{"id":"https://openalex.org/W2995765451","doi":"https://doi.org/10.1126/science.aaz8941","title":"Genome studies must account for history\u2014Response","display_name":"Genome studies must account for history\u2014Response","publication_year":2019,"publication_date":"2019-12-20","ids":{"openalex":"https://openalex.org/W2995765451","doi":"https://doi.org/10.1126/science.aaz8941","mag":"2995765451","pmid":"https://pubmed.ncbi.nlm.nih.gov/31857477"},"language":"en","primary_location":{"id":"doi:10.1126/science.aaz8941","doi":"https://doi.org/10.1126/science.aaz8941","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.aaz8941","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"letter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.amsterdamumc.nl/ws/files/178268343/Genome-studies-must-account-for-history-response.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073500794","display_name":"Andrea Ganna","orcid":"https://orcid.org/0000-0002-8147-240X","observed_orcids":["https://orcid.org/0000-0002-8147-240X"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4392738323","display_name":"Stanley Center for Psychiatric Research","ror":"https://ror.org/01tm9b530","country_code":"US","type":"facility","lineage":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}],"countries":["SE","US"],"is_corresponding":true,"raw_author_name":"Andrea Ganna","raw_affiliation_strings":["Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA","Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA","Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078744084","display_name":"Karin J. H. Verweij","orcid":"https://orcid.org/0000-0001-9868-7821","observed_orcids":["https://orcid.org/0000-0001-9868-7821"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Karin J.H. Verweij","raw_affiliation_strings":["Department of Psychiatry, Amsterdam UMC, University of Amsterdam, 1105 AZ, Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Amsterdam UMC, University of Amsterdam, 1105 AZ, Amsterdam, Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008837404","display_name":"Michel Guillaume Nivard","orcid":"https://orcid.org/0000-0003-2015-1888","observed_orcids":["https://orcid.org/0000-0003-2015-1888"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michel G. Nivard","raw_affiliation_strings":["Department of Biological Psychology, VU University, 1081 BT, Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Psychology, VU University, 1081 BT, Amsterdam, Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert Maier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4392738323","display_name":"Stanley Center for Psychiatric Research","ror":"https://ror.org/01tm9b530","country_code":"US","type":"facility","lineage":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Maier","raw_affiliation_strings":["Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA","Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA","Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031813106","display_name":"Robbee Wedow","orcid":"https://orcid.org/0000-0002-3108-7087","observed_orcids":["https://orcid.org/0000-0002-3108-7087"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4392738323","display_name":"Stanley Center for Psychiatric Research","ror":"https://ror.org/01tm9b530","country_code":"US","type":"facility","lineage":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robbee Wedow","raw_affiliation_strings":["Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA","Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA","Department of Sociology, Harvard University, Cambridge, MA 02138, USA","Department of Sociology, University of Colorado, Boulder, CO 80309\u20130483, USA","Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Sociology, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Sociology, University of Colorado, Boulder, CO 80309\u20130483, USA","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059793960","display_name":"Alexander Siegfried Busch","orcid":"https://orcid.org/0000-0003-4417-569X","observed_orcids":["https://orcid.org/0000-0003-4417-569X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]},{"id":"https://openalex.org/I4210158597","display_name":"MRC Epidemiology Unit","ror":"https://ror.org/052578691","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210158597","https://openalex.org/I90344618"]}],"countries":["DK","GB"],"is_corresponding":false,"raw_author_name":"Alexander S. Busch","raw_affiliation_strings":["Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark","International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, Copenhagen, Denmark","MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]},{"raw_affiliation_string":"International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802709434"]},{"raw_affiliation_string":"MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210158597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016324375","display_name":"Abdel