{"id":"https://openalex.org/W2997216738","doi":"https://doi.org/10.1038/s41598-019-56723-1","title":"Estradiol and high fat diet associate with changes in gut microbiota in female ob/ob mice","display_name":"Estradiol and high fat diet associate with changes in gut microbiota in female ob/ob mice","publication_year":2019,"publication_date":"2019-12-27","ids":{"openalex":"https://openalex.org/W2997216738","doi":"https://doi.org/10.1038/s41598-019-56723-1","mag":"2997216738","pmid":"https://pubmed.ncbi.nlm.nih.gov/31882890","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6934844"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-019-56723-1","doi":"https://doi.org/10.1038/s41598-019-56723-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-56723-1","pdf_url":"https://www.nature.com/articles/s41598-019-56723-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-019-56723-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084212471","display_name":"Kalpana D. Acharya","orcid":"https://orcid.org/0000-0001-6263-4357","observed_orcids":["https://orcid.org/0000-0001-6263-4357"]},"institutions":[{"id":"https://openalex.org/I189731429","display_name":"Wellesley College","ror":"https://ror.org/01srpnj69","country_code":"US","type":"education","lineage":["https://openalex.org/I189731429"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kalpana D. Acharya","raw_affiliation_strings":["Neuroscience Department, Wellesley College, Wellesley, MA, 02481, USA. kacharya@wellesley.edu","Neuroscience Department, Wellesley College, Wellesley, MA, 02481, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Department, Wellesley College, Wellesley, MA, 02481, USA. kacharya@wellesley.edu","institution_ids":["https://openalex.org/I189731429"]},{"raw_affiliation_string":"Neuroscience Department, Wellesley College, Wellesley, MA, 02481, USA","institution_ids":["https://openalex.org/I189731429"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103200928","display_name":"Xing Gao","orcid":"https://orcid.org/0000-0003-4544-8848","observed_orcids":["https://orcid.org/0000-0003-4544-8848"]},"institutions":[{"id":"https://openalex.org/I189731429","display_name":"Wellesley College","ror":"https://ror.org/01srpnj69","country_code":"US","type":"education","lineage":["https://openalex.org/I189731429"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xing Gao","raw_affiliation_strings":["Neuroscience Department, Wellesley College, Wellesley, MA, 02481, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Department, Wellesley College, Wellesley, MA, 02481, USA","institution_ids":["https://openalex.org/I189731429"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001606463","display_name":"Elizabeth P. Bless","orcid":"https://orcid.org/0000-0001-7429-5057","observed_orcids":["https://orcid.org/0000-0001-7429-5057"]},"institutions":[{"id":"https://openalex.org/I189731429","display_name":"Wellesley College","ror":"https://ror.org/01srpnj69","country_code":"US","type":"education","lineage":["https://openalex.org/I189731429"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth P. Bless","raw_affiliation_strings":["Neuroscience Department, Wellesley College, Wellesley, MA, 02481, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Department, Wellesley College, Wellesley, MA, 02481, USA","institution_ids":["https://openalex.org/I189731429"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100450167","display_name":"Jun Chen","orcid":"https://orcid.org/0000-0002-1273-5624","observed_orcids":["https://orcid.org/0000-0002-1273-5624"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Chen","raw_affiliation_strings":["Department of Health Sciences Research & Center for Individualized Medicine, Mayo Clinic, Rochester, MN, 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research & Center for Individualized Medicine, Mayo Clinic, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059458473","display_name":"Marc J. Tetel","orcid":"https://orcid.org/0000-0002-9843-4071","observed_orcids":["https://orcid.org/0000-0002-9843-4071"]},"institutions":[{"id":"https://openalex.org/I189731429","display_name":"Wellesley College","ror":"https://ror.org/01srpnj69","country_code":"US","type":"education","lineage":["https://openalex.org/I189731429"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc J. Tetel","raw_affiliation_strings":["Neuroscience Department, Wellesley College, Wellesley, MA, 02481, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Department, Wellesley College, Wellesley, MA, 02481, USA","institution_ids":["https://openalex.org/I189731429"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5084212471"],"corresponding_institution_ids":["https://openalex.org/I189731429"],"apc_list":{"value":1790,"currency":"USD","value_usd":1790},"apc_paid":{"value":1790,"currency":"USD","value_usd":1790},"fwci":3.1149,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.93455831,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"9","issue":"1","first_page":"20192","last_page":"20192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8949999809265137},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.777999997138977},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9919999837875366},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8790000081062317},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.7960000038146973},{"id":"https://openalex.org/keywords/ob-ob-mice","display_name":"ob/ob