{"id":"https://openalex.org/W2995375199","doi":"https://doi.org/10.3389/fvets.2019.00477","title":"Multi-Level Safety Studies of Anti Fel d 1 IgY Ingredient in Cat Food","display_name":"Multi-Level Safety Studies of Anti Fel d 1 IgY Ingredient in Cat Food","publication_year":2020,"publication_date":"2020-01-08","ids":{"openalex":"https://openalex.org/W2995375199","doi":"https://doi.org/10.3389/fvets.2019.00477","mag":"2995375199","pmid":"https://pubmed.ncbi.nlm.nih.gov/31970163","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6960183"},"language":"en","primary_location":{"id":"doi:10.3389/fvets.2019.00477","doi":"https://doi.org/10.3389/fvets.2019.00477","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2019.00477","pdf_url":"https://www.frontiersin.org/articles/10.3389/fvets.2019.00477/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fvets.2019.00477/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057922661","display_name":"Ray A. Matulka","orcid":"https://orcid.org/0000-0003-4286-4272","observed_orcids":["https://orcid.org/0000-0003-4286-4272"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ray A. Matulka","raw_affiliation_strings":["Burdock Group Consultants, Orlando, FL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burdock Group Consultants, Orlando, FL, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Larry Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127940","display_name":"Nestl\u00e9 (United States)","ror":"https://ror.org/0368qtc02","country_code":"US","type":"company","lineage":["https://openalex.org/I4210112383","https://openalex.org/I4210127940"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry Thompson","raw_affiliation_strings":["Nestl\u00e9 Purina PetCare Global Resources, Inc., St. Louis, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nestl\u00e9 Purina PetCare Global Resources, Inc., St. Louis, MO, United States","institution_ids":["https://openalex.org/I4210127940"]}]},{"author_position":"last","author":{"id":null,"display_name":"David Corley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127940","display_name":"Nestl\u00e9 (United States)","ror":"https://ror.org/0368qtc02","country_code":"US","type":"company","lineage":["https://openalex.org/I4210112383","https://openalex.org/I4210127940"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Corley","raw_affiliation_strings":["Nestl\u00e9 Purina PetCare Global Resources, Inc., St. Louis, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nestl\u00e9 Purina PetCare Global Resources, Inc., St. Louis, MO, United States","institution_ids":["https://openalex.org/I4210127940"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5057922661"],"corresponding_institution_ids":[],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.5593,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.52638108,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"6","issue":null,"first_page":"477","last_page":"477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.5151000022888184,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.5151000022888184,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":0.42309999465942383,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fel-d-1","display_name":"Fel d 1","score":0.9459999799728394},{"id":"https://openalex.org/keywords/feline-allergens","display_name":"feline allergens","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cat-food","display_name":"cat food","score":0.578000009059906},{"id":"https://openalex.org/keywords/chicken-egg-yolk","display_name":"chicken egg yolk","score":0.5950000286102295},{"id":"https://openalex.org/keywords/food-safety","display_name":"food safety","score":0.5360000133514404},{"id":"https://openalex.org/keywords/tolerance-study","display_name":"tolerance study","score":0.4740000069141388},{"id":"https://openalex.org/keywords/mutagenicity","display_name":"mutagenicity","score":0.9649999737739563},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ames-test","display_name":"Ames test","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C2780589914","wikidata":"https://www.wikidata.org/wiki/Q10675206","display_name":"Ingredient","level":2,"score":0.7498255372047424},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.5580765008926392},{"id":"https://openalex.org/C516717267","wikidata":"https://www.wikidata.org/wiki/Q909821","display_name":"Food safety","level":2,"score":0.46205416321754456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36918890476226807},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.36839595437049866}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fvets.2019.00477","doi":"https://doi.org/10.3389/fvets.2019.00477","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2019.00477","pdf_url":"https://www.frontiersin.org/articles/10.3389/fvets.2019.00477/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6960183","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6960183","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Vet