{"id":"https://openalex.org/W2996843232","doi":"https://doi.org/10.3390/cancers12010125","title":"Advancing CAR T-Cell Therapy for Solid Tumors: Lessons Learned from Lymphoma Treatment","display_name":"Advancing CAR T-Cell Therapy for Solid Tumors: Lessons Learned from Lymphoma Treatment","publication_year":2020,"publication_date":"2020-01-03","ids":{"openalex":"https://openalex.org/W2996843232","doi":"https://doi.org/10.3390/cancers12010125","mag":"2996843232","pmid":"https://pubmed.ncbi.nlm.nih.gov/31947775","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7016531"},"language":"en","primary_location":{"id":"doi:10.3390/cancers12010125","doi":"https://doi.org/10.3390/cancers12010125","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cancers12010125","pdf_url":"https://www.mdpi.com/2072-6694/12/1/125/pdf?version=1578291027","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/12/1/125/pdf?version=1578291027","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074919240","display_name":"Aleksei Titov","orcid":"https://orcid.org/0000-0003-4077-3924","observed_orcids":["https://orcid.org/0000-0003-4077-3924"]},"institutions":[{"id":"https://openalex.org/I21203515","display_name":"Kazan Federal University","ror":"https://ror.org/05256ym39","country_code":"RU","type":"education","lineage":["https://openalex.org/I21203515"]},{"id":"https://openalex.org/I4210100648","display_name":"National Medical Research Center for Hematology","ror":"https://ror.org/015fskz95","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210100648","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Aleksei Titov","raw_affiliation_strings":["Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia","Laboratory of Transplantation Immunology, National Hematology Research Centre, 125167 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia","institution_ids":["https://openalex.org/I21203515"]},{"raw_affiliation_string":"Laboratory of Transplantation Immunology, National Hematology Research Centre, 125167 Moscow, Russia","institution_ids":["https://openalex.org/I4210100648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051598161","display_name":"Aygul Valiullina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21203515","display_name":"Kazan Federal University","ror":"https://ror.org/05256ym39","country_code":"RU","type":"education","lineage":["https://openalex.org/I21203515"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Aygul Valiullina","raw_affiliation_strings":["Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia","institution_ids":["https://openalex.org/I21203515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053991782","display_name":"Ekaterina Zmievskaya","orcid":"https://orcid.org/0000-0003-1337-4370","observed_orcids":["https://orcid.org/0000-0003-1337-4370"]},"institutions":[{"id":"https://openalex.org/I21203515","display_name":"Kazan Federal University","ror":"https://ror.org/05256ym39","country_code":"RU","type":"education","lineage":["https://openalex.org/I21203515"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ekaterina Zmievskaya","raw_affiliation_strings":["Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia","institution_ids":["https://openalex.org/I21203515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038054740","display_name":"Ekaterina Konstantinovna Zaikova","orcid":"https://orcid.org/0000-0003-0584-2330","observed_orcids":["https://orcid.org/0000-0003-0584-2330"]},"institutions":[{"id":"https://openalex.org/I3018698992","display_name":"Federal Almazov North-West Medical Research Centre","ror":"https://ror.org/03qepc107","country_code":"RU","type":"facility","lineage":["https://openalex.org/I3018698992"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ekaterina Zaikova","raw_affiliation_strings":["Institute of Hematology, Almazov National Medical Research Center, 197341 Saint Petersburg, Russia"],"raw_orcid":"https://orcid.org/0000-0003-0584-2330","affiliations":[{"raw_affiliation_string":"Institute of Hematology, Almazov National Medical Research Center, 197341 Saint Petersburg, Russia","institution_ids":["https://openalex.org/I3018698992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072869764","display_name":"Alexey Petukhov","orcid":"https://orcid.org/0000-0002-7298-5238","observed_orcids":["https://orcid.org/0000-0002-7298-5238"]},"institutions":[{"id":"https://openalex.org/I21203515","display_name":"Kazan Federal University","ror":"https://ror.org/05256ym39","country_code":"RU","type":"education","lineage":["https://openalex.org/I21203515"]},{"id":"https://openalex.org/I3018698992","display_name":"Federal Almazov North-West Medical Research Centre","ror":"https://ror.org/03qepc107","country_code":"RU","type":"facility","lineage":["https://openalex.org/I3018698992"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexey Petukhov","raw_affiliation_strings":["Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia","Institute