{"id":"https://openalex.org/W2997370786","doi":null,"title":"MiR-21b-3p protects NS2OY cells against oxygen-glucose deprivation/reperfusion-induced injury by down-regulating cyclooxygenase-2.","display_name":"MiR-21b-3p protects NS2OY cells against oxygen-glucose deprivation/reperfusion-induced injury by down-regulating cyclooxygenase-2.","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2997370786","mag":"2997370786","pmid":"https://pubmed.ncbi.nlm.nih.gov/31217870","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6556624"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6556624","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6556624","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6556624","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102772102","display_name":"Xiaona Wu","orcid":"https://orcid.org/0009-0004-1617-3771","observed_orcids":["https://orcid.org/0009-0004-1617-3771","https://orcid.org/0009-0007-2556-3108"]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaona Wu","raw_affiliation_strings":["Department of Neurology, General Hospital of Southern Theater Command, PLA Guangzhou, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, General Hospital of Southern Theater Command, PLA Guangzhou, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085832300","display_name":"Kairun Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kairun Peng","raw_affiliation_strings":["Department of Neurology, General Hospital of Southern Theater Command, PLA Guangzhou, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, General Hospital of Southern Theater Command, PLA Guangzhou, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005291738","display_name":"Huai Huang","orcid":"https://orcid.org/0000-0001-5841-751X","observed_orcids":["https://orcid.org/0000-0001-5841-751X"]},"institutions":[{"id":"https://openalex.org/I4210099466","display_name":"General Hospital of Guangzhou Military Command","ror":"https://ror.org/00hfbva78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099466"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huai Huang","raw_affiliation_strings":["Department Two of Nerve Rehabilitation, Guangzhou General Hospital, Guangzhou Military Region Guangzhou, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Two of Nerve Rehabilitation, Guangzhou General Hospital, Guangzhou Military Region Guangzhou, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210099466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101777909","display_name":"Zhensheng Li","orcid":"https://orcid.org/0000-0002-6928-0050","observed_orcids":["https://orcid.org/0000-0002-6928-0050"]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhensheng Li","raw_affiliation_strings":["Department of Neurology, General Hospital of Southern Theater Command, PLA Guangzhou, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, General Hospital of Southern Theater Command, PLA Guangzhou, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Xiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Xiang","raw_affiliation_strings":["Department of Neurology, General Hospital of Southern Theater Command, PLA Guangzhou, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, General Hospital of Southern Theater Command, PLA Guangzhou, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102795200","display_name":"Wenting Deng","orcid":"https://orcid.org/0000-0003-3199-8064","observed_orcids":["https://orcid.org/0000-0003-3199-8064"]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenting Deng","raw_affiliation_strings":["Department of Neurology, General Hospital of Southern Theater Command, PLA Guangzhou, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, General Hospital of Southern Theater Command, PLA Guangzhou, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100324289","display_name":"Liu Liu","orcid":"https://orcid.org/0000-0002-8983-4137","observed_orcids":["https://orcid.org/0000-0002-8983-4137"]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liu Liu","raw_affiliation_strings":["Department of Neurology, General Hospital of Southern Theater Command, PLA Guangzhou, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, General Hospital of Southern Theater Command, PLA Guangzhou, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318325","display_name":"W\u011bi Li","orcid":"https://orcid.org/0000-0002-9522-4474","observed_orcids":["https://orcid.org/0000-0002-9522-4474","https://orcid.org/0000-0003-4136-3409","https://orcid.org/0009-0009-9141-6389"]},"institutions":[{"id":"https://openalex.org/I4210129955","display_name":"General Hospital of Shenyang Military Region","ror":"https://ror.org/0340t0585","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129955"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["General Hospital of Northern Theater Command, PLA Shenyang, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Hospital of Northern Theater Command, PLA Shenyang, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I4210129955"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012476587","display_name":"Tao Zhang","orcid":"https://orcid.org/0000-0002-3193-6421","observed_orcids":["https://orcid.org/0000-0002-3193-6421"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao Zhang","raw_affiliation_strings":["Department of Orthopaedics, General Hospital of Southern Theater Command, PLA Guangzhou, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, General Hospital of Southern Theater Command, PLA Guangzhou, Guangdong, People's Republic of China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2321,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.42263865,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"11","issue":"5","first_page":"3007","last_page":"3017"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oxygen-glucose-deprivation-reoxygenation","display_name":"oxygen-glucose deprivation/reoxygenation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cerebral-ischemia-reperfusion-injury","display_name":"cerebral ischemia-reperfusion injury","score":0.8769999742507935},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.6840000152587891},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.902999997138977},{"id":"https://openalex.org/keywords/microrna-target-regulation","display_name":"microRNA target regulation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/3-utr-binding","display_name":"3' UTR