Abdellaoui","orcid":"https://orcid.org/0000-0003-1088-6784","observed_orcids":["https://orcid.org/0000-0003-1088-6784"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Abdel Abdellaoui","raw_affiliation_strings":["Department of Psychiatry, Amsterdam UMC, University of Amsterdam, 1105 AZ, Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Amsterdam UMC, University of Amsterdam, 1105 AZ, Amsterdam, Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016069407","display_name":"Shengru Guo","orcid":"https://orcid.org/0000-0003-4141-6267","observed_orcids":["https://orcid.org/0000-0003-4141-6267"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shengru Guo","raw_affiliation_strings":["Department of Human Genetics, University of Miami, Miami, FL 33136, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, University of Miami, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035306788","display_name":"J. Fah Sathirapongsasuti","orcid":"https://orcid.org/0000-0002-8157-3665","observed_orcids":["https://orcid.org/0000-0002-8157-3665"]},"institutions":[{"id":"https://openalex.org/I4210097491","display_name":"23andMe (United States)","ror":"https://ror.org/00q62jx03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097491"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Fah Sathirapongsasuti","raw_affiliation_strings":["23andMe, Inc., Sunnyvale, CA 94086, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"23andMe, Inc., Sunnyvale, CA 94086, USA","institution_ids":["https://openalex.org/I4210097491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046450925","display_name":"Paul Lichtenstein","orcid":"https://orcid.org/0000-0003-3037-5287","observed_orcids":["https://orcid.org/0000-0003-3037-5287"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Paul Lichtenstein","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082017848","display_name":"Sebastian Lundstr\u00f6m","orcid":"https://orcid.org/0000-0001-7235-8499","observed_orcids":["https://orcid.org/0000-0001-7235-8499"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sebastian Lundstr\u00f6m","raw_affiliation_strings":["Centre for Ethics, Law, and Mental Health, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Ethics, Law, and Mental Health, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087866141","display_name":"Niklas L\u00e5ngstr\u00f6m","orcid":"https://orcid.org/0000-0002-2686-6799","observed_orcids":["https://orcid.org/0000-0002-2686-6799"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Niklas L\u00e5ngstr\u00f6m","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047245152","display_name":"Adam Auton","orcid":"https://orcid.org/0000-0002-1630-1225","observed_orcids":["https://orcid.org/0000-0002-1630-1225"]},"institutions":[{"id":"https://openalex.org/I4210097491","display_name":"23andMe (United States)","ror":"https://ror.org/00q62jx03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097491"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Auton","raw_affiliation_strings":["23andMe, Inc., Sunnyvale, CA 94086, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"23andMe, Inc., Sunnyvale, CA 94086, USA","institution_ids":["https://openalex.org/I4210097491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037541907","display_name":"Kathleen Mullan Harris","orcid":"https://orcid.org/0000-0001-9757-1026","observed_orcids":["https://orcid.org/0000-0001-9757-1026"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen Mullan Harris","raw_affiliation_strings":["Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA","Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020855307","display_name":"Gary W. Beecham","orcid":"https://orcid.org/0000-0002-7061-6332","observed_orcids":["https://orcid.org/0000-0002-7061-6332"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary W. Beecham","raw_affiliation_strings":["Department of Human Genetics, University of Miami, Miami, FL 33136, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, University of Miami, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083429290","display_name":"Eden R. Martin","orcid":"https://orcid.org/0000-0002-4035-9152","observed_orcids":["https://orcid.org/0000-0002-4035-9152"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eden R. Martin","raw_affiliation_strings":["Department of Human Genetics, University of Miami, Miami, FL 33136, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, University of Miami, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014402793","display_name":"Alan R. Sanders","orcid":"https://orcid.org/0000-0001-6629-4011","observed_orcids":["https://orcid.org/0000-0001-6629-4011"]},"institutions":[{"id":"https://openalex.org/I1339509835","display_name":"Endeavor Health","ror":"https://ror.org/04tpp9d61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1339509835"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan R. Sanders","raw_affiliation_strings":["Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA","Department of Psychiatry and Behavioral Sciences, NorthShore University HealthSystem Research