{"id":"https://openalex.org/W2996468037","doi":null,"title":"MiR-424 is over-expressed and attenuates ischemia-reperfusion kidney injury via p53 and death receptor 6 pathway.","display_name":"MiR-424 is over-expressed and attenuates ischemia-reperfusion kidney injury via p53 and death receptor 6 pathway.","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2996468037","mag":"2996468037","pmid":"https://pubmed.ncbi.nlm.nih.gov/31105811","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6511784"},"language":"en","primary_location":{"id":"pmid:31105811","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31105811","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6511784/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025858228","display_name":"Shunjie Chen","orcid":"https://orcid.org/0000-0002-3147-7501","observed_orcids":["https://orcid.org/0000-0002-3147-7501"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shunjie Chen","raw_affiliation_strings":["Department of Nephrology, Xinhua Hospital Affiliated to Medicine School of Shanghai Jiaotong University Shanghai 200092, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Xinhua Hospital Affiliated to Medicine School of Shanghai Jiaotong University Shanghai 200092, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389460","display_name":"Yao Yao","orcid":"https://orcid.org/0009-0006-3344-1947","observed_orcids":["https://orcid.org/0009-0006-3344-1947","https://orcid.org/0009-0007-2296-175X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Yao","raw_affiliation_strings":["Department of Nephrology, Xinhua Hospital Affiliated to Medicine School of Shanghai Jiaotong University Shanghai 200092, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Xinhua Hospital Affiliated to Medicine School of Shanghai Jiaotong University Shanghai 200092, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005377372","display_name":"Fujun Fiona Lin","orcid":"https://orcid.org/0000-0002-1887-545X","observed_orcids":["https://orcid.org/0000-0002-1887-545X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fujun Lin","raw_affiliation_strings":["Department of Nephrology, Xinhua Hospital Affiliated to Medicine School of Shanghai Jiaotong University Shanghai 200092, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Xinhua Hospital Affiliated to Medicine School of Shanghai Jiaotong University Shanghai 200092, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100966501","display_name":"Fan Bian","orcid":"https://orcid.org/0009-0000-8946-700X","observed_orcids":["https://orcid.org/0009-0000-8946-700X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Bian","raw_affiliation_strings":["Department of Nephrology, Xinhua Hospital Affiliated to Medicine School of Shanghai Jiaotong University Shanghai 200092, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Xinhua Hospital Affiliated to Medicine School of Shanghai Jiaotong University Shanghai 200092, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110364961","display_name":"Chun Zhu","orcid":"https://orcid.org/0000-0001-5026-3317","observed_orcids":["https://orcid.org/0000-0001-5026-3317"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun Zhu","raw_affiliation_strings":["Department of Nephrology, Xinhua Hospital (Chongming Branch) Affiliated to Medicine School of Shanghai Jiaotong University Shanghai 200092, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Xinhua Hospital (Chongming Branch) Affiliated to Medicine School of Shanghai Jiaotong University Shanghai 200092, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101606114","display_name":"Gengru Jiang","orcid":"https://orcid.org/0009-0006-0708-0252","observed_orcids":["https://orcid.org/0009-0006-0708-0252"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gengru Jiang","raw_affiliation_strings":["Department of Nephrology, Xinhua Hospital Affiliated to Medicine School of Shanghai Jiaotong University Shanghai 200092, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Xinhua Hospital Affiliated to Medicine School of Shanghai Jiaotong University Shanghai 200092, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1546,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.76335802,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"11","issue":"4","first_page":"1965","last_page":"1979"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.15549999475479126,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-424","display_name":"miR-424","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8799999952316284},{"id":"https://openalex.org/keywords/kidney-injury","display_name":"kidney injury","score":0.8830000162124634},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9919999837875366},{"id":"https://openalex.org/keywords/death-receptor-6","display_name":"death receptor 6","score":0.9449999928474426},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7300000190734863},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C2780721119","wikidata":"https://www.wikidata.org/wiki/Q7312492","display_name":"Renal