{"id":"https://openalex.org/W2996683327","doi":"https://doi.org/10.1097/bpo.0000000000001483","title":"Incidence of Pediatric Venous Thromboembolism After Elective Spine and Lower-Extremity Surgery in Children With Neuromuscular Complex Chronic Conditions: Do we Need Prophylaxis?","display_name":"Incidence of Pediatric Venous Thromboembolism After Elective Spine and Lower-Extremity Surgery in Children With Neuromuscular Complex Chronic Conditions: Do we Need Prophylaxis?","publication_year":2019,"publication_date":"2019-12-03","ids":{"openalex":"https://openalex.org/W2996683327","doi":"https://doi.org/10.1097/bpo.0000000000001483","mag":"2996683327","pmid":"https://pubmed.ncbi.nlm.nih.gov/31821246"},"language":"en","primary_location":{"id":"doi:10.1097/bpo.0000000000001483","doi":"https://doi.org/10.1097/bpo.0000000000001483","is_oa":false,"landing_page_url":"https://doi.org/10.1097/bpo.0000000000001483","pdf_url":null,"source":{"id":"https://openalex.org/S44433048","display_name":"Journal of Pediatric Orthopaedics","issn_l":"0271-6798","issn":["0271-6798","1539-2570"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Orthopaedics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001880156","display_name":"Benjamin J. Shore","orcid":"https://orcid.org/0000-0002-5380-4307","observed_orcids":["https://orcid.org/0000-0002-5380-4307"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Benjamin J. Shore","raw_affiliation_strings":["Orthopedic Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopedic Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060383813","display_name":"Matt Hall","orcid":"https://orcid.org/0000-0001-7778-5887","observed_orcids":["https://orcid.org/0000-0001-7778-5887"]},"institutions":[{"id":"https://openalex.org/I4210156367","display_name":"Children's Hospital Association","ror":"https://ror.org/05avqph76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210156367"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matt Hall","raw_affiliation_strings":["Children\u2019s Hospital Association, Lenexa, KS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital Association, Lenexa, KS","institution_ids":["https://openalex.org/I4210156367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063768870","display_name":"Travis H. Matheney","orcid":"https://orcid.org/0000-0002-2557-820X","observed_orcids":["https://orcid.org/0000-0002-2557-820X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Travis H. Matheney","raw_affiliation_strings":["Orthopedic Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopedic Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033229659","display_name":"Brian D. Snyder","orcid":"https://orcid.org/0000-0003-1482-9509","observed_orcids":["https://orcid.org/0000-0003-1482-9509"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Brian Snyder","raw_affiliation_strings":["Orthopedic Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopedic Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084389353","display_name":"Cameron C. Trenor","orcid":"https://orcid.org/0000-0003-3954-7882","observed_orcids":["https://orcid.org/0000-0003-3954-7882"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cameron C. Trenor","raw_affiliation_strings":["Hematology and Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Oncology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031766530","display_name":"Jay G. Berry","orcid":"https://orcid.org/0000-0003-3917-4465","observed_orcids":["https://orcid.org/0000-0003-3917-4465"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay G. Berry","raw_affiliation_strings":["Complex Care Service, Division of General Pediatrics, Boston Children\u2019s Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complex Care Service, Division of General Pediatrics, Boston Children\u2019s Hospital, Boston, MA","institution_ids":["https://openalex.org/I1288882113"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001880156","https://openalex.org/A5033229659","https://openalex.org/A5063768870"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9837,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.88394729,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"40","issue":"5","first_page":"e375","last_page":"e379"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11929","display_name":"Cerebral