{"id":"https://openalex.org/W2995370221","doi":"https://doi.org/10.1002/bit.27253","title":"Real\u2010time dissolved carbon dioxide monitoring I: Application of a novel in situ sensor for CO2 monitoring and control","display_name":"Real\u2010time dissolved carbon dioxide monitoring I: Application of a novel in situ sensor for CO2 monitoring and control","publication_year":2019,"publication_date":"2019-12-16","ids":{"openalex":"https://openalex.org/W2995370221","doi":"https://doi.org/10.1002/bit.27253","mag":"2995370221","pmid":"https://pubmed.ncbi.nlm.nih.gov/31840812","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7079146"},"language":"en","primary_location":{"id":"doi:10.1002/bit.27253","doi":"https://doi.org/10.1002/bit.27253","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bit.27253","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bit.27253","source":{"id":"https://openalex.org/S151564723","display_name":"Biotechnology and Bioengineering","issn_l":"0006-3592","issn":["0006-3592","1097-0290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and Bioengineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bit.27253","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013884490","display_name":"Viki Chopda","orcid":"https://orcid.org/0000-0003-1952-5520","observed_orcids":["https://orcid.org/0000-0003-1952-5520"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Viki R. Chopda","raw_affiliation_strings":["Department of Chemical, Biochemical and Environmental Engineering, Center for Advanced Sensor Technology, University of Maryland, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical, Biochemical and Environmental Engineering, Center for Advanced Sensor Technology, University of Maryland, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035035270","display_name":"Timothy R Holzberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Holzberg","raw_affiliation_strings":["Department of Chemical, Biochemical and Environmental Engineering, Center for Advanced Sensor Technology, University of Maryland, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical, Biochemical and Environmental Engineering, Center for Advanced Sensor Technology, University of Maryland, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018497661","display_name":"Xudong Ge","orcid":"https://orcid.org/0000-0003-1733-398X","observed_orcids":["https://orcid.org/0000-0003-1733-398X"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xudong Ge","raw_affiliation_strings":["Department of Chemical, Biochemical and Environmental Engineering, Center for Advanced Sensor Technology, University of Maryland, Baltimore, Maryland"],"raw_orcid":"https://orcid.org/0000-0003-1733-398X","affiliations":[{"raw_affiliation_string":"Department of Chemical, Biochemical and Environmental Engineering, Center for Advanced Sensor Technology, University of Maryland, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072964860","display_name":"Brandon Folio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon Folio","raw_affiliation_strings":["Department of Chemical, Biochemical and Environmental Engineering, Center for Advanced Sensor Technology, University of Maryland, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical, Biochemical and Environmental Engineering, Center for Advanced Sensor Technology, University of Maryland, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027508364","display_name":"Michael Tolosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Tolosa","raw_affiliation_strings":["Department of Chemical, Biochemical and Environmental Engineering, Center for Advanced Sensor Technology, University of Maryland, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical, Biochemical and Environmental Engineering, Center for Advanced Sensor Technology, University of Maryland, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046823574","display_name":"Yordan V. Kostov","orcid":"https://orcid.org/0000-0002-7903-9682","observed_orcids":["https://orcid.org/0000-0002-7903-9682"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yordan Kostov","raw_affiliation_strings":["Department of Chemical, Biochemical and Environmental Engineering, Center for Advanced Sensor Technology, University of Maryland, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical, Biochemical and Environmental Engineering, Center for Advanced Sensor Technology, University of Maryland, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043940183","display_name":"Leah M. Tolosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leah Tolosa","raw_affiliation_strings":["Department of Chemical, Biochemical and Environmental Engineering, Center for Advanced Sensor Technology, University of Maryland, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical, Biochemical and Environmental Engineering, Center for Advanced Sensor Technology, University of Maryland, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050140316","display_name":"Govind Rao","orcid":"https://orcid.org/0000-0001-6140-7582","observed_orcids":["https://orcid.org/0000-0001-6140-7582"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Govind Rao","raw_affiliation_strings":["Department of Chemical, Biochemical and Environmental Engineering, Center