{"id":"https://openalex.org/W2995461524","doi":null,"title":"Tretinoin 0.05% Lotion for the Once-Daily Treatment of Moderate and Severe Acne Vulgaris in Females: Effect of Age on Efficacy and Tolerability","display_name":"Tretinoin 0.05% Lotion for the Once-Daily Treatment of Moderate and Severe Acne Vulgaris in Females: Effect of Age on Efficacy and Tolerability","publication_year":2019,"publication_date":"2019-12-01","ids":{"openalex":"https://openalex.org/W2995461524","mag":"2995461524","pmid":"https://pubmed.ncbi.nlm.nih.gov/31860209"},"language":"en","primary_location":{"id":"pmid:31860209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31860209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of drugs in dermatology : JDD","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048521405","display_name":"Linda Stein Gold","orcid":"https://orcid.org/0000-0002-2758-1605","observed_orcids":["https://orcid.org/0000-0002-2758-1605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Linda Stein Gold","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070890272","display_name":"David M. Pariser","orcid":"https://orcid.org/0000-0003-2250-9361","observed_orcids":["https://orcid.org/0000-0003-2250-9361"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David M. Pariser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5024204845","display_name":"Eric Guenin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Guenin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7787,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.6958381,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"18","issue":"12","first_page":"1218","last_page":"1225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.8709999918937683},{"id":"https://openalex.org/keywords/acne-vulgaris","display_name":"acne","score":0.8759999871253967},{"id":"https://openalex.org/keywords/adult-female-acne","display_name":"adult female acne","score":0.9269999861717224},{"id":"https://openalex.org/keywords/retinoid-therapy","display_name":"retinoid therapy","score":0.5879999995231628},{"id":"https://openalex.org/keywords/acne-severity","display_name":"acne severity","score":0.4440000057220459},{"id":"https://openalex.org/keywords/comedones","display_name":"comedones","score":0.6029999852180481},{"id":"https://openalex.org/keywords/inflammatory-lesions","display_name":"inflammatory lesions","score":0.5320000052452087},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6140000224113464},{"id":"https://openalex.org/keywords/adolescent-girls","display_name":"adolescent girls","score":0.3799999952316284},{"id":"https://openalex.org/keywords/post-hoc-analysis","display_name":"post hoc analysis","score":0.5249999761581421},{"id":"https://openalex.org/keywords/skin-tolerability","display_name":"skin tolerability","score":0.32100000977516174},{"id":"https://openalex.org/keywords/eczema-area-and-severity-index","display_name":"Eczema Area and Severity Index","score":0.5}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9495171308517456},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.9360716938972473},{"id":"https://openalex.org/C2777673923","wikidata":"https://www.wikidata.org/wiki/Q79928","display_name":"Acne","level":2,"score":0.894878625869751},{"id":"https://openalex.org/C2780986958","wikidata":"https://www.wikidata.org/wiki/Q1871151","display_name":"Lotion","level":2,"score":0.8687222003936768},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.6211698055267334},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5955143570899963},{"id":"https://openalex.org/C2779963572","wikidata":"https://www.wikidata.org/wiki/Q29417","display_name":"Tretinoin","level":4,"score":0.5737934112548828},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.48619192838668823},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.4793970584869385},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.45550867915153503},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.44639620184898376},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.4119443893432617},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3554335832595825},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.06424078345298767},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007641","descriptor_name":"Keratolytic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007641","descriptor_name":"Keratolytic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063465","descriptor_name":"Skin Cream","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:31860209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31860209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of drugs in dermatology : JDD","raw_type":"Journal