{"id":"https://openalex.org/W2996537546","doi":"https://doi.org/10.1186/s43088-019-0025-9","title":"Potential role of cinnamaldehyde and costunolide to counteract metabolic syndrome induced by excessive fructose consumption","display_name":"Potential role of cinnamaldehyde and costunolide to counteract metabolic syndrome induced by excessive fructose consumption","publication_year":2019,"publication_date":"2019-12-01","ids":{"openalex":"https://openalex.org/W2996537546","doi":"https://doi.org/10.1186/s43088-019-0025-9","mag":"2996537546"},"language":"en","primary_location":{"id":"doi:10.1186/s43088-019-0025-9","doi":"https://doi.org/10.1186/s43088-019-0025-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43088-019-0025-9","pdf_url":"https://bjbas.springeropen.com/track/pdf/10.1186/s43088-019-0025-9","source":{"id":"https://openalex.org/S2764610058","display_name":"Beni-Suef University Journal of Basic and Applied Sciences","issn_l":"2314-8535","issn":["2314-8535","2314-8543"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Beni-Suef University Journal of Basic and Applied Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bjbas.springeropen.com/track/pdf/10.1186/s43088-019-0025-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045689941","display_name":"Ayat S. Rashwan","orcid":"https://orcid.org/0000-0002-6591-663X","observed_orcids":["https://orcid.org/0000-0002-6591-663X"]},"institutions":[{"id":"https://openalex.org/I114794399","display_name":"Suez Canal University","ror":"https://ror.org/02m82p074","country_code":"EG","type":"education","lineage":["https://openalex.org/I114794399"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Ayat S. Rashwan","raw_affiliation_strings":["Department of Biochemistry, Faculty of Vet. Medicine, Suez Canal University, Ismailia, Egypt"],"raw_orcid":"https://orcid.org/0000-0002-6591-663X","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Vet. Medicine, Suez Canal University, Ismailia, Egypt","institution_ids":["https://openalex.org/I114794399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110673912","display_name":"Marwa A. El-Beltagy","orcid":"https://orcid.org/0000-0001-6068-0843","observed_orcids":["https://orcid.org/0000-0001-6068-0843"]},"institutions":[{"id":"https://openalex.org/I114794399","display_name":"Suez Canal University","ror":"https://ror.org/02m82p074","country_code":"EG","type":"education","lineage":["https://openalex.org/I114794399"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Marwa A. El-Beltagy","raw_affiliation_strings":["Department of Biochemistry, Faculty of Vet. Medicine, Suez Canal University, Ismailia, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Vet. Medicine, Suez Canal University, Ismailia, Egypt","institution_ids":["https://openalex.org/I114794399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016813303","display_name":"Sherif Y. Saleh","orcid":"https://orcid.org/0000-0002-0145-6953","observed_orcids":["https://orcid.org/0000-0002-0145-6953"]},"institutions":[{"id":"https://openalex.org/I114794399","display_name":"Suez Canal University","ror":"https://ror.org/02m82p074","country_code":"EG","type":"education","lineage":["https://openalex.org/I114794399"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Sherif Y. Saleh","raw_affiliation_strings":["Department of Biochemistry, Faculty of Vet. Medicine, Suez Canal University, Ismailia, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Vet. Medicine, Suez Canal University, Ismailia, Egypt","institution_ids":["https://openalex.org/I114794399"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113428308","display_name":"Ibrahim A. Ibrahim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114794399","display_name":"Suez Canal University","ror":"https://ror.org/02m82p074","country_code":"EG","type":"education","lineage":["https://openalex.org/I114794399"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Ibrahim A. Ibrahim","raw_affiliation_strings":["Department of Biochemistry, Faculty of Vet. Medicine, Suez Canal University, Ismailia, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Vet. Medicine, Suez Canal University, Ismailia, Egypt","institution_ids":["https://openalex.org/I114794399"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045689941","https://openalex.org/A5113428308"],"corresponding_institution_ids":["https://openalex.org/I114794399"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":1.0519,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.81043025,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cinnamaldehyde","display_name":"cinnamaldehyde","score":0.9929999709129333},{"id":"https://openalex.org/keywords/costunolide","display_name":"costunolide","score":1.0},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9940000176429749},{"id":"https://openalex.org/keywords/high-fructose-diet","display_name":"high-fructose