{"id":"https://openalex.org/W2996274635","doi":"https://doi.org/10.3389/fimmu.2019.02975","title":"Labile Heme Aggravates Renal Inflammation and Complement Activation After Ischemia Reperfusion Injury","display_name":"Labile Heme Aggravates Renal Inflammation and Complement Activation After Ischemia Reperfusion Injury","publication_year":2019,"publication_date":"2019-12-20","ids":{"openalex":"https://openalex.org/W2996274635","doi":"https://doi.org/10.3389/fimmu.2019.02975","mag":"2996274635","pmid":"https://pubmed.ncbi.nlm.nih.gov/31921212"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2019.02975","doi":"https://doi.org/10.3389/fimmu.2019.02975","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.02975","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.02975/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.02975/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100336237","display_name":"Li Wang","orcid":"https://orcid.org/0000-0003-3881-3149","observed_orcids":["https://orcid.org/0000-0003-3881-3149"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Li Wang","raw_affiliation_strings":["Department of Nephrology, Hannover Medical School, Hanover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hannover Medical School, Hanover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061863999","display_name":"Vijith Vijayan","orcid":"https://orcid.org/0009-0008-1435-069X","observed_orcids":["https://orcid.org/0009-0008-1435-069X"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vijith Vijayan","raw_affiliation_strings":["Institute for Transfusion Medicine, Hannover Medical School, Hanover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Transfusion Medicine, Hannover Medical School, Hanover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016769431","display_name":"Mi-Sun Jang","orcid":"https://orcid.org/0009-0008-3145-3420","observed_orcids":["https://orcid.org/0009-0008-3145-3420"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mi-Sun Jang","raw_affiliation_strings":["Department of Nephrology, Hannover Medical School, Hanover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hannover Medical School, Hanover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025069419","display_name":"Anja Thorenz","orcid":"https://orcid.org/0000-0001-8149-0045","observed_orcids":["https://orcid.org/0000-0001-8149-0045"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anja Thorenz","raw_affiliation_strings":["Department of Nephrology, Hannover Medical School, Hanover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hannover Medical School, Hanover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079966075","display_name":"Robert Greite","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert Greite","raw_affiliation_strings":["Department of Nephrology, Hannover Medical School, Hanover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hannover Medical School, Hanover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066875692","display_name":"Song Rong","orcid":"https://orcid.org/0000-0001-9985-1515","observed_orcids":["https://orcid.org/0000-0001-9985-1515"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Song Rong","raw_affiliation_strings":["Department of Nephrology, Hannover Medical School, Hanover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hannover Medical School, Hanover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081380558","display_name":"Rongjun Chen","orcid":"https://orcid.org/0000-0002-8133-5472","observed_orcids":["https://orcid.org/0000-0002-8133-5472"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rongjun Chen","raw_affiliation_strings":["Department of Nephrology, Hannover Medical School, Hanover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hannover Medical School, Hanover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042237095","display_name":"Nelli Shushakova","orcid":"https://orcid.org/0000-0003-3772-4136","observed_orcids":["https://orcid.org/0000-0003-3772-4136"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nelli Shushakova","raw_affiliation_strings":["Department of Nephrology, Hannover Medical School, Hanover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hannover Medical School, Hanover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079491654","display_name":"I. Tudorache","orcid":"https://orcid.org/0000-0002-7556-8229","observed_orcids":["https://orcid.org/0000-0002-7556-8229"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Igor Tudorache","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Hannover Medical School, Hanover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Hannover Medical School, Hanover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002298834","display_name":"Katja Derlin","orcid":"https://orcid.org/0000-0002-3195-4400","observed_orcids":["https://orcid.org/0000-0002-3195-4400"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katja Derlin","raw_affiliation_strings":["Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pooja Pradhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Pooja Pradhan","raw_affiliation_strings":["Institute for Transfusion Medicine, Hannover Medical School, Hanover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Transfusion Medicine, Hannover Medical