{"id":"https://openalex.org/W2995486142","doi":"https://doi.org/10.32873/unmc.dc.gmerj.1.1.077","title":"Three Cases of Laryngeal Histoplasmosis in the Midwestern United States","display_name":"Three Cases of Laryngeal Histoplasmosis in the Midwestern United States","publication_year":2019,"publication_date":"2019-12-01","ids":{"openalex":"https://openalex.org/W2995486142","doi":"https://doi.org/10.32873/unmc.dc.gmerj.1.1.077","mag":"2995486142"},"language":"en","primary_location":{"id":"doi:10.32873/unmc.dc.gmerj.1.1.077","doi":"https://doi.org/10.32873/unmc.dc.gmerj.1.1.077","is_oa":true,"landing_page_url":"https://doi.org/10.32873/unmc.dc.gmerj.1.1.077","pdf_url":"https://digitalcommons.unmc.edu/cgi/viewcontent.cgi?article=1083&context=gmerj","source":{"id":"https://openalex.org/S4210227318","display_name":"Graduate Medical Education Research Journal","issn_l":"2578-6091","issn":["2578-6091","2578-6105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Graduate Medical Education Research Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://digitalcommons.unmc.edu/cgi/viewcontent.cgi?article=1083&context=gmerj","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Blecha, Jonathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blecha, Jonathan","raw_affiliation_strings":["University of Nebraska Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067002979","display_name":"Christopher M. Bingcang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bingcang, Christopher","raw_affiliation_strings":["University of Nebraska Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"last","author":{"id":null,"display_name":"Oltman, Justin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oltman, Justin","raw_affiliation_strings":["University of Nebraska Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I59130452"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21056022,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histoplasma-capsulatum","display_name":"Histoplasma capsulatum","score":0.9340000152587891},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8989999890327454},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9879999756813049},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.4480000138282776},{"id":"https://openalex.org/keywords/dysphagia","display_name":"dysphagia","score":0.7789999842643738},{"id":"https://openalex.org/keywords/odynophagia","display_name":"odynophagia","score":0.9010000228881836},{"id":"https://openalex.org/keywords/hoarseness","display_name":"hoarseness","score":0.9369999766349792},{"id":"https://openalex.org/keywords/gomori-methenamine-silver-stain","display_name":"Gomori methenamine silver stain","score":0.8579999804496765},{"id":"https://openalex.org/keywords/antifungal-therapy","display_name":"antifungal therapy","score":0.8629999756813049},{"id":"https://openalex.org/keywords/disseminated-histoplasmosis","display_name":"disseminated histoplasmosis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/misdiagnosis-as-malignancy","display_name":"misdiagnosis as malignancy","score":0.7440000176429749},{"id":"https://openalex.org/keywords/fungal-culture","display_name":"fungal culture","score":0.30799999833106995}],"concepts":[{"id":"https://openalex.org/C2780318139","wikidata":"https://www.wikidata.org/wiki/Q627625","display_name":"Histoplasmosis","level":2,"score":0.9291546940803528},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.441588819026947},{"id":"https://openalex.org/C2778803964","wikidata":"https://www.wikidata.org/wiki/Q143747","display_name":"Histoplasma capsulatum","level":3,"score":0.4260309934616089},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3746553063392639},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.34324994683265686}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.32873/unmc.dc.gmerj.1.1.077","doi":"https://doi.org/10.32873/unmc.dc.gmerj.1.1.077","is_oa":true,"landing_page_url":"https://doi.org/10.32873/unmc.dc.gmerj.1.1.077","pdf_url":"https://digitalcommons.unmc.edu/cgi/viewcontent.cgi?article=1083&context=gmerj","source":{"id":"https://openalex.org/S4210227318","display_name":"Graduate Medical Education Research Journal","issn_l":"2578-6091","issn":["2578-6091","2578-6105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Graduate Medical Education Research Journal","raw_type":"journal-article"},{"id":"pmh:oai:digitalcommons.unmc.edu:gmerj-1083","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unmc.edu/cgi/viewcontent.cgi?article=1083&context=gmerj","pdf_url":null,"source":{"id":"https://openalex.org/S7407097584","display_name":"DigitalCommons@UNMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59130452","host_organization_name":"University