for Advanced Sensor Technology, University of Maryland, Baltimore, Maryland"],"raw_orcid":"https://orcid.org/0000-0001-6140-7582","affiliations":[{"raw_affiliation_string":"Department of Chemical, Biochemical and Environmental Engineering, Center for Advanced Sensor Technology, University of Maryland, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050140316"],"corresponding_institution_ids":["https://openalex.org/I126744593"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":{"value":4035,"currency":"EUR","value_usd":4351},"fwci":1.0535,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.732464,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"117","issue":"4","first_page":"981","last_page":"991"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10864","display_name":"Fluid Dynamics and Mixing","score":0.9018999934196472,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10864","display_name":"Fluid Dynamics and Mixing","score":0.9018999934196472,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.060600001364946365,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dissolved-carbon-dioxide","display_name":"dissolved CO2","score":0.9829999804496765},{"id":"https://openalex.org/keywords/real-time-monitoring","display_name":"real-time monitoring","score":0.75},{"id":"https://openalex.org/keywords/in-situ-sensors","display_name":"in situ sensors","score":0.8429999947547913},{"id":"https://openalex.org/keywords/partial-pressure-measurement","display_name":"partial pressure measurement","score":0.7540000081062317},{"id":"https://openalex.org/keywords/bioprocess-control","display_name":"bioprocess control","score":0.871999979019165},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8980000019073486},{"id":"https://openalex.org/keywords/yarrowia-lipolytica","display_name":"Yarrowia lipolytica","score":0.9940000176429749},{"id":"https://openalex.org/keywords/shake-flask","display_name":"shake flask","score":0.6990000009536743},{"id":"https://openalex.org/keywords/mini-bioreactors","display_name":"mini-bioreactors","score":0.8640000224113464},{"id":"https://openalex.org/keywords/online-process-monitoring","display_name":"real-time process monitoring","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.7517800331115723},{"id":"https://openalex.org/C530467964","wikidata":"https://www.wikidata.org/wiki/Q1997","display_name":"Carbon dioxide","level":2,"score":0.6380302309989929},{"id":"https://openalex.org/C139149728","wikidata":"https://www.wikidata.org/wiki/Q335201","display_name":"Laboratory flask","level":2,"score":0.5945875644683838},{"id":"https://openalex.org/C165838908","wikidata":"https://www.wikidata.org/wiki/Q736777","display_name":"Calibration","level":2,"score":0.578423023223877},{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.48914578557014465},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.46285855770111084},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.4246790111064911},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.41694340109825134},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.4030541479587555},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.399615079164505},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3864818811416626},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.372843861579895},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.34030789136886597},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.22042226791381836},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11688345670700073},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.10958606004714966},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025062","descriptor_name":"Yarrowia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1002/bit.27253","doi":"https://doi.org/10.1002/bit.27253","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bit.27253","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bit.27253","source":{"id":"https://openalex.org/S151564723","display_name":"Biotechnology and Bioengineering","issn_l":"0006-3592","issn":["0006-3592","1097-0290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and Bioengineering","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6036150","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7079146","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7079146","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7079146","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnol Bioeng","raw_type":"Text"},{"id":"pmid:31840812","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31840812","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and bioengineering","raw_type":"Journal Article"},{"id":"pmh:oai:mdsoar.org:11603/17204","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11603/17204","pdf_url":null,"source":{"id":"https://openalex.org/S4306402556","display_name":"Maryland Shared Open Access Repository (USMAI Consortium)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"doi:10.13016/m2djrp-eota","doi":"https://doi.org/10.13016/m2djrp-eota","is_oa":true,"landing_page_url":"https://doi.org/10.13016/m2djrp-eota","pdf_url":null,"source":{"id":"https://openalex.org/S4306402644","display_name":"Digital Repository at the University of Maryland (University of Maryland College Park)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1002/bit.27253","doi":"https://doi.org/10.1002/bit.27253","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bit.27253","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bit.27253","source":{"id":"https://openalex.org/S151564723","display_name":"Biotechnology and Bioengineering","issn_l":"0006-3592","issn":["0006-3592","1097-0290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and Bioengineering","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2995370221.pdf","grobid_xml":"https://content.openalex.org/works/W2995370221.