{"id":"https://openalex.org/W2996645183","doi":"https://doi.org/10.1111/luts.12297","title":"How long does the effect of botulinum toxin in neurogenic patients last? An analysis of the subset of \u201cgood responders\u201d","display_name":"How long does the effect of botulinum toxin in neurogenic patients last? An analysis of the subset of \u201cgood responders\u201d","publication_year":2019,"publication_date":"2019-12-19","ids":{"openalex":"https://openalex.org/W2996645183","doi":"https://doi.org/10.1111/luts.12297","mag":"2996645183","pmid":"https://pubmed.ncbi.nlm.nih.gov/31856406"},"language":"en","primary_location":{"id":"doi:10.1111/luts.12297","doi":"https://doi.org/10.1111/luts.12297","is_oa":false,"landing_page_url":"https://doi.org/10.1111/luts.12297","pdf_url":null,"source":{"id":"https://openalex.org/S206653124","display_name":"LUTS Lower Urinary Tract Symptoms","issn_l":"1757-5664","issn":["1757-5664","1757-5672"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"LUTS: Lower Urinary Tract Symptoms","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061636138","display_name":"In\u00e8s Dominique","orcid":"https://orcid.org/0000-0002-8350-7290","observed_orcids":["https://orcid.org/0000-0002-8350-7290"]},"institutions":[{"id":"https://openalex.org/I4210113288","display_name":"H\u00f4pital Lyon Sud","ror":"https://ror.org/023xgd207","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210113288"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"In\u00e8s Dominique","raw_affiliation_strings":["Lyon Sud\u2010Pierre B\u00e9nite Teaching Hospital  Pierre\u2010B\u00e9nite France"],"raw_orcid":"https://orcid.org/0000-0002-8350-7290","affiliations":[{"raw_affiliation_string":"Lyon Sud\u2010Pierre B\u00e9nite Teaching Hospital  Pierre\u2010B\u00e9nite France","institution_ids":["https://openalex.org/I4210113288"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015089720","display_name":"Benjamin Tremblais","orcid":"https://orcid.org/0000-0003-3569-149X","observed_orcids":["https://orcid.org/0000-0003-3569-149X"]},"institutions":[{"id":"https://openalex.org/I4210113288","display_name":"H\u00f4pital Lyon Sud","ror":"https://ror.org/023xgd207","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210113288"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Benjamin Tremblais","raw_affiliation_strings":["Lyon Sud\u2010Pierre B\u00e9nite Teaching Hospital  Pierre\u2010B\u00e9nite France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lyon Sud\u2010Pierre B\u00e9nite Teaching Hospital  Pierre\u2010B\u00e9nite France","institution_ids":["https://openalex.org/I4210113288"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056094184","display_name":"Kathleen F. Charvier","orcid":"https://orcid.org/0000-0002-5309-7729","observed_orcids":["https://orcid.org/0000-0002-5309-7729"]},"institutions":[{"id":"https://openalex.org/I4210113288","display_name":"H\u00f4pital Lyon Sud","ror":"https://ror.org/023xgd207","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210113288"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Kathleen Charvier","raw_affiliation_strings":["Lyon Sud\u2010Pierre B\u00e9nite Teaching Hospital  Pierre\u2010B\u00e9nite France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lyon Sud\u2010Pierre B\u00e9nite Teaching Hospital  Pierre\u2010B\u00e9nite France","institution_ids":["https://openalex.org/I4210113288"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maria C. S. Nogueira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113288","display_name":"H\u00f4pital Lyon Sud","ror":"https://ror.org/023xgd207","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210113288"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Maria C. S. Nogueira","raw_affiliation_strings":["Lyon Sud\u2010Pierre B\u00e9nite Teaching Hospital  Pierre\u2010B\u00e9nite France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lyon Sud\u2010Pierre B\u00e9nite Teaching Hospital  Pierre\u2010B\u00e9nite France","institution_ids":["https://openalex.org/I4210113288"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113516467","display_name":"P. Paparel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113288","display_name":"H\u00f4pital Lyon Sud","ror":"https://ror.org/023xgd207","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210113288"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Paparel","raw_affiliation_strings":["Lyon Sud\u2010Pierre B\u00e9nite Teaching Hospital  Pierre\u2010B\u00e9nite France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lyon Sud\u2010Pierre B\u00e9nite Teaching Hospital  Pierre\u2010B\u00e9nite France","institution_ids":["https://openalex.org/I4210113288"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006876365","display_name":"Nicolas Morel Journel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113288","display_name":"H\u00f4pital