{"id":"https://openalex.org/W2996526774","doi":"https://doi.org/10.1158/1538-7445.panca19-b49","title":"Abstract B49: Precision targeting of M2-like macrophages by the innate defense regulator RP-182 in pancreatic cancer and noncancerous diseases","display_name":"Abstract B49: Precision targeting of M2-like macrophages by the innate defense regulator RP-182 in pancreatic cancer and noncancerous diseases","publication_year":2019,"publication_date":"2019-12-13","ids":{"openalex":"https://openalex.org/W2996526774","doi":"https://doi.org/10.1158/1538-7445.panca19-b49","mag":"2996526774"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.panca19-b49","doi":"https://doi.org/10.1158/1538-7445.panca19-b49","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.panca19-b49","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091392055","display_name":"Rushikesh V. Sable","orcid":"https://orcid.org/0000-0002-6128-2190","observed_orcids":["https://orcid.org/0000-0002-6128-2190"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rushikesh Sable","raw_affiliation_strings":["1National Cancer Institute, Bethesda, MD,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Bethesda, MD,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037013779","display_name":"Jesse M. Jaynes","orcid":"https://orcid.org/0000-0001-7795-8952","observed_orcids":["https://orcid.org/0000-0001-7795-8952"]},"institutions":[{"id":"https://openalex.org/I6026837","display_name":"Tuskegee University","ror":"https://ror.org/0137n4m74","country_code":"US","type":"education","lineage":["https://openalex.org/I6026837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesse Jaynes","raw_affiliation_strings":["2Tuskegee University, Tuskegee, AL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Tuskegee University, Tuskegee, AL,","institution_ids":["https://openalex.org/I6026837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030966054","display_name":"Michael H. Ronzetti","orcid":"https://orcid.org/0000-0001-5034-7692","observed_orcids":["https://orcid.org/0000-0001-5034-7692"]},"institutions":[{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Ronzetti","raw_affiliation_strings":["3National Center for Advancing Translational Sciences, Shady Grove, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3National Center for Advancing Translational Sciences, Shady Grove, MD","institution_ids":["https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wendy Guzman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy Guzman","raw_affiliation_strings":["1National Cancer Institute, Bethesda, MD,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Bethesda, MD,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025375072","display_name":"Zachary Knotts","orcid":"https://orcid.org/0000-0001-7557-1922","observed_orcids":["https://orcid.org/0000-0001-7557-1922"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary Knotts","raw_affiliation_strings":["1National Cancer Institute, Bethesda, MD,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Bethesda, MD,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063310304","display_name":"Natalia de Val","orcid":"https://orcid.org/0000-0002-1506-2023","observed_orcids":["https://orcid.org/0000-0002-1506-2023"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalia de Val","raw_affiliation_strings":["1National Cancer Institute, Bethesda, MD,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Bethesda, MD,","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012124287","display_name":"Juan Morgan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Morgan","raw_affiliation_strings":["3National Center for Advancing Translational Sciences, Shady Grove, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3National Center for Advancing Translational Sciences, Shady Grove, MD","institution_ids":["https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060515951","display_name":"Clayton Clopton Yates","orcid":"https://orcid.org/0000-0001-5420-9852","observed_orcids":["https://orcid.org/0000-0001-5420-9852"]},"institutions":[{"id":"https://openalex.org/I6026837","display_name":"Tuskegee University","ror":"https://ror.org/0137n4m74","country_code":"US","type":"education","lineage":["https://openalex.org/I6026837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clayton