":"0007-1323","issn":["0007-1323","1365-2168"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Surgery","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://bjssjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bjs.11348","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026907525","display_name":"Simon J. Schimmack","orcid":"https://orcid.org/0000-0003-0722-7286","observed_orcids":["https://orcid.org/0000-0003-0722-7286"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S Schimmack","raw_affiliation_strings":["Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0722-7286","affiliations":[{"raw_affiliation_string":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029490503","display_name":"J\u00f6rg Kaiser","orcid":"https://orcid.org/0000-0003-3980-4340","observed_orcids":["https://orcid.org/0000-0003-3980-4340"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Kaiser","raw_affiliation_strings":["Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg, Germany","Study Centre of the German Surgical Society, University of Heidelberg , Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Study Centre of the German Surgical Society, University of Heidelberg , Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018838202","display_name":"Pascal Probst","orcid":"https://orcid.org/0000-0002-0895-4015","observed_orcids":["https://orcid.org/0000-0002-0895-4015"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P Probst","raw_affiliation_strings":["Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg, Germany","Study Centre of the German Surgical Society, University of Heidelberg , Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0895-4015","affiliations":[{"raw_affiliation_string":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Study Centre of the German Surgical Society, University of Heidelberg , Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074146576","display_name":"Eva Kalkum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E Kalkum","raw_affiliation_strings":["Study Centre of the German Surgical Society, University of Heidelberg , Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Study Centre of the German Surgical Society, University of Heidelberg , Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029412852","display_name":"Markus K. Diener","orcid":"https://orcid.org/0000-0003-0319-3090","observed_orcids":["https://orcid.org/0000-0003-0319-3090"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M K Diener","raw_affiliation_strings":["Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg, Germany","Study Centre of the German Surgical Society, University of Heidelberg , Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Study Centre of the German Surgical Society, University of Heidelberg , Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058627314","display_name":"Oliver Strobel","orcid":"https://orcid.org/0000-0001-5100-8449","observed_orcids":["https://orcid.org/0000-0001-5100-8449"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"O Strobel","raw_affiliation_strings":["Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5100-8449","affiliations":[{"raw_affiliation_string":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5058627314"],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":{"value":2850,"currency":"GBP","value_usd":4300},"apc_paid":null,"fwci":2.0785,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.89762869,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"107","issue":"2","first_page":"e102","last_page":"e108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11930","display_name":"Cardiac, Anesthesia and Surgical Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pheochromocytoma","display_name":"pheochromocytoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/adrenalectomy","display_name":"adrenalectomy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/perioperative-cardiovascular-complications","display_name":"perioperative cardiovascular complications","score":0.6980000138282776},{"id":"https://openalex.org/keywords/intraoperative-blood-pressure","display_name":"intraoperative blood pressure","score":0.8600000143051147},{"id":"https://openalex.org/keywords/perioperative-mortality","display_name":"perioperative mortality","score":0.8320000171661377},{"id":"https://openalex.org/keywords/alpha-blockers","display_name":"alpha-blockers","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9730697870254517},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.7719271183013916},{"id":"https://openalex.org/C2780087391","wikidata":"https://www.wikidata.org/wiki/Q366774","display_name":"Adrenalectomy","level":2,"score":0.6792665719985962},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.6762934327125549},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6352067589759827},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6050741076469421},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.597460150718689},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5129808783531189},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.43587106466293335},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4317344129085541},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2897515296936035},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D000315","descriptor_name":"Adrenalectomy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000315","descriptor_name":"Adrenalectomy","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000317","descriptor_name":"Adrenergic