{"id":"https://openalex.org/W2995817705","doi":"https://doi.org/10.1097/md.0000000000018347","title":"Prognostic significance and molecular mechanisms of adenosine triphosphate-binding cassette subfamily C members in gastric cancer","display_name":"Prognostic significance and molecular mechanisms of adenosine triphosphate-binding cassette subfamily C members in gastric cancer","publication_year":2019,"publication_date":"2019-12-01","ids":{"openalex":"https://openalex.org/W2995817705","doi":"https://doi.org/10.1097/md.0000000000018347","mag":"2995817705","pmid":"https://pubmed.ncbi.nlm.nih.gov/31852133","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6922578"},"language":"en","primary_location":{"id":"doi:10.1097/md.0000000000018347","doi":"https://doi.org/10.1097/md.0000000000018347","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000018347","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/md.0000000000018347","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002486177","display_name":"Xianshuang Mao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xianshuang Mao","raw_affiliation_strings":["Department of Hepatobiliary Gastrointestinal Surgery, The People's Hospital of Hezhou City, Hezhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Gastrointestinal Surgery, The People's Hospital of Hezhou City, Hezhou","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102019976","display_name":"Zhenhua He","orcid":"https://orcid.org/0000-0003-1417-0767","observed_orcids":["https://orcid.org/0000-0003-1417-0767"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhenhua He","raw_affiliation_strings":["Department of Hepatobiliary Gastrointestinal Surgery, The People's Hospital of Hezhou City, Hezhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Gastrointestinal Surgery, The People's Hospital of Hezhou City, Hezhou","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060489243","display_name":"Fengsheng Zhou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fengsheng Zhou","raw_affiliation_strings":["Department of Hepatobiliary Gastrointestinal Surgery, The People's Hospital of Hezhou City, Hezhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Gastrointestinal Surgery, The People's Hospital of Hezhou City, Hezhou","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000501089","display_name":"Yongchu Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yongchu Huang","raw_affiliation_strings":["Department of Hepatobiliary Gastrointestinal Surgery, The People's Hospital of Hezhou City, Hezhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Gastrointestinal Surgery, The People's Hospital of Hezhou City, Hezhou","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022434547","display_name":"Guangzhi Zhu","orcid":"https://orcid.org/0000-0001-5958-7289","observed_orcids":["https://orcid.org/0000-0001-5958-7289"]},"institutions":[{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guangzhi Zhu","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Province, China","institution_ids":["https://openalex.org/I4210126060"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5022434547"],"corresponding_institution_ids":["https://openalex.org/I4210126060"],"apc_list":{"value":1950,"currency":"USD","value_usd":1950},"apc_paid":{"value":1950,"currency":"USD","value_usd":1950},"fwci":1.6784,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.84883144,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"98","issue":"50","first_page":"e18347","last_page":"e18347"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.6499999761581421},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9620000123977661},{"id":"https://openalex.org/keywords/mrp1","display_name":"MRP1","score":0.8119999766349792},{"id":"https://openalex.org/keywords/abcc3","display_name":"ABCC3","score":0.9869999885559082},{"id":"https://openalex.org/keywords/abcc8","display_name":"ABCC8","score":0.9800000190734863},{"id":"https://openalex.org/keywords/abcc9","display_name":"ABCC9","score":0.9980000257492065},{"id":"https://openalex.org/keywords/abcc10","display_name":"ABCC10","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mrp2","display_name":"MRP2","score":0.8560000061988831},{"id":"https://openalex.org/keywords/abcc6","display_name":"ABCC6","score":0.8270000219345093},{"id":"https://openalex.org/keywords/abcc5","display_name":"ABCC5","score":0.8230000138282776},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.6800000071525574},{"id":"https://openalex.org/keywords/atpase-activity","display_name":"ATPase activity","score":0.671999990940094},{"id":"https://openalex.org/keywords/membrane-transport","display_name":"membrane transport","score":0.9279999732971191},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.4950000047683716},{"id":"https://openalex.org/keywords/lauren-classification","display_name":"Lauren classification","score":0.7630000114440918},{"id":"https://openalex.org/keywords/disease-stage","display_name":"disease stage","score":0.7229999899864197},{"id":"https://openalex.org/keywords/kaplan-meier-plotter","display_name":"Kaplan-Meier plotter","score":0.8569999933242798}],"concepts":[{"id":"https://openalex.org/C63443662","wikidata":"https://www.wikidata.org/wiki/Q18029287","display_name":"ABCC1","level":5,"score":0.736468493938446},{"id":"https://openalex.org/C36201501","wikidata":"https://www.wikidata.org/wiki/Q17907816","display_name":"Multidrug resistance-associated protein 2","level":5,"score":0.646077573299408},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6339541673660278},{"id":"https://openalex.org/C50929876","wikidata":"https://www.wikidata.org/wiki/Q164280","display_name":"Subfamily","level":3,"score":0.4896734058856964},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.4873429238796234},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46946775913238525},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34651216864585876},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3224526643753052},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3072303533554077},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28396767377853394},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18456202745437622},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.0916488766670227},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.060632556676864624}],"mesh":[{"descriptor_ui":"D000089762","descriptor_name":"Multidrug