Sci","raw_type":"Text"},{"id":"pmid:31970163","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31970163","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in veterinary science","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9c600aacbdd44bafb30505e677e99e5b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9c600aacbdd44bafb30505e677e99e5b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Veterinary Science, Vol 6 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fvets.2019.00477","doi":"https://doi.org/10.3389/fvets.2019.00477","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2019.00477","pdf_url":"https://www.frontiersin.org/articles/10.3389/fvets.2019.00477/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Zero hunger","score":0.5666999816894531,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2995375199.pdf","grobid_xml":"https://content.openalex.org/works/W2995375199.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W113781936","https://openalex.org/W127622546","https://openalex.org/W394242761","https://openalex.org/W1523928054","https://openalex.org/W1598639882","https://openalex.org/W1785061951","https://openalex.org/W2014734409","https://openalex.org/W2018503391","https://openalex.org/W2026069783","https://openalex.org/W2028128492","https://openalex.org/W2029406043","https://openalex.org/W2056745094","https://openalex.org/W2074097233","https://openalex.org/W2082108279","https://openalex.org/W2102062329","https://openalex.org/W2109621308","https://openalex.org/W2112310824","https://openalex.org/W2116496606","https://openalex.org/W2120329947","https://openalex.org/W2120796496","https://openalex.org/W2122113107","https://openalex.org/W2133518232","https://openalex.org/W2139026093","https://openalex.org/W2144338899","https://openalex.org/W2204514039","https://openalex.org/W2291611461","https://openalex.org/W2321132933","https://openalex.org/W2323673080","https://openalex.org/W2557138576","https://openalex.org/W2620079877","https://openalex.org/W2621149636","https://openalex.org/W2767198896","https://openalex.org/W2770456618","https://openalex.org/W2783541246","https://openalex.org/W2804582076","https://openalex.org/W2921613611","https://openalex.org/W2957018352","https://openalex.org/W3021151381","https://openalex.org/W4239374987"],"related_works":["https://openalex.org/W4392468630","https://openalex.org/W2921613611","https://openalex.org/W7134285765","https://openalex.org/W2742193372","https://openalex.org/W2957018352","https://openalex.org/W4395695807","https://openalex.org/W4247620836","https://openalex.org/W2360948922","https://openalex.org/W2900734249","https://openalex.org/W1984067948"],"abstract_inverted_index":{"Chickens":[0],"exposed":[1,14],"to":[2,10,125,136,147],"antigens":[3],"produce":[4],"IgY":[5,32],"antibodies,":[6],"similar":[7],"in":[8,25,38,52,60,63,71,160,167,174,186],"structure":[9],"mammalian":[11],"IgG.":[12],"Hens":[13],"with":[15,76,176],"an":[16],"allergen":[17],"produced":[18],"by":[19],"cats":[20,61,187],"(Fel":[21],"d":[22,29],"1)":[23],"results":[24],"production":[26],"of":[27,123,145],"anti-Fel":[28],"1":[30],"specific":[31],"(AFD1),":[33],"which":[34],"is":[35],"naturally":[36],"concentrated":[37],"egg":[39,43],"yolk.":[40],"A":[41],"chicken":[42],"product":[44],"ingredient":[45],"containing":[46,80],"AFD1":[47,108,183],"was":[48,74,109,184],"evaluated":[49,110],"for":[50,65,111,129],"safety":[51],"a":[53],"26-week":[54],"randomized,":[55],"controlled,":[56],"blinded":[57],"tolerance":[58],"study":[59,73,200],"and":[62,67,103,105,128,156,191],"vitro":[64],"mutagenic":[66,113,195],"genotoxic":[68],"effects.":[69],"The":[70],"vivo":[72],"conducted":[75],"groups":[77,159],"fed":[78],"kibble":[79],"0,":[81],"7,":[82],"39,":[83],"or":[84,169,177,196],"66":[85],"ppm":[86,127],"AFD1.":[87],"Parameters":[88],"examined":[89],"included:":[90],"clinical":[91],"observations,":[92],"body":[93],"weights,":[94],"food":[95],"consumption,":[96],"serum":[97],"chemistry,":[98],"hematology,":[99],"blood":[100,141],"coagulation,":[101],"urinalyses,":[102],"mortality":[104],"morbidity":[106],"checks.":[107],"potential":[112,130],"effects":[114],"utilizing":[115],"the":[116],"bacterial":[117],"reverse":[118],"mutation":[119],"assay":[120],"at":[121,134,188],"concentrations":[122],"up":[124,135],"2.78":[126],"structural":[131],"chromosomal":[132,170,197],"aberrations":[133,171,198],"3ppm":[137],"using":[138],"human":[139],"peripheral":[140],"lymphocytes.":[142],"After":[143],"6-months":[144],"feeding":[146],"cats,":[148],"there":[149],"were":[150,172],"no":[151],"significant":[152,165],"differences":[153],"between":[154],"control":[155],"any":[157,161],"test":[158],"parameters":[162],"analyzed.":[163],"No":[164],"increases":[166],"mutations":[168],"observed":[173],"tests":[175],"without":[178],"S9.":[179],"These":[180],"studies":[181],"show":[182],"well-tolerated":[185],"levels":[189],"tested":[190],"does":[192],"not":[193],"induce":[194],"under":[199],"conditions.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-12-26T00:00:00"}