Lyon Sud","ror":"https://ror.org/023xgd207","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210113288"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Morel Journel","raw_affiliation_strings":["Lyon Sud\u2010Pierre B\u00e9nite Teaching Hospital  Pierre\u2010B\u00e9nite France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lyon Sud\u2010Pierre B\u00e9nite Teaching Hospital  Pierre\u2010B\u00e9nite France","institution_ids":["https://openalex.org/I4210113288"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026135868","display_name":"A. Ruffion","orcid":"https://orcid.org/0000-0003-0512-3459","observed_orcids":["https://orcid.org/0000-0003-0512-3459"]},"institutions":[{"id":"https://openalex.org/I4210113288","display_name":"H\u00f4pital Lyon Sud","ror":"https://ror.org/023xgd207","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210113288"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alain Ruffion","raw_affiliation_strings":["Lyon Sud\u2010Pierre B\u00e9nite Teaching Hospital  Pierre\u2010B\u00e9nite France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lyon Sud\u2010Pierre B\u00e9nite Teaching Hospital  Pierre\u2010B\u00e9nite France","institution_ids":["https://openalex.org/I4210113288"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5061636138"],"corresponding_institution_ids":["https://openalex.org/I4210113288"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.5847,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.67844111,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"12","issue":"2","first_page":"155","last_page":"161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.045099999755620956,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/botulinum-toxin-type-a","display_name":"botulinum toxin type A","score":0.9350000023841858},{"id":"https://openalex.org/keywords/neurogenic-detrusor-overactivity","display_name":"neurogenic detrusor overactivity","score":0.9929999709129333},{"id":"https://openalex.org/keywords/intradetrusor-injection","display_name":"intradetrusor injection","score":0.8709999918937683},{"id":"https://openalex.org/keywords/long-term-efficacy","display_name":"long-term efficacy","score":0.7450000047683716},{"id":"https://openalex.org/keywords/treatment-durability","display_name":"treatment durability","score":0.6370000243186951},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.7699999809265137},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":1.0},{"id":"https://openalex.org/keywords/cystometry","display_name":"cystometry","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7622067928314209},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.7285377979278564},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.5905836820602417},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.5008358955383301},{"id":"https://openalex.org/C2780073493","wikidata":"https://www.wikidata.org/wiki/Q7523837","display_name":"Single Center","level":2,"score":0.4856220781803131},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.48395827412605286},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.4785642921924591},{"id":"https://openalex.org/C2777478456","wikidata":"https://www.wikidata.org/wiki/Q208413","display_name":"Botulinum toxin","level":2,"score":0.46971645951271057},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4474577009677887},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.36996549367904663},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3343238830566406},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.1160203218460083},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001750","descriptor_name":"Urinary Bladder, Neurogenic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001750","descriptor_name":"Urinary Bladder, Neurogenic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008365","descriptor_name":"Manometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009465","descriptor_name":"Neuromuscular Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013995","descriptor_name":"Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014563","descriptor_name":"Urodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019274","descriptor_name":"Botulinum Toxins, Type A","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D053201","descriptor_name":"Urinary Bladder, Overactive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D053201","descriptor_name":"Urinary Bladder, Overactive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D053201","descriptor_name":"Urinary Bladder, Overactive","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/luts.12297","doi":"https://doi.org/10.1111/luts.12297","is_oa":false,"landing_page_url":"https://doi.org/10.1111/luts.12297","pdf_url":null,"source":{"id":"https://openalex.org/S206653124","display_name":"LUTS Lower Urinary