{"id":"https://openalex.org/W2996802422","doi":null,"title":"[Our experience with sirolimus for the treatment of complicated vascular anomalies].","display_name":"[Our experience with sirolimus for the treatment of complicated vascular anomalies].","publication_year":2019,"publication_date":"2019-01-21","ids":{"openalex":"https://openalex.org/W2996802422","mag":"2996802422","pmid":"https://pubmed.ncbi.nlm.nih.gov/30714698"},"language":"es","primary_location":{"id":"pmid:30714698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30714698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057209276","display_name":"C Gim\u00e9nez Aleixandre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150677","display_name":"Hospital Universitario Virgen de la Arrixaca","ror":"https://ror.org/058thx797","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210150677"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"C Gim\u00e9nez-Aleixandre","raw_affiliation_strings":["Servicio de Cirug\u00eda Pedi\u00e1trica. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Cirug\u00eda Pedi\u00e1trica. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia","institution_ids":["https://openalex.org/I4210150677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014945469","display_name":"Nery Alfredo M\u00e9ndez Aguirre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150677","display_name":"Hospital Universitario Virgen de la Arrixaca","ror":"https://ror.org/058thx797","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210150677"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"N A M\u00e9ndez-Aguirre","raw_affiliation_strings":["Servicio de Cirug\u00eda Pedi\u00e1trica. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Cirug\u00eda Pedi\u00e1trica. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia","institution_ids":["https://openalex.org/I4210150677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026121150","display_name":"Teresa Mart\u00ednez\u2010Mench\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150677","display_name":"Hospital Universitario Virgen de la Arrixaca","ror":"https://ror.org/058thx797","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210150677"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"T Mart\u00ednez-Mench\u00f3n","raw_affiliation_strings":["Servicio de Dermatolog\u00eda. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Dermatolog\u00eda. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia","institution_ids":["https://openalex.org/I4210150677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012266374","display_name":"\u00d3scar Gir\u00f3n Vallejo","orcid":"https://orcid.org/0000-0002-3229-6219","observed_orcids":["https://orcid.org/0000-0002-3229-6219"]},"institutions":[{"id":"https://openalex.org/I4210150677","display_name":"Hospital Universitario Virgen de la Arrixaca","ror":"https://ror.org/058thx797","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210150677"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"\u00d3 Gir\u00f3n Vallejo","raw_affiliation_strings":["Servicio de Cirug\u00eda Pedi\u00e1trica. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Cirug\u00eda Pedi\u00e1trica. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia","institution_ids":["https://openalex.org/I4210150677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009922746","display_name":"Mar\u00eda Fern\u00e1ndez-Ibieta","orcid":"https://orcid.org/0000-0002-0489-4027","observed_orcids":["https://orcid.org/0000-0002-0489-4027"]},"institutions":[{"id":"https://openalex.org/I4210150677","display_name":"Hospital Universitario Virgen de la Arrixaca","ror":"https://ror.org/058thx797","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210150677"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M Fern\u00e1ndez-Ibieta","raw_affiliation_strings":["Servicio de Cirug\u00eda Pedi\u00e1trica. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Cirug\u00eda Pedi\u00e1trica. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia","institution_ids":["https://openalex.org/I4210150677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036445415","display_name":"Bel\u00e9n Ferri-\u00d1\u00edguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150677","display_name":"Hospital Universitario Virgen de la Arrixaca","ror":"https://ror.org/058thx797","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210150677"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"B Ferri-\u00d1\u00edguez","raw_affiliation_strings":["Servicio de Anatom\u00eda Patol\u00f3gica. