{"id":"https://openalex.org/W2995423111","doi":"https://doi.org/10.1111/jgh.14962","title":"Clinical relevance of innovative immunoassays for serum ustekinumab and anti\u2010ustekinumab antibody levels in Crohn's disease","display_name":"Clinical relevance of innovative immunoassays for serum ustekinumab and anti\u2010ustekinumab antibody levels in Crohn's disease","publication_year":2019,"publication_date":"2019-12-20","ids":{"openalex":"https://openalex.org/W2995423111","doi":"https://doi.org/10.1111/jgh.14962","mag":"2995423111","pmid":"https://pubmed.ncbi.nlm.nih.gov/31860733"},"language":"en","primary_location":{"id":"doi:10.1111/jgh.14962","doi":"https://doi.org/10.1111/jgh.14962","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jgh.14962","pdf_url":null,"source":{"id":"https://openalex.org/S131037608","display_name":"Journal of Gastroenterology and Hepatology","issn_l":"0815-9319","issn":["0815-9319","1440-1746"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology and Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070676345","display_name":"Yasuhiro Morita","orcid":"https://orcid.org/0000-0002-4875-662X","observed_orcids":["https://orcid.org/0000-0002-4875-662X"]},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Morita","raw_affiliation_strings":["Department of Medicine, Shiga University of Medical Science, Otsu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Shiga University of Medical Science, Otsu, Japan","institution_ids":["https://openalex.org/I160046202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070420222","display_name":"Takayuki Imai","orcid":"https://orcid.org/0000-0002-9170-4075","observed_orcids":["https://orcid.org/0000-0002-9170-4075"]},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Imai","raw_affiliation_strings":["Department of Medicine, Shiga University of Medical Science, Otsu, Japan"],"raw_orcid":"https://orcid.org/0000-0002-9170-4075","affiliations":[{"raw_affiliation_string":"Department of Medicine, Shiga University of Medical Science, Otsu, Japan","institution_ids":["https://openalex.org/I160046202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080791902","display_name":"Shigeki Bamba","orcid":"https://orcid.org/0000-0002-4108-5894","observed_orcids":["https://orcid.org/0000-0002-4108-5894"]},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeki Bamba","raw_affiliation_strings":["Division of Clinical Nutrition, Shiga University of Medical Science, Otsu, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4108-5894","affiliations":[{"raw_affiliation_string":"Division of Clinical Nutrition, Shiga University of Medical Science, Otsu, Japan","institution_ids":["https://openalex.org/I160046202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103025670","display_name":"Kenichiro Takahashi","orcid":"https://orcid.org/0000-0002-3522-9740","observed_orcids":["https://orcid.org/0000-0002-3522-9740"]},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichiro Takahashi","raw_affiliation_strings":["Department of Medicine, Shiga University of Medical Science, Otsu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Shiga University of Medical Science, Otsu, Japan","institution_ids":["https://openalex.org/I160046202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071176378","display_name":"Osamu Inatomi","orcid":"https://orcid.org/0000-0002-5837-6575","observed_orcids":["https://orcid.org/0000-0002-5837-6575"]},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Inatomi","raw_affiliation_strings":["Department of Medicine, Shiga University of Medical Science, Otsu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Shiga University of Medical Science, Otsu, Japan","institution_ids":["https://openalex.org/I160046202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108724539","display_name":"Takako Miyazaki","orcid":"https://orcid.org/0000-0003-3255-4932","observed_orcids":["https://orcid.org/0000-0003-3255-4932"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takako Miyazaki","raw_affiliation_strings":["Department of Intestinal Inflammation Research, Hyogo College of Medicine, Hyogo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intestinal Inflammation Research, Hyogo College of Medicine, Hyogo, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045329864","display_name":"Kenji Watanabe","orcid":"https://orcid.org/0000-0002-3781-4724","observed_orcids":["https://orcid.org/0000-0002-3781-4724","https://orcid.org/0000-0003-3701-8119"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Watanabe","raw_affiliation_strings":["Department of Intestinal Inflammation Research, Hyogo College of Medicine, Hyogo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3781-4724","affiliations":[{"raw_affiliation_string":"Department of Intestinal Inflammation Research, Hyogo College of Medicine, Hyogo, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062739693","display_name":"Shir\u00f4 Nakamura","orcid":"https://orcid.org/0000-0003-4435-1294","observed_orcids":["https://orcid.org/0000-0003-4435-1294"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shiro Nakamura","raw_affiliation_strings":["Department of Intestinal Inflammation Research, Hyogo College of Medicine, Hyogo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intestinal