binding","score":0.7250000238418579},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9409999847412109}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7760034203529358},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.7605605125427246},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.7216974496841431},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6495165228843689},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.6004197001457214},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5266896486282349},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48626577854156494},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.47244197130203247},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.34875476360321045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2958054840564728},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.2648569941520691},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1958225667476654},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17198556661605835},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08944588899612427},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08478802442550659}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:6556624","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6556624","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"pmid:31217870","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31217870","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"mag:2997370786","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31217870","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6556624","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6556624","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1507695852","https://openalex.org/W1526678238","https://openalex.org/W1601292221","https://openalex.org/W1929567634","https://openalex.org/W1970607854","https://openalex.org/W1981159707","https://openalex.org/W1982863746","https://openalex.org/W1991703365","https://openalex.org/W1993213847","https://openalex.org/W1994269019","https://openalex.org/W1995005155","https://openalex.org/W2009313692","https://openalex.org/W2016731950","https://openalex.org/W2019238071","https://openalex.org/W2022016756","https://openalex.org/W2028383092","https://openalex.org/W2039237627","https://openalex.org/W2055087658","https://openalex.org/W2057622336","https://openalex.org/W2059646584","https://openalex.org/W2066395665","https://openalex.org/W2074194694","https://openalex.org/W2086810915","https://openalex.org/W2101736298","https://openalex.org/W2103596667","https://openalex.org/W2107277218","https://openalex.org/W2112215250","https://openalex.org/W2119863126","https://openalex.org/W2121419639","https://openalex.org/W2131264952","https://openalex.org/W2134732424","https://openalex.org/W2147575530","https://openalex.org/W2168540880","https://openalex.org/W2192080449","https://openalex.org/W2293977658","https://openalex.org/W2371948111","https://openalex.org/W2409516189","https://openalex.org/W2410702932","https://openalex.org/W2462702806","https://openalex.org/W2508908572","https://openalex.org/W2528036020","https://openalex.org/W2531620033","https://openalex.org/W2770652529","https://openalex.org/W2774274550","https://openalex.org/W2962860949","https://openalex.org/W4240619060"],"related_works":["https://openalex.org/W3016374680","https://openalex.org/W2069706904","https://openalex.org/W2988822572","https://openalex.org/W3006485780","https://openalex.org/W3023267686","https://openalex.org/W2947585729","https://openalex.org/W3000700435","https://openalex.org/W4386360192","https://openalex.org/W2888044088","https://openalex.org/W3124581381"],"abstract_inverted_index":{"Recent":[0],"studies":[1],"have":[2,55,143],"shown":[3],"abnormal":[4],"expression":[5,20,69,150,156,208],"levels":[6],"of":[7,31,70,104,157,209,227,229],"cyclooxygenase-2":[8],"(COX-2)":[9],"and":[10,25,43,60,72,83,99,106,111,123,139,148,200,216],"miR-21b-3p":[11,32,71,105,158,192,223],"in":[12,46,91,162,173],"cerebral":[13],"ischemia-reperfusion":[14],"(I/R)":[15],"rat":[16],"models.":[17],"Decreased":[18],"COX-2":[19,73,107,146,195,210],"could":[21,27,211],"reduce":[22],"brain":[23],"injury":[24,48,236],"thus":[26],"be":[28],"a":[29],"target":[30,226],"according":[33],"to":[34,133,188],"the":[35,84,102,135,155,207,225],"miRNA":[36],"databases":[37],"(miRDB)":[38],"analysis.":[39],"However,":[40],"its":[41],"functions":[42,103],"underlying":[44],"mechanisms":[45],"I/R":[47],"remain":[49],"unclear.":[50],"In":[51,203],"our":[52],"study,":[53],"we":[54,232],"established":[56],"an":[57],"oxygen/glucose":[58],"deprivation":[59],"reperfusion":[61],"(OGD/R)":[62],"model":[63],"by":[64,76,89,237],"using":[65,115],"NS2OY":[66,163,184],"cells.":[67],"The":[68,141,168],"was":[74,131,159],"determined":[75],"quantitative":[77],"real-time":[78],"PCR":[79],"or":[80,95],"Western":[81],"blot,":[82],"fluorescence":[85,90],"intensities":[86],"were":[87,113,151,170,186],"detected":[88,114],"situ":[92],"hybridization":[93],"(FISH)":[94],"immunofluorescence.":[96],"After":[97],"transfection":[98],"OGD/R":[100,166,189],"treatments,":[101],"on":[108],"cell":[109,198,214],"viability":[110,199,215],"apoptosis":[112],"cell-counting":[116],"kit":[117],"8,":[118],"Edu":[119],"staining,":[120,125],"flow":[121],"cytometry":[122],"Hoechst":[124],"respectively.":[126],"Finally,":[127],"dual-luciferase":[128],"reporter":[129,220],"assay":[130],"used":[132],"explore":[134],"relationship":[136],"between":[137],"miR-21-b-3p":[138],"COX-2.":[140,230,239],"results":[142],"showed":[144,181,222],"that":[145,182,234],"mRNA":[147],"protein":[149],"significantly":[152,193],"increased;":[153],"however,":[154],"remarkably":[160],"reduced":[161],"cells":[164,185],"after":[165],"treatment.":[167],"changes":[169],"most":[171],"remarkable":[172],"OGD":[174],"2":[175],"h/R24":[176],"group.":[177],"Function":[178],"analysis":[179],"has":[180],"when":[183],"exposed":[187],"injury,":[190],"overexpressed":[191],"downregulated":[194],"expression,":[196],"increased":[197],"decreased":[201],"apoptosis.":[202,218],"addition,":[204],"knocking":[205],"down":[206],"also":[212],"increase":[213],"decrease":[217],"Dual-luciferase":[219],"assays":[221],"as":[224],"3'-UTR":[228],"Therefore,":[231],"concluded":[233],"OGD/R-induced":[235],"down-regulating":[238]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-01-10T00:00:00"}