of Hematology, Almazov National Medical Research Center, 197341 Saint Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia","institution_ids":["https://openalex.org/I21203515"]},{"raw_affiliation_string":"Institute of Hematology, Almazov National Medical Research Center, 197341 Saint Petersburg, Russia","institution_ids":["https://openalex.org/I3018698992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034428756","display_name":"\u041c\u0438\u0444\u0442\u0430\u0445\u043e\u0432\u0430 \u0420\u0435\u0433\u0438\u043d\u0430 \u0420\u0438\u0444\u043a\u0430\u0442\u043e\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0002-6686-1968","observed_orcids":["https://orcid.org/0000-0002-6686-1968"]},"institutions":[{"id":"https://openalex.org/I21203515","display_name":"Kazan Federal University","ror":"https://ror.org/05256ym39","country_code":"RU","type":"education","lineage":["https://openalex.org/I21203515"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Regina Miftakhova","raw_affiliation_strings":["Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"],"raw_orcid":"https://orcid.org/0000-0002-6686-1968","affiliations":[{"raw_affiliation_string":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia","institution_ids":["https://openalex.org/I21203515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074962652","display_name":"Emil Bulatov","orcid":"https://orcid.org/0000-0003-2961-0032","observed_orcids":["https://orcid.org/0000-0003-2961-0032"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I21203515","display_name":"Kazan Federal University","ror":"https://ror.org/05256ym39","country_code":"RU","type":"education","lineage":["https://openalex.org/I21203515"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Emil Bulatov","raw_affiliation_strings":["Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia","Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0003-2961-0032","affiliations":[{"raw_affiliation_string":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia","institution_ids":["https://openalex.org/I21203515"]},{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066414193","display_name":"Albert Anatolyevich Rizvanov","orcid":"https://orcid.org/0000-0002-9427-5739","observed_orcids":["https://orcid.org/0000-0002-9427-5739"]},"institutions":[{"id":"https://openalex.org/I21203515","display_name":"Kazan Federal University","ror":"https://ror.org/05256ym39","country_code":"RU","type":"education","lineage":["https://openalex.org/I21203515"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Albert Rizvanov","raw_affiliation_strings":["Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"],"raw_orcid":"https://orcid.org/0000-0002-9427-5739","affiliations":[{"raw_affiliation_string":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia","institution_ids":["https://openalex.org/I21203515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5066414193","https://openalex.org/A5074962652"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I21203515","https://openalex.org/I4210105571"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2324},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2324},"fwci":2.1348,"has_fulltext":true,"cited_by_count":91,"citation_normalized_percentile":{"value":0.90674261,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"12","issue":"1","first_page":"125","last_page":"125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cd19","display_name":"CD19","score":0.7749999761581421},{"id":"https://openalex.org/keywords/sarcoma","display_name":"sarcoma","score":0.6570000052452087},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":1.0},{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.7519999742507935},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.8270000219345093},{"id":"https://openalex.org/keywords/immunosuppressive-tumor-microenvironment","display_name":"immunosuppressive tumor microenvironment","score":0.7549999952316284},{"id":"https://openalex.org/keywords/car-t-cell-engineering","display_name":"CAR-T cell engineering","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.8438799977302551},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6534211039543152},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.6244507431983948},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.529628574848175},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5123354196548462},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.49342384934425354},{"id":"https://openalex.org/C2993640289","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Solid tumor","level":3,"score":0.48959070444107056},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48021969199180603},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42388835549354553},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4222838282585144},{"id":"https://openalex.org/C3018890749","wikidata":"https://www.wikidata.org/wiki/Q204711","display_name":"Food and