{"id":"https://openalex.org/W2996013185","doi":"https://doi.org/10.1186/s13073-019-0704-0","title":"Genomics of circadian rhythms in health and disease","display_name":"Genomics of circadian rhythms in health and disease","publication_year":2019,"publication_date":"2019-12-01","ids":{"openalex":"https://openalex.org/W2996013185","doi":"https://doi.org/10.1186/s13073-019-0704-0","mag":"2996013185","pmid":"https://pubmed.ncbi.nlm.nih.gov/31847894","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6916512"},"language":"en","primary_location":{"id":"doi:10.1186/s13073-019-0704-0","doi":"https://doi.org/10.1186/s13073-019-0704-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13073-019-0704-0","pdf_url":"https://genomemedicine.biomedcentral.com/track/pdf/10.1186/s13073-019-0704-0","source":{"id":"https://openalex.org/S149201819","display_name":"Genome Medicine","issn_l":"1756-994X","issn":["1756-994X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://genomemedicine.biomedcentral.com/track/pdf/10.1186/s13073-019-0704-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010386609","display_name":"Filipa Rijo\u2010Ferreira","orcid":"https://orcid.org/0000-0002-4003-020X","observed_orcids":["https://orcid.org/0000-0002-4003-020X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Filipa Rijo-Ferreira","raw_affiliation_strings":["Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390-9111, USA","Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390-9111, USA"],"raw_orcid":"https://orcid.org/0000-0002-4003-020X","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390-9111, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390-9111, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076767575","display_name":"Joseph S. Takahashi","orcid":"https://orcid.org/0000-0003-0384-8878","observed_orcids":["https://orcid.org/0000-0003-0384-8878"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph S. Takahashi","raw_affiliation_strings":["Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390-9111, USA. joseph.takahashi@utsouthwestern.edu","Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390-9111, USA. joseph.takahashi@utsouthwestern.edu","Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390-9111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390-9111, USA. joseph.takahashi@utsouthwestern.edu","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390-9111, USA. joseph.takahashi@utsouthwestern.edu","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390-9111, USA","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5076767575"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"],"apc_list":{"value":3680,"currency":"USD","value_usd":3680},"apc_paid":{"value":3680,"currency":"USD","value_usd":3680},"fwci":6.0778,"has_fulltext":true,"cited_by_count":536,"citation_normalized_percentile":{"value":0.98491379,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"11","issue":"1","first_page":"82","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-clock","display_name":"circadian clock","score":0.8859999775886536},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.9549999833106995},{"id":"https://openalex.org/keywords/sleep-regulation","display_name":"sleep regulation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/metabolic-regulation","display_name":"metabolic regulation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/circadian-gene-expression","display_name":"circadian gene expression","score":0.5910000205039978},{"id":"https://openalex.org/keywords/cardiovascular-system","display_name":"cardiovascular system","score":0.656000018119812},{"id":"https://openalex.org/keywords/nervous-system","display_name":"nervous system","score":0.9890000224113464},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":1.0},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9440000057220459},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8399999737739563},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.9049999713897705}],"concepts":[{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.8560695648193359},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.672020673751831},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6387320756912231},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6062348484992981},{"id":"https://openalex.org/C184738001","wikidata":"https://www.wikidata.org/wiki/Q14908739","display_name":"CLOCK","level":4,"score":0.5566561222076416},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45764678716659546},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.43384724855422974},{"id":"https://openalex.org/C130679736","wikidata":"https://www.wikidata.org/wiki/Q3454009","display_name":"Bacterial circadian rhythms","level":4,"score":0.42392444610595703},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.41107162833213806},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.343191921710968},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.332127183675766},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2888050675392151},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2613206207752228},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2282000184059143},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22693249583244324},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12352332472801208}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020178","descriptor_name":"Sleep Disorders, Circadian Rhythm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020178","descriptor_name":"Sleep