{"id":"https://openalex.org/W2995752933","doi":null,"title":"PLVAP as the gatekeeper of endothelial cell permeability and leukocyte migration","display_name":"PLVAP as the gatekeeper of endothelial cell permeability and leukocyte migration","publication_year":2019,"publication_date":"2019-10-11","ids":{"openalex":"https://openalex.org/W2995752933","mag":"2995752933"},"language":"en","primary_location":{"id":"pmh:oai:utupub.fi:11111/27186","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/27186","pdf_url":"https://www.utupub.fi/bitstreams/5a8c1315-46af-4326-a1bd-fff7a26cbc4d/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/148274","raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.utupub.fi/bitstreams/5a8c1315-46af-4326-a1bd-fff7a26cbc4d/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033082235","display_name":"Norma J\u00e4ppinen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Norma J\u00e4ppinen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033082235"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plvap","display_name":"PLVAP","score":0.9279999732971191},{"id":"https://openalex.org/keywords/endothelial-permeability","display_name":"endothelial permeability","score":0.8930000066757202},{"id":"https://openalex.org/keywords/lymphatic-endothelium","display_name":"lymphatic endothelium","score":0.8679999709129333},{"id":"https://openalex.org/keywords/lymph-nodes","display_name":"lymph nodes","score":0.8149999976158142},{"id":"https://openalex.org/keywords/tissue-resident-macrophages","display_name":"tissue-resident macrophages","score":0.8149999976158142},{"id":"https://openalex.org/keywords/f4-80","display_name":"F4/80","score":0.9129999876022339},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.8529999852180481},{"id":"https://openalex.org/keywords/mammary-gland","display_name":"mammary gland","score":0.8360000252723694},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.5479999780654907},{"id":"https://openalex.org/keywords/caveolae","display_name":"caveolae","score":0.843999981880188},{"id":"https://openalex.org/keywords/fenestrae","display_name":"fenestrae","score":0.8029999732971191},{"id":"https://openalex.org/keywords/transendothelial-channels","display_name":"transendothelial channels","score":0.8019999861717224},{"id":"https://openalex.org/keywords/leukocyte-migration","display_name":"leukocyte migration","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.48951256275177},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4313869774341583},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4247705638408661},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3789770007133484},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2134668231010437},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16373580694198608},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09950235486030579},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:utupub.fi:11111/27186","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/27186","pdf_url":"https://www.utupub.fi/bitstreams/5a8c1315-46af-4326-a1bd-fff7a26cbc4d/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/148274","raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},{"id":"pmh:oai:www.utupub.fi:10024/148274","doi":null,"is_oa":false,"landing_page_url":"https://www.utupub.fi/handle/10024/148274","pdf_url":null,"source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},{"id":"mag:2995752933","doi":null,"is_oa":false,"landing_page_url":"https://www.utupub.fi/bitstream/10024/148274/1/AnnalesD1445J%c3%a4ppinen.