Resistance-Associated Protein 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/md.0000000000018347","doi":"https://doi.org/10.1097/md.0000000000018347","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000018347","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6922578","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6922578/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6922578/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine (Baltimore)","raw_type":"Text"},{"id":"pmid:31852133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31852133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/md.0000000000018347","doi":"https://doi.org/10.1097/md.0000000000018347","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000018347","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2995817705.pdf","grobid_xml":"https://content.openalex.org/works/W2995817705.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W234954058","https://openalex.org/W1504187995","https://openalex.org/W1721237546","https://openalex.org/W1745204207","https://openalex.org/W1754555893","https://openalex.org/W1935567550","https://openalex.org/W1975482089","https://openalex.org/W1975732216","https://openalex.org/W1977754424","https://openalex.org/W1985998919","https://openalex.org/W1990939093","https://openalex.org/W2000610587","https://openalex.org/W2004631441","https://openalex.org/W2005064657","https://openalex.org/W2005160619","https://openalex.org/W2016708274","https://openalex.org/W2039599894","https://openalex.org/W2040315766","https://openalex.org/W2043103956","https://openalex.org/W2046460191","https://openalex.org/W2049914201","https://openalex.org/W2050767064","https://openalex.org/W2053706150","https://openalex.org/W2058076233","https://openalex.org/W2058093850","https://openalex.org/W2077796674","https://openalex.org/W2080320008","https://openalex.org/W2080938154","https://openalex.org/W2081213990","https://openalex.org/W2081545862","https://openalex.org/W2090297795","https://openalex.org/W2092435069","https://openalex.org/W2094527054","https://openalex.org/W2100808729","https://openalex.org/W2104140688","https://openalex.org/W2119311749","https://openalex.org/W2127002937","https://openalex.org/W2133465414","https://openalex.org/W2144824336","https://openalex.org/W2158217645","https://openalex.org/W2159675211","https://openalex.org/W2162097287","https://openalex.org/W2166078169","https://openalex.org/W2166542841","https://openalex.org/W2171030481","https://openalex.org/W2337762305","https://openalex.org/W2463600666","https://openalex.org/W2517303366","https://openalex.org/W2737785069","https://openalex.org/W2799866416","https://openalex.org/W2885373656","https://openalex.org/W2889646458","https://openalex.org/W2900569176","https://openalex.org/W2915769855","https://openalex.org/W2922884849","https://openalex.org/W2952622820","https://openalex.org/W4211066405"],"related_works":["https://openalex.org/W4220953145","https://openalex.org/W4220802746","https://openalex.org/W3031576712","https://openalex.org/W3155970260","https://openalex.org/W4389495958","https://openalex.org/W4285744377","https://openalex.org/W4328051885","https://openalex.org/W2416354460","https://openalex.org/W2787942027","https://openalex.org/W4387892991"],"abstract_inverted_index":{"Gastric":[0],"cancer":[1],"(GC)":[2],"is":[3],"one":[4],"of":[5,10,21,46,61,65,117,181,198],"the":[6,43,81,101,149],"major":[7],"leading":[8],"causes":[9],"tumor-related":[11],"deaths":[12],"worldwide.":[13],"Adenosine":[14],"triphosphate-binding":[15],"cassette":[16],"subfamily":[17,48],"C":[18],"(ABCC)":[19],"consists":[20],"13":[22],"members,":[23],"ABCC1":[24],"to":[25,41],"13,":[26],"which":[27],"were":[28,54,78,162,173,211,219],"examined":[29,79],"for":[30,83,128,148,237],"their":[31],"associations":[32],"with":[33,165,176,193],"GC.The":[34],"online":[35],"Kaplan-Meier":[36],"Plotter":[37],"database":[38,82],"was":[39,190],"used":[40],"determine":[42],"prognostic":[44,98,146],"significance":[45,99,147],"ABCC":[47,119],"members":[49,121],"in":[50,100,105,213],"GC.":[51],"Stratified":[52,133],"analyses":[53,134],"performed":[55],"using":[56,80],"gender,":[57],"disease":[58,167],"stage,":[59],"degree":[60],"tumor":[62],"differentiation,":[63],"expression":[64,96,116,144],"human":[66],"epidermal":[67],"growth":[68],"factor":[69],"receptor":[70],"2":[71],"(HER2),":[72],"and":[73,86,94,104,107,142,156,160,171,188,230,243],"Lauren":[74,178],"classification.":[75],"Molecular":[76],"mechanisms":[77],"annotation,":[84],"visualization,":[85],"integrated":[87],"discovery":[88],"database.ABCC1,":[89],"ABCC3,":[90,138,183,226],"ABCC7,":[91,139,185,227],"ABCC8,":[92,140,186,228],"ABCC9,":[93,141,187,229],"ABCC10":[95,143,189,231],"showed":[97,145],"whole":[102,150],"population":[103],"male":[106,155],"female":[108,157],"subpopulations":[109],"(all":[110,201,222],"P":[111,202,223],"\u2264":[112,203,224],".05).":[113,132,204],"Furthermore,":[114],"high":[115],"most":[118],"family":[120],"always":[122],"suggested":[123],"a":[124],"poor":[125],"prognosis,":[126],"except":[127],"ABCC7":[129],"(P":[130],">":[131],"revealed":[135],"that":[136,208],"ABCC1,":[137,182],"population,":[151],"as":[152,154,240],"well":[153],"populations.":[158],"ABCC2":[159,170],"ABCC9":[161],"significantly":[163,174,191],"correlated":[164,175,192],"all":[166,177],"stages,":[168],"while":[169],"ABCC6":[172],"classifications.":[179],"Expression":[180],"ABCC5,":[184],"either":[194],"negative":[195],"or":[196,218],"positive":[197],"HER2":[199],"status":[200],"Enrichment":[205],"analysis":[206],"indicated":[207],"these":[209],"genes":[210],"involved":[212],"ATPase":[214,245],"activity,":[215],"transmembrane":[216],"transport,":[217],"ABC":[220,241],"transporters":[221,242],".05).ABCC1,":[225],"may":[232],"be":[233],"potential":[234],"prognosis":[235],"biomarkers":[236],"GC,":[238],"acting":[239],"via":[244],"activity.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2019-12-26T00:00:00"}