Inflammation Research, Hyogo College of Medicine, Hyogo, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030259706","display_name":"Atsushi Yoshida","orcid":"https://orcid.org/0000-0001-5536-132X","observed_orcids":["https://orcid.org/0000-0001-5536-132X"]},"institutions":[{"id":"https://openalex.org/I4405256203","display_name":"Ofuna Chuo Hospital","ror":"https://ror.org/03wm0hx40","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405256203"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Yoshida","raw_affiliation_strings":["Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan","institution_ids":["https://openalex.org/I4405256203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041646818","display_name":"Yutaka Endo","orcid":"https://orcid.org/0000-0001-7187-0124","observed_orcids":["https://orcid.org/0000-0001-7187-0124"]},"institutions":[{"id":"https://openalex.org/I4405256203","display_name":"Ofuna Chuo Hospital","ror":"https://ror.org/03wm0hx40","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405256203"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yutaka Endo","raw_affiliation_strings":["Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Gastroenterology and Inflammatory Bowel Disease, Ofuna Chuo Hospital, Kamakura, Japan","institution_ids":["https://openalex.org/I4405256203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010022936","display_name":"Naoki Ohmiya","orcid":"https://orcid.org/0000-0002-7651-402X","observed_orcids":["https://orcid.org/0000-0002-7651-402X"]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]},{"id":"https://openalex.org/I4210124875","display_name":"Fujita Health University Hospital","ror":"https://ror.org/02r3zks97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210124875"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki Ohmiya","raw_affiliation_strings":["Department of Gastroenterology, Fujita Health University School of Medicine, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Fujita Health University School of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I145673806","https://openalex.org/I4210124875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004149456","display_name":"Tomoyuki Tsujikawa","orcid":"https://orcid.org/0000-0002-8351-5936","observed_orcids":["https://orcid.org/0000-0002-8351-5936"]},"institutions":[{"id":"https://openalex.org/I4405282641","display_name":"National Hospital Organization Higashi-Ohmi General Medical Center","ror":"https://ror.org/006j23f14","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4405282641"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyuki Tsujikawa","raw_affiliation_strings":["Department of Gastroenterology, National Hospital Organization Higashi-Ohmi General Medical Center, Higashi-Ohmi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, National Hospital Organization Higashi-Ohmi General Medical Center, Higashi-Ohmi, Japan","institution_ids":["https://openalex.org/I4405282641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088713000","display_name":"Akira Andoh","orcid":"https://orcid.org/0000-0001-8533-2669","observed_orcids":["https://orcid.org/0000-0001-8533-2669"]},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akira Andoh","raw_affiliation_strings":["Department of Medicine, Shiga University of Medical Science, Otsu, Japan"],"raw_orcid":"https://orcid.org/0000-0001-8533-2669","affiliations":[{"raw_affiliation_string":"Department of Medicine, Shiga University of Medical Science, Otsu, Japan","institution_ids":["https://openalex.org/I160046202"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5088713000"],"corresponding_institution_ids":["https://openalex.org/I160046202"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":1.2764,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.79491467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"35","issue":"7","first_page":"1163","last_page":"1170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ustekinumab","display_name":"ustekinumab","score":1.0},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9459999799728394},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.9549999833106995},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.6119999885559082},{"id":"https://openalex.org/keywords/immunoassay-validation","display_name":"immunoassay validation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/trough-concentration","display_name":"trough concentration","score":0.6259999871253967},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8270000219345093},{"id":"https://openalex.org/keywords/biologic-naive-patients","display_name":"biologic-naive patients","score":0.8080000281333923},{"id":"https://openalex.org/keywords/biologic-experienced-patients","display_name":"biologic-experienced patients","score":0.7990000247955322},{"id":"https://openalex.org/keywords/il-12-23-inhibition","display_name":"IL-12/IL-23 