{"id":"https://openalex.org/W2995502004","doi":null,"title":"Effects of acarbose and siglitine on blood glucose fluctuation and islet \u03b2-cell function in patients with type 2 diabetes mellitus.","display_name":"Effects of acarbose and siglitine on blood glucose fluctuation and islet \u03b2-cell function in patients with type 2 diabetes mellitus.","publication_year":2019,"publication_date":"2019-03-01","ids":{"openalex":"https://openalex.org/W2995502004","mag":"2995502004","pmid":"https://pubmed.ncbi.nlm.nih.gov/30972995"},"language":"en","primary_location":{"id":"pmid:30972995","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30972995","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056763455","display_name":"R R Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R R Wang","raw_affiliation_strings":["Department of Endocrinology, Jiamusi Central Hospital of Heilongjiang Province, Jiamusi, Heilongjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Jiamusi Central Hospital of Heilongjiang Province, Jiamusi, Heilongjiang, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030766162","display_name":"Zhi-dong Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102410","display_name":"First Affiliated Hospital of Jiamusi University","ror":"https://ror.org/01djnt473","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102410"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Z M Lv","raw_affiliation_strings":["Department of Endocrinology, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, China","institution_ids":["https://openalex.org/I4210102410"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y P Dan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102410","display_name":"First Affiliated Hospital of Jiamusi University","ror":"https://ror.org/01djnt473","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102410"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y P Dan","raw_affiliation_strings":["Department of Endocrinology, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, China","institution_ids":["https://openalex.org/I4210102410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079026542","display_name":"K Y Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102410","display_name":"First Affiliated Hospital of Jiamusi University","ror":"https://ror.org/01djnt473","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102410"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"K Y Chen","raw_affiliation_strings":["Department of Endocrinology, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, China","institution_ids":["https://openalex.org/I4210102410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048054447","display_name":"C Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102410","display_name":"First Affiliated Hospital of Jiamusi University","ror":"https://ror.org/01djnt473","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102410"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"C Zhang","raw_affiliation_strings":["Department of Endocrinology, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, China","institution_ids":["https://openalex.org/I4210102410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.526,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.7039232,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"33","issue":"2","first_page":"365","last_page":"374"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acarbose","display_name":"acarbose","score":0.984000027179718},{"id":"https://openalex.org/keywords/sitagliptin","display_name":"sitagliptin","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9890000224113464},{"id":"https://openalex.org/keywords/blood-glucose-fluctuation","display_name":"blood glucose fluctuation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.8690000176429749},{"id":"https://openalex.org/keywords/continuous-subcutaneous-insulin-infusion","display_name":"insulin pump therapy","score":0.9430000185966492},{"id":"https://openalex.org/keywords/continuous-glucose-monitoring","display_name":"continuous glucose monitoring","score":0.7609999775886536},{"id":"https://openalex.org/keywords/glycemic-variability","display_name":"glycemic