School, Hanover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057482121","display_name":"Kukuh Madyaningrana","orcid":"https://orcid.org/0000-0003-1634-6949","observed_orcids":["https://orcid.org/0000-0003-1634-6949"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kukuh Madyaningrana","raw_affiliation_strings":["Institute for Transfusion Medicine, Hannover Medical School, Hanover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Transfusion Medicine, Hannover Medical School, Hanover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029557630","display_name":"N. Madrahimov","orcid":"https://orcid.org/0000-0001-8434-7324","observed_orcids":["https://orcid.org/0000-0001-8434-7324"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nodir Madrahimov","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Hannover Medical School, Hanover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Hannover Medical School, Hanover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079953015","display_name":"Jan Hinrich Br\u00e4sen","orcid":"https://orcid.org/0000-0002-2863-3067","observed_orcids":["https://orcid.org/0000-0002-2863-3067"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan Hinrich Br\u00e4sen","raw_affiliation_strings":["Department of Pathology, Hannover Medical School, Hanover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hannover Medical School, Hanover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021276076","display_name":"Ralf Lichtinghagen","orcid":"https://orcid.org/0000-0003-4659-9453","observed_orcids":["https://orcid.org/0000-0003-4659-9453"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf Lichtinghagen","raw_affiliation_strings":["Department of Laboratory Medicine, Hannover Medical School, Hanover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Hannover Medical School, Hanover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069641539","display_name":"Cees van Kooten","orcid":"https://orcid.org/0000-0002-6257-0899","observed_orcids":["https://orcid.org/0000-0002-6257-0899"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Cees van Kooten","raw_affiliation_strings":["Department of Nephrology, Leiden University Medical Centre, Leiden, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Leiden University Medical Centre, Leiden, Netherlands","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024003678","display_name":"Markus Stefan Huber-Lang","orcid":"https://orcid.org/0000-0003-2359-6516","observed_orcids":["https://orcid.org/0000-0003-2359-6516"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Huber-Lang","raw_affiliation_strings":["Institute of Clinical and Experimental Trauma-Immunology, University Hospital of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical and Experimental Trauma-Immunology, University Hospital of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110143117","display_name":"Hermann G. Haller","orcid":"https://orcid.org/0000-0002-8361-6446","observed_orcids":["https://orcid.org/0000-0002-8361-6446","https://orcid.org/0009-0000-5740-838X"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hermann Haller","raw_affiliation_strings":["Department of Nephrology, Hannover Medical School, Hanover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hannover Medical School, Hanover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068930382","display_name":"Stephan Immenschuh","orcid":"https://orcid.org/0000-0003-3722-5791","observed_orcids":["https://orcid.org/0000-0003-3722-5791"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephan Immenschuh","raw_affiliation_strings":["Institute for Transfusion Medicine, Hannover Medical School, Hanover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Transfusion Medicine, Hannover Medical School, Hanover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113787654","display_name":"Faikah Gueler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Faikah Gueler","raw_affiliation_strings":["Department of Nephrology, Hannover Medical School, Hanover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hannover Medical School, Hanover, Germany","institution_ids":["https://openalex.org/I34809795"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5113787654"],"corresponding_institution_ids":["https://openalex.org/I34809795"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.6462,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.84324159,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"10","issue":null,"first_page":"2975","last_page":"2975"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.5170999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.5170999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.17960000038146973,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.16130000352859497,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9340000152587891},{"id":"https://openalex.org/keywords/renal-inflammation","display_name":"renal inflammation","score":0.5139999985694885},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/c5a-receptor","display_name":"C5a receptor","score":0.9819999933242798},{"id":"https://openalex.org/keywords/warm-ischemia-time","display_name":"warm ischemia