{"id":"https://openalex.org/W2996511552","doi":"https://doi.org/10.1186/s12967-019-02175-0","title":"Lupus serum IgG induces microglia activation through Fc fragment dependent way and modulated by B-cell activating factor","display_name":"Lupus serum IgG induces microglia activation through Fc fragment dependent way and modulated by B-cell activating factor","publication_year":2019,"publication_date":"2019-12-01","ids":{"openalex":"https://openalex.org/W2996511552","doi":"https://doi.org/10.1186/s12967-019-02175-0","mag":"2996511552","pmid":"https://pubmed.ncbi.nlm.nih.gov/31864410","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6925475"},"language":"en","primary_location":{"id":"doi:10.1186/s12967-019-02175-0","doi":"https://doi.org/10.1186/s12967-019-02175-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-019-02175-0","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-019-02175-0","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-019-02175-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103166169","display_name":"Chunshu Yang","orcid":"https://orcid.org/0000-0001-7377-7249","observed_orcids":["https://orcid.org/0000-0001-7377-7249"]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunshu Yang","raw_affiliation_strings":["Department of 1st Cancer Institute, First Affiliated Hospital, China Medical University, Shenyang, 110001, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of 1st Cancer Institute, First Affiliated Hospital, China Medical University, Shenyang, 110001, People's Republic of China","institution_ids":["https://openalex.org/I4210140515","https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065816927","display_name":"Xiaoyu Hou","orcid":"https://orcid.org/0000-0001-5409-8785","observed_orcids":["https://orcid.org/0000-0001-5409-8785"]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyu Hou","raw_affiliation_strings":["Department of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, 110001, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, 110001, People's Republic of China","institution_ids":["https://openalex.org/I4210140515","https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062823032","display_name":"Qianhui Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianhui Feng","raw_affiliation_strings":["Department of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, 110001, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, 110001, People's Republic of China","institution_ids":["https://openalex.org/I4210140515","https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011414541","display_name":"Yingzhuo Li","orcid":"https://orcid.org/0009-0005-1583-7561","observed_orcids":["https://orcid.org/0009-0005-1583-7561","https://orcid.org/0000-0003-3956-2580"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingzhuo Li","raw_affiliation_strings":["Department of Physiology, School of Life Science, China Medical University, Shenyang, 110122, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Life Science, China Medical University, Shenyang, 110122, People's Republic of China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100617083","display_name":"Xuejiao Wang","orcid":"https://orcid.org/0000-0002-3273-280X","observed_orcids":["https://orcid.org/0000-0002-3273-280X"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuejiao Wang","raw_affiliation_strings":["Department of Physiology, School of Life Science, China Medical University, Shenyang, 110122, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Life Science, China Medical University, Shenyang, 110122, People's Republic of China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057518610","display_name":"Ling Qin","orcid":"https://orcid.org/0000-0001-8717-3833","observed_orcids":["https://orcid.org/0000-0001-8717-3833"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Qin","raw_affiliation_strings":["Department of Physiology, School of Life Science, China Medical University, Shenyang, 110122, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Life Science, China Medical University, Shenyang, 110122, People's Republic of China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002582123","display_name":"Pingting Yang","orcid":"https://orcid.org/0000-0002-2800-7947","observed_orcids":["https://orcid.org/0000-0002-2800-7947"]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Pingting Yang","raw_affiliation_strings":["Department of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, 110001, People's Republic of China. yangpingtingting@163.com","Department of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, 110001, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-2800-7947","affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, 110001, People's Republic of China. yangpingtingting@163.com","institution_ids":["https://openalex.org/I4210140515","https://openalex.org/I91656880"]},{"raw_affiliation_string":"Department of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, 110001, People's Republic of