{"id":"https://openalex.org/W2996955136","doi":"https://doi.org/10.1007/s10295-019-02257-4","title":"A regulated synthetic operon facilitates stable overexpression of multigene terpenoid pathway in Bacillus subtilis","display_name":"A regulated synthetic operon facilitates stable overexpression of multigene terpenoid pathway in Bacillus subtilis","publication_year":2020,"publication_date":"2020-01-02","ids":{"openalex":"https://openalex.org/W2996955136","doi":"https://doi.org/10.1007/s10295-019-02257-4","mag":"2996955136","pmid":"https://pubmed.ncbi.nlm.nih.gov/31894423"},"language":"en","primary_location":{"id":"doi:10.1007/s10295-019-02257-4","doi":"https://doi.org/10.1007/s10295-019-02257-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10295-019-02257-4","pdf_url":"https://academic.oup.com/jimb/article-pdf/47/2/243/36799201/jimb0243.pdf","source":{"id":"https://openalex.org/S107262989","display_name":"Journal of Industrial Microbiology & Biotechnology","issn_l":"1367-5435","issn":["1367-5435","1476-5535"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Industrial Microbiology and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/jimb/article-pdf/47/2/243/36799201/jimb0243.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087452962","display_name":"Ingy I. Abdallah","orcid":"https://orcid.org/0000-0003-0934-4822","observed_orcids":["https://orcid.org/0000-0003-0934-4822"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ingy I Abdallah","raw_affiliation_strings":["grid.4830.f 0000 0004 0407 1981 Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy University of Groningen Antonius Deusinglaan 1 9713 AV Groningen The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"grid.4830.f 0000 0004 0407 1981 Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy University of Groningen Antonius Deusinglaan 1 9713 AV Groningen The Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064261255","display_name":"Dan Xue","orcid":"https://orcid.org/0000-0002-0162-980X","observed_orcids":["https://orcid.org/0000-0002-0162-980X"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Dan Xue","raw_affiliation_strings":["grid.4830.f 0000 0004 0407 1981 Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy University of Groningen Antonius Deusinglaan 1 9713 AV Groningen The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"grid.4830.f 0000 0004 0407 1981 Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy University of Groningen Antonius Deusinglaan 1 9713 AV Groningen The Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056487416","display_name":"Hegar Pramastya","orcid":"https://orcid.org/0000-0002-4585-219X","observed_orcids":["https://orcid.org/0000-0002-4585-219X"]},"institutions":[{"id":"https://openalex.org/I134635517","display_name":"Bandung Institute of Technology","ror":"https://ror.org/00apj8t60","country_code":"ID","type":"education","lineage":["https://openalex.org/I134635517"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I4404532933","display_name":"Universitas Teknologi Bandung","ror":"https://ror.org/00rj2jz45","country_code":"ID","type":"education","lineage":["https://openalex.org/I4404532933"]}],"countries":["ID","NL"],"is_corresponding":false,"raw_author_name":"Hegar Pramastya","raw_affiliation_strings":["grid.434933.a 0000 0004 1808 0563 Pharmaceutical Biology Research Group, School of Pharmacy Institut Teknologi Bandung 40132 Bandung Indonesia","grid.4830.f 0000 0004 0407 1981 Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy University of Groningen Antonius Deusinglaan 1 9713 AV Groningen The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"grid.434933.a 0000 0004 1808 0563 Pharmaceutical Biology Research Group, School of Pharmacy Institut Teknologi Bandung 40132 Bandung Indonesia","institution_ids":["https://openalex.org/I134635517","https://openalex.org/I4404532933"]},{"raw_affiliation_string":"grid.4830.f 0000 0004 0407 1981 Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy University of Groningen Antonius Deusinglaan 1 9713 AV Groningen The Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068183883","display_name":"Ronald van Merkerk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ronald van Merkerk","raw_affiliation_strings":["grid.4830.f 0000 0004 0407 1981 Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy University of Groningen Antonius Deusinglaan 1 9713 AV Groningen The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"grid.4830.f 0000 0004 0407 1981 Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy University of Groningen Antonius Deusinglaan 1 9713 AV Groningen The Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084961817","display_name":"Rita Setroikromo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rita Setroikromo","raw_affiliation_strings":["grid.4830.f 0000 0004 0407 1981 Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy University of Groningen Antonius Deusinglaan 1 9713 AV Groningen The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"grid.4830.f 0000 0004 0407 1981 Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy University of Groningen Antonius Deusinglaan 1 9713 AV Groningen The Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006246608","display_name":"Wim