{"id":"https://openalex.org/W2996484335","doi":"https://doi.org/10.29200/acsmedchemrev-v54.ch8","title":"Recent Advances in DHODH Inhibition for Acute Myeloid Leukemia","display_name":"Recent Advances in DHODH Inhibition for Acute Myeloid Leukemia","publication_year":2019,"publication_date":"2019-12-18","ids":{"openalex":"https://openalex.org/W2996484335","doi":"https://doi.org/10.29200/acsmedchemrev-v54.ch8","mag":"2996484335"},"language":"en","primary_location":{"id":"doi:10.29200/acsmedchemrev-v54.ch8","doi":"https://doi.org/10.29200/acsmedchemrev-v54.ch8","is_oa":false,"landing_page_url":"https://doi.org/10.29200/acsmedchemrev-v54.ch8","pdf_url":null,"source":{"id":"https://openalex.org/S4210190561","display_name":"Medicinal chemistry reviews","issn_l":"2575-9175","issn":["2575-9175","2575-9183"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Chemistry Reviews","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4255623006","display_name":"2019 Medicinal Chemistry Reviews"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011825573","display_name":"Scott D. Kuduk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott D. Kuduk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049193983","display_name":"Justin S. Cisar","orcid":"https://orcid.org/0000-0002-8693-9670","observed_orcids":["https://orcid.org/0000-0002-8693-9670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Justin S. Cisar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079301906","display_name":"E. Christine Pietsch","orcid":"https://orcid.org/0000-0003-4744-1666","observed_orcids":["https://orcid.org/0000-0003-4744-1666"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Christine Pietsch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5509,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.84431525,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"177","last_page":"194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.23680000007152557,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.031300000846385956,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dhodh-inhibition","display_name":"DHODH inhibition","score":0.8510000109672546},{"id":"https://openalex.org/keywords/dihydroorotate-dehydrogenase","display_name":"dihydroorotate dehydrogenase","score":0.9300000071525574},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.996999979019165},{"id":"https://openalex.org/keywords/antileukemic-agents","display_name":"antileukemic agents","score":0.6710000038146973},{"id":"https://openalex.org/keywords/pyrimidine-metabolism","display_name":"pyrimidine metabolism","score":0.47200000286102295},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7762891054153442},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4418879747390747},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41764140129089355}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.29200/acsmedchemrev-v54.ch8","doi":"https://doi.org/10.29200/acsmedchemrev-v54.ch8","is_oa":false,"landing_page_url":"https://doi.org/10.29200/acsmedchemrev-v54.ch8","pdf_url":null,"source":{"id":"https://openalex.org/S4210190561","display_name":"Medicinal chemistry reviews","issn_l":"2575-9175","issn":["2575-9175","2575-9183"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Chemistry Reviews","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2909782141","https://openalex.org/W2995094966","https://openalex.org/W2909071034","https://openalex.org/W2994872134","https://openalex.org/W4205632629","https://openalex.org/W2909997533","https://openalex.org/W2909033310","https://openalex.org/W2910326962","https://openalex.org/W2885627100","https://openalex.org/W2885494459"],"abstract_inverted_index":{"Medicinal":[0],"Chemistry":[1],"Reviews":[2],"is":[3,21],"an":[4],"outstanding":[5],"680":[6],"page":[7],"volume":[8],"providing":[9],"timely":[10],"and":[11,45],"critical":[12],"reviews":[13],"of":[14,24,42],"important":[15],"topics":[16],"in":[17,29],"medicinal":[18],"chemistry.":[19],"It":[20],"provided":[22],"free":[23],"charge":[25],"to":[26],"MEDI":[27],"members":[28],"electronic":[30],"format.":[31],"Members":[32],"can":[33],"also":[34],"order":[35],"a":[36],"print":[37],"copy,":[38],"for":[39],"the":[40],"cost":[41],"printing,":[43],"shipping":[44],"handling":[46]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-12-26T00:00:00"}