{"id":"https://openalex.org/W2995541967","doi":"https://doi.org/10.11606/t.5.2019.tde-09122019-163223","title":"Avalia\u00e7\u00e3o dos mecanismos determinantes de limita\u00e7\u00e3o ao esfor\u00e7o e da capacidade de exerc\u00edcio em pacientes com histiocitose pulmonar de c\u00e9lulas de Langerhans","display_name":"Avalia\u00e7\u00e3o dos mecanismos determinantes de limita\u00e7\u00e3o ao esfor\u00e7o e da capacidade de exerc\u00edcio em pacientes com histiocitose pulmonar de c\u00e9lulas de Langerhans","publication_year":2019,"publication_date":"2019-12-10","ids":{"openalex":"https://openalex.org/W2995541967","doi":"https://doi.org/10.11606/t.5.2019.tde-09122019-163223","mag":"2995541967"},"language":"pt","primary_location":{"id":"doi:10.11606/t.5.2019.tde-09122019-163223","doi":"https://doi.org/10.11606/t.5.2019.tde-09122019-163223","is_oa":true,"landing_page_url":"https://doi.org/10.11606/t.5.2019.tde-09122019-163223","pdf_url":"http://www.teses.usp.br/teses/disponiveis/5/5150/tde-09122019-163223/publico/GlauciaItamaroHeiden.pdf","source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.teses.usp.br/teses/disponiveis/5/5150/tde-09122019-163223/publico/GlauciaItamaroHeiden.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061663451","display_name":"Gl\u00e1ucia Itamaro Heiden","orcid":"https://orcid.org/0009-0000-7717-2431","observed_orcids":["https://orcid.org/0009-0000-7717-2431"]},"institutions":[{"id":"https://openalex.org/I4104125","display_name":"Universidade Federal de Santa Catarina","ror":"https://ror.org/041akq887","country_code":"BR","type":"education","lineage":["https://openalex.org/I4104125"]},{"id":"https://openalex.org/I4210126369","display_name":"Polydoro Ernani de S\u00e3o Thiago University Hospital","ror":"https://ror.org/0303d1x26","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210126369"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Glaucia Itamaro Heiden","raw_affiliation_strings":["da resid\u00eancia em cl\u00ednica m\u00e9dica HU-UFSC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"da resid\u00eancia em cl\u00ednica m\u00e9dica HU-UFSC","institution_ids":["https://openalex.org/I4104125","https://openalex.org/I4210126369"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061663451"],"corresponding_institution_ids":["https://openalex.org/I4104125","https://openalex.org/I4210126369"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.3555000126361847,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.3555000126361847,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.28859999775886536,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":0.1941000074148178,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-langerhans-cell-histiocytosis","display_name":"pulmonary Langerhans cell histiocytosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/exercise-limitation","display_name":"exercise limitation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/exercise-capacity","display_name":"exercise capacity","score":0.9869999885559082},{"id":"https://openalex.org/keywords/dynamic-hyperinflation","display_name":"dynamic hyperinflation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.9110000133514404},{"id":"https://openalex.org/keywords/ventilatory-limitation","display_name":"ventilatory limitation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/diffusing-capacity-for-carbon-monoxide","display_name":"diffusing capacity for carbon monoxide","score":0.8029999732971191},{"id":"https://openalex.org/keywords/right-heart-catheterization","display_name":"right heart catheterization","score":0.6570000052452087},{"id":"https://openalex.org/keywords/6-minute-walk-test","display_name":"6-minute walk test","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cardiopulmonary-exercise-testing","display_name":"cardiopulmonary exercise testing","score":0.7559999823570251},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.4359999895095825},{"id":"https://openalex.org/keywords/dyspnea","display_name":"dyspnea","score":0.6489999890327454},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.46299999952316284},{"id":"https://openalex.org/keywords/air-trapping","display_name":"air trapping","score":0.49799999594688416},{"id":"https://openalex.org/keywords/obstructive-pattern","display_name":"obstructive pattern","score":0.39100000262260437},{"id":"https://openalex.org/keywords/hemodynamic-characteristics","display_name":"hemodynamic