{"id":"https://openalex.org/W2996018990","doi":"https://doi.org/10.1016/j.chembiol.2019.11.012","title":"Clofarabine Commandeers the RNR-\u03b1-ZRANB3 Nuclear Signaling Axis","display_name":"Clofarabine Commandeers the RNR-\u03b1-ZRANB3 Nuclear Signaling Axis","publication_year":2019,"publication_date":"2019-12-10","ids":{"openalex":"https://openalex.org/W2996018990","doi":"https://doi.org/10.1016/j.chembiol.2019.11.012","mag":"2996018990","pmid":"https://pubmed.ncbi.nlm.nih.gov/31836351","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6980387"},"language":"en","primary_location":{"id":"doi:10.1016/j.chembiol.2019.11.012","doi":"https://doi.org/10.1016/j.chembiol.2019.11.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2019.11.012","pdf_url":"http://www.cell.com/article/S2451945619303940/pdf","source":{"id":"https://openalex.org/S4210231961","display_name":"Cell chemical biology","issn_l":"2451-9448","issn":["2451-9448","2451-9456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S2451945619303940/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060276866","display_name":"Marcus J. C. Long","orcid":"https://orcid.org/0000-0002-0343-9671","observed_orcids":["https://orcid.org/0000-0002-0343-9671"]},"institutions":[{"id":"https://openalex.org/I2799649839","display_name":"Bishop Burton College","ror":"https://ror.org/009w3qm52","country_code":"GB","type":"education","lineage":["https://openalex.org/I2799649839"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marcus J.C. Long","raw_affiliation_strings":["Bishop Burton, Beverley, East Riding of Yorkshire HU17 8QH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bishop Burton, Beverley, East Riding of Yorkshire HU17 8QH, UK","institution_ids":["https://openalex.org/I2799649839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012937873","display_name":"Yi Zhao","orcid":"https://orcid.org/0000-0002-6049-1943","observed_orcids":["https://orcid.org/0000-0002-6049-1943"]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Yi Zhao","raw_affiliation_strings":["Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne 1015, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne 1015, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012739930","display_name":"Yimon Aye","orcid":"https://orcid.org/0000-0002-1256-4159","observed_orcids":["https://orcid.org/0000-0002-1256-4159"]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Yimon Aye","raw_affiliation_strings":["Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne 1015, Switzerland. Electronic address: yimon.aye@epfl.ch","Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne 1015, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne 1015, Switzerland. Electronic address: yimon.aye@epfl.ch","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne 1015, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012739930"],"corresponding_institution_ids":["https://openalex.org/I5124864"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":0.4961,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.60043589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"27","issue":"1","first_page":"122","last_page":"133.e5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clofarabine","display_name":"clofarabine","score":0.996999979019165},{"id":"https://openalex.org/keywords/zranb3","display_name":"ZRANB3","score":0.9729999899864197},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.4970000088214874},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6439999938011169},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6759999990463257},{"id":"https://openalex.org/keywords/oncogene-addiction","display_name":"oncogene addiction","score":0.8949999809265137},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C4710235","wikidata":"https://www.wikidata.org/wiki/Q420089","display_name":"Ribonucleotide reductase","level":4,"score":0.794613242149353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4783318042755127},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.46688902378082275},{"id":"https://openalex.org/C2777198975","wikidata":"https://www.wikidata.org/wiki/Q5134875","display_name":"Clofarabine","level":4,"score":0.46496206521987915},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4639989733695984},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.42790350317955017},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3922402262687683},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37049761414527893},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34310442209243774},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3223220407962799},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25259536504745483},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.16142648458480835},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08325162529945374},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077866","descriptor_name":"Clofarabine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012264","descriptor_name":"Ribonucleotide Reductases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D012264","descriptor_name":"Ribonucleotide Reductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.chembiol.2019.11.012","doi":"https://doi.org/10.1016/j.chembiol.2019.11.