{"id":"https://openalex.org/W2995368367","doi":"https://doi.org/10.1007/s00580-019-03079-7","title":"Apoptosis and regeneration of hepatocytes in rats orally exposed to caffeinated energy drinks","display_name":"Apoptosis and regeneration of hepatocytes in rats orally exposed to caffeinated energy drinks","publication_year":2019,"publication_date":"2019-12-14","ids":{"openalex":"https://openalex.org/W2995368367","doi":"https://doi.org/10.1007/s00580-019-03079-7","mag":"2995368367"},"language":"en","primary_location":{"id":"doi:10.1007/s00580-019-03079-7","doi":"https://doi.org/10.1007/s00580-019-03079-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00580-019-03079-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210222653","display_name":"Comparative Clinical Pathology","issn_l":"0938-7714","issn":["0938-7714","1433-2973","1618-5641","1618-565X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative Clinical Pathology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2995368367"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Galina Gubina-Vakulyck","orcid":"https://orcid.org/0000-0003-1207-2688","observed_orcids":["https://orcid.org/0000-0003-1207-2688"]},"institutions":[{"id":"https://openalex.org/I76407603","display_name":"Kharkiv National Medical University","ror":"https://ror.org/01sks0025","country_code":"UA","type":"education","lineage":["https://openalex.org/I76407603"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Galina Gubina-Vakulyck","raw_affiliation_strings":["Department of Pathological Anatomy, Kharkiv National Medical University, Nauky av. 4, Kharkiv, 61022, Ukraine"],"raw_orcid":"https://orcid.org/0000-0003-1207-2688","affiliations":[{"raw_affiliation_string":"Department of Pathological Anatomy, Kharkiv National Medical University, Nauky av. 4, Kharkiv, 61022, Ukraine","institution_ids":["https://openalex.org/I76407603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103707055","display_name":"\u0422\u0430\u0442\u044c\u044f\u043d\u0430 \u0412\u0438\u043a\u0442\u043e\u0440\u043e\u0432\u043d\u0430 \u0413\u043e\u0440\u0431\u0430\u0447","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76407603","display_name":"Kharkiv National Medical University","ror":"https://ror.org/01sks0025","country_code":"UA","type":"education","lineage":["https://openalex.org/I76407603"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Tatiana Gorbach","raw_affiliation_strings":["Department of Biochemistry, Kharkiv National Medical University, Nauky av. 4, Kharkiv, 61022, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Kharkiv National Medical University, Nauky av. 4, Kharkiv, 61022, Ukraine","institution_ids":["https://openalex.org/I76407603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068565106","display_name":"Anatolii I. Onishchenko","orcid":"https://orcid.org/0000-0002-2122-2361","observed_orcids":["https://orcid.org/0000-0002-2122-2361"]},"institutions":[{"id":"https://openalex.org/I76407603","display_name":"Kharkiv National Medical University","ror":"https://ror.org/01sks0025","country_code":"UA","type":"education","lineage":["https://openalex.org/I76407603"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Anatolii Onishchenko","raw_affiliation_strings":["Department of Biochemistry, Kharkiv National Medical University, Nauky av. 4, Kharkiv, 61022, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Kharkiv National Medical University, Nauky av. 4, Kharkiv, 61022, Ukraine","institution_ids":["https://openalex.org/I76407603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013894065","display_name":"\u0412\u0456\u043a\u0442\u043e\u0440\u0456\u044f \u041d\u043e\u0432\u0456\u043a\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0003-0403-3590","observed_orcids":["https://orcid.org/0000-0003-0403-3590"]},"institutions":[{"id":"https://openalex.org/I4210142883","display_name":"Kharkiv Petro Vasylenko National Technical University of Agriculture","ror":"https://ror.org/04srpf911","country_code":"UA","type":"education","lineage":["https://openalex.org/I4210142883"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Viktoriia Novikova","raw_affiliation_strings":["Department of Processing and Food Production Technologies, Kharkiv National Technical University of Agriculture, Alchevskyh St, 44, Kharkiv, 61002, Ukraine"],"raw_orcid":"https://orcid.org/0000-0003-0403-3590","affiliations":[{"raw_affiliation_string":"Department of Processing and Food Production Technologies, Kharkiv National Technical University of Agriculture, Alchevskyh St, 44, Kharkiv, 61002, Ukraine","institution_ids":["https://openalex.org/I4210142883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028726687","display_name":"\u041e\u043a\u0441\u0430\u043d\u0430 \u0410\u043d\u0430\u0442\u043e\u043b\u0456\u0457\u0432\u043d\u0430 \u041d\u0430\u043a\u043e\u043d\u0435\u0447\u043d\u0430","orcid":"https://orcid.org/0000-0002-2614-1587","observed_orcids":["https://orcid.org/0000-0002-2614-1587"]},"institutions":[{"id":"https://openalex.org/I76407603","display_name":"Kharkiv National Medical University","ror":"https://ror.org/01sks0025","country_code":"UA","type":"education","lineage":["https://openalex.org/I76407603"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Oksana Nakonechna","raw_affiliation_strings":["Department of Biochemistry, Kharkiv National Medical University, Nauky av. 4, Kharkiv, 61022, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Kharkiv National Medical University, Nauky av. 4, Kharkiv, 61022, Ukraine","institution_ids":["https://openalex.org/I76407603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034798303","display_name":"N.S. Tryfonova","orcid":"https://orcid.org/0000-0003-3939-3772","observed_orcids":["https://orcid.org/0000-0003-3939-3772"]},"institutions":[{"id":"https://openalex.org/I76407603","display_name":"Kharkiv National Medical University","ror":"https://ror.org/01sks0025","country_code":"UA","type":"education","lineage":["https://openalex.org/I76407603"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Nataliia Tryfonova","raw_affiliation_strings":["Department of Propaedeutics of Internal Medicine No 2 and Nursing Care, Kharkiv National Medical University, Nauky av. 4, Kharkiv, 61022, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Propaedeutics of Internal Medicine No 2 and Nursing Care, Kharkiv National Medical University, Nauky av. 4, Kharkiv, 61022, Ukraine","institution_ids":["https://openalex.org/I76407603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052216165","display_name":"Tetiana Butova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8765205","display_name":"V. N. Karazin Kharkiv National