{"id":"https://openalex.org/W2995463243","doi":"https://doi.org/10.1016/j.phrs.2019.104609","title":"Properties of FDA-approved small molecule protein kinase inhibitors: A 2020 update","display_name":"Properties of FDA-approved small molecule protein kinase inhibitors: A 2020 update","publication_year":2019,"publication_date":"2019-12-17","ids":{"openalex":"https://openalex.org/W2995463243","doi":"https://doi.org/10.1016/j.phrs.2019.104609","mag":"2995463243","pmid":"https://pubmed.ncbi.nlm.nih.gov/31862477"},"language":"en","primary_location":{"id":"doi:10.1016/j.phrs.2019.104609","doi":"https://doi.org/10.1016/j.phrs.2019.104609","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phrs.2019.104609","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2995463243"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050801402","display_name":"Robert Jr. Roskoski","orcid":"https://orcid.org/0000-0001-9861-4139","observed_orcids":["https://orcid.org/0000-0001-9861-4139"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Robert Roskoski","raw_affiliation_strings":["Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116, Box 19, Horse Shoe, North Carolina, 28742-8814, United States. Electronic address: rrj@brimr.org","Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116, Box 19, Horse Shoe, North Carolina, 28742-8814, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116, Box 19, Horse Shoe, North Carolina, 28742-8814, United States. Electronic address: rrj@brimr.org","institution_ids":[]},{"raw_affiliation_string":"Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116, Box 19, Horse Shoe, North Carolina, 28742-8814, United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5050801402"],"corresponding_institution_ids":[],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":null,"fwci":8.8216,"has_fulltext":false,"cited_by_count":587,"citation_normalized_percentile":{"value":0.99193891,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"152","issue":null,"first_page":"104609","last_page":"104609"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.3472000062465668,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.3472000062465668,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.30219998955726624,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.06300000101327896,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fda-approved-drugs","display_name":"FDA-approved drugs","score":0.7680000066757202},{"id":"https://openalex.org/keywords/protein-kinase-inhibitors","display_name":"protein kinase inhibitors","score":0.8859999775886536},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.7680000066757202},{"id":"https://openalex.org/keywords/ntrk-fusion","display_name":"NTRK fusion","score":0.5709999799728394},{"id":"https://openalex.org/keywords/ros1","display_name":"ROS1","score":0.7279999852180481},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-receptor","display_name":"fibroblast growth factor receptor","score":0.7440000176429749},{"id":"https://openalex.org/keywords/csf1r","display_name":"CSF1R","score":0.9890000224113464},{"id":"https://openalex.org/keywords/jak2","display_name":"JAK2","score":0.9039999842643738},{"id":"https://openalex.org/keywords/myelofibrosis","display_name":"myelofibrosis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.6980000138282776},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.5120000243186951},{"id":"https://openalex.org/keywords/temsirolimus","display_name":"temsirolimus","score":0.7929999828338623},{"id":"https://openalex.org/keywords/netarsudil","display_name":"netarsudil","score":0.8529999852180481},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.6880000233650208},{"id":"https://openalex.org/keywords/ruxolitinib","display_name":"ruxolitinib","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6304143071174622},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5891908407211304},{"id":"https://openalex.org/C2777736865","wikidata":"https://www.wikidata.org/wiki/Q17915111","display_name":"DYRK1A","level":3,"score":0.587072491645813},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5678839683532715},{"id":"https://openalex.org/C2775999482","wikidata":"https://www.wikidata.org/wiki/Q18031208","display_name":"ROS1","level":4,"score":0.4969828426837921},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4855768084526062},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.47851240634918213},{"id":"https://openalex.org/C2776112149","wikidata":"https://www.wikidata.org/wiki/Q7383611","display_name":"Ruxolitinib","level":4,"score":0.47486186027526855},{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.328645795583725},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32020092010498047},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.26031309366226196},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.220816969871521},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16215819120407104},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.08706513047218323},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07753169536590576},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014486","descriptor_name":"United