{"id":"https://openalex.org/W2997271517","doi":"https://doi.org/10.1016/j.jinorgbio.2019.110975","title":"Anticancer and antimetastatic activity of copper(II)-tropolone complex against human breast cancer cells, breast multicellular spheroids and mammospheres","display_name":"Anticancer and antimetastatic activity of copper(II)-tropolone complex against human breast cancer cells, breast multicellular spheroids and mammospheres","publication_year":2019,"publication_date":"2019-12-26","ids":{"openalex":"https://openalex.org/W2997271517","doi":"https://doi.org/10.1016/j.jinorgbio.2019.110975","mag":"2997271517","pmid":"https://pubmed.ncbi.nlm.nih.gov/31911364"},"language":"en","primary_location":{"id":"doi:10.1016/j.jinorgbio.2019.110975","doi":"https://doi.org/10.1016/j.jinorgbio.2019.110975","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jinorgbio.2019.110975","pdf_url":null,"source":{"id":"https://openalex.org/S155362585","display_name":"Journal of Inorganic Biochemistry","issn_l":"0162-0134","issn":["0162-0134","1873-3344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Inorganic Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059464097","display_name":"Luc\u00eda M. Balsa","orcid":"https://orcid.org/0000-0001-6896-9326","observed_orcids":["https://orcid.org/0000-0001-6896-9326"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210138160","display_name":"Centro Cient\u00edfico Tecnol\u00f3gico - La Plata","ror":"https://ror.org/03qan4b12","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Lucia M. Balsa","raw_affiliation_strings":["Inorganic Chemistry Center (CEQUINOR, CONICET), Exact School Sciences, National University of La Plata, Bv 120 1465, 1900 La Plata, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inorganic Chemistry Center (CEQUINOR, CONICET), Exact School Sciences, National University of La Plata, Bv 120 1465, 1900 La Plata, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210138160","https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100714659","display_name":"Mar\u00eda C. Ruiz","orcid":"https://orcid.org/0000-0003-0268-9959","observed_orcids":["https://orcid.org/0000-0003-0268-9959"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210138160","display_name":"Centro Cient\u00edfico Tecnol\u00f3gico - La Plata","ror":"https://ror.org/03qan4b12","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Maria C. Ruiz","raw_affiliation_strings":["Inorganic Chemistry Center (CEQUINOR, CONICET), Exact School Sciences, National University of La Plata, Bv 120 1465, 1900 La Plata, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inorganic Chemistry Center (CEQUINOR, CONICET), Exact School Sciences, National University of La Plata, Bv 120 1465, 1900 La Plata, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210138160","https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084120752","display_name":"Luc\u00eda Santa Maria de la Parra","orcid":"https://orcid.org/0000-0002-4577-139X","observed_orcids":["https://orcid.org/0000-0002-4577-139X"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210138160","display_name":"Centro Cient\u00edfico Tecnol\u00f3gico - La Plata","ror":"https://ror.org/03qan4b12","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Lucia Santa Maria de la Parra","raw_affiliation_strings":["Inorganic Chemistry Center (CEQUINOR, CONICET), Exact School Sciences, National University of La Plata, Bv 120 1465, 1900 La Plata, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inorganic Chemistry Center (CEQUINOR, CONICET), Exact School Sciences, National University of La Plata, Bv 120 1465, 1900 La Plata, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210138160","https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077526432","display_name":"Enrique J. Baran","orcid":"https://orcid.org/0000-0002-7181-1519","observed_orcids":["https://orcid.org/0000-0002-7181-1519"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210138160","display_name":"Centro Cient\u00edfico Tecnol\u00f3gico - La Plata","ror":"https://ror.org/03qan4b12","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Enrique J. Baran","raw_affiliation_strings":["Inorganic Chemistry Center (CEQUINOR, CONICET), Exact School Sciences, National University of La Plata, Bv 120 1465, 1900 La Plata, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inorganic Chemistry Center (CEQUINOR, CONICET), Exact School Sciences, National University of La Plata, Bv 120 1465, 1900 La Plata, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210138160","https://openalex.org/I874386039"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020678694","display_name":"Ign\u00e1cio E. Le\u00f3n","orcid":"https://orcid.org/0000-0003-1010-3997","observed_orcids":["https://orcid.org/0000-0003-1010-3997"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4210138160","display_name":"Centro Cient\u00edfico Tecnol\u00f3gico - La Plata","ror":"https://ror.org/03qan4b12","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Ignacio E. Le\u00f3n","raw_affiliation_strings":["Inorganic Chemistry Center (CEQUINOR, CONICET), Exact School Sciences, National University of La Plata, Bv 120 1465, 1900 La Plata, Argentina. Electronic address: ileon@biol.unlp.edu.ar","Inorganic Chemistry Center (CEQUINOR, CONICET), Exact School Sciences, National University of La Plata, Bv 120 1465, 1900 La Plata, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inorganic Chemistry Center (CEQUINOR, CONICET), Exact School Sciences, National University of La Plata, Bv 120 1465, 1900 La Plata, Argentina. Electronic address: ileon@biol.unlp.edu.ar","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210138160","https://openalex.org/I874386039"]},{"raw_affiliation_string":"Inorganic Chemistry Center (CEQUINOR, CONICET), Exact School Sciences, National University of La Plata, Bv 120 1465, 1900 La Plata, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210138160","https://openalex.org/I874386039"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020678694"],"corresponding_institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210138160","https://openalex.org/I874386039"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":2.4712,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.91198824,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"204","issue":null,"first_page":"110975","last_page":"110975"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8190000057220459},{"id":"https://openalex.org/keywords/antimetastatic-activity","display_name":"antimetastatic