characteristics","score":0.33399999141693115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41070204973220825},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3575752079486847},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.32538217306137085},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.07749924063682556}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.11606/t.5.2019.tde-09122019-163223","doi":"https://doi.org/10.11606/t.5.2019.tde-09122019-163223","is_oa":true,"landing_page_url":"https://doi.org/10.11606/t.5.2019.tde-09122019-163223","pdf_url":"http://www.teses.usp.br/teses/disponiveis/5/5150/tde-09122019-163223/publico/GlauciaItamaroHeiden.pdf","source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},{"id":"pmh:oai:americanae.aecid.es:2202818","doi":null,"is_oa":true,"landing_page_url":"http://www.teses.usp.br/teses/disponiveis/5/5150/tde-09122019-163223/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da USP","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:teses.usp.br:tde-09122019-163223","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.11606/T.5.2019.tde-09122019-163223","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"doi:10.11606/t.5.2019.tde-09122019-163223","doi":"https://doi.org/10.11606/t.5.2019.tde-09122019-163223","is_oa":true,"landing_page_url":"https://doi.org/10.11606/t.5.2019.tde-09122019-163223","pdf_url":"http://www.teses.usp.br/teses/disponiveis/5/5150/tde-09122019-163223/publico/GlauciaItamaroHeiden.pdf","source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2995541967.pdf","grobid_xml":"https://content.openalex.org/works/W2995541967.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W31990271","https://openalex.org/W1594921540","https://openalex.org/W1781015672","https://openalex.org/W1965235028","https://openalex.org/W1967981332","https://openalex.org/W1968262352","https://openalex.org/W1968528172","https://openalex.org/W1971910531","https://openalex.org/W1975033578","https://openalex.org/W1976961493","https://openalex.org/W1977828088","https://openalex.org/W1978010838","https://openalex.org/W1981434879","https://openalex.org/W1982645332","https://openalex.org/W1986599134","https://openalex.org/W1989584416","https://openalex.org/W1989594057","https://openalex.org/W1989980464","https://openalex.org/W1992672455","https://openalex.org/W1995105141","https://openalex.org/W1998629549","https://openalex.org/W2000993407","https://openalex.org/W2001916379","https://openalex.org/W2002234178","https://openalex.org/W2004008756","https://openalex.org/W2006268804","https://openalex.org/W2008264527","https://openalex.org/W2010423439","https://openalex.org/W2013026986","https://openalex.org/W2015134755","https://openalex.org/W2023402104","https://openalex.org/W2025877774","https://openalex.org/W2027620575","https://openalex.org/W2031845442","https://openalex.org/W2037376182","https://openalex.org/W2037377025","https://openalex.org/W2044507143","https://openalex.org/W2055147321","https://openalex.org/W2058322765","https://openalex.org/W2076579116","https://openalex.org/W2085673384","https://openalex.org/W2090877741","https://openalex.org/W2091375963","https://openalex.org/W2096328141","https://openalex.org/W2096396493","https://openalex.org/W2098400986","https://openalex.org/W2100422140","https://openalex.org/W2100681411","https://openalex.org/W2100710359","https://openalex.org/W2107829061","https://openalex.org/W2110861135","https://openalex.org/W2113836310","https://openalex.org/W2122930773","https://openalex.org/W2126114280","https://openalex.org/W2129718853","https://openalex.org/W2131890806","https://openalex.org/W2132742794","https://openalex.org/W2136611140","https://openalex.org/W2140575740","https://openalex.org/W2144845371","https://openalex.org/W2147203905","https://openalex.org/W2147841420","https://openalex.org/W2150599441","https://openalex.org/W2159672704","https://openalex.org/W2165407045","https://openalex.org/W2165833527","https://openalex.org/W2295097092","https://openalex.org/W2339801427","https://openalex.org/W2517312660","https://openalex.org/W2561638494","https://openalex.org/W2569189071","https://openalex.org/W2591201074","https://openalex.org/W2605017716","https://openalex.org/W2607003585","https://openalex.org/W2621360946","https://openalex.org/W2729417204","https://openalex.org/W2746295071","https://openalex.org/W2748726920","https://openalex.org/W2751274509","https://openalex.org/W2758320090","https://openalex.org/W2759657035","https://openalex.org/W2762528462","https://openalex.org/W2799838447","https://openalex.org/W2808789209","https://openalex.org/W2883709508","https://openalex.org/W2904180601","https://openalex.org/W4211149499","https://openalex.org/W4249896096","https://openalex.org/W4255036252","https://openalex.org/W4290422017"],"related_works":["https://openalex.org/W2780245101","https://openalex.org/W7120289622","https://openalex.org/W3037678860","https://openalex.org/W2104315243","https://openalex.org/W2569189071","https://openalex.org/W2332