Yates","raw_affiliation_strings":["2Tuskegee University, Tuskegee, AL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Tuskegee University, Tuskegee, AL,","institution_ids":["https://openalex.org/I6026837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035678820","display_name":"Bolormaa Baljinnyam","orcid":"https://orcid.org/0000-0001-9548-4965","observed_orcids":["https://orcid.org/0000-0001-9548-4965"]},"institutions":[{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baljinnyam Bolormaa","raw_affiliation_strings":["3National Center for Advancing Translational Sciences, Shady Grove, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3National Center for Advancing Translational Sciences, Shady Grove, MD","institution_ids":["https://openalex.org/I4210148682"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028439777","display_name":"Udo Rudloff","orcid":"https://orcid.org/0000-0003-2137-9040","observed_orcids":["https://orcid.org/0000-0003-2137-9040"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Udo Rudloff","raw_affiliation_strings":["1National Cancer Institute, Bethesda, MD,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Institute, Bethesda, MD,","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"24_Supplement","first_page":"B49","last_page":"B49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.8019999861717224},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.996999979019165},{"id":"https://openalex.org/keywords/cd206","display_name":"CD206","score":0.8659999966621399},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.8029999732971191},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5809999704360962},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.6869999766349792},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.8270000219345093},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9580000042915344},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitor-therapy","display_name":"immune checkpoint therapy","score":0.6190000176429749},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.6029999852180481},{"id":"https://openalex.org/keywords/peptide-drug-development","display_name":"peptide drug development","score":0.39500001072883606},{"id":"https://openalex.org/keywords/carbohydrate-recognition-domain","display_name":"carbohydrate recognition domain","score":0.5600000023841858},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6583821177482605},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6473731398582458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6301096081733704},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5457330346107483},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.536700427532196},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.528915286064148},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4474586546421051},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.42886096239089966},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4259505569934845},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.423306941986084},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20302972197532654},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.panca19-b49","doi":"https://doi.org/10.1158/1538-7445.panca19-b49","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.panca19-b49","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4402048589","https://openalex.org/W3006438030","https://openalex.org/W4409184696","https://openalex.org/W4387769707","https://openalex.org/W2364821648","https://openalex.org/W2535172734","https://openalex.org/W4393087507","https://openalex.org/W2093619322","https://openalex.org/W2791979355","https://openalex.org/W3028578182"],"abstract_inverted_index":{"Abstract":[0],"Immunologically":[1],"\u201ccold\u201d":[2],"tumors":[3],"are":[4,39,54],"not":[5],"responsive":[6],"to":[7,99,116,167],"current":[8],"immunotherapies.":[9],"The":[10],"impact":[11],"of":[12,29,59,113,121,142,180,193,203,227,238,254,344,362],"T-cell":[13,36],"activation":[14],"with":[15,131,258,267,274,311],"immune":[16,49,241,308],"checkpoint":[17,242],"inhibition":[18,112],"or":[19,33,119],"vaccines":[20],"is":[21,126,265],"limited":[22],"in":[23