{"id":"https://openalex.org/W2996652855","doi":"https://doi.org/10.1097/sap.0000000000002110","title":"Amifostine Prophylaxis in Irradiated Breast Reconstruction","display_name":"Amifostine Prophylaxis in Irradiated Breast Reconstruction","publication_year":2019,"publication_date":"2019-12-17","ids":{"openalex":"https://openalex.org/W2996652855","doi":"https://doi.org/10.1097/sap.0000000000002110","mag":"2996652855","pmid":"https://pubmed.ncbi.nlm.nih.gov/31850964","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7295666"},"language":"en","primary_location":{"id":"doi:10.1097/sap.0000000000002110","doi":"https://doi.org/10.1097/sap.0000000000002110","is_oa":false,"landing_page_url":"https://doi.org/10.1097/sap.0000000000002110","pdf_url":null,"source":{"id":"https://openalex.org/S11131942","display_name":"Annals of Plastic Surgery","issn_l":"0148-7043","issn":["0148-7043","1536-3708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Plastic Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC7295666","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003898248","display_name":"Alexandra O. Luby","orcid":"https://orcid.org/0000-0002-5847-1492","observed_orcids":["https://orcid.org/0000-0002-5847-1492"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alexandra O. Luby","raw_affiliation_strings":["Section of Plastic Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Plastic Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075065118","display_name":"Chitra Subramanian","orcid":"https://orcid.org/0000-0003-1871-2834","observed_orcids":["https://orcid.org/0000-0003-1871-2834"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chitra Subramanian","raw_affiliation_strings":["Section of General Surgery, Department of Surgery, University of Michigan Health Systems, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of General Surgery, Department of Surgery, University of Michigan Health Systems, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007678593","display_name":"Lauren K. Buchman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lauren K. Buchman","raw_affiliation_strings":["Section of Plastic Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Plastic Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022702039","display_name":"Jeremy V. Lynn","orcid":"https://orcid.org/0000-0001-7107-3635","observed_orcids":["https://orcid.org/0000-0001-7107-3635"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jeremy V. Lynn","raw_affiliation_strings":["Section of Plastic Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Plastic Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025759132","display_name":"Kevin M. Urlaub","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kevin M. Urlaub","raw_affiliation_strings":["Section of Plastic Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Plastic Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109893680","display_name":"Noah S. Nelson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Noah S. Nelson","raw_affiliation_strings":["Section of Plastic Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Plastic Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050327233","display_name":"Alexis Donneys","orcid":"https://orcid.org/0000-0001-8690-0971","observed_orcids":["https://orcid.org/0000-0001-8690-0971"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alexis Donneys","raw_affiliation_strings":["Section of Plastic Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Plastic Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057675169","display_name":"Mark Steven Cohen","orcid":"https://orcid.org/0000-0002-2517-0757","observed_orcids":["https://orcid.org/0000-0002-2517-0757"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark S. Cohen","raw_affiliation_strings":["Section of General Surgery, Department of Surgery, University of Michigan Health Systems, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of General Surgery, Department of Surgery, University of Michigan Health Systems, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036135458","display_name":"Steven R. Buchman","orcid":"https://orcid.org/0000-0001-9742-558X","observed_orcids":["https://orcid.org/0000-0001-9742-558X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Steven R. Buchman","raw_affiliation_strings":["Section of Plastic Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Plastic