time","score":0.8299999833106995},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.6589999794960022},{"id":"https://openalex.org/keywords/lps","display_name":"LPS","score":0.5249999761581421},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6869999766349792},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9509999752044678},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.8270000219345093},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":0.8059999942779541},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6885021924972534},{"id":"https://openalex.org/C2780721119","wikidata":"https://www.wikidata.org/wiki/Q7312492","display_name":"Renal ischemia","level":4,"score":0.6780455112457275},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6719424724578857},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.6658234000205994},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6531022787094116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5685117244720459},{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.5289183855056763},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.51915043592453},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5111647248268127},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.45755091309547424},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3742891550064087},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3607558012008667},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33953478932380676},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32393479347229004},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28781360387802124},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15281754732131958},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07614108920097351}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D044087","descriptor_name":"Receptor, Anaphylatoxin C5a","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D044087","descriptor_name":"Receptor, Anaphylatoxin C5a","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D044087","descriptor_name":"Receptor, Anaphylatoxin C5a","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.3389/fimmu.2019.02975","doi":"https://doi.org/10.3389/fimmu.2019.02975","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.02975","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.02975/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:31921212","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31921212","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6933315","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6933315","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_2987851","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/122610","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, 10. FRONTIERS MEDIA SA","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:alma.31UKB_LEU:9940753055902711","doi":null,"is_oa":false,"landing_page_url":"https://scholarlypublications.universiteitleiden.nl/handle/1887/122610","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:3b0f66c1fa424dad859f1b2aa1b0c995","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3b0f66c1fa424dad859f1b2aa1b0c995","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 10 (2019)","raw_type":"article"},{"id":"pmh:oai:oparu.uni-ulm.de:123456789/39610","doi":null,"is_oa":true,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-39610-8","pdf_url":null,"source":{"id":"https://openalex.org/S4306400353","display_name":"OPen Access Repositorium der Universit\u00e4t Ulm (OPARU) (Ulm University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I196349391","host_organization_name":"Universit\u00e4t Ulm","host_organization_lineage":["https://openalex.org/I196349391"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doc-type:article"},{"id":"pmh:oai:openaccess.leidenuniv.nl:1887/122610","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/122610","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"10","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_2987851","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/122610","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology","raw_type":"Article / Letter to editor"},{"id":"doi:10.18725/oparu-39534","doi":"https://doi.org/10.18725/oparu-39534","is_oa":true,"landing_page_url":"https://doi.org/10.18725/oparu-39534","pdf_url":null,"source":{"id":"https://openalex.org/S7407052964","display_name":"Universit\u00e4t Ulm, Kommunikations- und Informationszentrum (kiz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Other"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2019.02975","doi":"https://doi.org/10.3389/fimmu.2019.02975","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.02975","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.02975/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1642386351","display_name":null,"funder_award_id":"GU613/1-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8628837409","display_name":null,"funder_award_id":"IM 20/4-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2996274635.pdf","grobid_xml":"https://content.openalex.org/works/W2996274635.