{"id":"https://openalex.org/W2995472573","doi":null,"title":"Anti-vascular endothelial growth factor indications in ocular disease.","display_name":"Anti-vascular endothelial growth factor indications in ocular disease.","publication_year":2015,"publication_date":"2015-10-01","ids":{"openalex":"https://openalex.org/W2995472573","mag":"2995472573","pmid":"https://pubmed.ncbi.nlm.nih.gov/29450313","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5712945"},"language":"en","primary_location":{"id":"pmid:29450313","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29450313","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian journal of ophthalmology","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5712945/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112479863","display_name":"Cornel \u015etefan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135041","display_name":"Spitalul Universitar de Urgen\u0163\u0103 Militar Central Dr. Carol Davila","ror":"https://ror.org/03h2qaw95","country_code":"RO","type":"healthcare","lineage":["https://openalex.org/I4210135041"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Stefan Cornel","raw_affiliation_strings":["Central Military Emergency University Hospital \"Dr.Carol Davila\", Ophthalmology Department"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Military Emergency University Hospital \"Dr.Carol Davila\", Ophthalmology Department","institution_ids":["https://openalex.org/I4210135041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076297250","display_name":"Daniela Adriana Iliescu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iliescu Daniela Adriana","raw_affiliation_strings":["Emergency Eye Hospital Bucharest"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emergency Eye Hospital Bucharest","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020059594","display_name":"Cristina Mihaela Timaru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135041","display_name":"Spitalul Universitar de Urgen\u0163\u0103 Militar Central Dr. Carol Davila","ror":"https://ror.org/03h2qaw95","country_code":"RO","type":"healthcare","lineage":["https://openalex.org/I4210135041"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Timaru Cristina Mihaela","raw_affiliation_strings":["Central Military Emergency University Hospital \"Dr.Carol Davila\", Ophthalmology Department"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Military Emergency University Hospital \"Dr.Carol Davila\", Ophthalmology Department","institution_ids":["https://openalex.org/I4210135041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059549755","display_name":"Speran\u0163a Schmitzer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Schmitzer Speranta","raw_affiliation_strings":["Emergency Eye Hospital Bucharest"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emergency Eye Hospital Bucharest","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074466520","display_name":"De Simone Algerino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135041","display_name":"Spitalul Universitar de Urgen\u0163\u0103 Militar Central Dr. Carol Davila","ror":"https://ror.org/03h2qaw95","country_code":"RO","type":"healthcare","lineage":["https://openalex.org/I4210135041"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"De Simone Algerino","raw_affiliation_strings":["Central Military Emergency University Hospital \"Dr.Carol Davila\", Ophthalmology Department"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Military Emergency University Hospital \"Dr.Carol Davila\", Ophthalmology Department","institution_ids":["https://openalex.org/I4210135041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046285894","display_name":"Batras Mehdi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135041","display_name":"Spitalul Universitar de Urgen\u0163\u0103 Militar Central Dr. Carol Davila","ror":"https://ror.org/03h2qaw95","country_code":"RO","type":"healthcare","lineage":["https://openalex.org/I4210135041"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Batras Mehdi","raw_affiliation_strings":["Central Military Emergency University Hospital \"Dr.Carol Davila\", Ophthalmology Department"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Military Emergency University Hospital \"Dr.Carol Davila\", Ophthalmology Department","institution_ids":["https://openalex.org/I4210135041"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010409943","display_name":"Hosseini-Ramhormozi Jalaladin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135041","display_name":"Spitalul Universitar de Urgen\u0163\u0103 Militar Central Dr. Carol Davila","ror":"https://ror.org/03h2qaw95","country_code":"RO","type":"healthcare","lineage":["https://openalex.org/I4210135041"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Hosseini-Ramhormozi Jalaladin","raw_affiliation_strings":["Central Military Emergency University Hospital \"Dr.Carol Davila\", Ophthalmology Department"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Military Emergency University Hospital \"Dr.Carol Davila\", Ophthalmology Department","institution_ids":["https://openalex.org/I4210135041"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1745,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.15794066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"59","issue":"4","first_page":"235","last_page":"242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.984000027179718},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9369999766349792},{"id":"https://openalex.org/keywords/eye-diseases","display_name":"eye diseases","score":0.9089999794960022},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9729999899864197},{"id":"https://openalex.org/keywords/retinal-vein-occlusion","display_name":"retinal vein occlusion","score":0.996999979019165},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":1.0},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.8379999995231628},{"id":"https://openalex.org/keywords/ocular-angiogenesis","display_name":"ocular angiogenesis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/macular-edema","display_name":"macular edema","score":0.9990000128746033},{"id":"https://openalex.org/keywords/visual-acuity-outcomes","display_name":"visual acuity outcomes","score":0.8539999723434448},{"id":"https://openalex.org/keywords/retinal-disease","display_name":"retinal disease","score":0.8889999985694885},{"id":"https://openalex.org/keywords/anterior-segment-diseases","display_name":"anterior segment