{"id":"https://openalex.org/W2996933729","doi":null,"title":"[Excitation-contraction coupling and junctional membrane structures.]","display_name":"[Excitation-contraction coupling and junctional membrane structures.]","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2996933729","mag":"2996933729","pmid":"https://pubmed.ncbi.nlm.nih.gov/28232646"},"language":"ja","primary_location":{"id":"pmid:28232646","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28232646","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008069470","display_name":"Daisuke Takei","orcid":"https://orcid.org/0000-0001-7804-8790","observed_orcids":["https://orcid.org/0000-0001-7804-8790"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Takei","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Kyoto University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Kyoto University, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024358171","display_name":"Hiroshi Takeshima","orcid":"https://orcid.org/0000-0003-4525-3725","observed_orcids":["https://orcid.org/0000-0003-4525-3725"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Takeshima","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Kyoto University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Kyoto University, Japan","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I22299242"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"27","issue":"3","first_page":"333","last_page":"338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.5015000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.5015000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.4765999913215637,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/excitation-contraction-coupling","display_name":"excitation-contraction coupling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/junctophilin","display_name":"junctophilin","score":0.8669999837875366},{"id":"https://openalex.org/keywords/junctophilin-2","display_name":"junctophilin-2","score":0.7649999856948853},{"id":"https://openalex.org/keywords/t-tubules","display_name":"T-tubules","score":0.7699999809265137},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum","display_name":"sarcoplasmic reticulum","score":1.0},{"id":"https://openalex.org/keywords/calcium-release","display_name":"calcium release","score":0.8389999866485596},{"id":"https://openalex.org/keywords/striated-muscle","display_name":"striated muscle","score":0.8019999861717224},{"id":"https://openalex.org/keywords/heart-disease","display_name":"heart disease","score":0.6990000009536743},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6910675168037415},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6059390902519226},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.5924832820892334},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5788615942001343},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.5361573100090027},{"id":"https://openalex.org/C114908165","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Excitation\u2013contraction coupling","level":3,"score":0.5335021018981934},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5004525184631348},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.4774101972579956},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.4753548800945282},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4621734023094177},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.45696917176246643},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41935858130455017},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.41437941789627075},{"id":"https://openalex.org/C2778996579","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac muscle","level":2,"score":0.4102093577384949},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3392783999443054},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2596844434738159},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1882803738117218},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18747803568840027},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.15264087915420532},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056966","descriptor_name":"Excitation Contraction Coupling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:28232646","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28232646","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"Journal Article"},{"id":"mag:2996933729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28232646","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W41516964","https://openalex.org/W58690323","https://openalex.org/W93053989","https://openalex.org/W1501473386","https://openalex.org/W1547733031","https://openalex.org/W1594144334","https://openalex.org/W2008492357","https://openalex.org/W2014707628","https://openalex.org/W2045562495","https://openalex.org/W2066613071","https://openalex.org/W2098511755","https://openalex.org/W2100604852","https://openalex.org/W2101503666","https://openalex.org/W2105894548","https://openalex.org/W2142099365","https://openalex.org/W2144930991","https://openalex.org/W2150891147","https://openalex.org/W2172421250","https://openalex.org/W2337485820","https://openalex.org/W2409360547","https://openalex.org/W2409679560","https://openalex.org/W2414044484","https://openalex.org/W2508997451","https://openalex.org/W2520211681","https://openalex.org/W2542822064","https://openalex.org/W2769671204","https://openalex.org/W2791309620","https://openalex.org/W2895903821","https://openalex.org/W2909894833","https://openalex.org/W2981617674","https://openalex.org/W2990840371","https://openalex.org/W3016852213","https://openalex.org/W3016940380","https://openalex.org/W3025259451","https://openalex.org/W3028330817","https://openalex.org/W3034225365","https://openalex.org/W3035467903","https://openalex.org/W3036451283","https://openalex.org/W3092541624","https://openalex.org/W3147479802","https://openalex.org/W6776928405"],"related_works":["https://openalex.org/W2036336174","https://openalex.org/W3138543617","https://openalex.org/W1995628893","https://openalex.org/W4235408016","https://openalex.org/W2156022181","https://openalex.org/W1971255655","https://openalex.org/W3084142227","https://openalex.org/W4205346084","https://openalex.org/W7095445257","https://openalex.org/W2000758607"],"abstract_inverted_index":{"Striated":[0],"muscle":[1],"cells":[2],"form":[3],"specialized":[4],"junctional":[5],"membrane":[6,41],"complexes(JMCs)between":[7],"the":[8,17,39,44,51],"cell-surface":[9],"transverse":[10],"tubule":[11],"and":[12,42,53,71,78],"sarcoplasmic":[13],"reticulum(SR)for":[14],"setting":[15],"up":[16],"excitation-contraction":[18],"coupling":[19],"machinery":[20],"converting":[21],"depolarization":[22],"into":[23],"Ca2+":[24,66],"release":[25],"signals.":[26],"Junctophilin":[27],"subtypes,":[28],"namely":[29],"JP1-JP4,":[30],"are":[31],"proteins":[32],"that":[33,50],"construct":[34],"JMCs":[35],"by":[36],"binding":[37],"to":[38],"cell":[40],"spanning":[43],"SR":[45],"membrane.":[46],"Recent":[47],"studies":[48],"demonstrated":[49],"mutations":[52],"altered":[54],"expression":[55],"of":[56,85],"JP2":[57],"take":[58],"part":[59],"in":[60,68,76,82],"cardiac":[61],"diseases.":[62,87],"JPs":[63],"dominantly":[64],"affect":[65],"signaling":[67],"striated":[69],"muscle,":[70],"thus":[72],"may":[73],"be":[74],"involved":[75],"pathogeneses":[77],"progressive":[79],"pathophysiological":[80],"conditions":[81],"a":[83],"variety":[84],"muscle-related":[86]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-01-10T00:00:00"}