{"id":"https://openalex.org/W2995944259","doi":"https://doi.org/10.1631/jzus.b1900551","title":"Carfilzomib inhibits the growth of lung adenocarcinoma via upregulation of Gadd45a expression","display_name":"Carfilzomib inhibits the growth of lung adenocarcinoma via upregulation of Gadd45a expression","publication_year":2019,"publication_date":"2019-12-21","ids":{"openalex":"https://openalex.org/W2995944259","doi":"https://doi.org/10.1631/jzus.b1900551","mag":"2995944259","pmid":"https://pubmed.ncbi.nlm.nih.gov/31898443","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6964995"},"language":"en","primary_location":{"id":"doi:10.1631/jzus.b1900551","doi":"https://doi.org/10.1631/jzus.b1900551","is_oa":false,"landing_page_url":"https://doi.org/10.1631/jzus.b1900551","pdf_url":null,"source":{"id":"https://openalex.org/S47715536","display_name":"Journal of Zhejiang University SCIENCE B","issn_l":"1673-1581","issn":["1673-1581","1862-1783"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Zhejiang University-SCIENCE B","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6964995","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101830158","display_name":"Fang Yang","orcid":"https://orcid.org/0000-0003-0688-5690","observed_orcids":["https://orcid.org/0000-0003-0688-5690"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fang Yang","raw_affiliation_strings":["Department of Pathology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"],"raw_orcid":"https://orcid.org/0000-0003-0688-5690","affiliations":[{"raw_affiliation_string":"Department of Pathology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wang-wang Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wang-wang Liu","raw_affiliation_strings":["Department of Pathology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hui Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Chen","raw_affiliation_strings":["Department of Pathology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100317538","display_name":"Jia Zhu","orcid":"https://orcid.org/0000-0003-3987-3557","observed_orcids":["https://orcid.org/0000-0003-3987-3557"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Zhu","raw_affiliation_strings":["Department of Pathology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087171794","display_name":"Aihua Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ai-hua Huang","raw_affiliation_strings":["Department of Pathology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008421599","display_name":"Fei Zhou","orcid":"https://orcid.org/0000-0002-5865-0052","observed_orcids":["https://orcid.org/0000-0002-5865-0052"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Zhou","raw_affiliation_strings":["Department of Radiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yi Gan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Gan","raw_affiliation_strings":["Department of Pathology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100671498","display_name":"Yanhua Zhang","orcid":"https://orcid.org/0000-0002-9105-8720","observed_orcids":["https://orcid.org/0000-0002-9105-8720"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-hua Zhang","raw_affiliation_strings":["Department of Pathology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":null,"display_name":"Li Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Ma","raw_affiliation_strings":["Department of Neurosurgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101830158"],"corresponding_institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"],"apc_list":{"value":4490,"currency":"USD","value_usd":4490},"apc_paid":null,"fwci":0.4099,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.56044201,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"1","first_page":"64","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carfilzomib","display_name":"carfilzomib","score":1.0},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9620000123977661},{"id":"https://openalex.org/keywords/gadd45a","display_name":"GADD45A","score":0.9419999718666077},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9380000233650208},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":1.0},{"id":"https://openalex.org/keywords/solid-tumor-therapy","display_name":"solid tumor therapy","score":0.8259999752044678},{"id":"https://openalex.org/keywords/drug-response-biomarkers","display_name":"drug response biomarkers","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C2780108899","wikidata":"https://www.wikidata.org/wiki/Q15366934","display_name":"Carfilzomib","level":4,"score":0.8014166355133057},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7257006764411926},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.721499502658844},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.6494010090827942},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6251674890518188},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5919070839881897},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.5906768441200256},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5718749165534973},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.45950692892074585},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4173037111759186},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3534478545188904},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3274439573287964},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27532950043678284},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26407432556152344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13284248113632202},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06103488802909851},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04895290732383728}],"mesh":[{"descriptor_ui":"D000071316","descriptor_name":"Forkhead Box Protein O3","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000097642","descriptor_name":"GADD45 Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1631/jzus.b1900551","doi":"https://doi.org/10.1631/jzus.b1900551","is_oa":false,"landing_page_url":"https://doi.org/10.1631/jzus.b1900551","pdf_url":null,"source":{"id":"https://openalex.org/S47715536","display_name":"Journal of Zhejiang University SCIENCE B","issn_l":"1673-1581","issn":["1673-1581","1862-1783"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Zhejiang University-SCIENCE B","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5927692","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6964995","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6964995","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6964995","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Zhejiang Univ Sci B","raw_type":"Text"},{"id":"pmid:31898443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31898443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Zhejiang University. Science. B","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5927692","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6964995","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3975757258","display_name":null,"funder_award_id":"81802986","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G558186559","display_name":null,"funder_award_id":"81601992","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8264097335","display_name":null,"funder_award_id":"LQ16H160008","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G904396359","display_name":null,"funder_award_id":"81601029","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W29530928","https://openalex.org/W1545043863","https://openalex.org/W1584173312","https://openalex.org/W1596182601","https://openalex.org/W1764910622","https://openalex.org/W1969795460","https://openalex.org/W1970218921","https://openalex.org/W1978300360","https://openalex.org/W2041771374","https://openalex.org/W2046623154","https://openalex.org/W2050841722","https://openalex.org/W2054298919","https://openalex.org/W2054838993","https://openalex.org/W2058078649","https://openalex.org/W2064474659","https://openalex.org/W2066013154","https://openalex.org/W2072489106","https://openalex.org/W2085871516","https://openalex.org/W2089311432","https://openalex.org/W2122557858","https://openalex.org/W2138024602","https://openalex.org/W2139141601","https://openalex.org/W2140074985","https://openalex.org/W2147166036","https://openalex.org/W2155953052","https://openalex.org/W2166761147","https://openalex.org/W2287368907","https://openalex.org/W2320481720","https://openalex.org/W2580091136","https://openalex.org/W2620680518","https://openalex.org/W2781525129","https://openalex.org/W2789897492","https://openalex.org/W2801501217","https://openalex.org/W2802775346","https://openalex.org/W2884819597","https://openalex.org/W2909401457","https://openalex.org/W2915478882","https://openalex.org/W2950765897"],"related_works":["https://openalex.org/W2140074985","https://openalex.org/W2317489111","https://openalex.org/W7151313803","https://openalex.org/W1733885106","https://openalex.org/W2558564545","https://openalex.org/W1995092890","https://openalex.org/W2005062144","https://openalex.org/W2021047252","https://openalex.org/W2197870853","https://openalex.org/W2012415856"],"abstract_inverted_index":{"Proteasome":[0],"inhibitors":[1,234],"have":[2,63],"shown":[3],"remarkable":[4],"success":[5],"in":[6,38,69,79,97,131,138,164,186,201,228,235],"the":[7,32,57,66,121,181,230],"treatment":[8],"of":[9,17,111,124,147,170,198,232],"hematologic":[10],"neoplasm.":[11],"There":[12],"has":[13,30,53,177],"been":[14,54],"a":[15,45,195,223],"lot":[16],"attention":[18],"to":[19,120,140],"applying":[20],"these":[21],"drugs":[22],"for":[23,213],"solid":[24,236],"tumor":[25,203,237],"treatment.":[26,154,191],"Recent":[27],"preclinical":[28],"study":[29],"signified":[31],"effectiveness":[33],"on":[34,208],"cell":[35,70,74,92,133],"proliferation":[36,71],"inhibition":[37],"lung":[39,80,98,112,214],"adenocarcinoma":[40,81,113],"treated":[41],"by":[42],"carfilzomib":[43],"(CFZ),":[44],"second":[46],"generation":[47],"proteasome":[48,199,233],"inhibitor.":[49],"However,":[50],"no":[51],"insight":[52],"gained":[55],"regarding":[56],"mechanism.":[58],"In":[59],"this":[60,171],"study,":[61],"we":[62],"systematically":[64],"investigated":[65],"CFZ":[67,88,107,153,190],"functions":[68],"and":[72,77,95,101,136,142,162,167,205],"growth,":[73],"cycle":[75,93,134],"arrest,":[76],"apoptosis":[78,96,137,163],"cells.":[82,114],"Flow":[83],"cytometry":[84],"experiments":[85],"showed":[86],"that":[87,106,180,218],"significantly":[89],"induced":[90],"G2/M":[91,160],"arrest":[94,135,161],"adenocarcinoma.":[99,215],"MTS":[100],"colony":[102],"formation":[103],"assays":[104],"revealed":[105],"substantially":[108],"inhibited":[109],"survival":[110],"All":[115],"results":[116],"were":[117],"consistently":[118],"correlated":[119],"upregulation":[122,146,188],"expression":[123,149,158,175,220],"Gadd45a,":[125],"which":[126],"is":[127,184],"an":[128],"important":[129],"gene":[130],"modulating":[132],"response":[139],"physiologic":[141],"environmental":[143],"stresses.":[144],"Here,":[145],"Gadd45a":[148,157,187,219],"was":[150],"observed":[151],"after":[152,189],"Knocking":[155],"down":[156],"suppressed":[159],"CFZ-treated":[165],"cells,":[166],"reduced":[168],"cytotoxicity":[169],"drug.":[172],"The":[173],"protein":[174],"analysis":[176],"further":[178],"identified":[179],"AKT/FOXO3a":[182],"pathway":[183],"involved":[185],"These":[192],"findings":[193],"unveil":[194],"novel":[196,209],"mechanism":[197],"inhibitor":[200],"anti-solid":[202],"activity,":[204],"shed":[206],"light":[207],"preferable":[210],"therapeutic":[211],"strategy":[212],"We":[216],"believe":[217],"can":[221],"be":[222],"highly":[224],"promising":[225],"candidate":[226],"predictor":[227],"evaluating":[229],"efficacy":[231],"therapy.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-26T00:00:00"}