{"id":"https://openalex.org/W2995823121","doi":null,"title":"Characterization of Neural Cells Derived from Reelin-deficient Schizophrenic Patient iPS Cells","display_name":"Characterization of Neural Cells Derived from Reelin-deficient Schizophrenic Patient iPS Cells","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2995823121","mag":"2995823121"},"language":"en","primary_location":{"id":"pmh:oai:stars.library.ucf.edu:etd-7196","doi":null,"is_oa":true,"landing_page_url":"https://stars.library.ucf.edu/etd/6196","pdf_url":null,"source":{"id":"https://openalex.org/S4210172555","display_name":"Journal of International Crisis and Risk Communication Research","issn_l":"2576-0017","issn":["2576-0017","2576-0025"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://stars.library.ucf.edu/etd/6196","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Nicole Roberts","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nicole Roberts","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15894988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.7050999999046326,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.7050999999046326,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.21960000693798065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reelin","display_name":"reelin","score":0.996999979019165},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/neural-progenitor-cells","display_name":"neural progenitor cells","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7630000114440918},{"id":"https://openalex.org/keywords/reeler-mice","display_name":"reeler mice","score":0.7049999833106995},{"id":"https://openalex.org/keywords/radial-glial-cells","display_name":"radial glia","score":0.8059999942779541},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.7940000295639038},{"id":"https://openalex.org/keywords/reelin-signaling","display_name":"Reelin signaling","score":0.5619999766349792},{"id":"https://openalex.org/keywords/disease-modeling","display_name":"disease modeling","score":0.7599999904632568},{"id":"https://openalex.org/keywords/ipsc-derived-neurons","display_name":"iPSC-derived neurons","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2778063154","wikidata":"https://www.wikidata.org/wiki/Q13561329","display_name":"Reelin","level":3,"score":0.9842886924743652},{"id":"https://openalex.org/C188209991","wikidata":"https://www.wikidata.org/wiki/Q14916487","display_name":"DAB1","level":4,"score":0.9416234493255615},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6253668069839478},{"id":"https://openalex.org/C2777734550","wikidata":"https://www.wikidata.org/wiki/Q657362","display_name":"Reeler","level":4,"score":0.6148697137832642},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.5888923406600952},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48565852642059326},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.466633141040802},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.4431355893611908},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.43938976526260376},{"id":"https://openalex.org/C39961270","wikidata":"https://www.wikidata.org/wiki/Q2927095","display_name":"Neuroblast","level":3,"score":0.43228572607040405},{"id":"https://openalex.org/C2776746469","wikidata":"https://www.wikidata.org/wiki/Q18033185","display_name":"NUMB","level":2,"score":0.43114277720451355},{"id":"https://openalex.org/C162746124","wikidata":"https://www.wikidata.org/wiki/Q7002675","display_name":"Neurosphere","level":5,"score":0.4213939309120178},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3649948239326477},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.35661643743515015},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.21163997054100037},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10105851292610168},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.07274192571640015},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:stars.library.ucf.edu:etd-7196","doi":null,"is_oa":true,"landing_page_url":"https://stars.library.ucf.edu/etd/6196","pdf_url":null,"source":{"id":"https://openalex.org/S4210172555","display_name":"Journal of International Crisis and Risk Communication Research","issn_l":"2576-0017","issn":["2576-0017","2576-0025"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"text"},{"id":"mag:2995823121","doi":null,"is_oa":false,"landing_page_url":"https://stars.library.ucf.edu/cgi/viewcontent.cgi?article=7196&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:stars.library.ucf.edu:etd-7196","doi":null,"is_oa":true,"landing_page_url":"https://stars.library.ucf.edu/etd/6196","pdf_url":null,"source":{"id":"https://openalex.org/S4210172555","display_name":"Journal of International Crisis and Risk Communication