{"id":"https://openalex.org/W2995623160","doi":"https://doi.org/10.1158/1538-7445.panca19-b21","title":"Abstract B21: Pharmacologic activation of G protein-coupled estrogen receptor inhibits pancreatic ductal adenocarcinoma","display_name":"Abstract B21: Pharmacologic activation of G protein-coupled estrogen receptor inhibits pancreatic ductal adenocarcinoma","publication_year":2019,"publication_date":"2019-12-13","ids":{"openalex":"https://openalex.org/W2995623160","doi":"https://doi.org/10.1158/1538-7445.panca19-b21","mag":"2995623160"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.panca19-b21","doi":"https://doi.org/10.1158/1538-7445.panca19-b21","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.panca19-b21","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009336063","display_name":"Christopher A. Natale","orcid":"https://orcid.org/0000-0003-4949-3849","observed_orcids":["https://orcid.org/0000-0003-4949-3849"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Natale","raw_affiliation_strings":["1Linnaeus Therapeutics, Haddonfield, NJ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Linnaeus Therapeutics, Haddonfield, NJ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100320426","display_name":"Jinyang Li","orcid":"https://orcid.org/0000-0001-8125-6603","observed_orcids":["https://orcid.org/0000-0001-8125-6603"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinyang Li","raw_affiliation_strings":["2University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032716167","display_name":"Tzvete Dentchev","orcid":"https://orcid.org/0000-0001-5488-2721","observed_orcids":["https://orcid.org/0000-0001-5488-2721"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tzvete Dentchev","raw_affiliation_strings":["2University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013617649","display_name":"Brian C. Capell","orcid":"https://orcid.org/0000-0002-7036-8359","observed_orcids":["https://orcid.org/0000-0002-7036-8359"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Capell","raw_affiliation_strings":["2University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064309595","display_name":"John T. Seykora","orcid":"https://orcid.org/0000-0003-0383-031X","observed_orcids":["https://orcid.org/0000-0003-0383-031X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Seykora","raw_affiliation_strings":["2University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057187872","display_name":"Ben Z. Stanger","orcid":"https://orcid.org/0000-0003-0410-4037","observed_orcids":["https://orcid.org/0000-0003-0410-4037"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben Stanger","raw_affiliation_strings":["2University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085814203","display_name":"Todd W. Ridky","orcid":"https://orcid.org/0000-0001-8482-1284","observed_orcids":["https://orcid.org/0000-0001-8482-1284"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Ridky","raw_affiliation_strings":["2University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"24_Supplement","first_page":"B21","last_page":"B21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.15139999985694885,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-coupled-estrogen-receptor","display_name":"G protein-coupled estrogen receptor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lns8801","display_name":"LNS8801","score":0.9769999980926514},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/sex-differences-in-cancer","display_name":"sex differences in cancer","score":0.8429999947547913},{"id":"https://openalex.org/keywords/estrogen-signaling","display_name":"estrogen signaling","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.7910000085830688},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9399999976158142},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.996999979019165},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C166471694","wikidata":"https://www.wikidata.org/wiki/Q18268232","display_name":"GPER","level":5,"score":0.9765555262565613},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6613331437110901},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6130001544952393},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5792146921157837},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5591217279434204},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45851823687553406},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