drug administration","level":2,"score":0.4103272557258606},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33984559774398804},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29319119453430176},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.19112280011177063},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15784448385238647},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/cancers12010125","doi":"https://doi.org/10.3390/cancers12010125","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cancers12010125","pdf_url":"https://www.mdpi.com/2072-6694/12/1/125/pdf?version=1578291027","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5997600","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7016531","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31947775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31947775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7016531","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7016531/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:6559292d62544798a968073f91b419ae","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6559292d62544798a968073f91b419ae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, Vol 12, Iss 1, p 125 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cancers12010125","doi":"https://doi.org/10.3390/cancers12010125","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cancers12010125","pdf_url":"https://www.mdpi.com/2072-6694/12/1/125/pdf?version=1578291027","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1730340623","display_name":null,"funder_award_id":"19-74-20026","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"},{"id":"https://openalex.org/G8665961980","display_name":null,"funder_award_id":"\u0421\u041f-227.2019.4","funder_id":"https://openalex.org/F4320335603","funder_display_name":"Council on grants of the President of the Russian Federation"}],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"},{"id":"https://openalex.org/F4320327643","display_name":"Kazan Federal University","ror":"https://ror.org/05256ym39"},{"id":"https://openalex.org/F4320335603","display_name":"Council on grants of the President of the Russian Federation","ror":"https://ror.org/05gxnjj05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2996843232.pdf","grobid_xml":"https://content.openalex.org/works/W2996843232.grobid-xml"},"referenced_works_count":145,"referenced_works":["https://openalex.org/W1492051324","https://openalex.org/W1889335134","https://openalex.org/W1965398961","https://openalex.org/W1983517349","https://openalex.org/W1985102142","https://openalex.org/W2006386545","https://openalex.org/W2007337091","https://openalex.org/W2009175518","https://openalex.org/W2023216402","https://openalex.org/W2023930907","https://openalex.org/W2026890342","https://openalex.org/W2027863358","https://openalex.org/W2028092387","https://openalex.org/W2038702089","https://openalex.org/W2039648189","https://openalex.org/W2044306073","https://openalex.org/W2049426330","https://openalex.org/W2052329251","https://openalex.org/W2064272625","https://openalex.org/W2064510700","https://openalex.org/W2064610182","https://openalex.org/W2067319054","https://openalex.org/W2068173904","https://openalex.org/W2071456955","https://openalex.org/W2086834665","https://openalex.org/W2087857484","https://openalex.org/W2094945699","https://openalex.org/W2103021272","https://openalex.org/W2107031620","https://openalex.org/W2110820382","https://openalex.org/W2113224683","https://openalex.org/W2118796952","https://openalex.org/W2136100686","https://openalex.org/W2137119270","https://openalex.org/W2138002048","https://openalex.org/W2139605769","https://openalex.org/W2139923932","https://openalex.org/W2147622445","https://openalex.org/W2148963453","https://openalex.org/W2157100766","https://openalex.org/W2160117150","https://openalex.org/W2162222767","https://openalex.org/W2166810745","https://openalex.org/W2169579205","https://openalex.org/W2170426732","https://openalex.org/W2179454156","https://openalex.org/W2187474063","https://openalex.org/W2197308868","https://openalex.org/W2261866842","https://openalex.org/W2266683146","https://openalex.org/W2291298003","https://openalex.org/W2297219066","https://openalex.org/W2299919100","https://openalex.org/W2321724422","https://openalex.org/W2342423058","https://openalex.org/W2403668839","https://openalex.org/W2410313936","https://openalex.org/W2465860350","https://openalex.org/W2481298264","https://openalex.org/W2490141287","https://openalex.org/W2497401689","https://openalex.org/W2504729294","https://openalex.org/W2526887159","https://openalex.org/W2543564489","https://openalex.org/W2550354355","https://openalex.org/W2553096714","https://openalex.org/W2557336488","https://openalex.org/W2560367415","https://openalex.org/W2561849178","https://openalex.org/W2578528809","https://openalex.org/W2579046240","https://openalex.org/W2583070206","https://openalex.org/W2602