ischemia","level":4,"score":0.7078803777694702},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6773735284805298},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6622757911682129},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.6411024928092957},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.576634407043457},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5549095273017883},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5023839473724365},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.4604663550853729},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.45869702100753784},{"id":"https://openalex.org/C2778176769","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Blood urea nitrogen","level":3,"score":0.45730334520339966},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.44433778524398804},{"id":"https://openalex.org/C154113507","wikidata":"https://www.wikidata.org/wiki/Q411149","display_name":"Terminal deoxynucleotidyl transferase","level":4,"score":0.4369448721408844},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.43411195278167725},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3986380100250244},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3598613739013672},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3330842852592468},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24918502569198608},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24768537282943726},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23873022198677063},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08051267266273499},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0653565526008606},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:31105811","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31105811","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6511784","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6511784/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"mag:2996468037","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31105811","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6511784","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6511784/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1569934359","https://openalex.org/W1868015714","https://openalex.org/W1965518526","https://openalex.org/W1971799714","https://openalex.org/W1974836020","https://openalex.org/W1975437957","https://openalex.org/W1975862909","https://openalex.org/W1995766341","https://openalex.org/W2019316722","https://openalex.org/W2030946712","https://openalex.org/W2044993806","https://openalex.org/W2045855955","https://openalex.org/W2063541540","https://openalex.org/W2073625832","https://openalex.org/W2076340756","https://openalex.org/W2088161934","https://openalex.org/W2101539899","https://openalex.org/W2102027021","https://openalex.org/W2103950684","https://openalex.org/W2112959832","https://openalex.org/W2114317477","https://openalex.org/W2114412986","https://openalex.org/W2123245461","https://openalex.org/W2124489451","https://openalex.org/W2134226393","https://openalex.org/W2144266435","https://openalex.org/W2146954847","https://openalex.org/W2147375079","https://openalex.org/W2154258399","https://openalex.org/W2155978870","https://openalex.org/W2161775276","https://openalex.org/W2162674813","https://openalex.org/W2163545533","https://openalex.org/W2470223656","https://openalex.org/W2739873258","https://openalex.org/W2793538997","https://openalex.org/W3011604768"],"related_works":["https://openalex.org/W2519391457","https://openalex.org/W2163545533","https://openalex.org/W3110543834","https://openalex.org/W3168740247","https://openalex.org/W2939518311","https://openalex.org/W3015251678","https://openalex.org/W2393981415","https://openalex.org/W4293764358","https://openalex.org/W3001939110","https://openalex.org/W4416910479"],"abstract_inverted_index":{"BACKGROUND:":[0],"Ischemic":[1],"reperfusion":[2],"injury":[3],"of":[4,29,78,92],"kidney":[5],"is":[6],"major":[7],"cause":[8],"for":[9,21,41,52,64,69],"renal":[10,32,53],"failure,":[11],"however":[12],"the":[13,76],"involved":[14],"pathogenesis":[15],"remains":[16],"unclear":[17],"creating":[18],"an":[19],"void":[20],"its":[22],"effective":[23],"treatment.":[24],"Here":[25],"we":[26],"studied":[27],"involvement":[28],"microRNA-424":[30],"in":[31],"injury.":[33,115],"METHODS:":[34],"studies.":[35],"Hoechst":[36],"33342":[37],"analysis":[38],"was":[39,50,67,96],"done":[40,51,68,97],"apoptosis.":[42,65],"Blood":[43],"urea":[44],"nitrogen":[45],"(BUN)":[46],"and":[47,58,71,83],"serum":[48],"creatinine":[49],"function,":[54],"Hematoxylin-eosin":[55],"tissue":[56],"damage":[57],"Terminal":[59],"transferase-dUTP":[60],"nick-end":[61],"labeling":[62],"assay":[63,73],"RT-PCR":[66],"miRNA":[70],"ChIP":[72],"to":[74,80,89],"identify":[75],"binding":[77],"p53":[79],"miR-424.":[81,93],"TargetScan":[82],"miRanda":[84],"data":[85],"base":[86],"were":[87],"scanned":[88],"find":[90],"targets":[91],"Protein":[94],"expression":[95],"by":[98],"western":[99],"blot":[100],"analysis.":[101],"RESULTS:":[102],".":[103],"CONCLUSION:":[104],"The":[105],"study":[106],"confirmed":[107],"p53/miR-424/DR6":[108],"as":[109],"a":[110],"protective":[111],"cascade":[112],"during":[113],"ischemic-reperfusion":[114]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-26T00:00:00"}