Institute, Evanston, IL 60201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, NorthShore University HealthSystem Research Institute, Evanston, IL 60201, USA","institution_ids":["https://openalex.org/I1339509835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027806970","display_name":"John R. B. Perry","orcid":"https://orcid.org/0000-0001-6483-3771","observed_orcids":["https://orcid.org/0000-0001-6483-3771"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210158597","display_name":"MRC Epidemiology Unit","ror":"https://ror.org/052578691","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210158597","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"John R.B. Perry","raw_affiliation_strings":["MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210158597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015235673","display_name":"Benjamin M. Neale","orcid":"https://orcid.org/0000-0003-1513-6077","observed_orcids":["https://orcid.org/0000-0003-1513-6077"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4392738323","display_name":"Stanley Center for Psychiatric Research","ror":"https://ror.org/01tm9b530","country_code":"US","type":"facility","lineage":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Benjamin M. Neale","raw_affiliation_strings":["Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA","Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA","Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089364263","display_name":"Brendan P. Zietsch","orcid":"https://orcid.org/0000-0003-0274-6140","observed_orcids":["https://orcid.org/0000-0003-0274-6140"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Brendan P. Zietsch","raw_affiliation_strings":["Centre for Psychology and Evolution, School of Psychology, University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Psychology and Evolution, School of Psychology, University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":20,"corresponding_author_ids":["https://openalex.org/A5015235673","https://openalex.org/A5027806970","https://openalex.org/A5073500794","https://openalex.org/A5078744084","https://openalex.org/A5089364263"],"corresponding_institution_ids":["https://openalex.org/I107606265","https://openalex.org/I165143802","https://openalex.org/I241749","https://openalex.org/I28166907","https://openalex.org/I4210087915","https://openalex.org/I4210151833","https://openalex.org/I4210158597","https://openalex.org/I4392738323","https://openalex.org/I887064364"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"366","issue":"6472","first_page":"1461","last_page":"1462"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13147","display_name":"Ethics and bioethics in healthcare","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.8180000185966492},{"id":"https://openalex.org/keywords/same-sex-sexual-behavior","display_name":"same-sex sexual behavior","score":0.9980000257492065},{"id":"https://openalex.org/keywords/uk-biobank","display_name":"UK Biobank","score":0.8529999852180481},{"id":"https://openalex.org/keywords/broad-consent","display_name":"broad consent","score":0.6660000085830688},{"id":"https://openalex.org/keywords/research-ethics","display_name":"research ethics","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.8510268926620483},{"id":"https://openalex.org/C83195618","wikidata":"https://www.wikidata.org/wiki/Q590951","display_name":"Cued speech","level":2,"score":0.6631376147270203},{"id":"https://openalex.org/C172497186","wikidata":"https://www.wikidata.org/wiki/Q328835","display_name":"Somatosensory system","level":2,"score":0.65474534034729},{"id":"https://openalex.org/C2780539906","wikidata":"https://www.wikidata.org/wiki/Q1422654","display_name":"Insular cortex","level":2,"score":0.5611173510551453},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4975159466266632},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.44631466269493103},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.43816694617271423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3314529359340668},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.31938672065734863}],"mesh":[{"descriptor_ui":"D007258","descriptor_name":"Informed Consent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1126/science.aaz8941","doi":"https://doi.org/10.1126/science.aaz8941","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.aaz8941","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:31857477","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31857477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Letter"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/7ff7b444-af38-45f4-a0ed-57e72c10eeda","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/7ff7b444-af38-45f4-a0ed-57e72c10eeda","pdf_url":"https://pure.amsterdamumc.nl/ws/files/178268343/Genome-studies-must-account-for-history-response.