,68,72,185,219,271,288,314,353,371],"these":[24],"cancers":[25],"by":[26,42,347],"a":[27,55,65,87,127,138,177,191,284,289],"lack":[28],"intertumoral":[30,47],"T":[31],"cells":[32],"an":[34,109],"\u201cexhausted\u201d":[35],"phenotype,":[37],"which":[38],"frequently":[40],"induced":[41],"abundant":[43],"immune-suppressive":[44,281],"cues":[45,83],"from":[46,137,301],"innate":[48,155,307,349],"cells.":[50],"Tumor-associated":[51],"macrophages":[52,190,346],"(TAMs)":[53],"major":[56],"cell":[57,309],"population":[58,253],"the":[60,168,181,236,246,250,259,348,363],"tumor":[61,70,208],"microenvironment":[62],"and":[63,81,96,147,154,164,183,187,196,212,229,240,316,356,373],"play":[64],"key":[66],"role":[67],"promoting":[69],"progression":[71],"many":[73],"solid":[74],"organ":[75],"cancers.":[76],"During":[77],"cancer":[78,91,205,222,232,355],"progression,":[79],"tumoral":[80],"microenvironmental":[82],"educate":[84],"TAMs":[85,106,255],"towards":[86],"M2-phenotype":[88],"that":[89,134,161,224,298],"nurtures":[90],"stem":[92],"cells,":[93],"accelerates":[94],"metastasis,":[95],"confers":[97],"resistance":[98],"chemotherapy.":[100],"Current":[101],"drug":[102],"development":[103],"efforts":[104],"targeting":[105,343],"primarily":[107],"focus":[108],"unselective":[110],"systemic":[111],"macrophage":[114],"recruitment":[115],"disease":[117],"sites":[118],"modulation":[120],"their":[122],"immuno-cytokine":[123],"profile.":[124],"RP-182":[125,162,206,234,247,278,352],"10mer":[128],"striapathic":[129],"peptide":[130,248],"immunomodulatory":[132],"function":[133],"was":[135],"derived":[136,300],"biophysical":[139,302],"homology":[140,303],"screen":[141],"carbohydrate":[143],"recognition":[144],"domain":[145],"patterns":[146],"naturally":[148],"occurring":[149],"host":[150],"defense":[151,156,350],"peptides":[152],"(HDP)":[153],"regulators":[157],"(IDR).":[158],"We":[159],"demonstrate":[160],"specifically":[163],"effectively":[165,305],"binds":[166],"mannose":[169],"receptor":[170,262],"MRC1/CD206":[171],"expressed":[172],"on":[173,367],"M2-like":[174,189,282,345],"macrophages,":[175,283],"induces":[176],"conformational":[178],"switch":[179],"receptor,":[182],"activates":[184],"human":[186,230],"murine":[188,201,228,291],"program":[192],"phagocytosis,":[194],"autophagy,":[195],"apoptosis.":[197],"In":[198,244],"genetically":[199],"engineered":[200],"models":[202,223],"pancreas":[204,275],"suppressed":[207],"growth,":[209],"extended":[210],"survival,":[211],"improved":[213,268],"antitumor":[214],"immunity,":[215],"findings":[216,296],"also":[217,286],"seen":[218],"other":[220],"syngeneic":[221],"include":[225],"variety":[226],"(PDX)":[231],"models.":[233],"enhanced":[235],"effects":[237],"chemo-":[239],"therapy.":[243],"conclusion,":[245],"depletes":[249],"immune-evasive":[251],"M2":[252],"via":[256],"engagement":[257],"M2-specific":[260],"lectin":[261],"CD206.":[263],"This":[264],"associated":[266],"clinical":[269],"outcome":[270],"transgenic":[272],"mice":[273],"cancer.":[276],"Similarly,":[277],"selectively":[279],"reduces":[280],"finding":[285],"made":[287],"noncancerous":[290,357],"fibrosis":[292],"model.":[293],"Collectively,":[294],"preclinical":[295],"show":[297],"HDPs/IDRs":[299],"studies":[304],"reduce":[306],"subpopulations":[310],"therapeutic":[312],"merit":[313],"cancerous":[315],"nonmalignant":[317],"diseases.":[318],"Citation":[319],"Format:":[320],"Rushikesh":[321],"Sable,":[322],"Jesse":[323],"Jaynes,":[324],"Michael":[325],"Ronzetti,":[326],"Wendy":[327],"Guzman,":[328],"Zachary":[329],"Knotts,":[330],"Natalia":[331],"de":[332],"Val,":[333],"Juan":[334],"Morgan,":[335],"Clayton":[336],"Yates,":[337],"Baljinnyam":[338],"Bolormaa,":[339],"Udo":[340],"Rudloff.":[341],"Precision":[342],"regulator":[351],"pancreatic":[354],"diseases":[358],"[abstract].":[359],"In:":[360],"Proceedings":[361],"AACR":[364],"Special":[365],"Conference":[366],"Pancreatic":[368],"Cancer:":[369],"Advances":[370],"Science":[372],"Clinical":[374],"Care;":[375],"2019":[376],"Sept":[377],"6-9;":[378],"Boston,":[379],"MA.":[380],"Philadelphia":[381],"(PA):":[382],"AACR;":[383],"Cancer":[384],"Res":[385],"2019;79(24":[386],"Suppl):Abstract":[387],"nr":[388],"B49.":[389]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2019-12-26T00:00:00"}