369513","https://openalex.org/W2607810264","https://openalex.org/W2609835530","https://openalex.org/W2611222875","https://openalex.org/W2618359715","https://openalex.org/W2623440667","https://openalex.org/W2655262992","https://openalex.org/W2738678436","https://openalex.org/W2746068181","https://openalex.org/W2750497670","https://openalex.org/W2754593132","https://openalex.org/W2755114342","https://openalex.org/W2756071038","https://openalex.org/W2763751953","https://openalex.org/W2767891987","https://openalex.org/W2767931551","https://openalex.org/W2768388636","https://openalex.org/W2773804840","https://openalex.org/W2778172184","https://openalex.org/W2788975052","https://openalex.org/W2793644168","https://openalex.org/W2796207838","https://openalex.org/W2799553179","https://openalex.org/W2799959526","https://openalex.org/W2801641802","https://openalex.org/W2802206159","https://openalex.org/W2802394123","https://openalex.org/W2803687381","https://openalex.org/W2804568941","https://openalex.org/W2807819616","https://openalex.org/W2886908265","https://openalex.org/W2889777858","https://openalex.org/W2890120543","https://openalex.org/W2891135967","https://openalex.org/W2892326722","https://openalex.org/W2893525181","https://openalex.org/W2893567440","https://openalex.org/W2894362481","https://openalex.org/W2896600825","https://openalex.org/W2898096094","https://openalex.org/W2900542760","https://openalex.org/W2902185751","https://openalex.org/W2903062212","https://openalex.org/W2905817704","https://openalex.org/W2907842906","https://openalex.org/W2913127457","https://openalex.org/W2913665794","https://openalex.org/W2914335731","https://openalex.org/W2914345456","https://openalex.org/W2914726601","https://openalex.org/W2915944698","https://openalex.org/W2920686366","https://openalex.org/W2924300946","https://openalex.org/W2941558054","https://openalex.org/W2945409711","https://openalex.org/W2946573760","https://openalex.org/W2947510427","https://openalex.org/W2947628157","https://openalex.org/W2947732194","https://openalex.org/W2947750550","https://openalex.org/W2947793769","https://openalex.org/W2948016128","https://openalex.org/W2948816402","https://openalex.org/W2950603908","https://openalex.org/W2954386163","https://openalex.org/W2955204520","https://openalex.org/W2965323336","https://openalex.org/W4233505457","https://openalex.org/W4239457183","https://openalex.org/W4246913549","https://openalex.org/W6700088533","https://openalex.org/W6723500488","https://openalex.org/W6751697589"],"related_works":["https://openalex.org/W2891089991","https://openalex.org/W2805378765","https://openalex.org/W4312116120","https://openalex.org/W3034770828","https://openalex.org/W2294478133","https://openalex.org/W2902483467","https://openalex.org/W4311501979","https://openalex.org/W3126332167","https://openalex.org/W7164821273","https://openalex.org/W2999779930"],"abstract_inverted_index":{",":[0],"have":[1],"been":[2,30],"approved":[3],"by":[4],"the":[5,12,35,88,97,101,116,125,129,137],"Food":[6],"and":[7,17,48,67,78,135,142],"Drug":[8],"Administration":[9,20],"(FDA)":[10],"for":[11,76],"treatment":[13,75],"of":[14,21,34,54,90,100,109,119,131,139,146,156],"lymphoblastic":[15],"leukemia":[16],"B-cell":[18],"lymphoma.":[19],"CAR":[22,55,132,157],"T-cells":[23],"to":[24,96],"control":[25],"solid":[26,91,120,140,161],"tumors":[27,141],"has":[28],"long":[29],"envisaged":[31],"as":[32],"one":[33,108],"most":[36],"difficult":[37],"therapeutic":[38],"tasks.":[39],"The":[40],"first":[41],"two":[42],"clinical":[43,52],"trials":[44],"conducted":[45],"in":[46,87,128],"sarcoma":[47],"neuroblastoma":[49],"patients":[50],"showed":[51],"benefits":[53],"T-cells,":[56],"yet":[57],"multiple":[58],"obstacles":[59],"still":[60],"hold":[61],"us":[62],"back":[63],"from":[64],"having":[65],"accessible":[66],"efficient":[68],"therapy.":[69],"Why":[70],"did":[71],"such":[72],"an":[73,151],"effective":[74],"relapsed":[77],"refractory":[79],"hematological":[80],"malignancies":[81],"demonstrate":[82],"only":[83],"relatively":[84],"modest":[85],"efficiency":[86],"context":[89],"tumors?":[92,121],"Is":[93],"it":[94],"due":[95],"lucky":[98],"selection":[99],"\"magic\"":[102],"CD19":[103],"antigen,":[104],"which":[105],"might":[106],"be":[107],"a":[110],"kind?":[111],"Or":[112],"do":[113],"lymphomas":[114],"lack":[115],"immunosuppressive":[117],"features":[118],"Here":[122],"we":[123],"review":[124],"existing":[126],"knowledge":[127],"field":[130],"T-cell":[133,158],"therapy":[134],"address":[136],"heterogeneity":[138],"their":[143],"diverse":[144],"strategies":[145],"immunoevasion.":[147],"We":[148],"also":[149],"provide":[150],"insight":[152],"into":[153],"prospective":[154],"developments":[155],"technologies":[159],"against":[160],"tumors.":[162]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":31},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":20}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-01-10T00:00:00"}