{"id":"https://openalex.org/W2996983628","doi":"https://doi.org/10.1007/s12602-019-09628-4","title":"The Evolution of Human Probiotics: Challenges and Prospects","display_name":"The Evolution of Human Probiotics: Challenges and Prospects","publication_year":2020,"publication_date":"2020-01-06","ids":{"openalex":"https://openalex.org/W2996983628","doi":"https://doi.org/10.1007/s12602-019-09628-4","mag":"2996983628","pmid":"https://pubmed.ncbi.nlm.nih.gov/31907861"},"language":"en","primary_location":{"id":"doi:10.1007/s12602-019-09628-4","doi":"https://doi.org/10.1007/s12602-019-09628-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12602-019-09628-4","pdf_url":null,"source":{"id":"https://openalex.org/S163406742","display_name":"Probiotics and Antimicrobial Proteins","issn_l":"1867-1306","issn":["1867-1306","1867-1314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Probiotics and Antimicrobial Proteins","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077451473","display_name":"Elizaveta A. Trush","orcid":"https://orcid.org/0000-0003-2449-6912","observed_orcids":["https://orcid.org/0000-0003-2449-6912"]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Elizaveta A. Trush","raw_affiliation_strings":["Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067141305","display_name":"Elena A. Poluektova","orcid":"https://orcid.org/0000-0003-1312-120X","observed_orcids":["https://orcid.org/0000-0003-1312-120X","https://orcid.org/0009-0008-1110-395X"]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Elena A. Poluektova","raw_affiliation_strings":["Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015570890","display_name":"\u0411\u0435\u043d\u0438\u0430\u0448\u0432\u0438\u043b\u0438 \u0410\u043b\u043b\u0430\u043d \u0413\u0435\u0440\u043e\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0002-5149-3760","observed_orcids":["https://orcid.org/0000-0002-5149-3760"]},"institutions":[{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Allan G. Beniashvilli","raw_affiliation_strings":["Mental Health Research Center, Federal State Budgetary Scientific Institution of the Ministry of Health of the Russian Federation, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mental Health Research Center, Federal State Budgetary Scientific Institution of the Ministry of Health of the Russian Federation, Moscow, Russia","institution_ids":["https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008683240","display_name":"Oleg S. Shifrin","orcid":"https://orcid.org/0000-0001-8148-2862","observed_orcids":["https://orcid.org/0000-0001-8148-2862"]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Oleg S. Shifrin","raw_affiliation_strings":["Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079169718","display_name":"Yuri M. Poluektov","orcid":"https://orcid.org/0000-0002-9710-7490","observed_orcids":["https://orcid.org/0000-0002-9710-7490"]},"institutions":[{"id":"https://openalex.org/I100098275","display_name":"Engelhardt Institute of Molecular Biology","ror":"https://ror.org/027hwkg23","country_code":"RU","type":"facility","lineage":["https://openalex.org/I100098275","https://openalex.org/I1313323035","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Yuri M. Poluektov","raw_affiliation_strings":["Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. yuripoul@gmail.com","Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0002-9710-7490","affiliations":[{"raw_affiliation_string":"Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. yuripoul@gmail.com","institution_ids":["https://openalex.org/I100098275","https://openalex.org/I1313323035"]},{"raw_affiliation_string":"Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia","institution_ids":["https://openalex.org/I100098275","https://openalex.org/I1313323035"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063490638","display_name":"Vladimir T Ivashkin","orcid":"https://orcid.org/0000-0002-6815-6015","observed_orcids":["https://orcid.org/0000-0002-6815-6015"]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vladimir T. Ivashkin","raw_affiliation_strings":["Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia","institution_ids":["https://openalex.org/I17877952"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5079169718"],"corresponding_institution_ids":["https://openalex.org/I100098275","https://openalex.org/I1313323035"],"apc_list":{"value":3260,"currency":"USD","value_usd":3260},"apc_paid":null,"fwci":1.1566,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.71914894,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"12","issue":"4","first_page":"1291","last_page":"1299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.9789999723434448},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9210000038146973},{"id":"https://openalex.org/keywords/multi-strain-probiotics","display_name":"multi-strain probiotics","score":1.0},{"id":"https://openalex.org/keywords/probiotic-delivery","display_name":"probiotic delivery","score":0.8240000009536743},{"id":"https://openalex.org/keywords/probiotic-shelf-life","display_name":"probiotic shelf life","score":0.8389999866485596},{"id":"https://openalex.org/keywords/probiotic-microencapsulation","display_name":"probiotic encapsulation","score":0.7160000205039978},{"id":"https://openalex.org/keywords/probiotic-production","display_name":"probiotic production","score":0.703000009059906},{"id":"https://openalex.org/keywords/diet-and-physical-activity","display_name":"diet and physical