{"id":"https://openalex.org/W2995383363","doi":"https://doi.org/10.1177/1120672119894847","title":"Evaluation of aqueous humor and serum cortistatin levels in diabetic patients with and without diabetic retinopathy","display_name":"Evaluation of aqueous humor and serum cortistatin levels in diabetic patients with and without diabetic retinopathy","publication_year":2019,"publication_date":"2019-12-10","ids":{"openalex":"https://openalex.org/W2995383363","doi":"https://doi.org/10.1177/1120672119894847","mag":"2995383363","pmid":"https://pubmed.ncbi.nlm.nih.gov/31822132"},"language":"en","primary_location":{"id":"doi:10.1177/1120672119894847","doi":"https://doi.org/10.1177/1120672119894847","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1120672119894847","pdf_url":null,"source":{"id":"https://openalex.org/S128637052","display_name":"European Journal of Ophthalmology","issn_l":"1120-6721","issn":["1120-6721","1724-6016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/11508/52994","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006588049","display_name":"Mehmet Balbaba","orcid":"https://orcid.org/0000-0003-1337-459X","observed_orcids":["https://orcid.org/0000-0003-1337-459X"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Mehmet Balbaba","raw_affiliation_strings":["Faculty of Medicine, Department of Ophthalmology, F\u0131rat University, Elaz\u0131\u011f, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-1337-459X","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Ophthalmology, F\u0131rat University, Elaz\u0131\u011f, Turkey","institution_ids":["https://openalex.org/I143396566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059784987","display_name":"Fatih Ula\u015f","orcid":"https://orcid.org/0000-0003-4468-3985","observed_orcids":["https://orcid.org/0000-0003-4468-3985"]},"institutions":[{"id":"https://openalex.org/I76973811","display_name":"Bolu Abant \u0130zzet Baysal University","ror":"https://ror.org/01x1kqx83","country_code":"TR","type":"education","lineage":["https://openalex.org/I76973811"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Fatih Ula\u015f","raw_affiliation_strings":["Faculty of Medicine, Department of Ophthalmology, Bolu Abant Izzet Baysal University, Bolu, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Ophthalmology, Bolu Abant Izzet Baysal University, Bolu, Turkey","institution_ids":["https://openalex.org/I76973811"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000820172","display_name":"Murat Erda\u011f","orcid":"https://orcid.org/0000-0001-8857-994X","observed_orcids":["https://orcid.org/0000-0001-8857-994X"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Murat Erda\u011f","raw_affiliation_strings":["Faculty of Medicine, Department of Ophthalmology, F\u0131rat University, Elaz\u0131\u011f, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Ophthalmology, F\u0131rat University, Elaz\u0131\u011f, Turkey","institution_ids":["https://openalex.org/I143396566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091261009","display_name":"Hakan Y\u0131ld\u0131r\u0131m","orcid":"https://orcid.org/0000-0001-6951-8260","observed_orcids":["https://orcid.org/0000-0001-6951-8260"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hakan Y\u0131ld\u0131r\u0131m","raw_affiliation_strings":["Faculty of Medicine, Department of Ophthalmology, F\u0131rat University, Elaz\u0131\u011f, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Ophthalmology, F\u0131rat University, Elaz\u0131\u011f, Turkey","institution_ids":["https://openalex.org/I143396566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057905322","display_name":"\u00dclk\u00fc \u00c7eliker","orcid":"https://orcid.org/0000-0002-9899-0959","observed_orcids":["https://orcid.org/0000-0002-9899-0959"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u00dclk\u00fc \u00c7eliker","raw_affiliation_strings":["Faculty of Medicine, Department of Ophthalmology, F\u0131rat University, Elaz\u0131\u011f, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Ophthalmology, F\u0131rat University, Elaz\u0131\u011f, Turkey","institution_ids":["https://openalex.org/I143396566"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074369258","display_name":"S\u00fcleyman Ayd\u0131n","orcid":"https://orcid.org/0000-0001-6162-3250","observed_orcids":["https://orcid.org/0000-0001-6162-3250"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"S\u00fcleyman Ayd\u0131n","raw_affiliation_strings":["Faculty of Medicine, Department of Biochemistry, F\u0131rat University, Elaz\u0131\u011f, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Biochemistry, F\u0131rat University, Elaz\u0131\u011f, Turkey","institution_ids":["https://openalex.org/I143396566"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006588049"],"corresponding_institution_ids":["https://openalex.org/I143396566"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.4833,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.6647909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"31","issue":"2","first_page":"638","last_page":"642"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cortistatin","display_name":"cortistatin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/aqueous-humor","display_name":"aqueous humor","score":0.8920000195503235},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9929999709129333},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.4440000057220459},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.7739999890327454},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.9750000238418579},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.828000009059906},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d","display_name":"25-hydroxyvitamin D","score":0.8579999804496765},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.7110000252723694},{"id":"https://openalex.org/keywords/retinopathy-pathogenesis","display_name":"retinopathy