inhibition","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C2778975655","wikidata":"https://www.wikidata.org/wiki/Q420305","display_name":"Ustekinumab","level":4,"score":0.9938510656356812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9231747388839722},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.603984534740448},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4247710406780243},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42231035232543945},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3303374648094177},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2911670207977295},{"id":"https://openalex.org/C2780132546","wikidata":"https://www.wikidata.org/wiki/Q348260","display_name":"Adalimumab","level":3,"score":0.06833454966545105}],"mesh":[{"descriptor_ui":"D000069549","descriptor_name":"Ustekinumab","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000069549","descriptor_name":"Ustekinumab","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000069549","descriptor_name":"Ustekinumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/jgh.14962","doi":"https://doi.org/10.1111/jgh.14962","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jgh.14962","pdf_url":null,"source":{"id":"https://openalex.org/S131037608","display_name":"Journal of Gastroenterology and Hepatology","issn_l":"0815-9319","issn":["0815-9319","1440-1746"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology and Hepatology","raw_type":"journal-article"},{"id":"pmid:31860733","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31860733","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastroenterology and hepatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322555","display_name":"Smoking Research Foundation","ror":"https://ror.org/04q4hbm31"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1480595770","https://openalex.org/W1965832974","https://openalex.org/W1966832454","https://openalex.org/W1966999437","https://openalex.org/W2003949246","https://openalex.org/W2072806283","https://openalex.org/W2075090387","https://openalex.org/W2077531651","https://openalex.org/W2085127303","https://openalex.org/W2094960644","https://openalex.org/W2118088660","https://openalex.org/W2118559127","https://openalex.org/W2149065814","https://openalex.org/W2162805528","https://openalex.org/W2167264906","https://openalex.org/W2198790708","https://openalex.org/W2521474688","https://openalex.org/W2560169101","https://openalex.org/W2603226668","https://openalex.org/W2786428497","https://openalex.org/W2786974934","https://openalex.org/W2803684936","https://openalex.org/W2804431571","https://openalex.org/W2883220140","https://openalex.org/W2903540483","https://openalex.org/W2905562946","https://openalex.org/W2912182261","https://openalex.org/W2913138591","https://openalex.org/W2914225473","https://openalex.org/W2922074884","https://openalex.org/W2923576761","https://openalex.org/W2944754729","https://openalex.org/W2948759662","https://openalex.org/W2976115484","https://openalex.org/W4205253993","https://openalex.org/W4211241312","https://openalex.org/W4233817719"],"related_works":["https://openalex.org/W4213088745","https://openalex.org/W4408376694","https://openalex.org/W2979678500","https://openalex.org/W3000464155","https://openalex.org/W3137309088","https://openalex.org/W2914431353","https://openalex.org/W4206930689","https://openalex.org/W4400347928","https://openalex.org/W2603226668","https://openalex.org/W2586192851"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIM:":[2],"Ustekinumab":[3,120,147],"is":[4,21],"a":[5],"human":[6,14],"monoclonal":[7],"antibody":[8,33],"to":[9,22,101],"the":[10,24],"p40":[11],"subunit":[12],"of":[13,18,76,99,191],"IL-12/IL-23.":[15],"The":[16,95],"purpose":[17],"this":[19],"report":[20],"verify":[23],"newly":[25],"developed":[26,170],"immunoassays":[27,53],"for":[28,82,173],"serum":[29,144,174],"ustekinumab":[30,43,61,66,89,100,175,196],"and":[31,36,46,74,92,133,138,140,177],"anti-ustekinumab":[32],"(AUA)":[34],"concentrations":[35],"assess":[37],"their":[38],"clinical":[39],"utility.":[40],"METHODS:":[41],"Serum":[42],"trough":[44,67,90,97,121,148,176],"levels":[45,48,68,91,106,149],"AUA":[47,93,166,178],"were":[49,69,80,150],"measured":[50],"using":[51],"new":[52,171,184],"in":[54,153,157,165],"38":[55,77],"patients":[56,78,155,194],"with":[57,127,143],"Crohn's":[58,134,192],"disease":[59,135,193],"under":[60,195],"maintenance":[62],"injection.":[63],"RESULTS:":[64],"Mean":[65],"2.54":[70],"\u00b1":[71],"2.1":[72],"\u03bcg/mL,":[73],"3":[75],"(7.9%)":[79],"positive":[81],"AUAs.":[83],"There":[84],"was":[85,110,162],"no":[86,163],"association":[87],"between":[88],"levels.":[94,146,167,179],"optimal":[96],"level":[98,122],"maintain":[102],"negative":[103],"C-reactive":[104,128],"protein":[105],"(\u2264":[107],"0.3":[108],"mg/dL)":[109],"1.67":[111],"\u03bcg/mL":[112],"determined":[113],"by":[114],"receiver":[115],"operating":[116],"characteristic":[117],"curve":[118],"analysis.":[119],"negatively":[123],"but":[124],"significantly":[125,141,151],"correlated":[126,142],"protein,":[129],"erythrocyte":[130],"sedimentation":[131],"rate,":[132],"activity":[136],"index":[137],"positively":[139],"albumin":[145],"higher":[152],"biologics-na\u00efve":[154],"than":[156],"biologics-experienced":[158],"patients,":[159],"although":[160],"there":[161],"difference":[164],"CONCLUSIONS:":[168],"We":[169],"assays":[172,181],"These":[180],"might":[182],"provide":[183],"insights":[185],"into":[186],"therapeutic":[187],"drug":[188],"monitoring-based":[189],"management":[190],"therapy.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-26T00:00:00"}