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Anatom\u00eda Patol\u00f3gica. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia","institution_ids":["https://openalex.org/I4210150677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022834288","display_name":"Vanesa Villamil","orcid":"https://orcid.org/0000-0002-2255-7067","observed_orcids":["https://orcid.org/0000-0002-2255-7067"]},"institutions":[{"id":"https://openalex.org/I4210150677","display_name":"Hospital Universitario Virgen de la Arrixaca","ror":"https://ror.org/058thx797","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210150677"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"V Villamil","raw_affiliation_strings":["Servicio de Cirug\u00eda Pedi\u00e1trica. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Cirug\u00eda Pedi\u00e1trica. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia","institution_ids":["https://openalex.org/I4210150677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101469383","display_name":"\u00c1 S\u00e1nchez S\u00e1nchez","orcid":"https://orcid.org/0009-0001-2630-7372","observed_orcids":["https://orcid.org/0009-0001-2630-7372"]},"institutions":[{"id":"https://openalex.org/I4210150677","display_name":"Hospital Universitario Virgen de la Arrixaca","ror":"https://ror.org/058thx797","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210150677"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"\u00c1 S\u00e1nchez-S\u00e1nchez","raw_affiliation_strings":["Servicio de Cirug\u00eda Pedi\u00e1trica. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Cirug\u00eda Pedi\u00e1trica. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia","institution_ids":["https://openalex.org/I4210150677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089566550","display_name":"Carlos Montoya-Rangel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150677","display_name":"Hospital Universitario Virgen de la Arrixaca","ror":"https://ror.org/058thx797","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210150677"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"C A Montoya-Rangel","raw_affiliation_strings":["Servicio de Cirug\u00eda Pedi\u00e1trica. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Cirug\u00eda Pedi\u00e1trica. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia","institution_ids":["https://openalex.org/I4210150677"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043577728","display_name":"Juan Pedro Hern\u00e1ndez-Bermejo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150677","display_name":"Hospital Universitario Virgen de la Arrixaca","ror":"https://ror.org/058thx797","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210150677"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J P Hern\u00e1ndez-Bermejo","raw_affiliation_strings":["Servicio de Cirug\u00eda Pedi\u00e1trica. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Cirug\u00eda Pedi\u00e1trica. Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. Murcia","institution_ids":["https://openalex.org/I4210150677"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210150677"],"apc_list":null,"apc_paid":null,"fwci":0.4771,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.68357992,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"32","issue":"1","first_page":"28","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":1.0},{"id":"https://openalex.org/keywords/mtor-inhibitors","display_name":"mTOR inhibitors","score":0.9139999747276306},{"id":"https://openalex.org/keywords/vascular-anomalies","display_name":"vascular anomalies","score":0.859000027179718},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.7910000085830688},{"id":"https://openalex.org/keywords/kaposiform-hemangioendothelioma","display_name":"kaposiform hemangioendothelioma","score":0.9440000057220459},{"id":"https://openalex.org/keywords/lymphatic-malformation","display_name":"lymphangioma","score":0.8479999899864197},{"id":"https://openalex.org/keywords/kaposiform-lymphangiomatosis","display_name":"kaposiform lymphangiomatosis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/rebound-effect","display_name":"rebound effect","score":0.6420000195503235},{"id":"https://openalex.org/keywords/elevated-liver-enzymes","display_name":"elevated liver enzymes","score":0.8100000023841858},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9900000095367432}],"concepts":[{"id":"https://openalex.org/C2776853793","wikidata":"https://www.wikidata.org/wiki/Q183390","display_name":"Lymphangiomatosis","level":3,"score":0.9374734163284302},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8912256956100464},{"id":"https://openalex.org/C2777921159","wikidata":"https://www.wikidata.org/wiki/Q32089","display_name":"Sirolimus","level":2,"score":0.8836431503295898},{"id":"https://openalex.org/C183713625","wikidata":"https://www.wikidata.org/wiki/Q5282002","display_name":"Discovery