States Food and Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017277","descriptor_name":"Drug Approval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.phrs.2019.104609","doi":"https://doi.org/10.1016/j.phrs.2019.104609","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phrs.2019.104609","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},{"id":"pmid:31862477","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31862477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":100,"referenced_works":["https://openalex.org/W255604760","https://openalex.org/W982662479","https://openalex.org/W1574994167","https://openalex.org/W1608710587","https://openalex.org/W1718256562","https://openalex.org/W1771087982","https://openalex.org/W1881469793","https://openalex.org/W1891334654","https://openalex.org/W1970174659","https://openalex.org/W1975436091","https://openalex.org/W1976096319","https://openalex.org/W1985865045","https://openalex.org/W1989221709","https://openalex.org/W1995436312","https://openalex.org/W2000390423","https://openalex.org/W2008525757","https://openalex.org/W2014446189","https://openalex.org/W2020293198","https://openalex.org/W2030205108","https://openalex.org/W2034975420","https://openalex.org/W2048411595","https://openalex.org/W2049885874","https://openalex.org/W2052016211","https://openalex.org/W2052420692","https://openalex.org/W2054466658","https://openalex.org/W2055380229","https://openalex.org/W2056184329","https://openalex.org/W2062458432","https://openalex.org/W2067405360","https://openalex.org/W2070072705","https://openalex.org/W2070727232","https://openalex.org/W2072981794","https://openalex.org/W2077384771","https://openalex.org/W2091455173","https://openalex.org/W2095675477","https://openalex.org/W2099354636","https://openalex.org/W2105496815","https://openalex.org/W2105649494","https://openalex.org/W2122995608","https://openalex.org/W2135732933","https://openalex.org/W2135906122","https://openalex.org/W2137111502","https://openalex.org/W2138778824","https://openalex.org/W2139046059","https://openalex.org/W2140974115","https://openalex.org/W2141528038","https://openalex.org/W2145442626","https://openalex.org/W2168867186","https://openalex.org/W2207535250","https://openalex.org/W2265028324","https://openalex.org/W2270636614","https://openalex.org/W2297912447","https://openalex.org/W2304533799","https://openalex.org/W2308989383","https://openalex.org/W2398437686","https://openalex.org/W2409743256","https://openalex.org/W2481496926","https://openalex.org/W2513403311","https://openalex.org/W2540314215","https://openalex.org/W2560660889","https://openalex.org/W2570230847","https://openalex.org/W2586891229","https://openalex.org/W2594726310","https://openalex.org/W2601673178","https://openalex.org/W2607581659","https://openalex.org/W2757177119","https://openalex.org/W2764282369","https://openalex.org/W2770808186","https://openalex.org/W2778033843","https://openalex.org/W2790254562","https://openalex.org/W2790706219","https://openalex.org/W2794353845","https://openalex.org/W2797137144","https://openalex.org/W2802805088","https://openalex.org/W2806290811","https://openalex.org/W2807821904","https://openalex.org/W2886399358","https://openalex.org/W2896424462","https://openalex.org/W2902263717","https://openalex.org/W2903084459","https://openalex.org/W2911070445","https://openalex.org/W2916967884","https://openalex.org/W2922159934","https://openalex.org/W2947886905","https://openalex.org/W2951817901","https://openalex.org/W2964014383","https://openalex.org/W2965739592","https://openalex.org/W2965810912","https://openalex.org/W2967609070","https://openalex.org/W2969349514","https://openalex.org/W2977600124","https://openalex.org/W2978551174","https://openalex.org/W2979035301","https://openalex.org/W2979979888","https://openalex.org/W2982688814","https://openalex.org/W2990627920","https://openalex.org/W2991876264","https://openalex.org/W4212994265","https://openalex.org/W4295216797","https://openalex.org/W6766258433"],"related_works":["https://openalex.org/W2947886905","https://openalex.org/W2922159934","https://openalex.org/W3123446037","https://openalex.org/W4200451060","https://openalex.org/W4309184823","https://openalex.org/W7125578568","https://openalex.org/W4390747020","https://openalex.org/W4409535190","https://openalex.org/W4384297429","https://openalex.org/W4410894086"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":27},{"year":2025,"cited_by_count":45},{"year":2024,"cited_by_count":73},{"year":2023,"cited_by_count":69},{"year":2022,"cited_by_count":119},{"year":2021,"cited_by_count":165},{"year":2020,"cited_by_count":88},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2019-12-26T00:00:00"}
