{"id":"https://openalex.org/W2995850416","doi":"https://doi.org/10.2139/ssrn.3503677","title":"Targeting Glutamate Metabolism in Melanoma","display_name":"Targeting Glutamate Metabolism in Melanoma","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W2995850416","doi":"https://doi.org/10.2139/ssrn.3503677","mag":"2995850416"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.3503677","doi":"https://doi.org/10.2139/ssrn.3503677","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.3503677","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["arxiv","crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.3503677","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062036720","display_name":"Simar J. Singh","orcid":"https://orcid.org/0000-0001-5785-8292","observed_orcids":["https://orcid.org/0000-0001-5785-8292"]},"institutions":[{"id":"https://openalex.org/I133879957","display_name":"St. George's University","ror":"https://ror.org/01m1s6313","country_code":"GD","type":"education","lineage":["https://openalex.org/I133879957"]}],"countries":["GD"],"is_corresponding":false,"raw_author_name":"Simar Singh","raw_affiliation_strings":["St. George's University, School of Medicine, University Centre, Saint Georges, Grenada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. George's University, School of Medicine, University Centre, Saint Georges, Grenada","institution_ids":["https://openalex.org/I133879957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080635465","display_name":"Raj Shah","orcid":"https://orcid.org/0000-0002-0440-0189","observed_orcids":["https://orcid.org/0000-0002-0440-0189"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raj Shah","raw_affiliation_strings":["Rutgers, the State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers, the State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, United States","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079683086","display_name":"Suzie Chen","orcid":"https://orcid.org/0000-0002-6384-5081","observed_orcids":["https://orcid.org/0000-0002-6384-5081"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzie Chen","raw_affiliation_strings":["Rutgers, the State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers, the State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, United States","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047057665","display_name":"Fabian V. Filipp","orcid":"https://orcid.org/0000-0001-9889-5727","observed_orcids":["https://orcid.org/0000-0001-9889-5727"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4405263983","display_name":"Institute of Computational Biology","ror":"https://ror.org/00kg2yq63","country_code":"DE","type":"education","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672","https://openalex.org/I4405263983"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Fabian Filipp","raw_affiliation_strings":["Cancer Systems Biology, Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen","School of Life Sciences Weihenstephan, Technical University M\u00fcnchen"],"raw_orcid":"https://orcid.org/0000-0001-9889-5727","affiliations":[{"raw_affiliation_string":"Cancer Systems Biology, Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4405263983"]},{"raw_affiliation_string":"School of Life Sciences Weihenstephan, Technical University M\u00fcnchen","institution_ids":["https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5047057665"],"corresponding_institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4405263983","https://openalex.org/I62916508"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.7588000297546387,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.7588000297546387,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.10509999841451645,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8230000138282776},{"id":"https://openalex.org/keywords/metabotropic-glutamate-receptor-1","display_name":"metabotropic glutamate receptor 1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/glutamate-metabolism","display_name":"glutamate metabolism","score":0.9810000061988831},{"id":"https://openalex.org/keywords/plasma-glutamate","display_name":"plasma glutamate","score":0.6460000276565552},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.8769999742507935},{"id":"https://openalex.org/keywords/mitogenic-signaling","display_name":"mitogenic signaling","score":0.8050000071525574},{"id":"https://openalex.org/keywords/metabolic-bottlenecks","display_name":"metabolic bottlenecks","score":0.6690000295639038},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.785624623298645},{"id":"https://openalex.org/C207951395","wikidata":"https://www.wikidata.org/wiki/Q288431","display_name":"Metabotropic glutamate receptor 1","level":5,"score":0.6621524691581726},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5276150703430176},{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.4855799078941345},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4534086287021637},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.4383009970188141},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4375648498535156},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.41602930426597595},{"id":"https://openalex.org/C41653306","wikidata":"https://www.wikidata.org/wiki/Q6589190","display_name":"Metabotropic glutamate receptor 5","level":5,"score":0.4146081209182739},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.411136269569397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.399833619594574},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3354598879814148},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.20949462056159973},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.2139/ssrn.3503677","doi":"https://doi.org/10.2139/ssrn.3503677","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.3503677","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:arXiv.org:1912.07668","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/1912.07668","pdf_url":"https://arxiv.org/pdf/1912.07668","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"mag:2995850416","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/pdf/1912.07668.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"arXiv (Cornell University)","raw_type":null},{"id":"doi:10.48550/arxiv.1912.07668","doi":"https://doi.org/10.48550/arxiv.1912.07668","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.1912.07668","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.2139/ssrn.3503677","doi":"https://doi.org/10.2139/ssrn.3503677","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.3503677","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3339627588","display_name":null,"funder_award_id":"CA-154887","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4452169749","display_name":null,"funder_award_id":"101BX003742","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5478279944","display_name":null,"funder_award_id":"CRN-17-427258","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7162248359","display_name":null,"funder_award_id":"ES007148","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000093710","display_name":null,"funder_award_id":"CA154887","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000176225","display_name":null,"funder_award_id":"CRN-17-427258","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000886892","display_name":"Training in Environmental Toxicology","funder_award_id":"T32ES007148","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306784","display_name":"New Jersey Health Foundation","ror":"https://ror.org/040may582"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320310706","display_name":"Bundesverband der Deutschen Industrie","ror":"https://ror.org/00xb58j90"},{"id":"https://openalex.org/F4320315321","display_name":"Cancer Research Coordinating Committee","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1490297017","https://openalex.org/W1519706104","https://openalex.org/W1525523952","https://openalex.org/W1950829641","https://openalex.org/W1976603231","https://openalex.org/W1977032718","https://openalex.org/W1977128911","https://openalex.org/W1986862647","https://openalex.org/W1987709528","https://openalex.org/W1997074238","https://openalex.org/W2000285890","https://openalex.org/W2004824621","https://openalex.org/W2005290724","https://openalex.org/W2005325329","https://openalex.org/W2010252891","https://openalex.org/W2012698812","https://openalex.org/W2016558185","https://openalex.org/W2017117125","https://openalex.org/W2019845973","https://openalex.org/W2025854374","https://openalex.org/W2029009477","https://openalex.org/W2030090912","https://openalex.org/W2035731794","https://openalex.org/W2043166209","https://openalex.org/W2051181260","https://openalex.org/W2059948605","https://openalex.org/W2062073691","https://openalex.org/W2066715779","https://openalex.org/W2077007445","https://openalex.org/W2087118276","https://openalex.org/W2091864571","https://openalex.org/W2096688677","https://openalex.org/W2118850482","https://openalex.org/W2131601310","https://openalex.org/W2137587070","https://openalex.org/W2138017475","https://openalex.org/W2143836666","https://openalex.org/W2166354753","https://openalex.org/W2205214010","https://openalex.org/W2264568396","https://openalex.org/W2314689571","https://openalex.org/W2752266924","https://openalex.org/W2783405303","https://openalex.org/W2792287598","https://openalex.org/W2886345135","https://openalex.org/W2905010835","https://openalex.org/W2936038815","https://openalex.org/W2965863523","https://openalex.org/W2978968057","https://openalex.org/W3179996438"],"related_works":["https://openalex.org/W2936038815","https://openalex.org/W3082421226","https://openalex.org/W2066715779","https://openalex.org/W2955214013","https://openalex.org/W2887633929","https://openalex.org/W3086808029","https://openalex.org/W2741568580","https://openalex.org/W2061539579","https://openalex.org/W2003130870","https://openalex.org/W4408829594"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2019-12-26T00:00:00"}