and development of mTOR inhibitors","level":4,"score":0.8334659337997437},{"id":"https://openalex.org/C2775958455","wikidata":"https://www.wikidata.org/wiki/Q7916449","display_name":"Vascular anomaly","level":2,"score":0.6403831243515015},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.44510433077812195},{"id":"https://openalex.org/C2777507709","wikidata":"https://www.wikidata.org/wiki/Q121576","display_name":"Vascular malformation","level":2,"score":0.4430631101131439},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.4092726707458496},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.33300524950027466},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10371541976928711},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D054079","descriptor_name":"Vascular Malformations","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D054079","descriptor_name":"Vascular Malformations","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:30714698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30714698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica","raw_type":"Journal Article"},{"id":"pmh:oai:hispana.mcu.es:61681992","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10201/199650","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2996802422","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30714698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2531935797","https://openalex.org/W2775832273","https://openalex.org/W3165173297","https://openalex.org/W4400734039","https://openalex.org/W4388735275","https://openalex.org/W2000239178","https://openalex.org/W7163123426","https://openalex.org/W3091051326","https://openalex.org/W3088847206","https://openalex.org/W4399866133"],"abstract_inverted_index":{"AIM":[0],"OF":[1],"THE":[2],"STUDY:":[3],"mTOR":[4],"inhibitors":[5],"are":[6],"being":[7],"used":[8],"to":[9,17],"treat":[10],"complex":[11,55,102,197],"vascular":[12,43,56],"anomalies":[13],"(VA)":[14],"without":[15,185],"response":[16,47,74],"conventional":[18],"treatments.":[19],"We":[20],"report":[21],"our":[22,200],"results":[23],"in":[24,78,88,138,199],"pediatric":[25],"patients":[26,34,53,140,153,172,180],"treated":[27,35],"with":[28,36,54,110,154,160],"sirolimus.":[29],"METHODS:":[30],"Retrospective":[31],"review":[32],"of":[33,150,168,196],"sirolimus":[37],"between":[38],"2014":[39],"and":[40,48,80,118,157,183],"2017,":[41],"analyzing":[42],"anomaly":[44],"type,":[45],"treatment":[46,126,167,195],"complications.":[49],"Treatment":[50],"protocol":[51],"included":[52],"anomalies,":[57],"after":[58,147,164,176],"signing":[59],"the":[60,158],"informed":[61],"consent.":[62],"The":[63],"initial":[64],"dose":[65],"was":[66,75,86,127,136,203],"0.8":[67],"mg/m2/12":[68],"h,":[69],"verifying":[70],"plasmatic":[71],"levels.":[72],"Favorable":[73],"defined":[76],"both":[77],"clinical":[79],"radiological":[81],"terms.":[82],"MAIN":[83],"RESULTS:":[84],"Sirolimus":[85,190],"employed":[87],"nine":[89],"patients,":[90],"median":[91,166],"age":[92],"14":[93],"months":[94,129,149],"old":[95],"(1":[96],"month-14":[97],"years),":[98],"66%":[99],"girls.":[100],"Five":[101],"micro-cystic":[103,155],"lymphatic":[104],"malformations":[105],"(LM),":[106],"one":[107,112,115,119,159],"multifocal":[108],"lynphangioendotheliomatosis":[109],"thrombocytopenia,":[111],"kaposiform":[113,120],"lymphangiomatosis,":[114],"lymphatic-venous":[116,161],"malformation":[117,162],"hemangioendothelioma":[121],"(KHE)":[122],"were":[123],"treated.":[124],"Median":[125],"4":[128],"(IQR":[130],"2-18":[131],"months).":[132],"Resolution":[133],"or":[134],"improvement":[135],"objectified":[137],"four":[139],"(44%).":[141],"KHE":[142],"patient":[143],"presented":[144,173,191],"complete":[145],"resolution":[146],"two":[148],"treatment.":[151,178,188],"Two":[152,171],"LM":[156],"improved":[163],"a":[165],"three":[169],"months.":[170],"rebound":[174],"effect":[175],"discontinuing":[177],"Three":[179],"had":[181],"hypertransaminasemia":[182],"hypercholesterolemia":[184],"requiring":[186],"medical":[187],"CONCLUSION:":[189],"mild":[192],"effects":[193],"for":[194],"VA":[198],"study,":[201],"but":[202],"highly":[204],"resolutive":[205],"at":[206],"KHE.":[207]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-01-10T00:00:00"}