Venous Sinus Thrombosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cerebral-palsy","display_name":"cerebral palsy","score":0.7599999904632568},{"id":"https://openalex.org/keywords/spine-surgery","display_name":"spinal surgery","score":0.6729999780654907},{"id":"https://openalex.org/keywords/lower-limb-surgery","display_name":"lower limb surgery","score":0.8740000128746033},{"id":"https://openalex.org/keywords/orthopedic-surgery","display_name":"orthopedic surgery","score":0.6769999861717224},{"id":"https://openalex.org/keywords/thromboprophylaxis","display_name":"thromboprophylaxis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/compression-devices","display_name":"compression devices","score":0.7250000238418579},{"id":"https://openalex.org/keywords/enoxaparin","display_name":"enoxaparin","score":0.9570000171661377},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.8949999809265137},{"id":"https://openalex.org/keywords/central-venous-catheters","display_name":"central venous catheters","score":0.703000009059906},{"id":"https://openalex.org/keywords/coagulopathy","display_name":"coagulopathy","score":0.7089999914169312},{"id":"https://openalex.org/keywords/children-with-mobility-impairments","display_name":"children with mobility impairments","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9838987588882446},{"id":"https://openalex.org/C2779421357","wikidata":"https://www.wikidata.org/wiki/Q210427","display_name":"Cerebral palsy","level":2,"score":0.7436124682426453},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.633187472820282},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4864168167114258},{"id":"https://openalex.org/C68312169","wikidata":"https://www.wikidata.org/wiki/Q216685","display_name":"Orthopedic surgery","level":2,"score":0.41609349846839905},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.32253581285476685},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.23362833261489868},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D002547","descriptor_name":"Cerebral Palsy","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D013131","descriptor_name":"Spine","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017558","descriptor_name":"Elective Surgical Procedures","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D019637","descriptor_name":"Orthopedic Procedures","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D035002","descriptor_name":"Lower Extremity","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D054556","descriptor_name":"Venous Thromboembolism","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D054556","descriptor_name":"Venous Thromboembolism","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D054556","descriptor_name":"Venous Thromboembolism","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/bpo.0000000000001483","doi":"https://doi.org/10.1097/bpo.0000000000001483","is_oa":false,"landing_page_url":"https://doi.org/10.1097/bpo.0000000000001483","pdf_url":null,"source":{"id":"https://openalex.org/S44433048","display_name":"Journal of Pediatric Orthopaedics","issn_l":"0271-6798","issn":["0271-6798","1539-2570"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Orthopaedics","raw_type":"journal-article"},{"id":"pmid:31821246","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31821246","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric orthopedics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W25693216","https://openalex.org/W181091954","https://openalex.org/W1553001318","https://openalex.org/W1915997968","https://openalex.org/W1968098708","https://openalex.org/W1985773741","https://openalex.org/W1990965188","https://openalex.org/W2000833230","https://openalex.org/W2011431993","https://openalex.org/W2050965072","https://openalex.org/W2063218351","https://openalex.org/W2069853038","https://openalex.org/W2070548450","https://openalex.org/W2076690712","https://openalex.org/W2079347479","https://openalex.org/W2100368551","https://openalex.org/W2100417532","https://openalex.org/W2106459062","https://openalex.org/W2130874036","https