mice","score":0.9070000052452087},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.8930000066757202},{"id":"https://openalex.org/keywords/obesity-in-women","display_name":"female obesity","score":0.6110000014305115},{"id":"https://openalex.org/keywords/microbial-diversity","display_name":"microbial diversity","score":0.7379999756813049},{"id":"https://openalex.org/keywords/coriobacteriaceae","display_name":"Coriobacteriaceae","score":0.9520000219345093},{"id":"https://openalex.org/keywords/clostridium","display_name":"Clostridium","score":0.9750000238418579},{"id":"https://openalex.org/keywords/lactobacillus","display_name":"Lactobacillus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.8420193195343018},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7716590166091919},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7322516441345215},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.6756358742713928},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5828120112419128},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5751742124557495},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.47487542033195496},{"id":"https://openalex.org/C2780192938","wikidata":"https://www.wikidata.org/wiki/Q5275043","display_name":"Diet-induced obese","level":4,"score":0.4546232521533966},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.4419528841972351},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.3278563618659973},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26351702213287354},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13879907131195068},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.09659472107887268}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015430","descriptor_name":"Weight Gain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-019-56723-1","doi":"https://doi.org/10.1038/s41598-019-56723-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-56723-1","pdf_url":"https://www.nature.com/articles/s41598-019-56723-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.1101/612283","doi":"https://doi.org/10.1101/612283","is_oa":true,"landing_page_url":"https://doi.org/10.1101/612283","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/07/12/612283.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:6934844","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6934844","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:31882890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31882890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f3fd306970c2447fa97054404b03eed1","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f3fd306970c2447fa97054404b03eed1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-019-56723-1","doi":"https://doi.org/10.1038/s41598-019-56723-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-56723-1","pdf_url":"https://www.nature.com/articles/s41598-019-56723-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1440959223","display_name":null,"funder_award_id":"DK61935","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4030837300","display_name":null,"funder_award_id":"NIH R01 DK61935","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6607237905","display_name":null,"funder_award_id":"NIH R01","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G894234630","display_name":"Mechanisms of Steroid Action in Brain","funder_award_id":"R01DK061935","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320308518","display_name":"Wellesley College","ror":"https://ror.org/01srpnj69"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2997216738.pdf","grobid_xml":"https://content.openalex.org/works/W2997216738.grobid-xml"},"referenced_works_count":125,"referenced_works":["https://openalex.org/W1883997870","https://openalex.org/W1899801274","https://openalex.org/W1965775065","https://openalex.org/W1968618595","https://openalex.org/W1970440826","https://openalex.org/W1971415551","https://openalex.org/W1973640443","https://openalex.org/W1979903836","https://openalex.org/W1984284869","https://openalex.org/W1993399595","https://openalex.org/W1998990856","https://openalex.org/W1999373531","https://openalex.org/W2000777408","https://openalex.org/W2002691853","https://openalex.org/W2003836872","https://openalex.org/W2004549986","https://openalex.org/W2007895806","https://openalex.org/W2007910255","https://openalex.org/W2008724101","https://openalex.org/W2013865699","https://openalex.org/W2014632252","https://openalex.org/W2015358846","https://openalex.org/W2018094441","https://openalex.org/W2018988881","https://openalex.org/W2032413234","https://openalex.org/W2034082915","https://openalex.org/W2044526208","https://openalex.org/W2045992972","https://openalex.org/W2048117553","https://openalex.org/W2048800387","https://openalex.org/W2051003250","https://openalex.org/W2055956383","https://openalex.org/W2056383195","https://openalex.org/W2056386675","https://openalex.org/W2060682066","https://openalex.org/W2061084753","https://openalex.org/W2064642161","https://openalex.org/W2070393006","https://openalex.org/W2071542414","https://openalex.org/W2073332363","https://openalex.org/W2073353512","https://openalex.org/W2080283023","https://openalex.org/W2082471133","https://openalex.org/W2082808164","https://openalex.org/W2084793748","https://openalex.org/W2093970033","https://openalex.org/W2096407616","https://openalex.org