diet","score":0.9179999828338623},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.7200000286102295},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7549999952316284},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.5389999747276306},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.5450000166893005},{"id":"https://openalex.org/keywords/cinnamomum-verum","display_name":"Cinnamomum zeylanicum","score":0.8849999904632568},{"id":"https://openalex.org/keywords/saussurea-lappa","display_name":"Saussurea lappa","score":0.9919999837875366},{"id":"https://openalex.org/keywords/sesquiterpene-lactones","display_name":"sesquiterpene lactones","score":0.8529999852180481},{"id":"https://openalex.org/keywords/antidiabetic-natural-products","display_name":"antidiabetic natural products","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6886162757873535},{"id":"https://openalex.org/C2777435628","wikidata":"https://www.wikidata.org/wiki/Q204036","display_name":"Cinnamaldehyde","level":3,"score":0.6252208948135376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.53608638048172},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.5279504656791687},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.5167507529258728},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4905673861503601},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.47147276997566223},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.46782320737838745},{"id":"https://openalex.org/C2776970464","wikidata":"https://www.wikidata.org/wiki/Q122043","display_name":"Fructose","level":2,"score":0.4467231035232544},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4151567816734314},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4020422101020813},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.39371052384376526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3420805037021637},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22515463829040527},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s43088-019-0025-9","doi":"https://doi.org/10.1186/s43088-019-0025-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43088-019-0025-9","pdf_url":"https://bjbas.springeropen.com/track/pdf/10.1186/s43088-019-0025-9","source":{"id":"https://openalex.org/S2764610058","display_name":"Beni-Suef University Journal of Basic and Applied Sciences","issn_l":"2314-8535","issn":["2314-8535","2314-8543"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Beni-Suef University Journal of Basic and Applied Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:048c75cb7d2a4723aa0e8c4ccfddb6b6","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/048c75cb7d2a4723aa0e8c4ccfddb6b6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Beni-Suef University Journal of Basic and Applied Sciences, Vol 8, Iss 1, Pp 1-8 (2019)","raw_type":"article"},{"id":"doi:10.60692/h19ca-ht247","doi":"https://doi.org/10.60692/h19ca-ht247","is_oa":true,"landing_page_url":"https://doi.org/10.60692/h19ca-ht247","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/jswh9-jb704","doi":"https://doi.org/10.60692/jswh9-jb704","is_oa":true,"landing_page_url":"https://doi.org/10.60692/jswh9-jb704","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/s43088-019-0025-9","doi":"https://doi.org/10.1186/s43088-019-0025-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43088-019-0025-9","pdf_url":"https://bjbas.springeropen.com/track/pdf/10.1186/s43088-019-0025-9","source":{"id":"https://openalex.org/S2764610058","display_name":"Beni-Suef University Journal of Basic and Applied Sciences","issn_l":"2314-8535","issn":["2314-8535","2314-8543"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Beni-Suef University Journal of Basic and Applied Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2996537546.pdf","grobid_xml":"https://content.openalex.org/works/W2996537546.