Article"},{"id":"mag:2995461524","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31860209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2998391088","https://openalex.org/W3013455703","https://openalex.org/W2898841566","https://openalex.org/W3003464760","https://openalex.org/W2983598110","https://openalex.org/W2989664014","https://openalex.org/W2909164502","https://openalex.org/W2987312729","https://openalex.org/W4282924803","https://openalex.org/W3083538959"],"abstract_inverted_index":{"BACKGROUND:":[0],"While":[1],"it":[2],"is":[3,33],"generally":[4,461],"considered":[5],"to":[6,38,66,140,292,524],"be":[7,67,279,293,525],"a":[8,201],"disease":[9],"of":[10,17,27,41,43,86,112,177,213,233,267,366,380,427],"adolescence,":[11],"acne":[12,72,97,136,239,408],"affects":[13],"an":[14,294],"increasing":[15],"number":[16],"adults,":[18],"especially":[19,445],"women.":[20],"Although":[21],"data":[22,48],"exist":[23],"on":[24,49,55],"the":[25,39,50,82,181,216,230,251,308,355,433,447,478],"use":[26],"retinoids":[28],"in":[29,71,91,155,166,215,260,274,297,318,383,399,411,421,446,472,477,502,512],"adult":[30,44,400,449,513,532],"females,":[31,480],"there":[32,290],"no":[34],"universal":[35],"agreement":[36],"as":[37],"age":[40,101,253,326,374,385,423],"onset":[42],"female":[45],"acne,":[46,228],"or":[47,76,95,134,145,519],"efficacy":[51,85,527],"and":[52,69,84,105,159,172,175,186,206,223,277,285,300,304,320,330,342,344,349,364,407,431,443,457,463,475,506,509,514,528],"tolerability":[53,194,458,529],"dependent":[54],"age.":[56],"A":[57],"novel":[58],"tretinoin":[59,88,142,390],"0.05%":[60,89,143,391,494],"lotion":[61,90,144,392,495],"formulation":[62],"has":[63],"been":[64],"shown":[65],"effective":[68,499],"well-tolerated":[70],"patients":[73],"with":[74,93,132,229,255,389,397,517],"moderate":[75,94,133,221,518],"severe":[77,96,135,226,238,520],"disease.":[78],"OBJECTIVE:":[79],"To":[80],"evaluate":[81],"safety":[83,456],"once-daily":[87,147],"women":[92,214,234],"categorized":[98],"into":[99],"different":[100],"groups":[102,311,357,375],"(13-19,":[103,328],"20-29,":[104,329],"30+":[106,129,331,452],"years).":[107,265,453],"METHODS:":[108],"Post":[109],"hoc":[110,218],"analysis":[111,219],"two":[113],"multicenter,":[114],"randomized,":[115],"double-blind,":[116],"vehicle-controlled":[117],"phase":[118],"3":[119,356],"studies.":[120],"Women":[121],"(aged":[122,263,451],"13-19":[123,264],"years,":[124,127,130],"N=357;":[125],"20-29":[126,242,403],"N=352;":[128],"N=156)":[131],"were":[137,248,312,335,376,393,418,429,439,460,469,488],"randomized":[138],"(1:1)":[139],"receive":[141],"vehicle,":[146],"for":[148,281,324,354],"12":[149,417],"weeks.":[150],"Efficacy":[151],"assessments":[152,459],"included":[153],"changes":[154,388],"baseline":[156,270],"inflammatory/noninflammatory":[157],"lesions":[158,258,511],"treatment":[160,305,436,504],"success":[161,306,353,505],"(at":[162],"least":[163],"2-grade":[164],"reduction":[165,317],"Evaluator\u2019s":[167],"Global":[168],"Severity":[169],"Score":[170],"[EGSS]":[171],"\u2018clear\u2019/\u2019almost":[173],"clear\u2019)":[174],"Quality":[176,266,379],"Life":[178,381],"(QoL)":[179],"using":[180,200],"validated":[182],"Acne-QoL":[183],"questionnaire.":[184],"Safety":[185],"adverse":[187],"events":[188],"(AEs)":[189],"where":[190,490],"evaluated":[191],"throughout;":[192],"cutaneous":[193,455],"assessed":[195],"at":[196,269,369,482],"each":[197,325,412],"study":[198],"visit":[199],"4-point":[202],"scale":[203],"(where":[204],"0=none":[205],"3=severe).":[207],"RESULTS:":[208],"At":[209,287],"baseline,":[210],"91.9%":[211],"(N=794)":[212],"post":[217],"had":[220],"(EGSS=3)":[222],"8.1%":[224],"(N=70)":[225],"(EGSS=4)":[227],"highest":[231],"proportion":[232],"(11.1%,":[235],"N=39)":[236],"having":[237],"being":[240],"aged":[241,402],"years.":[243],"Baseline":[244],"inflammatory":[245,299,319,508],"lesion":[246,302,322],"counts":[247,323],"similar":[249],"across":[250],"three":[252],"ranges,":[254],"more":[256,498],"comedonal":[257,510],"(44.5)":[259],"adolescent":[261,275,479,515],"females":[262,276,401,450,516],"life":[268],"was":[271,358,496],"much":[272],"better":[273],"may":[278],"age-related":[280,295,526],"some":[282],"domains":[283],"(self-perception":[284],"role-social).":[286],"week":[288,370,416,466,483],"12,":[289],"appeared":[291],"improvement":[296],"both":[298],"noninflammatory":[301,321],"counts,":[303],"although":[307,387],"differences":[309,372],"between":[310,373],"not":[313,377],"significant.":[314,378],"Mean":[315],"percent":[316],"group":[327],"years":[332,404],"old":[333],"respectively)":[334],"55.3%":[336],"(P=0.019":[337],"versus":[338],"vehicle),":[339],"55.8%":[340],"(P=0.080)":[341],"63.5%;":[343],"47.1%":[345],"(P<0.001),":[346],"55.2%":[347],"(P=0.002)":[348],"59.0%":[350],"(P=0.030).":[351],"Treatment":[352],"achieved":[359],"by":[360,415,465],"23.2%":[361],"(P=0.023),":[362],"21.3%,":[363],"30.7%":[365],"patients,":[367],"respectively,":[368],"12;":[371],"improved":[382,464],"all":[384,485],"groups,":[386],"only":[394],"significant":[395],"compared":[396],"vehicle":[398,501],"(self-perception,":[405],"role-emotional":[406],"symptoms);":[409],"improvements":[410],"domain":[413],"score":[414],"also":[419],"greatest":[420],"this":[422],"group.":[424],"The":[425],"majority":[426],"AEs":[428,438],"mild":[430,462],"transient;":[432],"most":[434],"common":[435],"emergent":[437],"application":[440],"site":[441],"pain":[442],"dryness":[444],"older":[448],"Local":[454],"12.":[467],"There":[468,522],"transient":[470],"increases":[471],"scaling,":[473],"burning":[474],"stinging":[476],"peaking":[481],"4;":[484],"mean":[486],"scores":[487],"\u22640.6":[489],"1=mild.":[491],"CONCLUSIONS:":[492],"Tretinoin":[493],"significantly":[497],"than":[500],"achieving":[503],"reducing":[507],"acne.":[521],"appear":[523],"benefits":[530],"favoring":[531],"females.":[533],"J":[534],"Drugs":[535],"Dermatol.":[536],"2019;18(12):1218-1225.":[537]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-26T00:00:00"}