Research","issn_l":"2576-0017","issn":["2576-0017","2576-0025"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1699657349","https://openalex.org/W1965698498","https://openalex.org/W1966161684","https://openalex.org/W1966171594","https://openalex.org/W1967321689","https://openalex.org/W1967888910","https://openalex.org/W1969861119","https://openalex.org/W1979890518","https://openalex.org/W1983795337","https://openalex.org/W1984708369","https://openalex.org/W1985605753","https://openalex.org/W1987077147","https://openalex.org/W1987336175","https://openalex.org/W1988486070","https://openalex.org/W1988502754","https://openalex.org/W1989700831","https://openalex.org/W2004881650","https://openalex.org/W2010230693","https://openalex.org/W2020237866","https://openalex.org/W2022230955","https://openalex.org/W2022428482","https://openalex.org/W2023441280","https://openalex.org/W2029437594","https://openalex.org/W2030680267","https://openalex.org/W2040901919","https://openalex.org/W2040922107","https://openalex.org/W2046286642","https://openalex.org/W2060585121","https://openalex.org/W2063466196","https://openalex.org/W2064117608","https://openalex.org/W2070828333","https://openalex.org/W2072095670","https://openalex.org/W2076566237","https://openalex.org/W2079396188","https://openalex.org/W2080240579","https://openalex.org/W2080341840","https://openalex.org/W2088164357","https://openalex.org/W2089993812","https://openalex.org/W2095201178","https://openalex.org/W2104516442","https://openalex.org/W2106128518","https://openalex.org/W2109217809","https://openalex.org/W2110286211","https://openalex.org/W2110411315","https://openalex.org/W2110710419","https://openalex.org/W2117879536","https://openalex.org/W2125925423","https://openalex.org/W2131871863","https://openalex.org/W2141654359","https://openalex.org/W2143950388","https://openalex.org/W2145178659","https://openalex.org/W2146264275","https://openalex.org/W2149754823","https://openalex.org/W2152067570","https://openalex.org/W2154267367","https://openalex.org/W2156126807","https://openalex.org/W2156305088","https://openalex.org/W2177553103","https://openalex.org/W2305886101","https://openalex.org/W2460340697"],"related_works":["https://openalex.org/W2104516442","https://openalex.org/W2555179303","https://openalex.org/W2128437561","https://openalex.org/W2252751502","https://openalex.org/W2150682032","https://openalex.org/W2836465009","https://openalex.org/W2533360669","https://openalex.org/W3155545332","https://openalex.org/W3114348203","https://openalex.org/W7000848207"],"abstract_inverted_index":{"Reelin":[0,36,54,86,108,141,150,194,200],"is":[1,124,235],"a":[2,78,125,130],"large,":[3],"extracellular":[4,253],"glycoprotein":[5],"that":[6,53,135,243],"binds":[7],"to":[8,25,73,99,114,223,252,256],"several":[9],"membrane":[10],"receptors":[11],"on":[12,140,187],"neural":[13,17,267],"stem":[14,163,180],"cells":[15,19,207,268],"(HNSCs),":[16],"progenitor":[18],"(NPCs),":[20],"and":[21,46,153,167,176,221,250,277],"neuroblasts":[22],"of":[23,35,39,61,103,118,132,189,196,198,231,248,259,280],"mammals":[24],"direct":[26],"their":[27],"migration.":[28],"Previously,":[29],"our":[30,177,257],"lab":[31],"established":[32],"the":[33,59,101,104,157,211,229,236],"presence":[34],"increased":[37],"migration":[38,82,188],"wild-type":[40],"fetal-derived":[41],"HNSC's,":[42],"both":[43],"in":[44,47,67,120,160],"vitro":[45],"vivo.":[48,121],"In":[49],"addition,":[50],"we":[51,183],"demonstrated":[52],"protein":[55],"treatment":[56,195],"also":[57],"increases":[58],"formation":[60],"radial":[62],"glia":[63,70],"via":[64],"Notch-1":[65],"signaling,":[66],"vitro.":[68],"Radial":[69],"are":[71,97,112,246],"precursors":[72],"NPCs,":[74],"as":[75,77],"well":[76],"scaffold":[79],"for":[80,273],"neuroblast":[81],"during":[83],"cortical":[84],"lamination.":[85],"has":[87],"long":[88],"been":[89,241],"associated":[90],"with":[91,129,179,210],"Schizophrenia":[92],"(SZ).":[93],"Because":[94],"post-mortem":[95],"brains":[96],"limited":[98],"describing":[100],"end-point":[102],"disease,":[105],"heterozygous":[106],"haplodeficient":[107],"knock-out":[109],"(Reeler)":[110],"mice":[111],"used":[113,272],"model":[115],"developmental":[116],"aspects":[117],"SZ":[119,123,171,244],"However,":[122],"complex,":[126],"polyfactoral":[127],"disease":[128,275],"myriad":[131],"dysfunctional":[133],"pathways":[134],"may":[136],"have":[137,240],"unforeseen":[138],"effects":[139,186],"signaling.":[142],"K.":[143],"Brennand":[144],"et":[145],"al.":[146],"(2014)":[147],"reported":[148],"low":[149],"mRNA":[151],"expression":[152],"cellular":[154,232],"characteristics":[155],"mirroring":[156],"Reeler":[158],"mouse":[159],"induced":[161],"pluripotent":[162],"(iPS)":[164],"cell-derived":[165,192,266],"NPCs":[166],"neurons":[168],"from":[169,201],"living":[170],"patients.":[172],"Building":[173],"upon":[174],"this":[175,234,260],"work":[178,263],"cells,":[181],"here":[182],"consider":[184],"Reelin's":[185],"Reelin-deficient":[190,281],"iPS":[191,265],"NPCs.":[193],"consists":[197],"secreted":[199],"transfected":[202],"human":[203],"embryonic":[204],"kidney":[205],"293":[206],"(HEK":[208],"293)":[209],"pCRL":[212],"RELN":[213],"gene-containing":[214],"plasmid":[215],"created":[216],"by":[217,225],"G.":[218],"D'Arcangelo":[219],"(1997)":[220],"given":[222],"us":[224],"T.":[226],"Curran.":[227],"Using":[228],"metric":[230],"migration,":[233],"first":[237],"time":[238],"it":[239],"shown":[242],"iNPCs":[245],"capable":[247],"receiving":[249],"reacting":[251],"Reelin.":[254],"Due":[255],"validation":[258],"model,":[261],"further":[262],"using":[264],"can":[269],"confidently":[270],"be":[271],"future":[274],"modeling":[276],"drug":[278],"discovery":[279],"SZ.":[282]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2019-12-26T00:00:00"}