China","institution_ids":["https://openalex.org/I4210140515","https://openalex.org/I91656880"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002582123"],"corresponding_institution_ids":["https://openalex.org/I4210140515","https://openalex.org/I91656880"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":1.8587,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.84022513,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"17","issue":"1","first_page":"426","last_page":"426"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9819999933242798},{"id":"https://openalex.org/keywords/neuropsychiatric-systemic-lupus-erythematosus","display_name":"neuropsychiatric lupus","score":0.8920000195503235},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/serum-igg","display_name":"serum IgG","score":0.7699999809265137},{"id":"https://openalex.org/keywords/fc-region","display_name":"Fc fragment","score":0.699999988079071},{"id":"https://openalex.org/keywords/fc-gamma-receptor","display_name":"Fc gamma receptor","score":0.6669999957084656},{"id":"https://openalex.org/keywords/b-cell-activating-factor","display_name":"B-cell activating factor","score":0.9700000286102295},{"id":"https://openalex.org/keywords/m1-microglia-polarization","display_name":"M1 microglia polarization","score":0.6869999766349792},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7829999923706055},{"id":"https://openalex.org/keywords/intraventricular-injection","display_name":"intraventricular injection","score":0.8140000104904175},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.7080000042915344},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6012572646141052},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.5734439492225647},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.5578914284706116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42904341220855713},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.41047725081443787},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.37973055243492126},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3714260458946228},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32379382848739624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29165858030319214},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.16096413135528564},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12452882528305054},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.08258509635925293}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D053264","descriptor_name":"B-Cell Activating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12967-019-02175-0","doi":"https://doi.org/10.1186/s12967-019-02175-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-019-02175-0","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-019-02175-0","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},{"id":"pmid:31864410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31864410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6925475","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6925475/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Transl Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a7bcd20b23634e97be2ce91cee780ca9","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a7bcd20b23634e97be2ce91cee780ca9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-15 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12967-019-02175-0","doi":"https://doi.org/10.1186/s12967-019-02175-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-019-02175-0","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-019-02175-0","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9891999959945679,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3228422671","display_name":null,"funder_award_id":"31671080","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G358368508","display_name":null,"funder_award_id":"2017225024","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3867600133","display_name":null,"funder_award_id":"2017001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3912983511","display_name":"\u5927\u8111\u542c\u76ae\u5c42\u5916\u4e2d\u67a2\u5728\u542c\u89c9\u6ce8\u610f\u72b6\u6001\u8c03\u63a7\u4e2d\u7684\u4f5c\u7528\u673a\u5236","funder_award_id":"31471057","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6842695345","display_name":null,"funder_award_id":"81271324","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327613","display_name":"Distinguished Professor of Liaoning Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2996511552.pdf","grobid_xml":"https://content.openalex.org/works/W2996511552.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W3979524","https://openalex.org/W756826172","https://openalex.org/W1484884286","https://openalex.org/W1526859003","https://openalex.org/W1581933655","https://openalex.org/W1605213317","https://openalex.org/W1625166229","https://openalex.org/W1641259203","https://openalex.org/W1830916283","https://openalex.org/W1919971299","https://openalex.org/W1935116877","https://openalex.org/W1964180982","https://openalex.org/W1964927867","https://openalex.org/W1973401711","https://openalex.org/W1973838846","https://openalex.org/W1974626393","https://openalex.org/W1975434091","https://openalex.org/W1976929282","https://openalex.org/W1978631987","https://openalex.org/W1989206786","https://openalex.org/W1989279522","https://openalex.org/W1993518357","https://openalex.org/W1999494818","https://openalex.org/W2000055469","https://openalex.org/W2000752313","https://openalex.org/W2001897468","https://openalex.org/W2001953810","https://openalex.org/W2006962652","https://openalex.org/W2007658177","https://openalex.org/W2011361113","https://openalex.org/W2014144616","https://openalex.org/W2014956545","https://openalex.org/W2017941203","https://openalex.org/W2022894037","https://openalex.org/W2028764793","https://openalex.org/W2034387476","https://openalex.org/W2043316586","https://openalex.org/W2061454749","https://openalex.org/W2066449499","https://openalex.org/W2070527591","https://openalex.org/W2071079524","https://openalex.org/W2075901113","https://openalex.org/W2079230263","https://openalex.org/W2080853135","https://openalex.org/W2082087950","https://openalex.org/W2086363047","https://openalex.org/W2088301466","https://openalex.org/W2088568397","https://openalex.org/W2088730075","https://openalex.org/W2093455511","https://openalex.org/W2093611886","https://openalex.org/W2094660330","https://openalex.org/W2103591034","https://openalex.org/W2116724928","https://openalex.org/W2122828560","https://openalex.org/W2124290467","https://openalex.org/W2125556789","https://openalex.org/W2137175445","https://openalex.org/W2146784784","https://openalex.org/W2147180300","https://openalex.org/W2155173051","https://openalex.org/W2170959966","https://openalex.org/W2336534940","https://openalex.org/W2342029969","https://openalex.org/W2395046960","https://openalex.org/W2586609554","https://openalex.org/W2607741101","https://openalex.org/W2621426836","https://openalex.org/W2737179331","https://openalex.org/W2773966647","https://openalex.org/W2791614554","https://openalex.org/W2809952590","https://openalex.org/W2898047747","https://openalex.org/W3148079033","https://openalex.org/W4323254039"],"related_works":["https://openalex.org/W2949902370","https://openalex.org/W2737179331","https://openalex.org/W4392922244","https://openalex.org/W4295426382","https://openalex.org/W2997996390","https://openalex.org/W2611894985","https://openalex.org/W2755913682","https://openalex.org/W1539983644","https://openalex.org/W4225414411","https://openalex.org/W4313386220"],"abstract_inverted_index":{"BACKGROUND:":[0],"Neuropsychiatric":[1],"manifestations":[2],"are":[3,34],"frequent":[4],"in":[5,20,57,66,76,91,165,265],"patients":[6,71,266],"with":[7,267],"systemic":[8],"lupus":[9,166,226,269],"erythematosus":[10],"(SLE),":[11],"yet":[12],"the":[13,25,40,67,73,81,99,147,204,211,236,241,251],"etiology":[14],"and":[15,30,80,98,113,124,139,181,201,240,255],"pathogenesis":[16],"of":[17,27,32,38,43,52,69,89,101,150,158,172,206,213,232,250,257],"brain":[18,49,173],"damage":[19],"SLE":[21,70],"remains":[22],"unclear.":[23],"Because":[24],"production":[26,100],"autoantibodies,":[28],"formation":[29],"deposition":[31],"immunocomplexes":[33],"major":[35],"serological":[36],"characteristics":[37],"SLE,":[39],"elevated":[41],"level":[42],"serum":[44,68,227],"immunoglobulin":[45,63],"may":[46,260],"contribute":[47],"to":[48,95,127,145,193,219],"tissue":[50],"injury":[51],"SLE.":[53],"To":[54],"testify":[55],"this,":[56],"this":[58,184],"study,":[59],"we":[60,188],"examined":[61],"whether":[62],"G":[64],"(IgG)":[65],"affects":[72],"cellular":[74],"functions":[75],"central":[77],"nervous":[78],"system":[79],"potential":[82],"mechanism.":[83],"METHODS:":[84],"In":[85,186],"vivo":[86],"intracerebral":[87],"injection":[88,177],"SLE-serum":[90],"mouse":[92],"was":[93,104,109,119],"used":[94,144],"activate":[96],"microglia":[97,174,194,233,258],"pro-inflammatory":[102],"cytokine":[103],"assessed":[105],"by":[106,234,246],"ELISA.":[107],"Sera":[108],"divided":[110,121],"into":[111,122,178],"IgG":[112,114,118,156,164,191,217,228],"depleted":[115],"fractions,":[116],"while":[117],"further":[120],"Fc":[123,196,207,237],"Fab":[125,199],"fragments":[126],"examine":[128],"which":[129],"part":[130],"has":[131],"an":[132],"effect":[133,149],"on":[134,155,210],"microglia.":[135,159,220],"Flow":[136],"cytometry,":[137],"immunofluorescence":[138],"quantitative":[140],"PCR":[141],"(qPCR)":[142],"were":[143],"verify":[146],"synergistic":[148],"B-cell":[151],"activating":[152],"factor":[153],"(BAFF)":[154],"stimulation":[157],"RESULTS:":[160],"We":[161],"found":[162],"that":[163,190,225],"sera":[167],"can":[168],"induce":[169],"M1":[170],"activation":[171,259],"following":[175],"intraventricular":[176],"normal":[179],"mice,":[180],"BAFF":[182,202],"facilitates":[183],"process.":[185],"vitro,":[187],"identified":[189],"bound":[192],"through":[195],"rather":[197],"than":[198],"fragments,":[200],"up-regulated":[203,245],"expression":[205],"receptors":[208],"(Fc\u03b3R)":[209],"surface":[212],"microglia,":[214],"consequently,":[215],"promote":[216],"binding":[218],"CONCLUSION:":[221],"Our":[222],"results":[223],"suggest":[224],"causes":[229],"inflammatory":[230],"responses":[231],"involving":[235],"signaling":[238,253],"pathway":[239,254],"activity":[242],"could":[243],"be":[244,261],"BAFF.":[247],"Accordingly,":[248],"disruption":[249],"Fc\u03b3R-mediated":[252],"blockade":[256],"a":[262],"therapeutic":[263],"target":[264],"neuropsychiatric":[268],"erythematosus.":[270]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-26T00:00:00"}