activity","score":0.5529999732971191},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.8670401573181152},{"id":"https://openalex.org/C3018122547","wikidata":"https://www.wikidata.org/wiki/Q5690813","display_name":"Health benefits","level":2,"score":0.47366437315940857},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.4680124521255493},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.46452438831329346},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.4550820291042328},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4435507655143738},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.434085488319397},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3795340061187744},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36724504828453064},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.20528018474578857},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.09545931220054626},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.09499338269233704},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.09386900067329407},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.08669212460517883},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000069983","descriptor_name":"Saccharomyces boulardii","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001430","descriptor_name":"Bacteriocins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001644","descriptor_name":"Bifidobacterium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002214","descriptor_name":"Capsules","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003015","descriptor_name":"Clostridium Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003015","descriptor_name":"Clostridium Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003015","descriptor_name":"Clostridium Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007778","descriptor_name":"Lactobacillus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010933","descriptor_name":"Plankton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D050296","descriptor_name":"Microbial Viability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s12602-019-09628-4","doi":"https://doi.org/10.1007/s12602-019-09628-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12602-019-09628-4","pdf_url":null,"source":{"id":"https://openalex.org/S163406742","display_name":"Probiotics and Antimicrobial Proteins","issn_l":"1867-1306","issn":["1867-1306","1867-1314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Probiotics and Antimicrobial Proteins","raw_type":"journal-article"},{"id":"pmid:31907861","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31907861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Probiotics and antimicrobial proteins","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W1965216234","https://openalex.org/W1976527947","https://openalex.org/W2002284499","https://openalex.org/W2005080411","https://openalex.org/W2011995221","https://openalex.org/W2014685170","https://openalex.org/W2015161836","https://openalex.org/W2024881961","https://openalex.org/W2025181044","https://openalex.org/W2031965772","https://openalex.org/W2041418306","https://openalex.org/W2045229527","https://openalex.org/W2048267974","https://openalex.org/W2054191023","https://openalex.org/W2055294982","https://openalex.org/W2061797039","https://openalex.org/W2066771219","https://openalex.org/W2068061066","https://openalex.org/W2070806663","https://openalex.org/W2077653833","https://openalex.org/W2078291672","https://openalex.org/W2080504946","https://openalex.org/W2085606597","https://openalex.org/W2093149639","https://openalex.org/W2096160104","https://openalex.org/W2098188459","https://openalex.org/W2102599521","https://openalex.org/W2105173502","https://openalex.org/W2106503480","https://openalex.org/W2108523527","https://openalex.org/W2118910851","https://openalex.org/W2119343060","https://openalex.org/W2122608498","https://openalex.org/W2131727615","https://openalex.org/W2134853329","https://openalex.org/W2152764938","https://openalex.org/W2159128703","https://openalex.org/W2161062702","https://openalex.org/W2165372937","https://openalex.org/W2167324010","https://openalex.org/W2168405728","https://openalex.org/W2169846007","https://openalex.org/W2170666048","https://openalex.org/W2314167679","https://openalex.org/W2511309421","https://openalex.org/W2523120806","https://openalex.org/W2534977774","https://openalex.org/W2543116431","https://openalex.org/W2548988315","https://openalex.org/W2549233669","https://openalex.org/W2554834191","https://openalex.org/W2568978875","https://openalex.org/W2586526765","https://openalex.org/W2601251086","https://openalex.org/W2602495529","https://openalex.org/W2734926347","https://openalex.org/W2740851935","https://openalex.org/W2746385392","https://openalex.org/W2760250728","https://openalex.org/W2765364244","https://openalex.org/W2791904618","https://openalex.org/W2803497813","https://openalex.org/W2805263854","https://openalex.org/W2895081508","https://openalex.org/W2950814172","https://openalex.org/W4244668759","https://openalex.org/W4247260407"],"related_works":["https://openalex.org/W2028102819","https://openalex.org/W7198734458","https://openalex.org/W4399556303","https://openalex.org/W3153049262","https://openalex.org/W7163761337","https://openalex.org/W7221273329","https://openalex.org/W4392309100","https://openalex.org/W3198181219","https://openalex.org/W2115682191","https://openalex.org/W2912374839"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":6}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-01-10T00:00:00"}