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"23andMe Research Team 2019, 'Genome studies must account for history-Response', Science, vol. 366, no. 6472, pp. 1461-1462. https://doi.org/10.1126/science.aaz8941","raw_type":"info:eu-repo/semantics/annotation"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/65cc2d2a-99dc-450f-94f1-8acab9ec4137","doi":null,"is_oa":true,"landing_page_url":"https://pure.amc.nl/en/publications/genome-studies-must-account-for-historyresponse(65cc2d2a-99dc-450f-94f1-8acab9ec4137).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Science, 366(6472), 1461 - 1462. American Association for the Advancement of Science","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research.vu.nl:openaire/ebbb8fa8-5e7f-4288-be5c-79718ed18611","doi":null,"is_oa":true,"landing_page_url":"https://research.vu.nl/en/publications/ebbb8fa8-5e7f-4288-be5c-79718ed18611","pdf_url":null,"source":{"id":"https://openalex.org/S4306401107","display_name":"VU Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"23Andme Research Team 2019, 'Genome studies must account for history-Response', Science (New York, N.Y.), vol. 366, no. 6472, pp. 1461-1462. https://doi.org/10.1126/science.aaz8941","raw_type":"article"},{"id":"pmh:vu:oai:research.vu.nl:publications/ebbb8fa8-5e7f-4288-be5c-79718ed18611","doi":null,"is_oa":true,"landing_page_url":"https://research.vu.nl/en/publications/ebbb8fa8-5e7f-4288-be5c-79718ed18611","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Science (New York, N.Y.), 366(6472), 1461 - 1462. American Association for the Advancement of Science","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/7ff7b444-af38-45f4-a0ed-57e72c10eeda","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/7ff7b444-af38-45f4-a0ed-57e72c10eeda","pdf_url":"https://pure.amsterdamumc.nl/ws/files/178268343/Genome-studies-must-account-for-history-response.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"23andMe Research Team 2019, 'Genome studies must account for history-Response', Science, vol. 366, no. 6472, pp. 1461-1462. https://doi.org/10.1126/science.aaz8941","raw_type":"info:eu-repo/semantics/annotation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/5","score":0.6000000238418579,"display_name":"Gender equality"},{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320309622","display_name":"Harvard University","ror":"https://ror.org/03vek6s52"},{"id":"https://openalex.org/F4320310609","display_name":"Harvard T.H. Chan School of Public Health","ror":"https://ror.org/03vek6s52"},{"id":"https://openalex.org/F4320314070","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142"},{"id":"https://openalex.org/F4320319101","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37"},{"id":"https://openalex.org/F4320321008","display_name":"Universiteit van Amsterdam","ror":"https://ror.org/04dkp9463"},{"id":"https://openalex.org/F4320321014","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50"},{"id":"https://openalex.org/F4320322315","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691"},{"id":"https://openalex.org/F4320333423","display_name":"Stanley Center for Psychiatric Research, Broad Institute","ror":"https://ror.org/01tm9b530"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2995765451.pdf","grobid_xml":"https://content.openalex.org/works/W2995765451.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W2051979792","https://openalex.org/W2128569464","https://openalex.org/W2306242687","https://openalex.org/W2598022332","https://openalex.org/W2768974342","https://openalex.org/W2895486342","https://openalex.org/W2906964061","https://openalex.org/W2952013316","https://openalex.org/W2952874474","https://openalex.org/W2963306470","https://openalex.org/W6600206964"],"related_works":["https://openalex.org/W6894334165","https://openalex.org/W4311946250","https://openalex.org/W2229113927","https://openalex.org/W2995919012","https://openalex.org/W2923816928","https://openalex.org/W2324352650","https://openalex.org/W2891824945","https://openalex.org/W4402359559","https://openalex.org/W2939354357","https://openalex.org/W1550422790"],"abstract_inverted_index":{"Our":[0],"genome-wide":[1],"association":[2],"study":[3,66],"(GWAS)":[4],"on":[5],"same-sex":[6],"sexual":[7],"behavior,":[8],"which":[9],"used":[10],"data":[11],"from":[12,32],"the":[13,22,37,45,75,78],"UK":[14,23],"Biobank":[15,24],"(1),":[16],"was":[17],"reviewed":[18],"and":[19,34,53,72],"approved":[20],"by":[21],"Access":[25],"Sub-Committee.":[26],"We":[27],"also":[28],"sought":[29],"stakeholder":[30],"input":[31],"allies":[33],"advocates":[35],"for":[36],"LGBTQIA+":[38],"community,":[39],"as":[40,70],"has":[41],"been":[42],"done":[43],"in":[44],"past":[46],"(2,":[47],"3).":[48],"Despite":[49],"these":[50],"efforts,":[51],"Holm":[52],"Ploug":[54],"contend":[55],"that":[56,64],"broad":[57],"biobank":[58],"consent":[59],"is":[60],"insufficient.":[61],"They":[62],"argue":[63],"our":[65],"only":[67],"tenuously":[68],"qualifies":[69],"\u201chealth-related\u201d":[71],"thus":[73],"stretches":[74],"bounds":[76],"of":[77],"participants'":[79],"consent.":[80]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-26T00:00:00"}