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W984814007","https://openalex.org/W1841434341","https://openalex.org/W1910179562","https://openalex.org/W1934000178","https://openalex.org/W1944440100","https://openalex.org/W1976741643","https://openalex.org/W1978134451","https://openalex.org/W1980663979","https://openalex.org/W1989897278","https://openalex.org/W1989903511","https://openalex.org/W1992573669","https://openalex.org/W2015182472","https://openalex.org/W2027473690","https://openalex.org/W2028318998","https://openalex.org/W2045439749","https://openalex.org/W2049828663","https://openalex.org/W2064345071","https://openalex.org/W2072164316","https://openalex.org/W2075035653","https://openalex.org/W2081544371","https://openalex.org/W2087058811","https://openalex.org/W2087587733","https://openalex.org/W2097622561","https://openalex.org/W2106951075","https://openalex.org/W2112772095","https://openalex.org/W2130768924","https://openalex.org/W2131124131","https://openalex.org/W2146402498","https://openalex.org/W2150637735","https://openalex.org/W2157039001","https://openalex.org/W2163433017","https://openalex.org/W2168143677","https://openalex.org/W2280388944","https://openalex.org/W2288882929","https://openalex.org/W2519917040","https://openalex.org/W2532600207","https://openalex.org/W2597594797","https://openalex.org/W2749542039","https://openalex.org/W2790426040","https://openalex.org/W2795424636","https://openalex.org/W2795473041","https://openalex.org/W2805458591","https://openalex.org/W2903913749","https://openalex.org/W2905125151"],"related_works":["https://openalex.org/W2109355820","https://openalex.org/W1910179562","https://openalex.org/W2996552337","https://openalex.org/W2117918392","https://openalex.org/W6940930805","https://openalex.org/W2311892490","https://openalex.org/W1978134451","https://openalex.org/W3031334260","https://openalex.org/W2955654336","https://openalex.org/W3035731964"],"abstract_inverted_index":{"Abstract":[0],"Dissolved":[1],"carbon":[2],"dioxide":[3],"(dCO2)":[4],"is":[5],"a":[6,68,95,139,218],"well\u2010known":[7],"critical":[8],"parameter":[9],"in":[10,51,57,77,169,183,196,209,224,227],"bioprocesses":[11],"due":[12,32],"to":[13,33,103,133,138,161],"its":[14,90],"significant":[15,225],"impact":[16],"on":[17,21],"cell":[18],"metabolism":[19],"and":[20,42,49,53,98,178,191,200],"product":[22],"quality":[23],"attributes.":[24],"Processes":[25],"run":[26],"at":[27],"small\u2010scale":[28,58],"faces":[29],"many":[30],"challenges":[31],"limited":[34],"options":[35],"for":[36,39,72],"modular":[37],"sensors":[38,45],"online":[40],"monitoring":[41,74],"control.":[43],"Traditional":[44],"are":[46],"bulky,":[47],"costly,":[48],"invasive":[50],"nature":[52],"do":[54],"not":[55],"fit":[56],"systems.":[59],"In":[60],"this":[61],"study,":[62],"we":[63,158,215],"present":[64],"the":[65,85,105,111,114,128,148,155,163,167,170,212],"implementation":[66],"of":[67,75,87,152,166],"novel,":[69],"rate\u2010based":[70],"technique":[71,173],"real\u2010time":[73],"dCO2":[76,168,208],"bioprocesses.":[78],"A":[79],"silicone":[80],"sampling":[81,156],"probe":[82,112,129,157],"that":[83,107,145,204],"allows":[84],"diffusion":[86,150],"CO2":[88,106,140,153],"through":[89,135],"wall":[91],"was":[92,118,130],"inserted":[93],"inside":[94,127],"shake":[96,198],"flask/bioreactor":[97],"then":[99,131],"flushed":[100],"with":[101,188],"air":[102,121],"remove":[104],"had":[108],"diffused":[109],"into":[110,154],"from":[113],"culture":[115],"broth":[116],"(sensor":[117],"calibrated":[119],"using":[120],"as":[122],"zero\u2010point":[123],"calibration).":[124],"The":[125],"gas":[126],"allowed":[132],"recirculate":[134],"gas\u2010impermeable":[136],"tubing":[137],"monitor.":[141],"We":[142],"have":[143],"shown":[144],"by":[146],"measuring":[147],"initial":[149],"rate":[151],"were":[159],"able":[160],"determine":[162],"partial":[164],"pressure":[165],"culture.":[171],"This":[172],"can":[174,180,206],"be":[175,181],"readily":[176],"automated,":[177],"measurements":[179],"made":[182],"minutes.":[184],"Demonstration":[185],"experiments":[186],"conducted":[187],"baker's":[189],"yeast":[190,194],"Yarrowia":[192],"lipolytica":[193],"cells":[195],"both":[197],"flasks":[199],"mini":[201],"bioreactors":[202],"showed":[203],"it":[205],"monitor":[207],"real\u2010time.":[210],"Using":[211],"proposed":[213],"sensor,":[214],"successfully":[216],"implemented":[217],"dCO2\u2010based":[219],"control":[220],"scheme,":[221],"which":[222],"resulted":[223],"improvement":[226],"process":[228],"performance.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2019-12-26T00:00:00"}