Surgery","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003898248","https://openalex.org/A5007678593","https://openalex.org/A5022702039","https://openalex.org/A5025759132","https://openalex.org/A5036135458","https://openalex.org/A5050327233","https://openalex.org/A5109893680"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3298,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.60988158,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"85","issue":"4","first_page":"424","last_page":"429"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amifostine","display_name":"amifostine","score":1.0},{"id":"https://openalex.org/keywords/radioprotectors","display_name":"radioprotective agents","score":0.7879999876022339},{"id":"https://openalex.org/keywords/breast-reconstruction","display_name":"breast reconstruction","score":0.7089999914169312},{"id":"https://openalex.org/keywords/adjuvant-radiotherapy","display_name":"adjuvant radiotherapy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9179999828338623},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.7239999771118164},{"id":"https://openalex.org/keywords/wr-1065","display_name":"WR-1065","score":0.9010000228881836},{"id":"https://openalex.org/keywords/oncologic-safety","display_name":"oncological safety","score":0.7480000257492065},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.7329999804496765},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9679999947547913},{"id":"https://openalex.org/keywords/mda-mb-468-cells","display_name":"MDA-MB-468","score":0.9539999961853027},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.5730000138282776},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9307437539100647},{"id":"https://openalex.org/C2779387952","wikidata":"https://www.wikidata.org/wiki/Q251698","display_name":"Amifostine","level":3,"score":0.9170362949371338},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7928295731544495},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.7187628746032715},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5791754126548767},{"id":"https://openalex.org/C2781001896","wikidata":"https://www.wikidata.org/wiki/Q994507","display_name":"Breast reconstruction","level":4,"score":0.526338517665863},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.520576536655426},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4941392242908478},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.46291878819465637},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4452056288719177},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.444095253944397},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4069057106971741},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3944469690322876},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.15336543321609497},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D004999","descriptor_name":"Amifostine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004999","descriptor_name":"Amifostine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011832","descriptor_name":"Radiation Injuries","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011837","descriptor_name":"Radiation-Protective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011837","descriptor_name":"Radiation-Protective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016462","descriptor_name":"Mammaplasty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/sap.0000000000002110","doi":"https://doi.org/10.1097/sap.0000000000002110","is_oa":false,"landing_page_url":"https://doi.org/10.1097/sap.0000000000002110","pdf_url":null,"source":{"id":"https://openalex.org/S11131942","display_name":"Annals of Plastic Surgery","issn_l":"0148-7043","issn":["0148-7043","1536-3708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Plastic Surgery","raw_type":"journal-article"},{"id":"pmid:31850964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31850964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of plastic surgery","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:7371038","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7295666","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7295666","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7295666","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ann Plast Surg","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:7371038","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7295666","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6455865345","display_name":"Translational Optimization of Bone Regeneration in the Irradiated