{"id":"https://openalex.org/W2995355405","doi":"https://doi.org/10.2147/ott.s228301","title":"Third-Generation TKI Resistance Due to SCLC Transformation: A Case Report and Brief Review","display_name":"Third-Generation TKI Resistance Due to SCLC Transformation: A Case Report and Brief Review","publication_year":2019,"publication_date":"2019-12-01","ids":{"openalex":"https://openalex.org/W2995355405","doi":"https://doi.org/10.2147/ott.s228301","mag":"2995355405","pmid":"https://pubmed.ncbi.nlm.nih.gov/31908495","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6927588"},"language":"en","primary_location":{"id":"doi:10.2147/ott.s228301","doi":"https://doi.org/10.2147/ott.s228301","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ott.s228301","pdf_url":"https://www.dovepress.com/getfile.php?fileID=54837","source":{"id":"https://openalex.org/S120324992","display_name":"OncoTargets and Therapy","issn_l":"1178-6930","issn":["1178-6930"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=54837","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100678062","display_name":"Chen Shen","orcid":"https://orcid.org/0000-0002-4672-2784","observed_orcids":["https://orcid.org/0000-0002-4672-2784"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shen Chen","raw_affiliation_strings":["Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-4672-2784","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100321791","display_name":"Yayi He","orcid":"https://orcid.org/0000-0002-2820-9119","observed_orcids":["https://orcid.org/0000-0002-2820-9119"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yayi He","raw_affiliation_strings":["Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-2820-9119","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100446339","display_name":"Juan Liu","orcid":"https://orcid.org/0000-0003-4013-2473","observed_orcids":["https://orcid.org/0000-0003-4013-2473"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan Liu","raw_affiliation_strings":["Department of Respiratory, Shanghai Fourth People Hospital, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory, Shanghai Fourth People Hospital, Shanghai, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101774813","display_name":"Xiaoxia Chen","orcid":"https://orcid.org/0009-0003-0321-1727","observed_orcids":["https://orcid.org/0009-0003-0321-1727","https://orcid.org/0000-0002-2421-747X"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoxia Chen","raw_affiliation_strings":["Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101841771","display_name":"Jia Yu","orcid":"https://orcid.org/0000-0002-4481-2022","observed_orcids":["https://orcid.org/0000-0002-4481-2022"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Yu","raw_affiliation_strings":["Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bin Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Chen","raw_affiliation_strings":["Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102441154","display_name":"Chenglong Sun","orcid":"https://orcid.org/0000-0002-1195-9896","observed_orcids":["https://orcid.org/0000-0002-1195-9896","https://orcid.org/0009-0008-1857-1852"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chenglong Sun","raw_affiliation_strings":["Department of Medical Oncology, Anhui No.2 Provincial People's Hospital, Anhui, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Anhui No.2 Provincial People's Hospital, Anhui, People's Republic of China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101598671","display_name":"Caicun Zhou","orcid":"https://orcid.org/0000-0002-7095-0381","observed_orcids":["https://orcid.org/0000-0002-7095-0381"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210127126","display_name":"Shanghai Pulmonary Hospital","ror":"https://ror.org/033nbnf69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127126"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Caicun Zhou","raw_affiliation_strings":["Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101598671"],"corresponding_institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210127126"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":2.5738,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.90391485,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"Volume 12","issue":null,"first_page":"11305","last_page":"11311"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.871999979019165},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.5429999828338623},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.7680000066757202},{"id":"https://openalex.org/keywords/third-generation-egfr-tki","display_name":"third-generation EGFR-TKI","score":0.7360000014305115},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.5529999732971191},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.44200000166893005},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.7419999837875366},{"id":"https://openalex.org/keywords/neuron-specific-enolase","display_name":"neuron-specific enolase","score":0.9639999866485596},{"id":"https://openalex.org/keywords/progastrin-releasing-peptide","display_name":"progastrin-releasing peptide","score":0.8700000047683716},{"id":"https://openalex.org/keywords/biomarker-monitoring","display_name":"biomarker