{"id":"https://openalex.org/W29967833","doi":null,"title":"Human retinal pigment epithelial cell interleukin-8 and monocyte chemotactic protein-1 modulation by T-lymphocyte products.","display_name":"Human retinal pigment epithelial cell interleukin-8 and monocyte chemotactic protein-1 modulation by T-lymphocyte products.","publication_year":1997,"publication_date":"1997-02-01","ids":{"openalex":"https://openalex.org/W29967833","mag":"29967833","pmid":"https://pubmed.ncbi.nlm.nih.gov/9040478"},"language":"en","primary_location":{"id":"pmid:9040478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9040478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082567021","display_name":"Victor Maurice Elner","orcid":"https://orcid.org/0000-0001-7708-1898","observed_orcids":["https://orcid.org/0000-0001-7708-1898"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S G Elner","raw_affiliation_strings":["Department of Ophthalmology, University of Michigan, Ann Arbor 48105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Michigan, Ann Arbor 48105, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082567021","display_name":"Victor Maurice Elner","orcid":"https://orcid.org/0000-0001-7708-1898","observed_orcids":["https://orcid.org/0000-0001-7708-1898"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V M Elner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102057156","display_name":"Z M Bian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z M Bian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088974704","display_name":"Nicholas W. Lukacs","orcid":"https://orcid.org/0000-0003-2403-6481","observed_orcids":["https://orcid.org/0000-0003-2403-6481"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N W Lukacs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111208642","display_name":"R M Kurtz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R M Kurtz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111782378","display_name":"Robert M. Strieter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R M Strieter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004928457","display_name":"Steven L. Kunkel","orcid":"https://orcid.org/0000-0002-5738-6341","observed_orcids":["https://orcid.org/0000-0002-5738-6341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S L Kunkel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7006,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.92303085,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"38","issue":"2","first_page":"446","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.13420000672340393,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.9129999876022339},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/chemokine-induction","display_name":"chemokine induction","score":0.7459999918937683},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.578000009059906},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7139999866485596},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.972000002861023},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9449999928474426},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cytokine-neutralization","display_name":"cytokine neutralization","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6641839146614075},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.5848221778869629},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5601262450218201},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4799768924713135},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.4529789686203003},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.44684073328971863},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.4172343909740448},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.41685158014297485},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.41076183319091797},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3630744218826294},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35416364669799805},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3429561257362366},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2805873155593872},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.24084976315498352},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.1660856008529663},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1616019904613495}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018106","descriptor_name":"CD28 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9040478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9040478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:29967833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9040478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4237093774","display_name":"RPE-Mphi Binding: Ca++_&O2-_Dependent AMD