variability","score":0.6110000014305115},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.6370000243186951},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.8259999752044678},{"id":"https://openalex.org/keywords/c-peptide","display_name":"C-peptide","score":0.5429999828338623},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.9051398634910583},{"id":"https://openalex.org/C2776617576","wikidata":"https://www.wikidata.org/wiki/Q338005","display_name":"Acarbose","level":3,"score":0.8929266929626465},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7931417226791382},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.733691930770874},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.6943435668945312},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6699949502944946},{"id":"https://openalex.org/C2779284873","wikidata":"https://www.wikidata.org/wiki/Q419832","display_name":"Sitagliptin","level":4,"score":0.5948822498321533},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.5449784994125366},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5204758644104004},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.47738760709762573},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.4475381076335907},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.4413778781890869},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.1880541443824768}],"mesh":[{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007332","descriptor_name":"Insulin Infusion Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020909","descriptor_name":"Acarbose","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:30972995","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30972995","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Journal Article"},{"id":"mag:2995502004","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30972995","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2389424840","https://openalex.org/W2167185923","https://openalex.org/W2362634275","https://openalex.org/W1909414612","https://openalex.org/W2179249254","https://openalex.org/W2091716889","https://openalex.org/W7099646242","https://openalex.org/W2374665583","https://openalex.org/W2364332847","https://openalex.org/W4409125862"],"abstract_inverted_index":{"The":[0,68,84,123,209,241],"effects":[1],"of":[2,95,99,108,131,148,214,245,255],"acarbose":[3,59],"and":[4,10,26,39,74,116,151,157,172,179,218,226,248,262,272,301],"sitagliptin":[5,66],"on":[6],"blood":[7,92,135,143,154,159,197,287],"glucose":[8,93,110,136,155,160,165,170,198,288],"fluctuation":[9,137,161,199,289],"islet":[11,297],"\u03b2-cell":[12],"function":[13,300],"in":[14,78,176,187,196,201,223,234],"patients":[15,28],"with":[16,29,33,58,65,191,280],"type":[17],"2":[18],"diabetes":[19],"mellitus":[20],"(T2DM)":[21],"were":[22,37,82,113,182,229],"studied.":[23],"One":[24],"hundred":[25],"three":[27,43,80,97,104],"poorly":[30],"controlled":[31],"T2DM":[32],"insulin":[34,49,85,282,294,307],"aspart":[35],"30":[36],"selected":[38],"randomly":[40],"divided":[41],"into":[42],"groups:":[44],"group":[45,54,61,177,180,188,192,202,224,227,235,256],"A":[46,236,257],"[continuous":[47],"subcutaneous":[48],"infusion":[50],"(CSII)":[51],"treatment":[52,69],"group],":[53],"B":[55,181,228,247,271,298],"(CSII":[56,63],"combined":[57,64,279],"treatment),":[60],"C":[62,178,203,225,249,273],"treatment).":[67],"lasted":[70],"for":[71],"two":[72],"weeks":[73],"the":[75,79,91,96,102,117,127,194,291],"clinical":[76],"indicators":[77],"groups":[81,98,246,270],"measured.":[83],"dosage":[86],"was":[87,120,204,250,264],"adjusted":[88],"according":[89],"to":[90],"statuses":[94],"patients.":[100],"In":[101],"final":[103],"days,":[105],"72":[106],"h":[107,140],"continuous":[109],"monitoring":[111],"(CGM)":[112],"carried":[114],"out,":[115],"OGTT":[118],"test":[119],"performed":[121],"again.":[122],"results":[124],"showed":[125],"that":[126,254],"MODD":[128],"(absolute":[129],"means":[130],"daily":[132],"difference),":[133],"intra-day":[134],"indices":[138,162,200],"[(24":[139],"MBG":[141],"(mean":[142],"glucose),":[144],"LAGE":[145],"(largest":[146],"amplitude":[147],"glycemic":[149],"excursions)":[150],"MAGE":[152],"(average":[153],"fluctuation)]":[156],"postprandial":[158],"[PGS":[163],"(postprandial":[164,169],"spike),":[166],"\u25b3t,":[167],"PPGE":[168],"excursion)":[171],"T":[173],"(time)":[174],"total]":[175],"significantly":[183,230,251],"lower":[184,252],"than":[185,232,239,253,260,276,305],"those":[186,233],"A.":[189],"Compared":[190],"B,":[193],"difference":[195,268],"not":[205],"statistically":[206,266],"significant":[207,267],"(P>0.05).":[208],"HOMA-islet":[210],"(homeostasis":[211],"model":[212],"assessment":[213],"islet)":[215],"(CP-DM)":[216],"index":[217,244],"FC-P":[219],"(Fasting":[220],"c-peptide)":[221],"levels":[222],"higher":[231],"(P":[237,258,274],"less":[238,259,275],"0.01).":[240],"HOMA-IR":[242],"(CP)":[243],"0.01),":[261],"there":[263],"no":[265],"between":[269],"0.05).":[277],"Sitagliptin":[278],"intensive":[281,306],"pump":[283,308],"therapy":[284,309],"can":[285],"reduce":[286,293,302],"throughout":[290],"day,":[292],"dosage,":[295],"improve":[296],"cell":[299],"hypoglycemia":[303],"better":[304],"alone.":[310]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-26T00:00:00"}