{"id":"https://openalex.org/W2995972002","doi":null,"title":"Engineering of Electrically Conductive Cardiac Microtissues to Study the Influence of Gold Nanomaterials on Maturation and Electrophysiology of Cardiomyocytes","display_name":"Engineering of Electrically Conductive Cardiac Microtissues to Study the Influence of Gold Nanomaterials on Maturation and Electrophysiology of Cardiomyocytes","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2995972002","mag":"2995972002"},"language":"en","primary_location":{"id":"mag:2995972002","doi":null,"is_oa":false,"landing_page_url":"https://repository.asu.edu/items/50568","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064487932","display_name":"Ali Navaei","orcid":"https://orcid.org/0000-0003-1394-6463","observed_orcids":["https://orcid.org/0000-0003-1394-6463"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ali Navaei","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1394-6463","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5064487932"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gold-nanomaterials","display_name":"gold nanomaterials","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cardiac-microtissues","display_name":"cardiac microtissues","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cardiomyocyte-maturation","display_name":"cardiomyocyte maturation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cardiac-electrophysiology","display_name":"cardiac electrophysiology","score":0.8159999847412109},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.5419999957084656},{"id":"https://openalex.org/keywords/electrical-conductivity","display_name":"electrical conductivity","score":0.6480000019073486},{"id":"https://openalex.org/keywords/stiffness","display_name":"stiffness","score":0.7979999780654907},{"id":"https://openalex.org/keywords/conduction-velocity","display_name":"conduction velocity","score":0.8109999895095825},{"id":"https://openalex.org/keywords/gap-junctions","display_name":"gap junctions","score":0.8230000138282776},{"id":"https://openalex.org/keywords/microelectrode-arrays","display_name":"microelectrode arrays","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cell-contractility","display_name":"cell contractility","score":0.4659999907016754},{"id":"https://openalex.org/keywords/cell-excitability","display_name":"cell excitability","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.6321960687637329},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.6085324883460999},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.5805202126502991},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5709877014160156},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5445449948310852},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.532128095626831},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.531118631362915},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5228407979011536},{"id":"https://openalex.org/C61381695","wikidata":"https://www.wikidata.org/wiki/Q3302130","display_name":"Cardiac electrophysiology","level":3,"score":0.45159339904785156},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.44342201948165894},{"id":"https://openalex.org/C3019225854","wikidata":"https://www.wikidata.org/wiki/Q12467174","display_name":"Bioresorbable scaffold","level":4,"score":0.4275061786174774},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.418001651763916},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.41733455657958984},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.37755075097084045},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37556198239326477},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3652753531932831},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3481181859970093},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30342796444892883},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20056962966918945},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.19419822096824646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16905447840690613},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2995972002","doi":null,"is_oa":false,"landing_page_url":"https://repository.asu.edu/items/50568