alpha-Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010673","descriptor_name":"Pheochromocytoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D011300","descriptor_name":"Preoperative Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/bjs.11348","doi":"https://doi.org/10.1002/bjs.11348","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bjs.11348","pdf_url":"https://bjssjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bjs.11348","source":{"id":"https://openalex.org/S61740008","display_name":"British journal of surgery","issn_l":"0007-1323","issn":["0007-1323","1365-2168"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Surgery","raw_type":"journal-article"},{"id":"pmid:31903584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31903584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of surgery","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1002/bjs.11348","doi":"https://doi.org/10.1002/bjs.11348","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bjs.11348","pdf_url":"https://bjssjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bjs.11348","source":{"id":"https://openalex.org/S61740008","display_name":"British journal of surgery","issn_l":"0007-1323","issn":["0007-1323","1365-2168"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2997396405.pdf","grobid_xml":"https://content.openalex.org/works/W2997396405.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W271610095","https://openalex.org/W1247968195","https://openalex.org/W1977380608","https://openalex.org/W1983519907","https://openalex.org/W1984030799","https://openalex.org/W1995180110","https://openalex.org/W1997843970","https://openalex.org/W2002834765","https://openalex.org/W2005501262","https://openalex.org/W2007872832","https://openalex.org/W2019006793","https://openalex.org/W2038198142","https://openalex.org/W2039731062","https://openalex.org/W2047759784","https://openalex.org/W2066365902","https://openalex.org/W2068212218","https://openalex.org/W2079729672","https://openalex.org/W2092078400","https://openalex.org/W2100791316","https://openalex.org/W2132386310","https://openalex.org/W2135003179","https://openalex.org/W2154460392","https://openalex.org/W2156098321","https://openalex.org/W2160466589","https://openalex.org/W2162943396","https://openalex.org/W2171992439","https://openalex.org/W2475031329","https://openalex.org/W2531269403","https://openalex.org/W2579176601","https://openalex.org/W2630564629","https://openalex.org/W2728090724","https://openalex.org/W2774736760","https://openalex.org/W2791989196","https://openalex.org/W3139756206","https://openalex.org/W4210969235"],"related_works":["https://openalex.org/W4283008938","https://openalex.org/W2968117641","https://openalex.org/W2778206237","https://openalex.org/W3204429645","https://openalex.org/W2579176601","https://openalex.org/W4363679336","https://openalex.org/W3137528244","https://openalex.org/W7161586967","https://openalex.org/W4409167236","https://openalex.org/W1985017135"],"abstract_inverted_index":{"BACKGROUND:":[0],"Preoperative":[1],"\u03b1-blockade":[2,62,161,173],"in":[3,45,63,162],"phaeochromocytoma":[4,64,108],"surgery":[5,65,163],"is":[6],"recommended":[7],"by":[8],"all":[9],"guidelines":[10],"to":[11,22,144,169],"prevent":[12],"intraoperative":[13,115,123],"cardiocirculatory":[14],"events.":[15],"The":[16,135],"aim":[17],"of":[18,26,48,97,137,148,157],"this":[19],"meta-analysis":[20,152],"was":[21,43,140],"assess":[23],"the":[24,138,145],"benefit":[25],"such":[27],"preoperative":[28,61,160,172],"treatment":[29,33],"compared":[30],"with":[31,88,131],"no":[32],"before":[34],"adrenalectomy":[35],"for":[36,159,164],"phaeochromocytoma.":[37,165],"METHODS:":[38],"A":[39,95],"systematic":[40],"literature":[41],"search":[42],"undertaken":[44],"MEDLINE,":[46],"Web":[47],"Science":[49],"and":[50,56,73,117,120],"CENTRAL":[51],"without":[52,133],"language":[53],"restrictions.":[54],"Randomized":[55],"non-randomized":[57],"comparative":[58,100],"studies":[59,101],"investigating":[60,104],"were":[66,75,79,102],"included.":[67],"Data":[68],"on":[69],"perioperative":[70],"safety,":[71],"effectiveness":[72],"outcomes":[74],"extracted.":[76],"Pooled":[77],"results":[78],"calculated":[80],"as":[81],"an":[82],"odds":[83],"ratio":[84],"or":[85,132],"mean":[86,113,121],"difference":[87],"95":[89],"per":[90],"cent":[91],"confidence":[92],"interval.":[93],"RESULTS:":[94],"total":[96],"four":[98],"retrospective":[99],"included":[103],"603":[105],"patients":[106,130],"undergoing":[107],"surgery.":[109],"Mortality,":[110],"cardiovascular":[111],"complications,":[112],"maximal":[114,122],"systolic":[116],"diastolic":[118],"BP,":[119],"heart":[124],"rate":[125],"did":[126],"not":[127],"differ":[128],"between":[129],"\u03b1-blockade.":[134],"certainty":[136],"evidence":[139,158],"very":[141],"low":[142],"owing":[143],"inferior":[146],"quality":[147],"studies.":[149],"CONCLUSION:":[150],"This":[151],"has":[153],"shown":[154],"a":[155],"lack":[156],"RCTs":[166],"are":[167],"needed":[168],"evaluate":[170],"whether":[171],"can":[174],"be":[175],"abandoned.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-01-10T00:00:00"}