of Nebraska Medical Center","host_organization_lineage":["https://openalex.org/I59130452"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Medical Education Research Journal","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:b05386260eba460c9dcb652b4f6535ec","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b05386260eba460c9dcb652b4f6535ec","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Medical Education Research Journal, Vol 1, Iss 1, Pp 61-61 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.32873/unmc.dc.gmerj.1.1.077","doi":"https://doi.org/10.32873/unmc.dc.gmerj.1.1.077","is_oa":true,"landing_page_url":"https://doi.org/10.32873/unmc.dc.gmerj.1.1.077","pdf_url":"https://digitalcommons.unmc.edu/cgi/viewcontent.cgi?article=1083&context=gmerj","source":{"id":"https://openalex.org/S4210227318","display_name":"Graduate Medical Education Research Journal","issn_l":"2578-6091","issn":["2578-6091","2578-6105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Graduate Medical Education Research Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2995486142.pdf","grobid_xml":"https://content.openalex.org/works/W2995486142.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3002868692","https://openalex.org/W4285009270","https://openalex.org/W2790242557","https://openalex.org/W2343475301","https://openalex.org/W2337523828","https://openalex.org/W4292526931","https://openalex.org/W2737841476","https://openalex.org/W4391027777","https://openalex.org/W2183658773","https://openalex.org/W7096290870"],"abstract_inverted_index":{"Mentor:":[0],"Christopher":[1],"Bingcang":[2],"Program:":[3],"Otolaryngolgy":[4],"Introduction:":[5],"Laryngeal":[6,31],"histoplasmosis":[7,35,170],"is":[8],"a":[9,60,129,155,162],"rare":[10],"entity,":[11],"with":[12,20,71,89,116,153,168,242],"<100":[13],"case":[14],"reports":[15],"in":[16,39,111,196,230],"the":[17,124,216,224,231],"literature.":[18],"Patients":[19],"laryngeal":[21,66,227],"involvement":[22],"often":[23],"report":[24],"hoarseness,":[25],"mucosal":[26],"ulcerations,":[27],"dysphagia,":[28],"and":[29,42,44,77,95,107,141,159,165,209,240,253],"odynophagia.":[30],"lesions":[32,106,136],"caused":[33],"by":[34,203],"are":[36],"highly":[37],"variable":[38],"both":[40],"location":[41],"appearance,":[43],"can":[45],"be":[46,237],"easily":[47],"misdiagnosed":[48],"as":[49],"either":[50],"malignancy,":[51],"tuberculosis,":[52],"or":[53],"granulomatous":[54],"diseases.":[55],"Case":[56],"description:":[57],"We":[58],"present":[59],"series":[61],"of":[62,65,86,219,226],"three":[63,113],"cases":[64,214],"histoplasmosis.":[67],"All":[68,79,198],"patients":[69,80,199],"presented":[70],"new":[72],"onset":[73],"voice":[74],"changes,":[75],"odynophagia,":[76],"dysphagia.":[78],"were":[81,109,137,143,200],"immunosuppressed":[82],"secondary":[83],"to":[84,189,222,249],"treatment":[85],"medical":[87],"co-morbidities":[88],"two":[90],"treated":[91],"for":[92,99,139,148],"Crohn\u2019s":[93,117],"disease":[94,118],"one":[96,151],"receiving":[97,126],"chemotherapy":[98,127],"prostate":[100],"cancer.":[101],"Upon":[102],"endoscopic":[103],"evaluation,":[104],"ulcerative":[105],"thickening":[108],"found":[110],"all":[112],"patients.":[114],"Those":[115],"had":[119,128],"diffuse":[120],"supraglottic":[121],"disease,":[122,205],"while":[123],"patient":[125,152,175],"unilateral":[130],"true":[131],"vocal":[132],"fold":[133],"lesion.":[134],"These":[135,213],"suspicious":[138],"malignancy":[140],"biopsies":[142],"obtained.":[144],"Biopsies":[145],"returned":[146],"negative":[147],"malignancy.":[149],"In":[150],"Crohn\u2019s,":[154],"biopsy":[156],"was":[157,166,176],"indeterminate,":[158],"subsequently":[160,201],"developed":[161],"bowel":[163],"perforation":[164],"diagnosed":[167,177],"disseminated":[169],"on":[171,207],"surgical":[172],"pathology.":[173],"One":[174],"after":[178],"fungal":[179],"cultures":[180],"grew":[181],"Histoplasma":[182],"at":[183],"four":[184],"weeks.":[185],"Increased":[186],"suspicion":[187,220],"led":[188],"diagnosis":[190,225,246],"via":[191],"Gomori":[192],"Methenamine":[193],"Silver":[194],"Stain":[195],"another.":[197],"followed":[202],"infectious":[204],"started":[206],"antifungals,":[208],"symptoms":[210],"resolved.":[211],"Discussion:":[212],"illustrate":[215],"high":[217],"index":[218],"required":[221],"make":[223],"histoplasmosis,":[228],"especially":[229],"Midwestern":[232],"United":[233],"States.":[234],"Diagnosis":[235],"may":[236,247],"made":[238],"quickly":[239],"cost-effectively":[241],"proper":[243],"staining.":[244],"Delayed":[245],"lead":[248],"dissemination,":[250],"increased":[251],"morbidity,":[252],"mortality.":[254]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-26T00:00:00"}