://openalex.org/W2133619004","https://openalex.org/W2139716972","https://openalex.org/W2143907400","https://openalex.org/W2151862192","https://openalex.org/W2580935941","https://openalex.org/W2613226128","https://openalex.org/W2754923247","https://openalex.org/W2808290696","https://openalex.org/W4239644696"],"related_works":["https://openalex.org/W7149331169","https://openalex.org/W2730184131","https://openalex.org/W3118700830","https://openalex.org/W4391612832","https://openalex.org/W2984466057","https://openalex.org/W4408423522","https://openalex.org/W4213176840","https://openalex.org/W3202962432","https://openalex.org/W3216757822","https://openalex.org/W3017089910"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,135,249],"incidence":[2,33,285],"of":[3,34,50,85,189,223,235,251,286],"venous":[4,101],"thromboembolism":[5],"(VTE)":[6],"after":[7,36],"elective":[8,37,55,293,311],"surgery":[9,41,78,115,212,257,315],"in":[10,42,65,258,270,288,306],"children":[11,43,51,109,158,166,175,204,259,289,307],"with":[12,17,44,52,110,205,255,260,290,308],"mobility":[13],"impairments,":[14],"including":[15],"those":[16],"a":[18,180,184,228],"neuromuscular":[19],"complex":[20],"chronic":[21],"condition":[22],"(NCCC),":[23],"is":[24,262,278,304],"unknown.":[25],"Therefore,":[26,198],"our":[27,275],"objectives":[28],"were":[29,103,107,124,140],"to":[30,62,98,162,171],"assess":[31,163,172],"the":[32,66,117,199,224,236,279,284],"VTE":[35,74,186,195,201,253,287],"spine":[38,211,296,314],"and":[39,83,88,130,145,150,243,265,295,313],"lower-extremity":[40,56,185,209],"NCCC.":[45],"METHODS:":[46],"A":[47],"retrospective":[48],"analysis":[49],"NCCC":[53,111,138,206,261,309],"undergoing":[54,207,292,310],"and/or":[57],"spinal":[58,146],"surgeries":[59],"from":[60],"2005":[61],"2009":[63],"included":[64],"Pediatric":[67],"Health":[68],"Information":[69],"Systems":[70],"Plus":[71],"(PHIS+)":[72],"database.":[73],"during":[75,116],"hospitalization":[76],"for":[77,183,203,246],"was":[79,213],"assessed":[80],"through":[81],"abstraction":[82],"review":[84],"ultrasound":[86],"(U/S)":[87],"computed":[89,169],"tomography":[90,170],"results":[91],"by":[92],"2":[93,192,225],"independent":[94],"reviewers.":[95],"VTEs":[96],"related":[97],"pre-existing":[99],"central":[100,151],"catheters":[102],"excluded.":[104],"RESULTS:":[105],"There":[106],"4,583":[108],"who":[112],"underwent":[113,160,168],"orthopaedic":[114,208,256],"study":[118,282],"period":[119],"at":[120],"6":[121],"centers.":[122],"Most":[123],"male":[125],"(56.3%),":[126],"non-Hispanic":[127],"whites":[128],"(72.7%),":[129],"had":[131,179,193,227],"private":[132],"insurance":[133],"(52.2%).":[134],"most":[136],"common":[137],"diagnoses":[139],"cerebral":[141,177],"palsy":[142],"(46.7%),":[143],"brain":[144],"cord":[147],"malformations":[148],"(31.1%),":[149],"nervous":[152],"system":[153],"degenerative":[154],"conditions":[155],"(14.5%).":[156],"Forty":[157],"(0.9%)":[159],"U/S":[161,182],"VTE.":[164,173],"Eighteen":[165],"(0.4%)":[167],"Four":[174],"(with":[176],"palsy)":[178],"positive":[181],"(10-18":[187],"y":[188],"age),":[190],"yet":[191],"their":[194],"before":[196],"surgery.":[197,297],"adjusted":[200],"rate":[202,250],"or":[210],"4":[214],"per":[215,219],"10,000":[216],"(2":[217],"cases":[218,226],"4583":[220],"surgeries).":[221],"Each":[222],"known":[229,318],"coagulation":[230],"disorder":[231],"preoperatively.":[232],"Only":[233],"10%":[234],"cohort":[237],"used":[238],"compression":[239],"devices,":[240],"3%":[241],"enoxaparin,":[242],"1.6%":[244],"aspirin":[245],"prophylaxis.":[247],"CONCLUSION:":[248],"non-central-venous-catheter-related":[252],"associated":[254],"very":[263],"low":[264],"lower":[266],"than":[267],"rates":[268],"reported":[269],"healthy":[271],"children.":[272],"SIGNIFICANCE:":[273],"To":[274],"knowledge,":[276],"this":[277],"first":[280],"multi-institutional":[281],"reporting":[283],"NCCCs":[291],"hip":[294,312],"These":[298],"data":[299],"support":[300],"no":[301],"additional":[302],"prophylaxis":[303],"required":[305],"unless":[316],"other":[317],"risk":[319],"factors":[320],"are":[321],"also":[322],"present.":[323]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-26T00:00:00"}