Responses","funder_award_id":"R01EY009441","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W14424920","https://openalex.org/W69115750","https://openalex.org/W99379277","https://openalex.org/W161719027","https://openalex.org/W197718532","https://openalex.org/W1001072904","https://openalex.org/W1486274120","https://openalex.org/W1504900014","https://openalex.org/W1622259699","https://openalex.org/W1810563907","https://openalex.org/W1979402470","https://openalex.org/W1988343605","https://openalex.org/W1992394132","https://openalex.org/W1993210315","https://openalex.org/W1997302825","https://openalex.org/W2000517438","https://openalex.org/W2013298309","https://openalex.org/W2016828078","https://openalex.org/W2019345741","https://openalex.org/W2021888919","https://openalex.org/W2022479590","https://openalex.org/W2025699735","https://openalex.org/W2029786286","https://openalex.org/W2029836713","https://openalex.org/W2037201423","https://openalex.org/W2068593333","https://openalex.org/W2069142706","https://openalex.org/W2072198264","https://openalex.org/W2072763133","https://openalex.org/W2081195149","https://openalex.org/W2081872210","https://openalex.org/W2081936911","https://openalex.org/W2098157239","https://openalex.org/W2107252809","https://openalex.org/W2122794487","https://openalex.org/W2130005272","https://openalex.org/W2173828780","https://openalex.org/W2222781730","https://openalex.org/W2396174247","https://openalex.org/W2411770267","https://openalex.org/W2414660814","https://openalex.org/W2415102736","https://openalex.org/W2416897117","https://openalex.org/W2416947132"],"related_works":["https://openalex.org/W2141875260","https://openalex.org/W2022137963","https://openalex.org/W1992394132","https://openalex.org/W1587057861","https://openalex.org/W2009616771","https://openalex.org/W2416897117","https://openalex.org/W2107324881","https://openalex.org/W2026730041","https://openalex.org/W2330512231","https://openalex.org/W2396571111"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1],"purpose":[2],"of":[3,11,90,92,235,262,314,335,366,372],"the":[4,9,88,284,333,336,343,370],"study":[5],"was":[6,71,155,265],"to":[7,86,95,116,123,130,167,242,268,362,383,405],"examine":[8],"effect":[10],"T-lymphocyte":[12,101,347,367],"products":[13],"on":[14],"human":[15],"retinal":[16],"pigment":[17],"epithelial":[18],"(HRPE)":[19],"cell":[20],"interleukin-8":[21],"(IL-8)":[22],"and":[23,29,109,161,171,173,188,209,231,255,264,289,306,317,352,356,359,375,393,397],"monocyte":[24],"chemotactic":[25],"protein-1":[26],"(MCP-1)":[27],"secretion":[28,190],"gene":[30,354],"expression.":[31],"METHODS:":[32],"HRPE":[33,96,103,186,229,253,297,325,350,373,380,399,408],"cells":[34,104],"were":[35,105,165],"stimulated":[36,51,100,106,195,274],"for":[37,107,369],"2,":[38],"4,":[39],"8,":[40],"or":[41,54,59,81,145,152,198,223,246,278,327,391,410],"24":[42,110,269],"hours":[43,111,261],"with":[44,52,73,112,148,196,220,237,275],"20%":[45],"conditioned":[46],"media":[47],"(CM)":[48],"from":[49,67,193,212,272],"T-lymphocytes":[50,70,194,273],"CD3":[53,68,197,199,276,279],"CD28":[55,201,281],"monoclonal":[56],"antibodies":[57],"(mAbs)":[58],"phorbol":[60,214],"myristic":[61,215],"acid.":[62],"In":[63],"some":[64],"experiments,":[65],"CM":[66,192,213,218,236,271,368],"mAb-stimulated":[69],"preincubated":[72,219],"neutralizing":[74,221,238],"anti-(alpha)-tumor":[75],"necrosis":[76],"factor":[77],"(TNF),":[78],"alpha-interferon-gamma":[79],"(IFN-gamma),":[80],"alpha-interleukin-1":[82],"(IL-1)":[83],"mAb":[84,225,240,277,282],"(control)":[85],"determine":[87,168],"contributions":[89],"each":[91],"these":[93],"cytokines":[94],"chemokine":[97],"induction":[98,371],"by":[99,191],"CM.":[102],"8":[108],"IL-1":[113,135,149,304,315,389,395],"beta":[114,305,316,390],"(0.2":[115,122],"20.0":[117,124],"ng/ml)":[118,125,143],"(positive":[119,126],"control),":[120,127],"TNF-alpha":[121],"IFN-gamma":[128,133,137,153,292,302,360,377],"(1":[129],"1000":[131],"U/ml),":[132],"+":[134,138,200,280],"beta,":[136,150],"TNF-alpha.":[139],"Interleukin-2":[140],"(IL-2;":[141],"100":[142],"alone":[144,378],"in":[146,185,207,287,296],"combination":[147],"TNF-alpha,":[151,392],"also":[154],"tested.":[156],"Enzyme-linked":[157],"immunosorbent":[158],"assay":[159],"(ELISA)":[160],"Northern":[162,248,339],"blot":[163,249,340],"analyses":[164],"performed":[166],"secreted":[169],"IL-8":[170,187,208,230,245,254,288,319,326,351,374,409],"MCP-1":[172,189,210,256,290,308,353],"their":[174],"steady":[175],"state":[176],"mRNA":[177,257],"expression,":[178],"respectively.":[179],"RESULTS:":[180],"ELISA":[181,344],"showed":[182,251,311],"significant":[183],"increases":[184,206,286,295],"mAb.":[202],"Smaller,":[203],"but":[204,299,310],"significant,":[205],"resulted":[211],"acid-stimulated":[216],"T-lymphocytes.":[217],"alpha-TNF":[222],"alpha-IFN-gamma":[224],"induced":[226,293],"significantly":[227],"less":[228],"MCP-1,":[232,298,328,381],"whereas":[233],"preincubation":[234],"alpha-IL-1":[239],"failed":[241],"inhibit":[243],"CM-induced":[244],"MCP-1.":[247,376,400,411],"analysis":[250,341],"increased":[252],"expression":[258,355],"within":[259],"2":[260],"stimulation":[263],"maintained":[266],"up":[267],"hours.":[270],"produced":[283],"greatest":[285],"mRNA.":[291],"dose-dependent":[294],"not":[300,323,403],"IL-8,":[301],"potentiated":[303],"TNF-alpha-induced":[307,318,398],"production,":[309],"little":[312],"modulation":[313],"production.":[320],"IL-2":[321,401],"did":[322,330],"induce":[324,349],"nor":[329],"it":[331],"modulate":[332,406],"effects":[334],"other":[337],"cytokines.":[338],"confirmed":[342],"results.":[345],"CONCLUSIONS:":[346],"secretions":[348],"secretion.":[357],"TNF":[358],"appear":[361,404],"be":[363],"necessary":[364],"components":[365],"induces":[379],"albeit":[382],"a":[384],"lesser":[385],"extent":[386],"than":[387],"would":[388],"potentiates":[394],"beta-":[396],"does":[402],"cytokine-induced":[407]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