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utupub.fi:11111/27186","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/27186","pdf_url":"https://www.utupub.fi/bitstreams/5a8c1315-46af-4326-a1bd-fff7a26cbc4d/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/148274","raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310907","display_name":"Alfred Kordelinin S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/0107h6s84"},{"id":"https://openalex.org/F4320321726","display_name":"Suomen Kulttuurirahasto","ror":"https://ror.org/027xav248"},{"id":"https://openalex.org/F4320322861","display_name":"Emil Aaltosen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/005rt3g54"},{"id":"https://openalex.org/F4320324148","display_name":"Orionin Tutkimuss\u00e4\u00e4ti\u00f6","ror":"https://ror.org/0296s4x19"},{"id":"https://openalex.org/F4320325101","display_name":"Instrumentariumin Tiedes\u00e4\u00e4ti\u00f6","ror":"https://ror.org/02w907m39"},{"id":"https://openalex.org/F4320335023","display_name":"Satakunnan Rahasto","ror":"https://ror.org/027xav248"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2995752933.pdf","grobid_xml":"https://content.openalex.org/works/W2995752933.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7005698011","https://openalex.org/W1977274736","https://openalex.org/W7056532122","https://openalex.org/W4320482076","https://openalex.org/W2477800596","https://openalex.org/W2982700265","https://openalex.org/W1859840488","https://openalex.org/W1966424086","https://openalex.org/W2095513517","https://openalex.org/W2516937074"],"abstract_inverted_index":{"Endothelial":[0],"cells":[1,48,145],"(EC)":[2],"line":[3],"the":[4,10,16,24,43,73,76,101,108,113,123,147,168,175,181,196,210,218],"lymphatic":[5,114,165],"and":[6,18,30,55,68,93,95,138,150,171,177,195,223],"vascular":[7],"vessels":[8],"of":[9,26,110,130,154,167,192,198,217],"body,":[11],"forming":[12],"a":[13,199,214],"barrier":[14],"between":[15],"lumen":[17],"surrounding":[19],"tissue.":[20],"ECs":[21,166],"actively":[22],"coordinate":[23],"exchange":[25],"migrating":[27],"cells,":[28],"fluids":[29],"molecules":[31],"thus":[32],"regulating":[33],"tissue":[34],"homeostasis.":[35],"Correctly":[36],"working":[37],"endothelium":[38,115],"is":[39,116,160,188],"also":[40],"important":[41],"during":[42,126],"embryonic":[44],"development,":[45],"as":[46],"progenitor":[47],"have":[49],"tight":[50],"time":[51],"windows":[52],"to":[53,60,64,99,134,142,180],"reach":[54],"colonize":[56],"target":[57],"tissues.":[58],"Failures":[59],"do":[61],"so":[62],"lead":[63],"perturbed":[65],"cell":[66],"composition":[67],"lasting":[69],"adverse":[70],"effects":[71],"in":[72,104,112,122,136,139,146,163,204],"adulthood.":[74],"In":[75,207],"blood":[77,105],"endothelium,":[78],"plasmalemma":[79],"vesicle-associated":[80],"protein":[81],"(PLVAP)":[82],"forms":[83],"diaphragms":[84],"on":[85],"specific":[86],"plasma":[87],"membrane":[88],"structures":[89],"(transendothelial":[90],"channels,":[91],"fenestrae":[92],"caveolae)":[94],"has":[96],"been":[97],"showed":[98],"regulate":[100],"EC":[102],"permeability":[103],"vessels.":[106],"However,":[107],"role":[109,121],"PLVAP":[111,159,173,186],"not":[117],"characterized,":[118],"nor":[119],"its":[120],"immune":[124],"system":[125],"development.":[127],"The":[128,152],"aim":[129],"this":[131,155],"thesis":[132,156],"was":[133],"use":[135],"vivo":[137],"vitro":[140],"-methods":[141],"investigate":[143],"endothelial":[144],"lymph":[148,169,182],"node":[149,170],"liver.":[151],"results":[153],"show":[157],"that":[158,224],"unexpectedly":[161],"expressed":[162],"distinct":[164],"there,":[172],"regulates":[174],"antigen":[176],"lymphocyte":[178],"entry":[179],"node.":[183],"During":[184],"development":[185],"expression":[187],"crucial":[189],"for":[190],"migration":[191],"macrophage":[193,202,221,233],"progenitors":[194],"emerging":[197],"F4/80Hi":[200,211],"tissue-resident":[201],"population":[203,216],"several":[205],"organs.":[206],"mammary":[208],"gland,":[209],"macrophages":[212],"form":[213],"major":[215],"steady":[219],"state":[220],"pool":[222],"their":[225],"unique":[226],"functions":[227],"cannot":[228],"be":[229],"performed":[230],"by":[231],"other":[232],"types.":[234]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2019-12-26T00:00:00"}