Mandible","funder_award_id":"R01CA125187","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W167359183","https://openalex.org/W1585259259","https://openalex.org/W1757407923","https://openalex.org/W1764487123","https://openalex.org/W1964812369","https://openalex.org/W1971915848","https://openalex.org/W1975289748","https://openalex.org/W1982415526","https://openalex.org/W1984683170","https://openalex.org/W1997476000","https://openalex.org/W2014169456","https://openalex.org/W2016271680","https://openalex.org/W2016899305","https://openalex.org/W2022601513","https://openalex.org/W2029178468","https://openalex.org/W2029217326","https://openalex.org/W2040881358","https://openalex.org/W2060798006","https://openalex.org/W2069039186","https://openalex.org/W2093023735","https://openalex.org/W2100025800","https://openalex.org/W2127390834","https://openalex.org/W2154113150","https://openalex.org/W2157885764","https://openalex.org/W2314746436","https://openalex.org/W2317453866","https://openalex.org/W2318129164","https://openalex.org/W2320845990","https://openalex.org/W2328625710","https://openalex.org/W2331872402","https://openalex.org/W2469508188","https://openalex.org/W2578420327","https://openalex.org/W2588602181","https://openalex.org/W2626252489","https://openalex.org/W2772725055","https://openalex.org/W2772956163","https://openalex.org/W2803753862","https://openalex.org/W2887844735"],"related_works":["https://openalex.org/W2942880644","https://openalex.org/W1489037272","https://openalex.org/W2364533838","https://openalex.org/W124699378","https://openalex.org/W2411733409","https://openalex.org/W2102595128","https://openalex.org/W2108879804","https://openalex.org/W2893861607","https://openalex.org/W2328625710","https://openalex.org/W2134865352"],"abstract_inverted_index":{"BACKGROUND:":[0],"Indications":[1],"for":[2],"adjuvant":[3],"radiation":[4,35,244],"therapy":[5],"(XRT)":[6],"in":[7,23,73,84,216,219,226],"breast":[8,27,81,98,159,203,217,241],"cancer":[9,57,82,99,160,204,218],"have":[10],"expanded.":[11],"Although":[12],"highly":[13],"effective,":[14],"XRT":[15,152,201],"damages":[16],"surrounding":[17],"tissues":[18],"and":[19,45,75,93,129,145],"vasculature,":[20],"often":[21],"resulting":[22],"delayed":[24],"or":[25,125],"compromised":[26],"reconstruction.":[28],"Thus,":[29],"effective":[30],"yet":[31],"safe":[32],"methods":[33],"of":[34,61,70,87,118,181,193,214,233],"injury":[36],"prophylaxis":[37],"would":[38],"be":[39],"desirable.":[40],"Amifostine":[41],"is":[42,223],"a":[43,237],"Food":[44],"Drug":[46],"Administration-approved":[47],"radioprotectant;":[48],"however,":[49],"concerns":[50],"about":[51],"its":[52,77],"potential":[53,232],"to":[54,65,195,228,239],"also":[55],"protect":[56,197],"remain.":[58],"The":[59],"purpose":[60],"this":[62],"study":[63,189],"was":[64,137],"evaluate":[66],"the":[67,85,115,178,191,211,230],"oncologic":[68,212],"safety":[69,213],"amifostine":[71],"(AMF)":[72],"vitro":[74],"determine":[76],"effect":[78],"on":[79],"human":[80],"cells":[83,131,161,170,199,205],"setting":[86],"XRT.":[88,127],"METHODS:":[89],"One":[90],"ER+/PR+/Her2-":[91],"(MCF-7)":[92],"two":[94],"ER-/PR-Her2-":[95],"(MDA-MB-231,":[96],"MDA-MB-468)":[97],"cell":[100,135,167,182],"lines":[101,162],"were":[102,106,111,132],"investigated.":[103],"Female":[104],"fibroblasts":[105,149],"used":[107],"as":[108,184,236],"controls.":[109,156,186],"Cells":[110],"treated":[112],"with":[113,154,165],"WR-1065,":[114],"active":[116],"metabolite":[117],"AMF,":[119],"20":[120],"minutes":[121],"before":[122],"0Gy,":[123],"10Gy,":[124],"20Gy":[126],"Live":[128],"dead":[130],"quantified;":[133],"percent":[134],"death":[136,150,183],"calculated.":[138],"RESULTS:":[139],"WR-1065":[140,175],"treatment":[141],"significantly":[142],"preserved":[143],"viability":[144],"reduced":[146],"healthy":[147,198],"female":[148],"after":[151,243],"compared":[153],"untreated":[155,185],"All":[157],"three":[158],"exhibited":[163],"radiosensitivity":[164,173],"substantial":[166],"death.":[168],"Cancer":[169],"retained":[171],"their":[172],"despite":[174],"pretreatment,":[176],"achieving":[177],"same":[179],"degree":[180],"CONCLUSIONS:":[187],"This":[188],"demonstrated":[190],"proficiency":[192],"AMF":[194,215,235],"selectively":[196],"from":[200],"while":[202],"remained":[206],"radiosensitive.":[207],"These":[208],"results":[209],"support":[210],"vitro.":[220],"Further":[221],"investigation":[222],"now":[224],"warranted":[225],"vivo":[227],"ascertain":[229],"translational":[231],"using":[234],"radioprotectant":[238],"improve":[240],"reconstruction":[242],"treatment.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-26T00:00:00"}