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2019.11.012","pdf_url":"http://www.cell.com/article/S2451945619303940/pdf","source":{"id":"https://openalex.org/S4210231961","display_name":"Cell chemical biology","issn_l":"2451-9448","issn":["2451-9448","2451-9456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Chemical Biology","raw_type":"journal-article"},{"id":"doi:10.1101/830745","doi":"https://doi.org/10.1101/830745","is_oa":true,"landing_page_url":"https://doi.org/10.1101/830745","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/11/04/830745.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:31836351","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31836351","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:6716933","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6980387","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6980387","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6980387","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Chem Biol","raw_type":"Text"},{"id":"pmh:oai:infoscience.epfl.ch:275614","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/275614","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"WoS","raw_type":"research article"}],"best_oa_location":{"id":"doi:10.1016/j.chembiol.2019.11.012","doi":"https://doi.org/10.1016/j.chembiol.2019.11.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2019.11.012","pdf_url":"http://www.cell.com/article/S2451945619303940/pdf","source":{"id":"https://openalex.org/S4210231961","display_name":"Cell chemical biology","issn_l":"2451-9448","issn":["2451-9448","2451-9456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Chemical Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2634063932","display_name":null,"funder_award_id":"#18C200","funder_id":"https://openalex.org/F4320322884","funder_display_name":"Novartis Stiftung\u00a0f\u00fcr\u00a0Medizinisch-Biologische Forschung"},{"id":"https://openalex.org/G5823208939","display_name":"Deconstructing precision signaling crosstalk regulated by native reactive electrophiles","funder_award_id":"184729","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G6741531243","display_name":"Deconvoluting Redox Biology with Targeted Chemistry","funder_award_id":"DP2GM114850","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320320915","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320322884","display_name":"Novartis Stiftung\u00a0f\u00fcr\u00a0Medizinisch-Biologische Forschung","ror":"https://ror.org/02f9zrr09"},{"id":"https://openalex.org/F4320323874","display_name":"Universit\u00e4t Z\u00fcrich","ror":"https://ror.org/02crff812"},{"id":"https://openalex.org/F4320331353","display_name":"National Center of Competence in Research Chemical Biology","ror":"https://ror.org/033f9yy33"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2996018990.pdf"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W397991607","https://openalex.org/W1125983182","https://openalex.org/W1177844361","https://openalex.org/W1446668622","https://openalex.org/W1481603599","https://openalex.org/W1593962234","https://openalex.org/W1837444448","https://openalex.org/W1872188472","https://openalex.org/W1963779075","https://openalex.org/W1973109316","https://openalex.org/W1986462630","https://openalex.org/W1987086578","https://openalex.org/W1989238401","https://openalex.org/W1992496728","https://openalex.org/W2001359497","https://openalex.org/W2003721745","https://openalex.org/W2014430898","https://openalex.org/W2026981180","https://openalex.org/W2030873172","https://openalex.org/W2032839609","https://openalex.org/W2038921550","https://openalex.org/W2056870028","https://openalex.org/W2060010987","https://openalex.org/W2061594584","https://openalex.org/W2063930374","https://openalex.org/W2068832995","https://openalex.org/W2077813812","https://openalex.org/W2094189284","https://openalex.org/W2105199418","https://openalex.org/W2115235864","https://openalex.org/W2135741369","https://openalex.org/W2141824173","https://openalex.org/W2147458973","https://openalex.org/W2148343731","https://openalex.org/W2224915174","https://openalex.org/W2332896428","https://openalex.org/W2346835974","https://openalex.org/W2553908226","https://openalex.org/W2751450140","https://openalex.org/W2758908832","https://openalex.org/W2759812252","https://openalex.org/W2788528130","https://openalex.org/W2789942745","https://openalex.org/W2888439550","https://openalex.org/W2907343944","https://openalex.org/W3145257564","https://openalex.org/W4240629327","https://openalex.org/W4241142746","https://openalex.org/W4256321774","https://openalex.org/W6628842544","https://openalex.org/W6638561306"],"related_works":["https://openalex.org/W2758399483","https://openalex.org/W2888439550","https://openalex.org/W2346835974","https://openalex.org/W1764736516","https://openalex.org/W1593962234","https://openalex.org/W1989238401","https://openalex.org/W4389019336","https://openalex.org/W4389024703","https://openalex.org/W1997112174","https://openalex.org/W2211440948"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-26T00:00:00"}