Disorders, Circadian Rhythm","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/s13073-019-0704-0","doi":"https://doi.org/10.1186/s13073-019-0704-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13073-019-0704-0","pdf_url":"https://genomemedicine.biomedcentral.com/track/pdf/10.1186/s13073-019-0704-0","source":{"id":"https://openalex.org/S149201819","display_name":"Genome Medicine","issn_l":"1756-994X","issn":["1756-994X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5874704","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6916512","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6916512","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6916512","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Med","raw_type":"Text"},{"id":"pmid:31847894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31847894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:605c07609d3e4420a35facf941a568fa","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/605c07609d3e4420a35facf941a568fa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome Medicine, Vol 11, Iss 1, Pp 1-16 (2019)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt9pd084qm","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/9pd084qm","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome Medicine, vol 11, iss 1","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13073-019-0704-0","doi":"https://doi.org/10.1186/s13073-019-0704-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13073-019-0704-0","pdf_url":"https://genomemedicine.biomedcentral.com/track/pdf/10.1186/s13073-019-0704-0","source":{"id":"https://openalex.org/S149201819","display_name":"Genome Medicine","issn_l":"1756-994X","issn":["1756-994X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2996013185.pdf","grobid_xml":"https://content.openalex.org/works/W2996013185.grobid-xml"},"referenced_works_count":193,"referenced_works":["https://openalex.org/W114098355","https://openalex.org/W1237751540","https://openalex.org/W1530925068","https://openalex.org/W1596600993","https://openalex.org/W1629086938","https://openalex.org/W1661083499","https://openalex.org/W1744822607","https://openalex.org/W1769711671","https://openalex.org/W1895114046","https://openalex.org/W1937904366","https://openalex.org/W1966782228","https://openalex.org/W1970130379","https://openalex.org/W1970252369","https://openalex.org/W1970657971","https://openalex.org/W1971883897","https://openalex.org/W1973788573","https://openalex.org/W1974495707","https://openalex.org/W1980682199","https://openalex.org/W1986608768","https://openalex.org/W1989505891","https://openalex.org/W1990192893","https://openalex.org/W1992494470","https://openalex.org/W1996003588","https://openalex.org/W1997151200","https://openalex.org/W1997364930","https://openalex.org/W1998736121","https://openalex.org/W2009077913","https://openalex.org/W2009132775","https://openalex.org/W2010928711","https://openalex.org/W2011072921","https://openalex.org/W2011104380","https://openalex.org/W2011282592","https://openalex.org/W2013333500","https://openalex.org/W2014699371","https://openalex.org/W2018257401","https://openalex.org/W2024493318","https://openalex.org/W2026058890","https://openalex.org/W2026520695","https://openalex.org/W2035809873","https://openalex.org/W2035853180","https://openalex.org/W2037938652","https://openalex.org/W2044458189","https://openalex.org/W2044925862","https://openalex.org/W2046577583","https://openalex.org/W2047902467","https://openalex.org/W2051145352","https://openalex.org/W2054513544","https://openalex.org/W2056265088","https://openalex.org/W2057573148","https://openalex.org/W2058237889","https://openalex.org/W2058887020","https://openalex.org/W2073036589","https://openalex.org/W2073742199","https://openalex.org/W2075175630","https://openalex.org/W2077676121","https://openalex.org/W2078689239","https://openalex.org/W2083279903","https://openalex.org/W2086473844","https://openalex.org/W2086508545","https://openalex.org/W2089749987","https://openalex.org/W2090816060","https://openalex.org/W2091531174","https://openalex.org/W2091947123","https://openalex.org/W2094874423","https://openalex.org/W2094914236","https://openalex.org/W2096186352","https://openalex.org/W2096352618","https://openalex.org/W2101600063","https://openalex.org/W2108988707","https://openalex.org/W2109053359","https://openalex.org/W2113297137","https://openalex.org/W2114904804","https://openalex.org/W2115505876","https://openalex.org/W2116756810","https://openalex.org/W2117296173","https://openalex.org/W2121075147","https://openalex.org/W2121847288","https://openalex.org/W2123319274","https://openalex.org/W2123345709","https://openalex.org/W2124325880","https://openalex.org/W2133918896","https://openalex.org/W2134047488","https://openalex.org/W2137252071","https://openalex.org/W2139030135","https://openalex.org/W2140233939","https://openalex.org/W2140464228","https://openalex.org/W2145018232","https://openalex.org/W2147712103","https://openalex.org/W2150076905","https://openalex.org/W2150729756","https://openalex.org/W2151131721","https://openalex.org/W2157959019","https://openalex.org/W2160091872","https://openalex.org/W2162155714","https://openalex.org/W2162650381","https://openalex.org/W2164628441","https://openalex.org/W2167008303","https://openalex.org/W2168054459","https://openalex.org/W2171666144","https://openalex.org/W2172131617","https://openalex.org/W2172259223","https://openalex.org/W2175535734","