diseases","score":0.9919999837875366}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8280491828918457},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.7201099991798401},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.675207257270813},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.6294523477554321},{"id":"https://openalex.org/C2908732032","wikidata":"https://www.wikidata.org/wiki/Q5062148","display_name":"Retinal Vein","level":3,"score":0.5958653092384338},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.5899380445480347},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5631802082061768},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.5631609559059143},{"id":"https://openalex.org/C2780347916","wikidata":"https://www.wikidata.org/wiki/Q1813737","display_name":"Macular edema","level":3,"score":0.5456952452659607},{"id":"https://openalex.org/C2778844676","wikidata":"https://www.wikidata.org/wiki/Q190831","display_name":"Central retinal vein occlusion","level":4,"score":0.5282769799232483},{"id":"https://openalex.org/C2781359195","wikidata":"https://www.wikidata.org/wiki/Q5105209","display_name":"Choroidal neovascularization","level":3,"score":0.5005741119384766},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.48179787397384644},{"id":"https://openalex.org/C2780261187","wikidata":"https://www.wikidata.org/wiki/Q4956400","display_name":"Branch retinal vein occlusion","level":4,"score":0.4472183883190155},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.44172239303588867},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4220895767211914},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.4102787971496582},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.4043636620044708},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2895405888557434},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.27559369802474976},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27140384912490845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17127999663352966},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.1336195468902588},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.06558692455291748},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.05810776352882385}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:29450313","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29450313","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian journal of ophthalmology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5712945","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5712945/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rom J Ophthalmol","raw_type":"Text"},{"id":"mag:2995472573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29450313","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5712945","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5712945/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rom J Ophthalmol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W42371937","https://openalex.org/W1500728559","https://openalex.org/W1562258262","https://openalex.org/W1563094820","https://openalex.org/W1565832645","https://openalex.org/W1872281589","https://openalex.org/W1898187276","https://openalex.org/W1965030185","https://openalex.org/W1967939040","https://openalex.org/W1968189763","https://openalex.org/W1970189151","https://openalex.org/W1974031680","https://openalex.org/W1980342089","https://openalex.org/W1983345433","https://openalex.org/W1983805190","https://openalex.org/W1985962931","https://openalex.org/W1985972159","https://openalex.org/W1989496815","https://openalex.org/W1995708259","https://openalex.org/W1996171994","https://openalex.org/W1996870435","https://openalex.org/W2000218315","https://openalex.org/W2003759790","https://openalex.org/W2024806987","https://openalex.org/W2030067542","https://openalex.org/W2031573728","https://openalex.org/W2031900708","https://openalex.org/W2038451782","https://openalex.org/W2049577742","https://openalex.org/W2050174594","https://openalex.org/W2062627489","https://openalex.org/W2068742492","https://openalex.org/W2075540320","https://openalex.org/W2076695448","https://openalex.org/W2079111025","https://openalex.org/W2086256951","https://openalex.org/W2108341916","https://openalex.org/W2109013365","https://openalex.org/W2113083452","https://openalex.org/W2118548020","https://openalex.org/W2124415048","https://openalex.org/W2137076161","https://openalex.org/W2138480916","https://openalex.org/W2140181275","https://openalex.org/W2146587653","https://openalex.org/W2154073405","https://openalex.org/W2160177190","https://openalex.org/W2171998177","https://openalex.org/W2252513412","https://openalex.org/W2317196257","https://openalex.org/W2330023307","https://openalex.org/W2608488415","https://openalex.org/W2738996050","https://openalex.org/W2889144835","https://openalex.org/W4211205882","https://openalex.org/W4229823998","https://openalex.org/W4240304626","https://openalex.org/W4250031098"],"related_works":["https://openalex.org/W1563094820","https://openalex.org/W7098493266","https://openalex.org/W2047301512","https://openalex.org/W198864342","https://openalex.org/W4414586666","https://openalex.org/W7199362390","https://openalex.org/W2123617249","https://openalex.org/W3030302143","https://openalex.org/W2539484214","https://openalex.org/W3030701191"],"abstract_inverted_index":{"The":[0,54],"purpose":[1],"of":[2,11,20,35,40,65],"this":[3],"systemic":[4],"review":[5],"was":[6,29],"to":[7],"investigate":[8],"the":[9,18,32,48],"indications":[10],"anti-vascular":[12],"endothelial":[13],"growth":[14],"factor":[15],"(anti-VEGF)":[16],"in":[17,37],"treatment":[19],"ocular":[21,83],"diseases.":[22],"For":[23],"this,":[24],"a":[25,38,62,101],"comprehensive":[26],"literature":[27],"research":[28],"performed":[30],"exploring":[31],"current":[33],"use":[34],"anti-VEGF":[36,55,98],"variety":[39],"retinal":[41,71],"or":[42,74],"anterior":[43],"segment":[44],"diseases":[45],"and":[46,85],"highlighting":[47],"visual":[49,92],"outcome":[50],"for":[51,61],"these":[52],"patients.":[53],"therapy":[56],"is":[57],"now":[58,95],"commonly":[59],"used":[60],"wide":[63],"range":[64],"pathologies":[66],"like":[67],"age-related":[68],"macular":[69,86],"degeneration,":[70],"vein":[72],"occlusion":[73],"diabetic":[75],"retinopathy.":[76],"Pathological":[77],"processes":[78],"such":[79],"as":[80],"abnormal":[81],"neovascularization,":[82],"angiogenesis":[84],"edema":[87],"which":[88],"can":[89],"greatly":[90],"reduce":[91],"acuity":[93],"are":[94],"targeted":[96],"by":[97],"treatment,":[99],"having":[100],"major":[102],"impact":[103],"on":[104],"vision.":[105]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-26T00:00:00"}