","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W1640158278","https://openalex.org/W1747672433","https://openalex.org/W1795880986","https://openalex.org/W1895538147","https://openalex.org/W1902881336","https://openalex.org/W1927278085","https://openalex.org/W1963763179","https://openalex.org/W1970526294","https://openalex.org/W1975589931","https://openalex.org/W1976531505","https://openalex.org/W1979284685","https://openalex.org/W1979499474","https://openalex.org/W1980377446","https://openalex.org/W1983844422","https://openalex.org/W1984992880","https://openalex.org/W1985122890","https://openalex.org/W1987612095","https://openalex.org/W1988398938","https://openalex.org/W1993066321","https://openalex.org/W2003418830","https://openalex.org/W2003956633","https://openalex.org/W2020647534","https://openalex.org/W2020902818","https://openalex.org/W2022336190","https://openalex.org/W2025295644","https://openalex.org/W2026494961","https://openalex.org/W2028781040","https://openalex.org/W2030496781","https://openalex.org/W2035049260","https://openalex.org/W2036893362","https://openalex.org/W2040383667","https://openalex.org/W2040489007","https://openalex.org/W2040718395","https://openalex.org/W2044372732","https://openalex.org/W2044867649","https://openalex.org/W2045357781","https://openalex.org/W2047205784","https://openalex.org/W2048095806","https://openalex.org/W2049195497","https://openalex.org/W2052318709","https://openalex.org/W2054706358","https://openalex.org/W2054767080","https://openalex.org/W2054850711","https://openalex.org/W2055162584","https://openalex.org/W2058095177","https://openalex.org/W2058657378","https://openalex.org/W2059219385","https://openalex.org/W2062145052","https://openalex.org/W2062164427","https://openalex.org/W2063882755","https://openalex.org/W2067127980","https://openalex.org/W2068161752","https://openalex.org/W2072740783","https://openalex.org/W2086669266","https://openalex.org/W2087217642","https://openalex.org/W2092017945","https://openalex.org/W2092700187","https://openalex.org/W2092804233","https://openalex.org/W2096237299","https://openalex.org/W2097105593","https://openalex.org/W2099739903","https://openalex.org/W2099851825","https://openalex.org/W2100458582","https://openalex.org/W2101986300","https://openalex.org/W2104461846","https://openalex.org/W2105127081","https://openalex.org/W2107651034","https://openalex.org/W2109826944","https://openalex.org/W2110721989","https://openalex.org/W2111643738","https://openalex.org/W2115542448","https://openalex.org/W2116764640","https://openalex.org/W2118465348","https://openalex.org/W2118728657","https://openalex.org/W2122135474","https://openalex.org/W2123735793","https://openalex.org/W2126875247","https://openalex.org/W2129322399","https://openalex.org/W2134053621","https://openalex.org/W2139109539","https://openalex.org/W2142998520","https://openalex.org/W2145306368","https://openalex.org/W2145580343","https://openalex.org/W2146058202","https://openalex.org/W2146066235","https://openalex.org/W2146934459","https://openalex.org/W2150155765","https://openalex.org/W2150960406","https://openalex.org/W2153811598","https://openalex.org/W2158442971","https://openalex.org/W2159348812","https://openalex.org/W2160045751","https://openalex.org/W2162171758","https://openalex.org/W2164248456","https://openalex.org/W2165272690","https://openalex.org/W2166637527","https://openalex.org/W2168624052","https://openalex.org/W2168725031","https://openalex.org/W2169224177","https://openalex.org/W2171177609","https://openalex.org/W2192862456","https://openalex.org/W2200325631","https://openalex.org/W2229865560","https://openalex.org/W2261586944","https://openalex.org/W2265140894","https://openalex.org/W2267597338","https://openalex.org/W2286555076","https://openalex.org/W2321178842","https://openalex.org/W2326741627","https://openalex.org/W2342005364","https://openalex.org/W2401034867","https://openalex.org/W2462759503","https://openalex.org/W2520836111","https://openalex.org/W2554080493","https://openalex.org/W2567466572","https://openalex.org/W2587677537","https://openalex.org/W2594961640","https://openalex.org/W2747163193","https://openalex.org/W2754486160","https://openalex.org/W4293084779"