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1839483610","https://openalex.org/W1847258812","https://openalex.org/W1937949410","https://openalex.org/W1971799714","https://openalex.org/W1972389070","https://openalex.org/W1984887661","https://openalex.org/W1996434091","https://openalex.org/W2006754144","https://openalex.org/W2007169151","https://openalex.org/W2012023814","https://openalex.org/W2018229946","https://openalex.org/W2025131562","https://openalex.org/W2026784781","https://openalex.org/W2029010155","https://openalex.org/W2035170959","https://openalex.org/W2037581234","https://openalex.org/W2056010015","https://openalex.org/W2057467676","https://openalex.org/W2062502161","https://openalex.org/W2090719292","https://openalex.org/W2101122309","https://openalex.org/W2106025920","https://openalex.org/W2132210870","https://openalex.org/W2138572847","https://openalex.org/W2155807513","https://openalex.org/W2166663693","https://openalex.org/W2174721344","https://openalex.org/W2219486185","https://openalex.org/W2331625369","https://openalex.org/W2570875062","https://openalex.org/W2597686836","https://openalex.org/W2604429438","https://openalex.org/W2649848430","https://openalex.org/W2662780534","https://openalex.org/W2745694840","https://openalex.org/W2750514629","https://openalex.org/W2775312572","https://openalex.org/W2789576122","https://openalex.org/W2809354111","https://openalex.org/W2809388136","https://openalex.org/W2898534034","https://openalex.org/W2903372787","https://openalex.org/W2915406286","https://openalex.org/W2942174565","https://openalex.org/W2967174867","https://openalex.org/W2971040102","https://openalex.org/W2973393767","https://openalex.org/W2975261360","https://openalex.org/W2999541385","https://openalex.org/W4239439764","https://openalex.org/W6640645186"],"related_works":["https://openalex.org/W1603801708","https://openalex.org/W2024696643","https://openalex.org/W2128120260","https://openalex.org/W4200044645","https://openalex.org/W2006864593","https://openalex.org/W2062493069","https://openalex.org/W1521258655","https://openalex.org/W2043583102","https://openalex.org/W2002217214","https://openalex.org/W2065101979"],"abstract_inverted_index":{"Background:":[0],"Ischemia":[1],"reperfusion":[2],"injury":[3,97,157],"(IRI)":[4],"plays":[5],"a":[6],"major":[7],"role":[8],"in":[9,27,42,75,101,129,169,198,243,266,294,312],"solid":[10],"organ":[11],"transplantion.":[12],"The":[13],"length":[14],"of":[15,24,39,50,141,162,188,233,254,269,273,283,291,322],"warm":[16,51,163,304],"ischemia":[17,52,95,164,226,249,305],"time":[18,87],"is":[19,45],"critical":[20],"for":[21,79],"the":[22,48,139,160,189,208,267,274,288,313],"extent":[23],"tissue":[25,44,96,156,171],"damage":[26],"renal":[28,43,70,111,170],"IRI.":[29,185,206,297],"In":[30,127,251],"this":[31],"experimental":[32,94],"study":[33],"we":[34],"hypothesized":[35],"that":[36,259,302],"local":[37,155],"release":[38,63,149,263],"labile":[40,98,285,309],"heme":[41,99,144,167,193,275,286,310],"triggered":[46],"by":[47,121],"duration":[49,161],"(15":[53,81,183],"versus":[54],"45":[55],"min":[56],"IRI)":[57],"and":[58,64,90,114,124,138,143,147,154,212,231,239,261,287,320],"mediates":[59],"complement":[60],"activation,":[61],"cytokine":[62,148],"inflammation.":[65],"Methods:":[66],"To":[67],"induce":[68],"IRI,":[69],"pedicle":[71],"clamping":[72],"was":[73,150,196],"performed":[74,146],"male":[76],"C57BL/6":[77],"mice":[78],"short":[80,182,205,225,248],"min)":[82,86,178,184],"or":[83],"prolonged":[84,176,303],"(45":[85,177],"periods.":[88],"Two":[89],"24":[91],"h":[92],"after":[93,175,200,204,221,247,296],"levels":[100,282,311],"kidney":[102],"were":[103,119,145,172,219,241,264],"determined":[104,120],"with":[105,136,159,256,317],"an":[106],"apo-horseradish":[107],"peroxidase":[108],"assay.":[109],"Moreover,":[110],"injury,":[112],"cytokines,":[113],"C5a":[115],"receptor":[116],"(C5aR)":[117],"expression":[118,187,290],"histology,":[122],"immunohistochemistry":[123],"qPCR,":[125],"respectively.":[126],"addition,":[128],"vitro":[130,252],"studies":[131],"stimulating":[132],"bone":[133],"marrow-derived":[134],"macrophages":[135,255],"LPS":[137,142,257],"combination":[140],"measured.":[151],"Results:":[152],"Inflammation":[153],"correlated":[158],"time.":[165],"Labile":[166],"concentrations":[168],"significantly":[173],"higher":[174],"as":[179,214,216,237],"compared":[180],"to":[181],"Notably,":[186],"inducible":[190],"heme-degrading":[191],"enzyme":[192],"oxygenase-1":[194],"(HO-1)":[195],"up-regulated":[197,220],"kidneys":[199,295],"prolonged,":[201,222,244],"but":[202,223,245],"not":[203,224,246],"C5aR,":[207],"pro-inflammatory":[209,292],"cytokines":[210,235,293],"IL-6":[211,262],"TNF\uf061":[213],"well":[215],"pERK":[217],"phospohorylation":[218],"times.":[227,250],"Consecutively,":[228],"neutrophil":[229],"infiltration":[230],"up-regulation":[232,321],"pro-fibrotic":[234],"such":[236],"CTGF":[238],"PAI":[240],"pronounced":[242],"stimulation":[253],"revealed":[258],"TNF":[260],"enhanced":[265],"presence":[268],"heme.":[270],"Finally,":[271],"administeration":[272],"scavenger":[276],"human":[277],"serum":[278],"albumin":[279],"(HSA)":[280],"reduced":[281],"circulating":[284],"subsequent":[289],"Conclusions:":[298],"Our":[299],"data":[300],"show":[301],"times":[306],"cause":[307],"increased":[308],"kidney,":[314],"which":[315],"correlate":[316],"IRI-dependent":[318],"inflammation":[319],"C5aR":[323],"expression.":[324]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9}],"updated_date":"2026-10-20T09:52:01.089006","created_date":"2025-10-10T00:00:00"}