J. Quax","orcid":"https://orcid.org/0000-0002-5162-9947","observed_orcids":["https://orcid.org/0000-0002-5162-9947"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Wim J Quax","raw_affiliation_strings":["grid.4830.f 0000 0004 0407 1981 Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy University of Groningen Antonius Deusinglaan 1 9713 AV Groningen The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"grid.4830.f 0000 0004 0407 1981 Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy University of Groningen Antonius Deusinglaan 1 9713 AV Groningen The Netherlands","institution_ids":["https://openalex.org/I169381384"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006246608"],"corresponding_institution_ids":["https://openalex.org/I169381384"],"apc_list":{"value":3260,"currency":"USD","value_usd":3260},"apc_paid":{"value":3260,"currency":"USD","value_usd":3260},"fwci":0.8106,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.66229773,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"47","issue":"2","first_page":"243","last_page":"249"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.29420000314712524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacillus-subtilis","display_name":"Bacillus subtilis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/synthetic-operon","display_name":"synthetic operon","score":0.9139999747276306},{"id":"https://openalex.org/keywords/methylerythritol-phosphate-pathway","display_name":"methylerythritol phosphate pathway","score":0.9610000252723694},{"id":"https://openalex.org/keywords/terpenoid-biosynthesis","display_name":"terpenoid biosynthesis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/theta-replication","display_name":"theta replication","score":0.8740000128746033},{"id":"https://openalex.org/keywords/rolling-circle-replication","display_name":"rolling circle replication","score":0.9869999885559082},{"id":"https://openalex.org/keywords/plasmid-stability","display_name":"plasmid stability","score":0.7590000033378601},{"id":"https://openalex.org/keywords/gene-overexpression","display_name":"gene overexpression","score":0.5809999704360962},{"id":"https://openalex.org/keywords/microbial-cell-factories","display_name":"microbial cell factories","score":0.8069999814033508},{"id":"https://openalex.org/keywords/natural-product-production","display_name":"natural product production","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.924676239490509},{"id":"https://openalex.org/C2777272437","wikidata":"https://www.wikidata.org/wiki/Q131238","display_name":"Bacillus subtilis","level":3,"score":0.8986117839813232},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.783394992351532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.683462381362915},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6125946640968323},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.49546802043914795},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3809669613838196},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.20867422223091125},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.16901174187660217},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053898","descriptor_name":"Biosynthetic Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s10295-019-02257-4","doi":"https://doi.org/10.1007/s10295-019-02257-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10295-019-02257-4","pdf_url":"https://academic.oup.com/jimb/article-pdf/47/2/243/36799201/jimb0243.pdf","source":{"id":"https://openalex.org/S107262989","display_name":"Journal of Industrial Microbiology & Biotechnology","issn_l":"1367-5435","issn":["1367-5435","1476-5535"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Industrial Microbiology and Biotechnology","raw_type":"journal-article"},{"id":"pmid:31894423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31894423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of industrial microbiology & biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire/eb4d3171-bd25-4646-bb02-e656e1875711","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11370/eb4d3171-bd25-4646-bb02-e656e1875711","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Abdallah, I I, Xue, D, Pramastya, H, van Merkerk, R, Setroikromo, R & Quax, W J 2020, 'A regulated synthetic operon facilitates stable overexpression of multigene terpenoid pathway in Bacillus subtilis', Journal of Industrial Microbiology & Biotechnology, vol. 47, no. 2, pp. 243-249. https://doi.org/10.1007/s10295-019-02257-4","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/a26e49f0-cdc4-4ee6-83ea-394261587d6b","doi":null,"is_oa":false,"landing_page_url":"https://www.rug.nl/research/portal/en/publications/a-regulated-synthetic-operon-facilitates-stable-overexpression-of-multigene-terpenoid-pathway-in-bacillus-subtilis(a26e49f0-cdc4-4ee6-83ea-394261587d6b).