https://openalex.org/W2175842441","https://openalex.org/W2217406169","https://openalex.org/W2219586409","https://openalex.org/W2263654516","https://openalex.org/W2265211954","https://openalex.org/W2321428190","https://openalex.org/W2342036008","https://openalex.org/W2345018973","https://openalex.org/W2345988342","https://openalex.org/W2440558121","https://openalex.org/W2460041770","https://openalex.org/W2505703250","https://openalex.org/W2512293483","https://openalex.org/W2512516821","https://openalex.org/W2516332895","https://openalex.org/W2527783799","https://openalex.org/W2534086390","https://openalex.org/W2536252358","https://openalex.org/W2537243438","https://openalex.org/W2544822495","https://openalex.org/W2548868034","https://openalex.org/W2548982769","https://openalex.org/W2549026759","https://openalex.org/W2551231535","https://openalex.org/W2556811098","https://openalex.org/W2557605785","https://openalex.org/W2559454592","https://openalex.org/W2560455606","https://openalex.org/W2567503091","https://openalex.org/W2570545046","https://openalex.org/W2575888567","https://openalex.org/W2588832772","https://openalex.org/W2592834736","https://openalex.org/W2596815715","https://openalex.org/W2597131514","https://openalex.org/W2603862537","https://openalex.org/W2605106690","https://openalex.org/W2605589086","https://openalex.org/W2605817048","https://openalex.org/W2608486237","https://openalex.org/W2624131315","https://openalex.org/W2725775500","https://openalex.org/W2735309017","https://openalex.org/W2743588819","https://openalex.org/W2744641317","https://openalex.org/W2751705979","https://openalex.org/W2752189362","https://openalex.org/W2752290816","https://openalex.org/W2755705867","https://openalex.org/W2762315232","https://openalex.org/W2765564279","https://openalex.org/W2766113377","https://openalex.org/W2770966420","https://openalex.org/W2773188027","https://openalex.org/W2779295427","https://openalex.org/W2783204408","https://openalex.org/W2785367402","https://openalex.org/W2785446117","https://openalex.org/W2785556914","https://openalex.org/W2786541194","https://openalex.org/W2787429377","https://openalex.org/W2790594012","https://openalex.org/W2790693735","https://openalex.org/W2792021696","https://openalex.org/W2793873509","https://openalex.org/W2796457593","https://openalex.org/W2796559433","https://openalex.org/W2798049216","https://openalex.org/W2801956706","https://openalex.org/W2803065468","https://openalex.org/W2805504202","https://openalex.org/W2806482186","https://openalex.org/W2807291844","https://openalex.org/W2883902554","https://openalex.org/W2888547429","https://openalex.org/W2889400183","https://openalex.org/W2889589921","https://openalex.org/W2889913897","https://openalex.org/W2900678737","https://openalex.org/W2905460695","https://openalex.org/W2910780660","https://openalex.org/W2912003143","https://openalex.org/W2914232633","https://openalex.org/W2916163456","https://openalex.org/W2919765855","https://openalex.org/W2950851884","https://openalex.org/W2965281435","https://openalex.org/W2967786139","https://openalex.org/W2973222460","https://openalex.org/W2973783131","https://openalex.org/W2996257621"],"related_works":["https://openalex.org/W2068734034","https://openalex.org/W2216588240","https://openalex.org/W6920662329","https://openalex.org/W4409130399","https://openalex.org/W3023313902","https://openalex.org/W2935163555","https://openalex.org/W4400781454","https://openalex.org/W1976540475","https://openalex.org/W2027629479","https://openalex.org/W2000485277"],"abstract_inverted_index":{"Circadian":[0],"clocks":[1],"are":[2],"endogenous":[3],"oscillators":[4],"that":[5,66],"control":[6,17,89],"24-h":[7],"physiological":[8],"and":[9,30,79,85,131],"behavioral":[10],"processes.":[11],"The":[12],"central":[13],"circadian":[14,47,72,88,109],"clock":[15,107],"exerts":[16],"over":[18],"myriad":[19],"aspects":[20],"of":[21,27,43,54,90,105,119,127,134,138],"mammalian":[22],"physiology,":[23],"including":[24],"the":[25,31,40,46,52,71,77,106,116,125,135],"regulation":[26,42,104,118],"sleep,":[28],"metabolism,":[29],"immune":[32],"system.":[33],"Here,":[34],"we":[35],"review":[36,63],"advances":[37],"in":[38,75,94],"understanding":[39,133],"genetic":[41],"sleep":[44],"through":[45,108],"system,":[48],"as":[49,51],"well":[50],"impact":[53],"dysregulated":[55],"gene":[56],"expression":[57],"on":[58,96],"metabolic":[59],"function.":[60],"We":[61],"also":[62],"recent":[64,100],"studies":[65],"have":[67],"begun":[68],"to":[69],"unravel":[70],"clock's":[73],"role":[74],"controlling":[76],"cardiovascular":[78],"nervous":[80],"systems,":[81],"gut":[82],"microbiota,":[83],"cancer,":[84],"aging.":[86],"Such":[87],"these":[91],"systems":[92],"relies,":[93],"part,":[95],"transcriptional":[97],"regulation,":[98],"with":[99],"evidence":[101],"for":[102,124],"genome-wide":[103],"chromosome":[110],"organization.":[111],"These":[112],"novel":[113],"insights":[114],"into":[115],"genomic":[117],"human":[120,139],"physiology":[121],"provide":[122],"opportunities":[123],"discovery":[126],"improved":[128],"treatment":[129],"strategies":[130],"new":[132],"biological":[136],"underpinnings":[137],"disease.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":60},{"year":2025,"cited_by_count":98},{"year":2024,"cited_by_count":88},{"year":2023,"cited_by_count":87},{"year":2022,"cited_by_count":91},{"year":2021,"cited_by_count":72},{"year":2020,"cited_by_count":40}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-26T00:00:00"}