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W174319729","https://openalex.org/W185214937","https://openalex.org/W1494021385","https://openalex.org/W1551586253","https://openalex.org/W1843991022","https://openalex.org/W1884365890","https://openalex.org/W1964950943","https://openalex.org/W1979114643","https://openalex.org/W1982844599","https://openalex.org/W1983515979","https://openalex.org/W1986108355","https://openalex.org/W1991775006","https://openalex.org/W1995992894","https://openalex.org/W1996298711","https://openalex.org/W2011801069","https://openalex.org/W2021280599","https://openalex.org/W2022856465","https://openalex.org/W2047516613","https://openalex.org/W2057643815","https://openalex.org/W2060546644","https://openalex.org/W2063623581","https://openalex.org/W2073531195","https://openalex.org/W2075590923","https://openalex.org/W2075784782","https://openalex.org/W2084389875","https://openalex.org/W2087579091","https://openalex.org/W2097049368","https://openalex.org/W2103574678","https://openalex.org/W2116404316","https://openalex.org/W2117080923","https://openalex.org/W2143295210","https://openalex.org/W2144590229","https://openalex.org/W2145540652","https://openalex.org/W2151933075","https://openalex.org/W2154024784","https://openalex.org/W2157231610","https://openalex.org/W2159397743","https://openalex.org/W2160137290","https://openalex.org/W2266929960","https://openalex.org/W2275882948","https://openalex.org/W2295817229","https://openalex.org/W2336147492","https://openalex.org/W2341382075","https://openalex.org/W2528731190","https://openalex.org/W2563678735","https://openalex.org/W2586513721","https://openalex.org/W2599020708","https://openalex.org/W2604133403","https://openalex.org/W2605491380","https://openalex.org/W2618790508","https://openalex.org/W2731503386","https://openalex.org/W2742934011","https://openalex.org/W2785494437","https://openalex.org/W2804322212","https://openalex.org/W2861644401","https://openalex.org/W2900446103","https://openalex.org/W2901112820","https://openalex.org/W2904762647","https://openalex.org/W2944374237","https://openalex.org/W2970039037","https://openalex.org/W4244129965","https://openalex.org/W4251812587"],"related_works":["https://openalex.org/W2000508726","https://openalex.org/W3015993513","https://openalex.org/W4385230135","https://openalex.org/W2075590923","https://openalex.org/W4385154397","https://openalex.org/W2949272737","https://openalex.org/W3008232504","https://openalex.org/W2134803404","https://openalex.org/W2123786556","https://openalex.org/W2560156779"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"One":[2],"of":[3,34,58,68,83,89,98,162,178,195,207,226],"the":[4,10,31,39,55,79,90,96,99,191],"serious":[5],"public":[6],"health":[7],"problems":[8],"in":[9,104],"world":[11],"is":[12,64,73,78,93],"metabolic":[13,35,227],"syndrome.":[14,228],"It":[15,126],"includes":[16],"visceral":[17],"obesity,":[18],"dyslipidemia,":[19],"insulin":[20,117],"resistance,":[21],"hyperglycemia,":[22],"and":[23,146,155,164,175,182,188,199,214],"hypertension.":[24],"As":[25],"a":[26,113],"contributor":[27],"to":[28,94,202],"almost":[29],"all":[30],"classic":[32],"signs":[33],"syndrome,":[36],"fructose":[37,122],"was":[38,127],"ideal":[40],"choice.":[41],"There":[42],"are":[43],"certain":[44],"shortcomings":[45],"with":[46,106],"existing":[47],"drugs":[48,221],"for":[49,116,222],"insulin-resistant":[50],"treatment.":[51],"Plants":[52],"still":[53],"represent":[54],"main":[56,80,87],"source":[57],"most":[59],"available":[60],"medicines.":[61],"Cinnamaldehyde":[62],"(CNA)":[63],"an":[65],"active":[66],"principle":[67],"Cinnamomum":[69],"zeylanicum.":[70],"Costunolide":[71],"(CE)":[72],"natural":[74,107],"sesquiterpene":[75],"lactones,":[76],"which":[77],"bioactive":[81],"constituent":[82],"Saussurea":[84],"lappa.":[85],"The":[86,205],"aim":[88],"present":[91],"study":[92,210],"investigate":[95],"effect":[97],"synthetic":[100],"antidiabetic":[101],"agent":[102],"(metformin)":[103],"comparison":[105],"constituents":[108],"(cinnamaldehyde,":[109],"costunolide)":[110],"after":[111],"developing":[112],"reliable":[114],"model":[115],"resistance":[118],"by":[119],"using":[120],"high":[121],"diet":[123],"(HFD).":[124],"Results":[125],"found":[128],"that":[129,212],"HFD":[130,150],"increased":[131,176],"plasma":[132,168,193],"glucose,":[133,169],"insulin,":[134],"glycosylated":[135],"hemoglobin,":[136],"HbA1c,":[137,170],"serum":[138],"total":[139,171],"cholesterol,":[140,172],"LDL-cholesterol,":[141,173],"triglyceride,":[142,174],"ALT,":[143,196],"AST,":[144,197],"creatinine,":[145,198],"uric":[147,200],"acid.":[148],"Moreover,":[149],"decreased":[151,167],"hepatic":[152,179],"reduced":[153,180],"glutathione":[154,181],"superoxide":[156,183],"dismutase":[157,184],"levels.":[158],"While":[159],"oral":[160],"administration":[161],"cinnamaldehyde":[163,187,213],"costunolide":[165,189,215],"significantly":[166],"level":[177],"activity.":[185],"Also,":[186],"restored":[190],"altered":[192],"levels":[194],"acid":[201],"normal.":[203],"Conclusions":[204],"results":[206],"this":[208],"experimental":[209],"showed":[211],"could":[216],"be":[217],"used":[218],"as":[219],"safe":[220],"treating":[223],"different":[224],"abnormalities":[225]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-26T00:00:00"}