pathogenesis","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.8188952207565308},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7384046316146851},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6291885375976562},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5546125173568726},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.4618161916732788},{"id":"https://openalex.org/C2993390227","wikidata":"https://www.wikidata.org/wiki/Q827681","display_name":"Aqueous humor","level":2,"score":0.4531919062137604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39485546946525574},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34830760955810547}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001082","descriptor_name":"Aqueous Humor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/1120672119894847","doi":"https://doi.org/10.1177/1120672119894847","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1120672119894847","pdf_url":null,"source":{"id":"https://openalex.org/S128637052","display_name":"European Journal of Ophthalmology","issn_l":"1120-6721","issn":["1120-6721","1724-6016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Ophthalmology","raw_type":"journal-article"},{"id":"pmid:31822132","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31822132","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of ophthalmology","raw_type":"Journal Article"},{"id":"pmh:oai:openaccess.firat.edu.tr:11508/52994","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11508/52994","pdf_url":null,"source":{"id":"https://openalex.org/S4377196733","display_name":"DSpace - FIRAT (F\u0131rat University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143396566","host_organization_name":"F\u0131rat University","host_organization_lineage":["https://openalex.org/I143396566"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:openaccess.firat.edu.tr:11508/52994","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11508/52994","pdf_url":null,"source":{"id":"https://openalex.org/S4377196733","display_name":"DSpace - FIRAT (F\u0131rat University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143396566","host_organization_name":"F\u0131rat University","host_organization_lineage":["https://openalex.org/I143396566"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W76979740","https://openalex.org/W108835131","https://openalex.org/W168040676","https://openalex.org/W1562028693","https://openalex.org/W1577441858","https://openalex.org/W1661423125","https://openalex.org/W1932477701","https://openalex.org/W1963637704","https://openalex.org/W1981127631","https://openalex.org/W1982228553","https://openalex.org/W1986827231","https://openalex.org/W1986991414","https://openalex.org/W2001029614","https://openalex.org/W2010906418","https://openalex.org/W2022931883","https://openalex.org/W2038424370","https://openalex.org/W2040503376","https://openalex.org/W2055707729","https://openalex.org/W2060141430","https://openalex.org/W2068472192","https://openalex.org/W2072431413","https://openalex.org/W2077722846","https://openalex.org/W2086322534","https://openalex.org/W2119073596","https://openalex.org/W2138480916","https://openalex.org/W2160241739","https://openalex.org/W2161517859","https://openalex.org/W2591965380","https://openalex.org/W2607378080","https://openalex.org/W2615012109"],"related_works":["https://openalex.org/W7154912159","https://openalex.org/W7098836362","https://openalex.org/W3023398250","https://openalex.org/W7151956099","https://openalex.org/W4416903455","https://openalex.org/W2102144827","https://openalex.org/W3177460185","https://openalex.org/W7216762187","https://openalex.org/W3113080662","https://openalex.org/W2897778136"],"abstract_inverted_index":{"Purpose:":[0],"To":[1],"evaluate":[2],"the":[3,60,104,124,180,234,267,276],"aqueous":[4,106,166],"humor":[5,67,107,143,167,246],"and":[6,14,18,54,63,68,81,95,99,117,136,152,190,209,213,227,255],"serum":[7,69,126],"cortistatin":[8,108,127,144,168,199,247,270],"levels":[9,109,128,145,169,200,229,248],"in":[10,87,100,148,174,251,266,275],"diabetic":[11,16,45,52,92,97,149,154,175,178,187,192,206,211,252,257,279],"patients":[12,43,50,93,150,176,188,207,253],"with":[13,21,32,44,59,94,151,177,189,208,254],"without":[15,51,96,153,191,210,256],"retinopathy":[17,98,155,193,212],"its":[19],"relationship":[20],"various":[22],"metabolic":[23],"markers":[24],"that":[25,262],"have":[26],"been":[27],"reported":[28],"to":[29,158,171],"be":[30,172],"associated":[31],"diabetes":[33,41,48],"mellitus.":[34],"Methods:":[35],"The":[36,259],"current":[37],"study":[38],"included":[39],"20":[40,47,55],"mellitus":[42,49],"retinopathy,":[46,53,179],"healthy":[56,101,159,214],"control":[57,102,215],"subjects":[58,216],"same":[61],"sex":[62],"age":[64],"characteristics.":[65],"Aqueous":[66,142,245],"cortistatin,":[70],"fasting":[71,224],"blood":[72,78,225],"glucose,":[73,226],"hemoglobinA1c,":[74],"25-hydroxyvitamin":[75],"D":[76],"levels,":[77],"lipid":[79],"profiles,":[80],"body":[82],"mass":[83,222],"index":[84],"were":[85,110,129,146,201,230,249],"measured":[86],"all":[88,241],"subjects.":[89],"Results:":[90],"In":[91],"subjects,":[103],"mean":[105,125],"25.55":[111],"\u00b1":[112,115,119,131,134,138],"2.03,":[113],"27.71":[114],"2.01,":[116],"32.76":[118],"3.43":[120],"ng/mL,":[121,140],"respectively.":[122,141],"Likewise,":[123],"6.16":[130],"1.08,":[132],"6.57":[133],"1.00,":[135],"7.56":[137],"1.51":[139],"decreased":[147,250],"when":[156],"compared":[157],"controls":[160],"(":[161,194,217,236],"p":[162,195,218,237],"<":[163,238],"0.001).":[164],"Although":[165],"tended":[170],"reduced":[173],"difference":[181],"was":[182],"not":[183,202],"statistically":[184,203],"significant":[185,204],"between":[186,205,233],"=":[196,219],"0.147).":[197],"Serum":[198],"0.166).":[220],"Body":[221],"index,":[223],"hemoglobinA1c":[228],"significantly":[231],"different":[232],"groups":[235],"0.05":[239],"for":[240],"parameters":[242],"tested).":[243],"Conclusion:":[244],"retinopathy.":[258,280],"results":[260],"suggest":[261],"a":[263,273],"local":[264],"decrease":[265],"amount":[268],"of":[269,278],"may":[271],"play":[272],"role":[274],"pathogenesis":[277]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-26T00:00:00"}