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Industrial Microbiology & Biotechnology. SPRINGER","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/eb4d3171-bd25-4646-bb02-e656e1875711","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/eb4d3171-bd25-4646-bb02-e656e1875711","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Industrial Microbiology & Biotechnology, 47(2), 243 - 249. SPRINGER","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1007/s10295-019-02257-4","doi":"https://doi.org/10.1007/s10295-019-02257-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10295-019-02257-4","pdf_url":"https://academic.oup.com/jimb/article-pdf/47/2/243/36799201/jimb0243.pdf","source":{"id":"https://openalex.org/S107262989","display_name":"Journal of Industrial Microbiology & Biotechnology","issn_l":"1367-5435","issn":["1367-5435","1476-5535"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Industrial Microbiology and Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5557309769","display_name":"Products from methanol by synthetic cell factories","funder_award_id":"289540","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320933","display_name":"Rijksuniversiteit Groningen","ror":"https://ror.org/012p63287"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320326056","display_name":"Alexandria University","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2996955136.pdf","grobid_xml":"https://content.openalex.org/works/W2996955136.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W266796750","https://openalex.org/W335986809","https://openalex.org/W880104831","https://openalex.org/W1416038593","https://openalex.org/W1579030151","https://openalex.org/W1756936797","https://openalex.org/W1819651794","https://openalex.org/W1970686424","https://openalex.org/W1975054585","https://openalex.org/W1980724032","https://openalex.org/W1981766841","https://openalex.org/W1990226486","https://openalex.org/W2002214664","https://openalex.org/W2009382469","https://openalex.org/W2009908116","https://openalex.org/W2015557312","https://openalex.org/W2016894948","https://openalex.org/W2032019813","https://openalex.org/W2041175202","https://openalex.org/W2043766886","https://openalex.org/W2052933288","https://openalex.org/W2070359728","https://openalex.org/W2076153820","https://openalex.org/W2103956246","https://openalex.org/W2104597175","https://openalex.org/W2105636172","https://openalex.org/W2107148353","https://openalex.org/W2118342572","https://openalex.org/W2121695681","https://openalex.org/W2124062841","https://openalex.org/W2127646692","https://openalex.org/W2135005905","https://openalex.org/W2136360997","https://openalex.org/W2169860455","https://openalex.org/W2212868467","https://openalex.org/W2302330316","https://openalex.org/W2463822315","https://openalex.org/W2469264705","https://openalex.org/W2588176324","https://openalex.org/W2754878945","https://openalex.org/W2903978922","https://openalex.org/W2949221001","https://openalex.org/W4236404432"],"related_works":["https://openalex.org/W7067558610","https://openalex.org/W2105636172","https://openalex.org/W3093715889","https://openalex.org/W1819651794","https://openalex.org/W7095654205","https://openalex.org/W4367394948","https://openalex.org/W2915193000","https://openalex.org/W4380363155","https://openalex.org/W4379375829","https://openalex.org/W4385064640"],"abstract_inverted_index":{"Abstract":[0],"The":[1,39,155],"creation":[2],"of":[3,10,24,41,72,100,140,153,157,185,192],"microbial":[4],"cell":[5,181],"factories":[6],"for":[7,15,159,183],"sustainable":[8],"production":[9,99,184],"natural":[11],"products":[12],"is":[13,44,188],"important":[14],"medical":[16],"and":[17,69,87,114,126,194],"industrial":[18],"applications.":[19],"This":[20,187],"requires":[21],"stable":[22,180],"expression":[23,71],"biosynthetic":[25],"pathways":[26],"in":[27,84,96,124,162,206],"a":[28,88,97,145,179,203],"host":[29],"organism":[30],"with":[31,110,116],"favorable":[32],"fermentation":[33],"properties":[34],"such":[35],"as":[36,167,178],"Bacillus":[37],"subtilis.":[38],"aim":[40],"this":[42,85,197],"study":[43],"to":[45,78,130],"construct":[46],"B.":[47,207],"subtilis":[48,208],"strains":[49],"that":[50,172],"produce":[51],"valuable":[52],"terpenoid":[53],"compounds":[54],"by":[55],"overexpressing":[56,136],"the":[57,67,141,150,163,189],"innate":[58],"methylerythritol":[59],"phosphate":[60],"(MEP)":[61],"pathway.":[62],"A":[63,134],"synthetic":[64],"operon":[65,86,164,199],"allowing":[66],"concerted":[68],"regulated":[70],"multiple":[73],"genes":[74,80,139],"was":[75,93,165],"developed.":[76],"Up":[77],"8":[79],"have":[81],"been":[82],"combined":[83],"stably":[89,195],"inherited":[90],"plasmid-based":[91,204],"vector":[92],"constructed":[94],"resulting":[95],"high":[98,210],"C30":[101,211],"carotenoids.":[102,154],"For":[103],"this,":[104],"two":[105],"vectors":[106],"were":[107,121],"examined,":[108],"one":[109],"rolling":[111,131],"circle":[112,132],"replication":[113],"another":[115],"theta":[117],"replication.":[118],"Theta-replication":[119],"constructs":[120],"clearly":[122,148],"superior":[123],"structural":[125],"segregational":[127],"stability":[128],"compared":[129],"constructs.":[133],"strain":[135,174],"all":[137],"eight":[138],"MEP":[142],"pathway":[143],"on":[144],"theta-replicating":[146],"plasmid":[147],"produced":[149],"highest":[151],"level":[152,156],"transcription":[158],"each":[160],"gene":[161],"similar":[166],"RT-qPCR":[168],"analysis":[169],"indicated.":[170],"Hence,":[171],"corresponding":[173],"can":[175],"be":[176],"used":[177],"factory":[182],"terpenoids.":[186],"first":[190],"report":[191],"merging":[193],"expressing":[196],"large-size":[198],"(eight":[200],"genes)":[201],"from":[202],"system":[205],"enabling":[209],"carotenoid":[212],"production.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-01-10T00:00:00"}