University","ror":"https://ror.org/03ftejk10","country_code":"UA","type":"education","lineage":["https://openalex.org/I8765205"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Tetiana Butova","raw_affiliation_strings":["Department of Internal Medicine, V. N. Karazin Kharkiv National University, Svobody Square, 4, Kharkiv, 61000, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, V. N. Karazin Kharkiv National University, Svobody Square, 4, Kharkiv, 61000, Ukraine","institution_ids":["https://openalex.org/I8765205"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075527617","display_name":"Anton S. Tkachenko","orcid":"https://orcid.org/0000-0002-1029-1636","observed_orcids":["https://orcid.org/0000-0002-1029-1636"]},"institutions":[{"id":"https://openalex.org/I76407603","display_name":"Kharkiv National Medical University","ror":"https://ror.org/01sks0025","country_code":"UA","type":"education","lineage":["https://openalex.org/I76407603"]}],"countries":["UA"],"is_corresponding":true,"raw_author_name":"Anton Tkachenko","raw_affiliation_strings":["Department of Biochemistry, Kharkiv National Medical University, Nauky av. 4, Kharkiv, 61022, Ukraine"],"raw_orcid":"https://orcid.org/0000-0002-1029-1636","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Kharkiv National Medical University, Nauky av. 4, Kharkiv, 61022, Ukraine","institution_ids":["https://openalex.org/I76407603"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5075527617"],"corresponding_institution_ids":["https://openalex.org/I76407603"],"apc_list":{"value":3140,"currency":"USD","value_usd":3140},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"29","issue":"2","first_page":"477","last_page":"483"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":0.8306000232696533,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":0.8306000232696533,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.12630000710487366,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caffeinated-energy-drinks","display_name":"caffeinated energy drinks","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hepatocyte-apoptosis","display_name":"hepatocyte apoptosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.7620000243186951},{"id":"https://openalex.org/keywords/hepatocyte-proliferation","display_name":"hepatocyte proliferation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9810000061988831},{"id":"https://openalex.org/keywords/poly-adp-ribose-polymerase","display_name":"poly(ADP-ribose) polymerase","score":0.7089999914169312},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.9789999723434448},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.8970000147819519},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":1.0},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.6809999942779541},{"id":"https://openalex.org/keywords/hepatocyte-cytolysis","display_name":"hepatocyte cytolysis","score":0.6349999904632568},{"id":"https://openalex.org/keywords/oral-exposure","display_name":"oral exposure","score":0.44699999690055847},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.7542437314987183},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7349429726600647},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.5466757416725159},{"id":"https://openalex.org/C2776795407","wikidata":"https://www.wikidata.org/wiki/Q19597761","display_name":"Liver regeneration","level":3,"score":0.4946591556072235},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4745137095451355},{"id":"https://openalex.org/C73588182","wikidata":"https://www.wikidata.org/wiki/Q2663023","display_name":"Cytolysis","level":4,"score":0.47207072377204895},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4566667377948761},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41172122955322266},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.41065657138824463},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.4028550088405609},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.36789125204086304},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34393951296806335},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29206323623657227},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2519755959510803},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24878829717636108},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14106485247612},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.105354905128479},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10290750861167908},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.09433403611183167},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08711734414100647}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s00580-019-03079-7","doi":"https://doi.org/10.1007/s00580-019-03079-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00580-019-03079-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210222653","display_name":"Comparative Clinical Pathology","issn_l":"0938-7714","issn":["0938-7714","1433-2973","1618-5641","1618-565X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative Clinical Pathology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W917477881","https://openalex.org/W1775749144","https://openalex.org/W1906943293","https://openalex.org/W1993028050","https://openalex.org/W2016540525","https://openalex.org/W2047936840","https://openalex.org/W2065184522","https://openalex.org/W2107060734","https://openalex.org/W2134161393","https://openalex.org/W2135870834","https://openalex.org/W2143612294","https://openalex.org/W2151213561","https://openalex.org/W2151407038","https://openalex.org/W2212615214","https://openalex.org/W2407306171","https://openalex.org/W2487036964","https://openalex.org/W2558958398","https://openalex.org/W2577851679","https://openalex.org/W2581443065","https://openalex.org/W2597260222","https://openalex.org/W2755415565","https://openalex.org/W2755601549","https://openalex.org/W2765694808","https://openalex.org/W2769748219","https://openalex.org/W2783366586","https://openalex.org/W2783621235","https://openalex.org/W2789646721","https://openalex.org/W2799644392","https://openalex.org/W2801162340","https://openalex.org/W2811386751","https://openalex.org/W2891073044","https://openalex.org/W2903228746","https://openalex.org/W2921402477","https://openalex.org/W4205545159"],"related_works":["https://openalex.org/W3087269109","https://openalex.org/W4417448258","https://openalex.org/W1520943608","https://openalex.org/W2973545537","https://openalex.org/W4381197041","https://openalex.org/W2976494862","https://openalex.org/W2338526250","https://openalex.org/W7217975148","https://openalex.org/W2361703781","https://openalex.org/W2095328507"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-26T00:00:00"}