/W2096702475","https://openalex.org/W2101654035","https://openalex.org/W2104890139","https://openalex.org/W2105231911","https://openalex.org/W2105270270","https://openalex.org/W2105329815","https://openalex.org/W2110065044","https://openalex.org/W2111609149","https://openalex.org/W2113382445","https://openalex.org/W2113576333","https://openalex.org/W2114942127","https://openalex.org/W2116846792","https://openalex.org/W2119244437","https://openalex.org/W2119948313","https://openalex.org/W2123609879","https://openalex.org/W2123652320","https://openalex.org/W2124407637","https://openalex.org/W2124738442","https://openalex.org/W2125312207","https://openalex.org/W2129917444","https://openalex.org/W2130207108","https://openalex.org/W2131536322","https://openalex.org/W2132929849","https://openalex.org/W2134427365","https://openalex.org/W2136552678","https://openalex.org/W2137788215","https://openalex.org/W2141671471","https://openalex.org/W2142435309","https://openalex.org/W2143269314","https://openalex.org/W2143659067","https://openalex.org/W2143777796","https://openalex.org/W2144079797","https://openalex.org/W2144568881","https://openalex.org/W2149421543","https://openalex.org/W2149573313","https://openalex.org/W2149745292","https://openalex.org/W2150712481","https://openalex.org/W2151083080","https://openalex.org/W2151299241","https://openalex.org/W2151350595","https://openalex.org/W2152398830","https://openalex.org/W2154846563","https://openalex.org/W2156831368","https://openalex.org/W2157570303","https://openalex.org/W2158630697","https://openalex.org/W2159990597","https://openalex.org/W2164659530","https://openalex.org/W2167062509","https://openalex.org/W2168270396","https://openalex.org/W2182306574","https://openalex.org/W2272673864","https://openalex.org/W2274927794","https://openalex.org/W2289724404","https://openalex.org/W2341046327","https://openalex.org/W2341191157","https://openalex.org/W2473313158","https://openalex.org/W2473762402","https://openalex.org/W2510905445","https://openalex.org/W2528189476","https://openalex.org/W2529341781","https://openalex.org/W2532068730","https://openalex.org/W2558169831","https://openalex.org/W2619706244","https://openalex.org/W2627775282","https://openalex.org/W2727314585","https://openalex.org/W2762815147","https://openalex.org/W2769209214","https://openalex.org/W2771387624","https://openalex.org/W2774072836","https://openalex.org/W2776197744","https://openalex.org/W2795111952","https://openalex.org/W2798022221","https://openalex.org/W2807828439","https://openalex.org/W2809439583","https://openalex.org/W2809642430","https://openalex.org/W2900494132","https://openalex.org/W2921613971","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2667777114","https://openalex.org/W3189034864","https://openalex.org/W2944233070","https://openalex.org/W2731958236","https://openalex.org/W4389022911","https://openalex.org/W7042771267","https://openalex.org/W2944794149","https://openalex.org/W4416223011","https://openalex.org/W4207052692","https://openalex.org/W4313826083"],"abstract_inverted_index":{"Abstract":[0],"Estrogens":[1,35],"protect":[2],"against":[3],"diet-induced":[4],"obesity":[5,52,105],"in":[6,17,43,62,76,100,156,188,200],"women":[7,19],"and":[8,33,53,71,109,159,169,186],"female":[9,179],"rodents.":[10],"For":[11],"example,":[12],"a":[13],"lack":[14],"of":[15,26,146,177,184],"estrogens":[16,70],"postmenopausal":[18],"is":[20,59],"associated":[21,112,141,153],"with":[22,37,113,134,142,154],"an":[23,143],"increased":[24,144],"risk":[25],"weight":[27,98],"gain,":[28],"cardiovascular":[29],"diseases,":[30],"low-grade":[31],"inflammation,":[32],"cancer.":[34],"act":[36],"leptin":[38,72,151,187],"to":[39],"regulate":[40],"energy":[41],"homeostasis":[42],"females.":[44],"Leptin-deficient":[45],"mice":[46,83,119,129],"(":[47,106],"ob/ob":[48,78,107,118],")":[49],"exhibit":[50],"morbid":[51],"insulin":[54],"resistance.":[55],"The":[56,65],"gut":[57,74,115,175,190],"microbiome":[58],"also":[60],"critical":[61],"regulating":[63,189],"metabolism.":[64],"present":[66],"study":[67],"investigates":[68],"whether":[69],"modulate":[73],"microbiota":[75,176,191],"ovariectomized":[77],"(obese)":[79],"or":[80,93],"heterozygote":[81],"(lean)":[82],"fed":[84],"high-fat":[85],"diet":[86],"(HFD)":[87],"that":[88],"received":[89],"either":[90],"17\u03b2-Estradiol":[91],"(E2)":[92],"vehicle":[94,135],"implants.":[95],"E2":[96,110,139,168,185],"attenuated":[97],"gain":[99],"both":[101,104,167],"genotypes.":[102],"Moreover,":[103],"mice)":[108],"were":[111,164],"reduced":[114,131],"microbial":[116],"diversity.":[117],"exhibited":[120],"lower":[121],"species":[122],"richness":[123],"than":[124],"control":[125],"mice,":[126],"while":[127,150],"E2-treated":[128],"had":[130],"evenness":[132],"compared":[133],"mice.":[136,180],"Regarding":[137],"taxa,":[138],"was":[140,152],"abundance":[145],"the":[147,182],"S24-7":[148],"family,":[149],"increases":[155],"Coriobacteriaceae,":[157],"Clostridium":[158],"Lactobacillus":[160],".":[161],"Some":[162],"taxa":[163],"affected":[165],"by":[166],"leptin,":[170],"suggesting":[171],"these":[172],"hormones":[173],"alter":[174],"HFD-fed":[178],"Understanding":[181],"role":[183],"will":[192],"provide":[193],"important":[194],"insights":[195],"into":[196],"hormone-dependent":[197],"metabolic":[198],"disorders":[199],"women.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-01-10T00:00:00"}