{"id":"https://openalex.org/W2996852014","doi":"https://doi.org/10.3390/ijms21010207","title":"High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra","display_name":"High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra","publication_year":2019,"publication_date":"2019-12-27","ids":{"openalex":"https://openalex.org/W2996852014","doi":"https://doi.org/10.3390/ijms21010207","mag":"2996852014","pmid":"https://pubmed.ncbi.nlm.nih.gov/31892244","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6981702"},"language":"en","primary_location":{"id":"doi:10.3390/ijms21010207","doi":"https://doi.org/10.3390/ijms21010207","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms21010207","pdf_url":"https://www.mdpi.com/1422-0067/21/1/207/pdf?version=1577456543","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2996852014"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/21/1/207/pdf?version=1577456543","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084934983","display_name":"Yu-Chia Kao","orcid":"https://orcid.org/0000-0002-9486-2597","observed_orcids":["https://orcid.org/0000-0002-9486-2597"]},"institutions":[{"id":"https://openalex.org/I4210091198","display_name":"E-Da Hospital","ror":"https://ror.org/00eh7f421","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210091198"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Chia Kao","raw_affiliation_strings":["Department of Pediatrics, E-DA Hospital, Kaohsiung 82445, Taiwan","Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-9486-2597","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, E-DA Hospital, Kaohsiung 82445, Taiwan","institution_ids":["https://openalex.org/I4210091198"]},{"raw_affiliation_string":"Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080112432","display_name":"Wei\u2010Yen Wei","orcid":"https://orcid.org/0009-0008-0105-8876","observed_orcids":["https://orcid.org/0009-0008-0105-8876"]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Yen Wei","raw_affiliation_strings":["Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001202613","display_name":"Kuen\u2010Jer Tsai","orcid":"https://orcid.org/0000-0002-2170-9735","observed_orcids":["https://orcid.org/0000-0002-2170-9735"]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Kuen-Jer Tsai","raw_affiliation_strings":["Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan","Research Center of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-2170-9735","affiliations":[{"raw_affiliation_string":"Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan","institution_ids":["https://openalex.org/I91807558"]},{"raw_affiliation_string":"Research Center of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan","institution_ids":["https://openalex.org/I4210158999","https://openalex.org/I91807558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103143590","display_name":"Liang\u2010Chao Wang","orcid":"https://orcid.org/0000-0003-4341-082X","observed_orcids":["https://orcid.org/0000-0003-4341-082X"]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Liang-Chao Wang","raw_affiliation_strings":["Division of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan","Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan","institution_ids":["https://openalex.org/I4210158999","https://openalex.org/I91807558"]},{"raw_affiliation_string":"Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5001202613","https://openalex.org/A5103143590"],"corresponding_institution_ids":["https://openalex.org/I4210158999","https://openalex.org/I91807558"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1824},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1824},"fwci":4.6418,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.95597297,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"21","issue":"1","first_page":"207","last_page":"207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9890000224113464},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8119999766349792},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.8420000076293945},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.9789999723434448},{"id":"https://openalex.org/keywords/peroxisome-proliferator-activated-receptors","display_name":"peroxisome proliferator-activated receptors","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.8529999852180481},{"id":"https://openalex.org/keywords/ppardelta","display_name":"PPAR\u03b4","score":0.9739999771118164},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.996999979019165},{"id":"https://openalex.org/keywords/dendritic-spine-density","display_name":"dendritic spine density","score":0.9390000104904175},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.7889999747276306},{"id":"https://openalex.org/keywords/ventral-tegmental-area","display_name":"ventral tegmental area","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.8562737703323364},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.8206034302711487},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7834252715110779},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7802004814147949},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.698874831199646},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.5737935900688171},{"id":"https://openalex.org/C2780948874","wikidata":"https://www.wikidata.org/wiki/Q640562","display_name":"Ventral tegmental area","level":4,"score":0.5088803768157959},{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.47324806451797485},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41176581382751465},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.30563539266586304},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2857385277748108},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.07490810751914978}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017557","descriptor_name":"Ventral Tegmental Area","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047492","descriptor_name":"Peroxisome