activity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8399999737739563},{"id":"https://openalex.org/keywords/3d-spheroids","display_name":"multicellular spheroids","score":0.8460000157356262},{"id":"https://openalex.org/keywords/mammospheres","display_name":"mammospheres","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.5789999961853027},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.9620000123977661},{"id":"https://openalex.org/keywords/metalloproteinases","display_name":"metalloproteinases","score":0.8849999904632568},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cisplatin-comparison","display_name":"cisplatin comparison","score":0.8149999976158142},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8529999852180481},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8585528135299683},{"id":"https://openalex.org/C2777509971","wikidata":"https://www.wikidata.org/wiki/Q19952843","display_name":"Tropolone","level":2,"score":0.812533974647522},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.6885318160057068},{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.5914162993431091},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5682917833328247},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.5374859571456909},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5092166662216187},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.4438292384147644},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34504085779190063},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3367222249507904},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2649868130683899},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2415907084941864},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16661542654037476},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.08341950178146362},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06504896283149719},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05332273244857788},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014334","descriptor_name":"Tropolone","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jinorgbio.2019.110975","doi":"https://doi.org/10.1016/j.jinorgbio.2019.110975","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jinorgbio.2019.110975","pdf_url":null,"source":{"id":"https://openalex.org/S155362585","display_name":"Journal of Inorganic Biochemistry","issn_l":"0162-0134","issn":["0162-0134","1873-3344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Inorganic Biochemistry","raw_type":"journal-article"},{"id":"pmid:31911364","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31911364","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of inorganic biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4055545550","display_name":null,"funder_award_id":"X/041","funder_id":"https://openalex.org/F4320322227","funder_display_name":"Universidad Nacional de La Plata"},{"id":"https://openalex.org/G4822681298","display_name":null,"funder_award_id":"PIP0034","funder_id":"https://openalex.org/F4320321594","funder_display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas"},{"id":"https://openalex.org/G4915592531","display_name":null,"funder_award_id":"2014-2223","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G5708519805","display_name":"C\u00e1ncer: b\u00fasqueda de nuevos metalocompuestos  como  potenciales agentes antitumorales. Mecanismos de acci\u00f3n en cultivos celulares y en modelos in vivo","funder_award_id":"PICT-2014-2223","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G6589690077","display_name":null,"funder_award_id":"2016-1574","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"}],"funders":[{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320322227","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929"},{"id":"https://openalex.org/F4320334832","display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/03stxzb56"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W641795583","https://openalex.org/W1801537031","https://openalex.org/W1944512909","https://openalex.org/W1966369019","https://openalex.org/W1968331094","https://openalex.org/W1974693247","https://openalex.org/W1984883623","https://openalex.org/W1995311865","https://openalex.org/W2001895730","https://openalex.org/W2004025165","https://openalex.org/W2022573308","https://openalex.org/W2024976878","https://openalex.org/W2034849620","https://openalex.org/W2036532356","https://openalex.org/W2039396871","https://openalex.org/W2041651158","https://openalex.org/W2045251122","https://openalex.org/W2071351488","https://openalex.org/W2072562302","https://openalex.org/W2086270282","https://openalex.org/W2092226746","https://openalex.org/W2096306846","https://openalex.org/W2114380849","https://openalex.org/W2114918609","https://openalex.org/W2119028086","https://openalex.org/W2127617517","https://openalex.org/W2143468862","https://openalex.org/W2155627938","https://openalex.org/W2157082106","https://openalex.org/W2168430833","https://openalex.org/W2179971431","https://openalex.org/W2188277759","https://openalex.org/W2269488902","https://openalex.org/W2282989227","https://openalex.org/W2414556705","https://openalex.org/W2514263689","https://openalex.org/W2526971864","https://openalex.org/W2539417294","https://openalex.org/W2560517026","https://openalex.org/W2586407709","https://openalex.org/W2588496926","https://openalex.org/W2591580144","https://openalex.org/W2619089870","https://openalex.org/W2625600807","https://openalex.org/W2724781718","https://openalex.org/W2753877769","https://openalex.org/W2754516505","https://openalex.org/W2769433773","https://openalex.org/W2789656641","https://openalex.org/W2790046898","https://openalex.org/W2790711236","https://openalex.org/W2790784188","https://openalex.org/W2884725671","https://openalex.org/W2889037271","https://openalex.org/W2895633654","https://openalex.org/W2899776574","https://openalex.org/W2909651596","https://openalex.org/W2913365458","https://openalex.org/W2917837889","https://openalex.org/W2935023445","https://openalex.org/W2943519282","https://openalex.org/W2951391765","https://openalex.org/W2969587894","https://openalex.org/W2993568914","https://openalex.org/W3209457879","https://openalex.org/W6744644851"],"related_works":["https://openalex.org/W4401585437","https://openalex.org/W4387422371","https://openalex.org/W3173370559","https://openalex.org/W4415781063","https://openalex.org/W4200205285","https://openalex.org/W7077307138","https://openalex.org/W1244502060","https://openalex.org/W4400240504","https://openalex.org/W2115003365","https://openalex.org/W2158787437"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-01-10T00:00:00"}