Tract Symptoms","issn_l":"1757-5664","issn":["1757-5664","1757-5672"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"LUTS: Lower Urinary Tract Symptoms","raw_type":"journal-article"},{"id":"pmid:31856406","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31856406","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lower urinary tract symptoms","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323878","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1208751892","https://openalex.org/W1257881779","https://openalex.org/W1767286810","https://openalex.org/W1965976972","https://openalex.org/W1993607794","https://openalex.org/W1995717681","https://openalex.org/W1998308259","https://openalex.org/W2002037387","https://openalex.org/W2018678082","https://openalex.org/W2021257414","https://openalex.org/W2021797341","https://openalex.org/W2023904242","https://openalex.org/W2028798749","https://openalex.org/W2034704564","https://openalex.org/W2038557164","https://openalex.org/W2039702240","https://openalex.org/W2043938107","https://openalex.org/W2063646746","https://openalex.org/W2074581746","https://openalex.org/W2080492051","https://openalex.org/W2081071477","https://openalex.org/W2090102990","https://openalex.org/W2110099116","https://openalex.org/W2157993246","https://openalex.org/W2160945626","https://openalex.org/W2171321375","https://openalex.org/W2179396169","https://openalex.org/W2328680462","https://openalex.org/W2335890257","https://openalex.org/W2341515385","https://openalex.org/W4231943573","https://openalex.org/W4245187582","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1964812034","https://openalex.org/W2039702240","https://openalex.org/W7062263439","https://openalex.org/W1993607794","https://openalex.org/W2748938772","https://openalex.org/W1982423525","https://openalex.org/W2896213022","https://openalex.org/W1861446723","https://openalex.org/W4403348079","https://openalex.org/W2020343186"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,50,74,104,145,154,236],"aim":[2],"of":[3,11,19,52,65,71,80,83,92,112,122,128,157,160,166,171,181,195,211,232,238,245,259,267,277],"this":[4],"study":[5,32,240],"was":[6,28,55,77,87,107,149,159,207],"to":[7,108,248],"assess":[8,109],"long-term":[9,81,120,230],"efficacity":[10,82,121],"botulinum":[12,270],"neurotoxin":[13],"A":[14,126,164],"(BoNT-A)":[15],"in":[16,33,188,255,274],"the":[17,78,90,95,110,119,123,179,243],"treatment":[18,177,197,254],"neurogenic":[20,260],"detrusor":[21],"overactivity":[22],"(NDO).":[23],"MATERIALS":[24],"AND":[25],"METHODS:":[26],"This":[27],"a":[29,34,69,193,256],"retrospective":[30],"monocentric":[31],"reference":[35],"center.":[36],"We":[37],"included":[38,132],"patients":[39,57,130,172,190,261],"who":[40],"received":[41],"intradetrusor":[42,66],"BoNT-A":[43,67,196,233,246],"for":[44],"NDO":[45,86],"between":[46],"2001":[47],"and":[48,98,116,139,252],"2015.":[49],"focus":[51],"our":[53,239],"analysis":[54],"on":[56,118,201,229],"defined":[58],"as":[59],"\"good":[60],"responders\"":[61],"(\u2265":[62],"5":[63],"injections":[64,158],"over":[68],"period":[70,148],"\u22655":[72],"years).":[73],"primary":[75],"endpoint":[76],"evaluation":[79],"BoNT-A.":[84],"Recurrent":[85],"monitored":[88],"by":[89,176],"use":[91],"cystomanometry":[93],"before":[94],"first":[96],"injection":[97],"1":[99],"month":[100],"after":[101,262],"each":[102],"injection.":[103],"secondary":[105],"objective":[106],"influence":[111],"NDO's":[113,221],"etiology,":[114],"age,":[115],"sex":[117,216],"treatment.":[124,234],"RESULTS:":[125],"total":[127,165],"107":[129],"were":[131,173],"(60.7%":[133],"with":[134,141,192],"spinal":[135],"cord":[136],"injury":[137],"[SCI]":[138],"36.4%":[140],"multiple":[142],"sclerosis":[143],"[MS]).":[144],"mean":[146,155],"follow-up":[147,183],"83.7":[150],"months":[151,200],"(66;":[152],"120).":[153],"number":[156,258],"8.9":[161],"(5;":[162],"21).":[163],"67.3%":[167],"(n":[168],"=":[169,214,218,227],"72)":[170],"still":[174],"controlled":[175],"at":[178,198],"end":[180],"their":[182],"period.":[184],"Therapeutic":[185],"failure":[186],"occurred":[187,273],"30":[189],"(26.1%)":[191],"cessation":[194],"76":[199],"average":[202],"(median:":[203],"82.5":[204],"months).":[205],"There":[206],"no":[208],"significant":[209],"impact":[210],"age":[212],"(P":[213,217],".42),":[215],".35),":[219],"or":[220],"etiology":[222],"(MS":[223],"vs":[224],"SCI;":[225],"P":[226],".54)":[228],"efficacy":[231],"CONCLUSION:":[235],"results":[237],"indicate":[241],"that":[242],"application":[244],"seems":[247],"be":[249],"an":[250],"effective":[251],"durable":[253],"large":[257],"more":[263],"than":[264],"10":[265],"years":[266],"follow-up.":[268],"However,":[269],"toxin":[271],"tolerance":[272],"approximately":[275],"25%":[276],"patients.":[278]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-26T00:00:00"}