506423","https://openalex.org/W2991111821","https://openalex.org/W4414120499","https://openalex.org/W4416638772","https://openalex.org/W1864857221"],"abstract_inverted_index":{"Heiden":[0],"GI.":[1],"Evaluation":[2],"of":[3,7,46,72,83,100,133,145,173,206,218,226,234,247,254,260,285,294,311,335,348,363,387,408],"the":[4,11,70,78,81,98,171,177,265,326,368,372],"mechanisms":[5,45,71,402],"determinants":[6],"exercise":[8,12,42,47,73,79,128,388],"limitation":[9,48,58,74,102,214,229,391],"and":[10,64,75,85,88,103,124,201,215,224,249,273,279,290,302,309,325,355,374,379,394,406],"capacity":[13,140,276],"in":[14,49,91,221,232,252,258,264,297,306,346,371,376,396,415],"patients":[15,92,110,135,184,322,397],"with":[16,93,111,131,136,150,160,190,202,343,398],"pulmonary":[17,61,121,179],"Langerhans":[18,29],"cell":[19,30],"histiocytosis[":[20],"]":[21],"\"":[22],"S\u00e3o":[23],"P":[24],"\";":[25],"2019":[26],"Introduction:":[27],"Pulmonary":[28],"histiocytosis":[31],"(PLCH)":[32],"is":[33,392,412],"a":[34,106,351],"smokingrelated":[35],"diffuse":[36],"cystic":[37],"disease,":[38],"which":[39],"determines":[40],"reduced":[41,251],"capacity.The":[43],"speculated":[44],"PLCH":[50,112],"include":[51,403],"ventilatory":[52,211],"limitation,":[53,212],"dynamic":[54],"hyperinflation":[55,256],"(DH),":[56],"cardiocirculatory":[57,213,405],"that":[59],"encompasses":[60],"hypertension":[62,411],"(PH)":[63],"impaired":[65],"gas":[66],"exchange.Objectives:":[67],"To":[68],"evaluate":[69,97],"to":[76,96,169,384],"define":[77],"capacity,":[80],"prevalence":[82,334],"PH":[84,162,174,219,336,409],"clinical,":[86],"functional":[87],"hemodynamic":[89],"characteristics":[90],"PLCH.In":[94],"addition,":[95],"predictors":[99],"effort":[101],"PH.Methods:":[104],"In":[105],"cross-sectional":[107],"study,":[108],"35":[109],"underwent":[113,164,323],"clinical":[114],"evaluation,":[115],"transthoracic":[116,148],"echocardiography,":[117],"six-minute":[118],"walk":[119],"test,":[120],"function":[122],"tests,":[123],"incremental":[125],"treadmill":[126],"cardiopulmonary":[127],"test":[129],"(CPET)":[130],"evaluation":[132],"DH.Those":[134],"carbon":[137],"monoxide":[138],"diffusion":[139],"(DLCO)":[141],"less":[142],"than":[143,156],"40%":[144],"predicted":[146],"and/or":[147,159],"echocardiogram":[149],"tricuspid":[151],"regurgitation":[152],"velocity":[153],"(TRV)":[154],"greater":[155],"2.5":[157],"m/s":[158],"indirect":[161],"signs":[163],"right":[165],"heart":[166],"catheterisation":[167],"(RHC)":[168],"confirm":[170],"diagnosis":[172],"based":[175],"on":[176],"mean":[178],"artery":[180],"pressure":[181],"(mPAP).Results:":[182],"Thirtyfive":[183],"were":[185,188,197,281],"included":[186],"(68%":[187],"women,":[189],"47":[191],"\u00b1":[192,208,245,283,288,292,331],"11":[193,289],"years":[194],"old,":[195],"91%":[196],"current":[198],"or":[199],"ex-smokers":[200],"baseline":[203],"dyspnea":[204],"index":[205],"8":[207],"3).At":[209],"CPET,":[210],"impairment":[216],"suggestive":[217,407],"occurred":[220,257,305],"58%,":[222],"63%,":[223],"29%":[225],"patients,":[227,312],"respectively.The":[228,313],"was":[230,243,250,315,329,337,350],"multifactorial":[231,393],"71%":[233],"cases.The":[235],"maximum":[236],"oxygen":[237],"consumption":[238],"(":[239],"O":[240,360,364],"2":[241,361,365],"peak)":[242],"73":[244],"19%":[246],"predicted,":[248,286,295],"70%":[253],"patients.Dynamic":[255],"68%":[259],"patients.Forced":[261],"expiratory":[262],"volume":[263,272],"first":[266],"second":[267],"(FEV":[268],"1":[269,357,378],"),":[270],"residual":[271],"total":[274],"lung":[275],"ratio":[277],"(RV/TLC)":[278],"DLCO":[280,380],"64":[282],"22%":[284],"44":[287],"56":[291],"21%":[293],"respectively.Reduction":[296],"DLCO,":[298,359],"an":[299],"obstructive":[300],"pattern,":[301],"air":[303],"trapping":[304],"80%,":[307],"77%":[308],"37%":[310],"TRV":[314,375],"3.0":[316],"(2.4":[317],"-3.2)":[318],"m":[319],"/":[320],"s.Eighteen":[321],"CCD,":[324],"mPAP":[327,354],"obtained":[328],"32":[330],"12":[332],"mmHg.The":[333],"41%":[338],"(CI95%":[339],"=":[340],"24":[341],"-59%),":[342],"pre-capillary":[344],"pattern":[345],"85%":[347],"cases.There":[349],"correlation":[352],"between":[353],"FEV":[356],",":[358],"%":[362],"peak":[366],"at":[367],"anaerobic":[369],"threshold":[370],"CPET":[373],"echocardiogram.FEV":[377],"presented":[381],"good":[382],"accuracy":[383],"predict":[385],"reduction":[386],"capacity.Conclusion:":[389],"Exercise":[390],"frequent":[395],"PLCH.The":[399],"most":[400],"prevalent":[401],"ventilatory,":[404],"limitations.Pulmonary":[410],"also":[413],"common":[414],"PLCH,":[416],"predominantly":[417],"pre-capillary.":[418]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2019-12-26T00:00:00"}