Proliferator-Activated Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms21010207","doi":"https://doi.org/10.3390/ijms21010207","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms21010207","pdf_url":"https://www.mdpi.com/1422-0067/21/1/207/pdf?version=1577456543","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5953604","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6981702","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31892244","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31892244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6981702","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6981702/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms21010207","doi":"https://doi.org/10.3390/ijms21010207","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms21010207","pdf_url":"https://www.mdpi.com/1422-0067/21/1/207/pdf?version=1577456543","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1805013757","display_name":null,"funder_award_id":"NCKUH-10802021","funder_id":"https://openalex.org/F4320322933","funder_display_name":"National Cheng Kung University Hospital"},{"id":"https://openalex.org/G6595145664","display_name":null,"funder_award_id":"MOST-105-2628-B-006-016-MY3 and MOST-106-2628-B-006-001-MY4","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320322933","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2996852014.pdf","grobid_xml":"https://content.openalex.org/works/W2996852014.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W431776825","https://openalex.org/W767309710","https://openalex.org/W1495087777","https://openalex.org/W1545110321","https://openalex.org/W1578544243","https://openalex.org/W1822935226","https://openalex.org/W1956056370","https://openalex.org/W1965746769","https://openalex.org/W1974055484","https://openalex.org/W1975002958","https://openalex.org/W1976072714","https://openalex.org/W1977258406","https://openalex.org/W1980282543","https://openalex.org/W1987478242","https://openalex.org/W1989360250","https://openalex.org/W1993606536","https://openalex.org/W2004069800","https://openalex.org/W2004579527","https://openalex.org/W2013764777","https://openalex.org/W2022048961","https://openalex.org/W2026088200","https://openalex.org/W2034137732","https://openalex.org/W2036620114","https://openalex.org/W2036940243","https://openalex.org/W2038498388","https://openalex.org/W2041112450","https://openalex.org/W2060896332","https://openalex.org/W2067147530","https://openalex.org/W2068144526","https://openalex.org/W2069968910","https://openalex.org/W2072084453","https://openalex.org/W2072798129","https://openalex.org/W2073874214","https://openalex.org/W2079554189","https://openalex.org/W2082302366","https://openalex.org/W2087931458","https://openalex.org/W2093500882","https://openalex.org/W2094969688","https://openalex.org/W2099440512","https://openalex.org/W2107251840","https://openalex.org/W2109618249","https://openalex.org/W2113328569","https://openalex.org/W2126690426","https://openalex.org/W2129205142","https://openalex.org/W2133121921","https://openalex.org/W2134512768","https://openalex.org/W2143959688","https://openalex.org/W2163684868","https://openalex.org/W2164125772","https://openalex.org/W2166878457","https://openalex.org/W2167976671","https://openalex.org/W2168606198","https://openalex.org/W2297925470","https://openalex.org/W2301316457","https://openalex.org/W2352501837","https://openalex.org/W2407831908","https://openalex.org/W2412971846","https://openalex.org/W2417724549","https://openalex.org/W2476078842","https://openalex.org/W2508360554","https://openalex.org/W2513082925","https://openalex.org/W2515349811","https://openalex.org/W2541262686","https://openalex.org/W2567447937","https://openalex.org/W2609793639","https://openalex.org/W2621103340","https://openalex.org/W2765198066","https://openalex.org/W2804587961","https://openalex.org/W2893325662","https://openalex.org/W2901046251","https://openalex.org/W2907865394","https://openalex.org/W4253660343"],"related_works":["https://openalex.org/W3093138119","https://openalex.org/W2068712725","https://openalex.org/W1965746769","https://openalex.org/W2161461930","https://openalex.org/W1990937715","https://openalex.org/W4391228294","https://openalex.org/W7045704522","https://openalex.org/W2028367714","https://openalex.org/W2272173714"],"abstract_inverted_index":{"Although":[0],"several":[1],"epidemiologic":[2],"and":[3,11,63,104,141,173],"animal":[4],"studies":[5],"have":[6],"revealed":[7],"correlations":[8],"between":[9],"obesity":[10,37],"neurodegenerative":[12],"disorders,":[13],"such":[14],"as":[15],"Parkinson":[16],"disease":[17],"(PD),":[18],"the":[19,33,39,66,69,78,86,92,102,110,139,142,186,190],"underlying":[20],"pathological":[21],"mechanisms":[22],"of":[23,35,112,146,169,178,192],"obesity-induced":[24],"PD":[25],"remain":[26],"unclear.":[27],"Our":[28],"study":[29,156,188],"aimed":[30],"to":[31,57,151],"assess":[32],"effect":[34],"diet-induced":[36],"on":[38,195],"brain":[40],"dopaminergic":[41,71,83,122,171,198],"pathway.":[42],"For":[43],"five":[44],"months,":[45],"starting":[46],"from":[47],"weaning,":[48],"we":[49],"gave":[50],"C57BL/6":[51],"mice":[52,114,148],"a":[53,159],"high-fat":[54],"diet":[55,67],"(HFD)":[56],"generate":[58],"an":[59,193],"obese":[60],"mouse":[61],"model":[62],"investigate":[64],"whether":[65],"reprogrammed":[68],"midbrain":[70,170],"system.":[72],"Tyrosine":[73],"hydroxylase":[74],"staining":[75],"showed":[76,157],"that":[77,118,158],"HFD":[79,120,147,161,194],"resulted":[80,174],"in":[81,85,101,109,138,153,175,197],"fewer":[82],"neurons":[84],"substantia":[87],"nigra":[88],"(SN),":[89],"but":[90],"not":[91],"striatum.":[93,105],"It":[94],"also":[95],"induced":[96,162],"neuroinflammation,":[97,163],"with":[98],"increased":[99],"astrogliosis":[100],"SN":[103,111,140],"Dendritic":[106],"spine":[107],"density":[108],"HFD-exposed":[113],"decreased,":[115],"which":[116],"suggested":[117],"prolonged":[119,160],"altered":[121],"neuroplasticity.":[123],"All":[124],"three":[125],"peroxisome":[126],"proliferator-activated":[127],"receptor":[128],"(PPAR)":[129],"subtype":[130],"(PPAR-\u03b1,":[131],"PPAR-\u03b2/\u03b4,":[132],"PPAR-\u03b3)":[133],"levels":[134],"were":[135],"significantly":[136],"reduced":[137],"ventral":[143],"tegmental":[144],"area":[145],"when":[149],"compared":[150],"those":[152],"controls.":[154],"This":[155],"suppressed":[164],"PPAR":[165],"levels,":[166],"caused":[167],"degeneration":[168],"neurons,":[172],"symptoms":[176],"reminiscent":[177],"human":[179],"PD.":[180],"To":[181],"our":[182],"knowledge,":[183],"this":[184],"is":[185],"first":[187],"documenting":[189],"effects":[191],"PPARs":[196],"neurons.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":9}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2020-01-10T00:00:00"}