4490630030632019},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.4467169940471649},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43823105096817017},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4215376377105713},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.37020671367645264},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.364946186542511},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32803839445114136},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21750366687774658}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.panca19-b21","doi":"https://doi.org/10.1158/1538-7445.panca19-b21","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.panca19-b21","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3023266462","https://openalex.org/W2978481825","https://openalex.org/W4283768262","https://openalex.org/W3137855011","https://openalex.org/W2165115991","https://openalex.org/W3010267425","https://openalex.org/W3181113088","https://openalex.org/W2049028226","https://openalex.org/W3077612677","https://openalex.org/W4387672520"],"abstract_inverted_index":{"Abstract":[0],"LNS8801":[1],"is":[2,53],"a":[3,33,188],"novel,":[4],"orally":[5],"bioavailable,":[6],"small-molecule":[7],"agonist":[8,122],"of":[9,22,111,144,167,190,206,228,240],"the":[10,20,64,109,120,163,207,241],"G":[11,229],"Protein":[12],"Coupled":[13],"Estrogen":[14],"Receptor":[15],"(GPER)":[16],"being":[17],"developed":[18],"for":[19,40,49],"treatment":[21],"pancreatic":[23,234],"ductal":[24,235],"adenocarcinoma":[25,236],"(PDAC)":[26],"and":[27,36,80,106,148,154,169,200,251],"other":[28,177],"advanced":[29],"cancers.":[30],"Women":[31],"have":[32],"lower":[34],"incidence":[35],"improved":[37],"clinical":[38],"outcomes":[39],"most":[41],"cancer":[42,178],"types,":[43,179],"including":[44],"PDAC.":[45,92],"The":[46],"mechanistic":[47],"basis":[48],"this":[50],"sex":[51,197],"difference":[52],"unknown.":[54],"We":[55],"hypothesized":[56],"that":[57,66,85,138,173,181,192,201],"estrogen":[58,71,231],"signaling":[59],"may":[60,184],"be":[61,185],"responsible,":[62],"despite":[63],"fact":[65],"PDAC":[67],"lacks":[68],"classic":[69],"nuclear":[70],"receptors.":[72],"Here":[73],"we":[74],"used":[75],"murine":[76],"syngeneic":[77],"tumor":[78,89,101,141,156],"models":[79],"human":[81],"xenografts":[82],"to":[83],"determine":[84],"agonizing":[86],"GPER":[87,95,121,145,168,174,182],"on":[88,245],"cells":[90],"inhibits":[91,176,233],"Systemically":[93],"administered":[94],"agonists":[96,183],"were":[97,132],"well":[98],"tolerated,":[99],"induced":[100],"regression,":[102],"significantly":[103],"prolonged":[104],"survival,":[105],"markedly":[107],"increased":[108,155],"efficacy":[110],"PD-1":[112,128],"targeted":[113,129],"immune":[114,130,136],"therapy.":[115],"Complete":[116],"responses,":[117],"observed":[118],"with":[119,127,134,162],"alone":[123],"or":[124],"in":[125,203,249],"combination":[126],"therapy,":[131],"associated":[133],"durable":[135],"memory":[137],"protected":[139],"against":[140,187],"rechallenge.":[142],"Activation":[143],"depleted":[146],"c-Myc":[147],"programmed":[149],"death":[150],"ligand":[151],"1":[152],"(PD-L1)":[153],"cell":[157],"immunogenicity.":[158],"These":[159],"data,":[160],"coupled":[161],"wide":[164],"tissue":[165],"distribution":[166],"previous":[170],"work":[171],"showing":[172],"activation":[175,227],"suggest":[180],"useful":[186],"range":[189],"cancers":[191],"are":[193],"not":[194],"classically":[195],"considered":[196],"hormone":[198],"responsive,":[199],"arise":[202],"tissues":[204],"outside":[205],"reproductive":[208],"system.":[209],"Citation":[210],"Format:":[211],"Christopher":[212],"Natale,":[213],"Jinyang":[214],"Li,":[215],"Tzvete":[216],"Dentchev,":[217],"Brian":[218],"Capell,":[219],"John":[220],"Seykora,":[221],"Ben":[222],"Stanger,":[223],"Todd":[224],"Ridky.":[225],"Pharmacologic":[226],"protein-coupled":[230],"receptor":[232],"[abstract].":[237],"In:":[238],"Proceedings":[239],"AACR":[242],"Special":[243],"Conference":[244],"Pancreatic":[246],"Cancer:":[247],"Advances":[248],"Science":[250],"Clinical":[252],"Care;":[253],"2019":[254],"Sept":[255],"6-9;":[256],"Boston,":[257],"MA.":[258],"Philadelphia":[259],"(PA):":[260],"AACR;":[261],"Cancer":[262],"Res":[263],"2019;79(24":[264],"Suppl):Abstract":[265],"nr":[266],"B21.":[267]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2019-12-26T00:00:00"}