],"related_works":["https://openalex.org/W3101652752","https://openalex.org/W3198722602","https://openalex.org/W2949609590","https://openalex.org/W4390904279","https://openalex.org/W3193741311","https://openalex.org/W3214740373","https://openalex.org/W2903291535","https://openalex.org/W4304959196","https://openalex.org/W3192485826","https://openalex.org/W1719748997"],"abstract_inverted_index":{"Myocardial":[0],"infarction":[1],"(MI)":[2],"remains":[3],"the":[4,11,27,64,70,119,123,149,167,182,188,192,208,226,246],"leading":[5],"cause\nof":[6],"mortality":[7],"and":[8,21,43,62,84,139,145,201,216,263,273],"morbidity":[9],"in":[10,236],"U.S.,":[12],"accounting":[13],"for":[14,54,90],"nearly\n140,000":[15],"deaths":[16],"per":[17],"year.":[18],"Heart":[19],"transplantation":[20],"implantation":[22],"of\nmechanical":[23],"assist":[24],"devices":[25],"are":[26,37,96],"options":[28],"of":[29,41,66,108,118,128,135,151,184,191,198,204,210,232,249,256,268],"last":[30],"resort":[31],"for\nintractable":[32],"heart":[33],"failure,":[34],"but":[35],"these":[36],"limited":[38],"by":[39],"lack":[40,107],"organ\ndonors":[42],"potential":[44,88],"surgical":[45],"complications.":[46],"In":[47,224],"this":[48,129,250],"regard,":[49],"there\nis":[50],"an":[51],"urgent":[52],"need":[53],"developing":[55],"new":[56],"effective":[57],"therapeutic\nstrategies":[58],"to":[59,132,147,165,207,253,264],"induce":[60],"regeneration":[61],"restore":[63],"loss\ncontractility":[65],"infarcted":[67],"myocardium.":[68],"Over":[69],"past":[71],"decades,\nregenerative":[72],"medicine":[73],"has":[74],"emerged":[75],"as":[76,87,112,114],"a":[77],"promising":[78],"strategy":[79],"to\ndevelop":[80],"scaffold-free":[81],"cell":[82,105],"therapies":[83],"scaffold-based":[85],"cardiac\npatches":[86],"approaches":[89,102],"MI":[91],"treatment.":[92],"Despite":[93],"the\nprogress,":[94],"there":[95],"still":[97],"critical":[98],"shortcomings":[99],"associated":[100],"with\nthese":[101],"regarding":[103],"low":[104],"retention,":[106],"global\ncardiomyocytes":[109],"(CMs)":[110],"synchronicity,":[111],"well":[113],"poor":[115],"maturation":[116,272],"and\nengraftment":[117],"transplanted":[120],"cells":[121],"within":[122],"native":[124],"myocardium.\nThe":[125],"overarching":[126],"objective":[127],"dissertation":[130],"was":[131,163,234],"develop":[133],"two\nclasses":[134],"nanoengineered":[136],"cardiac":[137,194,213,259],"patches":[138,260],"scaffold-free\nmicrotissues":[140],"with":[141],"superior":[142],"electrical,":[143],"structural,":[144],"biological\ncharacteristics":[146],"address":[148],"limitations":[150],"previously":[152],"developed\ntissue":[153],"models.":[154],"An":[155],"integrated":[156],"strategy,":[157],"based":[158],"on":[159,187,212,229,271],"micro-":[160],"and\nnanoscale":[161],"technologies,":[162],"utilized":[164],"fabricate":[166],"proposed\ntissue":[168],"models":[169],"using":[170,242],"functionalized":[171],"gold":[172],"nanomaterials":[173],"(GNMs).\nFurthermore,":[174],"comprehensive":[175],"mechanistic":[176],"studies":[177],"were":[178,218,252],"carried":[179],"out":[180],"to\nassess":[181],"influence":[183,227],"conductive":[185,258,269],"GNMs":[186,270],"electrophysiology\nand":[189],"maturity":[190],"engineered":[193,276],"tissues.":[195,277],"Specifically,":[196],"the\nrole":[197],"mechanical":[199],"stiffness":[200],"nano-scale":[202],"topographies":[203],"the\nscaffold,":[205],"due":[206],"incorporation":[209],"GNMs,":[211],"cells\nphenotype,":[214],"contractility,":[215],"excitability":[217],"dissected":[219],"from":[220],"the\nscaffold\u2019s":[221],"electrical":[222],"conductivity.":[223],"addition,":[225],"of\nGNMs":[228],"conduction":[230],"velocity":[231],"CMs":[233],"investigated":[235],"both":[237],"coupled\nand":[238],"uncoupled":[239],"gap":[240],"junctions":[241],"microelectrode":[243],"array":[244],"technology.\nOverall,":[245],"key":[247],"contributions":[248],"work":[251],"generate":[254],"new\nclasses":[255],"electrically":[257],"and\nscaffold-free":[261],"microtissues":[262],"mechanistically":[265],"investigate":[266],"the\ninfluence":[267],"electrophysiology":[274],"of\nthe":[275]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-26T00:00:00"}