{"id":"https://openalex.org/W299679402","doi":"https://doi.org/10.21236/ada431792","title":"Estrogen Metabolism Genes and Breast Cancer: An Innovative Approach","display_name":"Estrogen Metabolism Genes and Breast Cancer: An Innovative Approach","publication_year":2004,"publication_date":"2004-07-01","ids":{"openalex":"https://openalex.org/W299679402","doi":"https://doi.org/10.21236/ada431792","mag":"299679402"},"language":"en","primary_location":{"id":"doi:10.21236/ada431792","doi":"https://doi.org/10.21236/ada431792","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada431792","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003374278","display_name":"Habibul Ahsan","orcid":"https://orcid.org/0000-0001-9808-377X","observed_orcids":["https://orcid.org/0000-0001-9808-377X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Habibul Ahsan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5003374278"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.35740000009536743,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.35740000009536743,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.2451000064611435,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.20029999315738678,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cyp17","display_name":"CYP17","score":0.8149999976158142},{"id":"https://openalex.org/keywords/aromatase","display_name":"aromatase","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cyp1b1","display_name":"CYP1B1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/catechol-o-methyltransferase","display_name":"catechol-O-methyltransferase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9129999876022339},{"id":"https://openalex.org/keywords/family-based-association-study","display_name":"family-based association study","score":0.7850000262260437},{"id":"https://openalex.org/keywords/maternal-genotype","display_name":"maternal genotype","score":0.6700000166893005},{"id":"https://openalex.org/keywords/breast-cancer-registry","display_name":"breast cancer registry","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7270528674125671},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.673313558101654},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5874323844909668},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3985065817832947},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3797370493412018},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3683739900588989},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3637782335281372},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35738593339920044},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3532603979110718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3354252576828003},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27309685945510864}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21236/ada431792","doi":"https://doi.org/10.21236/ada431792","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada431792","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},{"id":"pmh:ADA431792","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA431792","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6600000262260437,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1486741682","https://openalex.org/W1543868019","https://openalex.org/W1577972870","https://openalex.org/W1953625275","https://openalex.org/W1993729278","https://openalex.org/W1996395058","https://openalex.org/W2030088966","https://openalex.org/W2053313981","https://openalex.org/W2063682634","https://openalex.org/W2101791172","https://openalex.org/W2106651415","https://openalex.org/W2160437131","https://openalex.org/W2184238405","https://openalex.org/W2517346518"],"related_works":["https://openalex.org/W1890995742","https://openalex.org/W1923126139","https://openalex.org/W2073061823","https://openalex.org/W2471725041","https://openalex.org/W1964140545","https://openalex.org/W2030266257","https://openalex.org/W187411173","https://openalex.org/W1499170854","https://openalex.org/W2892677547","https://openalex.org/W2557359331"],"abstract_inverted_index":{"We":[0,67,86,125],"proposed":[1],"to":[2,76,103,163],"examine":[3],"associations":[4],"of":[5,34,63,96,113,123,129,143],"CYP17,":[6,144],"CYPl9,":[7],"CYP1BI,":[8,145],"and":[9,12,157],"COMT":[10,147],"polymorphisms":[11],"breast":[13,80,107,132],"cancer":[14,81,108,133],"risk":[15,82,109,134],"using":[16],"an":[17],"innovative":[18],"family-based":[19],"design":[20],"among":[21],"families":[22],"participating":[23],"in":[24,59,83,110],"the":[25,35,60,69,114,152,165],"Metropolitan":[26],"New":[27],"York":[28],"Breast":[29,47],"Cancer":[30,40,48],"Registry":[31,45],"(MNYBCR),":[32],"one":[33],"six":[36],"sites":[37],"for":[38,46],"National":[39],"Institute":[41],"(NCT)-initiated":[42],"Cooperative":[43],"Family":[44],"Studies":[49],"(CFRBCS)":[50],"project.":[51],"To":[52,149],"date,":[53,150],"we":[54,158],"have":[55,159],"accomplished":[56],"all":[57,151],"tasks":[58],"approved":[61],"Statement":[62],"Work":[64],"as":[65],"planned.":[66],"found":[68,88,126],"CYPl9":[70,97,124],"allele":[71],"with":[72,79,99,106,135],"11":[73,100],"TTTA":[74],"repeats":[75,101],"be":[77,104],"associated":[78,105],"these":[84],"families.":[85],"also":[87],"that":[89],"maternal":[90],"(but":[91],"not":[92],"paternal)":[93],"carrier":[94],"status":[95],"alleles":[98],"tended":[102],"daughters":[111],"(independent":[112],"daughters'":[115],"own":[116,138],"genotype),":[117],"suggesting":[118],"a":[119,130],"possible":[120],"in-utero":[121],"effect":[122],"no":[127],"association":[128],"woman's":[131],"either":[136],"her":[137,140],"or":[139,146],"mother's":[141],"genotype":[142],"gene.":[148],"work":[153],"has":[154],"been":[155],"completed":[156],"published":[160],"two":[161],"manuscripts":[162],"report":[164],"findings.":[166]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}