monitoring","score":0.5630000233650208},{"id":"https://openalex.org/keywords/nab-paclitaxel","display_name":"nab-paclitaxel","score":0.8209999799728394},{"id":"https://openalex.org/keywords/apatinib","display_name":"apatinib","score":0.9580000042915344}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.824580192565918},{"id":"https://openalex.org/C2780668389","wikidata":"https://www.wikidata.org/wiki/Q27262801","display_name":"Apatinib","level":3,"score":0.728179931640625},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.6694076657295227},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.6157171130180359},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5780116319656372},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.5663211941719055},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5148298144340515},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5108415484428406},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.4941296875476837},{"id":"https://openalex.org/C188618488","wikidata":"https://www.wikidata.org/wiki/Q24776639","display_name":"Enolase","level":3,"score":0.4859372675418854},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.4677553176879883},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3877068758010864},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3506951928138733},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2076355218887329},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.19522345066070557},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.18332144618034363},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.05887302756309509}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/ott.s228301","doi":"https://doi.org/10.2147/ott.s228301","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ott.s228301","pdf_url":"https://www.dovepress.com/getfile.php?fileID=54837","source":{"id":"https://openalex.org/S120324992","display_name":"OncoTargets and Therapy","issn_l":"1178-6930","issn":["1178-6930"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5898986","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6927588","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6927588","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6927588","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Onco Targets Ther","raw_type":"Text"},{"id":"pmid:31908495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31908495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and therapy","raw_type":"Case Reports"},{"id":"pmh:oai:dovepress.com/50577","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/third-generation-tki-resistance-due-to-sclc-transformation-a-case-repo-peer-reviewed-article-OTT","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ott.s228301","doi":"https://doi.org/10.2147/ott.s228301","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ott.s228301","pdf_url":"https://www.dovepress.com/getfile.php?fileID=54837","source":{"id":"https://openalex.org/S120324992","display_name":"OncoTargets and Therapy","issn_l":"1178-6930","issn":["1178-6930"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7699999809265137,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[{"id":"https://openalex.org/G3624751900","display_name":null,"funder_award_id":"81802255","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6191048302","display_name":null,"funder_award_id":"2016YFC0902300","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2995355405.pdf","grobid_xml":"https://content.openalex.org/works/W2995355405.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1987283660","https://openalex.org/W2061932411","https://openalex.org/W2072922530","https://openalex.org/W2078632352","https://openalex.org/W2081801534","https://openalex.org/W2110182487","https://openalex.org/W2125448413","https://openalex.org/W2132870547","https://openalex.org/W2140334822","https://openalex.org/W2154149901","https://openalex.org/W2156537375","https://openalex.org/W2160982674","https://openalex.org/W2166418266","https://openalex.org/W2176919731","https://openalex.org/W2287519700","https://openalex.org/W2299139004","https://openalex.org/W2560717039","https://openalex.org/W2599728752","https://openalex.org/W2612786119","https://openalex.org/W2753428118","https://openalex.org/W2758889181","https://openalex.org/W2786429208","https://openalex.org/W2905529840"],"related_works":["https://openalex.org/W1992089244","https://openalex.org/W2619980402","https://openalex.org/W2361261189","https://openalex.org/W3137236253","https://openalex.org/W2792071154","https://openalex.org/W4399883272","https://openalex.org/W3001896450","https://openalex.org/W3135640823","https://openalex.org/W2901565453","https://openalex.org/W2078632352"],"abstract_inverted_index":{"Objective:":[0],"We":[1,105],"reported":[2],"a":[3,63,75,99],"case":[4],"of":[5,48,57,77,111,130,145,153,158,177,191],"pathologic":[6,37],"type":[7,38],"transformed":[8,40,172],"from":[9,41],"adenocarcinoma":[10,42,137],"to":[11,43],"small-cell":[12,207],"lung":[13,35,58,208],"cancer":[14,36],"(SCLC)":[15],"after":[16,45,79,127],"being":[17],"treated":[18,73],"with":[19,74,85,90,150],"third-generation":[20,49],"epidermal":[21,198],"growth":[22,199],"factor":[23,200],"receptor":[24,201],"tyrosine":[25,202],"kinase":[26,203],"inhibitor":[27],"(":[28],"EGFR":[29,50,205],"-TKI).":[30],"Materials":[31],"and":[32,66,94,116,138,155],"methods:":[33],"The":[34,143],"was":[39,72,148,180],"SCLC":[44,80,126,139,166,195],"the":[46,70,108,128,146,151,156,159,164,171,175,178,192],"treatment":[47,129,154],"-TKI":[51],"for":[52,163,170,188],"4.3":[53],"months.":[54],"Four":[55],"times":[56],"biopsies":[59],"were":[60,134,167],"conducted":[61],"at":[62],"different":[64,67],"time":[65],"lesions.":[68],"And":[69],"patient":[71],"variety":[76],"regimens":[78],"transformation,":[81,212],"including":[82],"etoposide":[83],"combined":[84,89],"carboplatin":[86],"(EC),":[87],"irinotecan":[88],"oxaliplatin":[91],"(IO),":[92],"Abraxane,":[93],"Apatinib.":[95],"These":[96],"treatments":[97],"got":[98],"good":[100],"response,":[101],"but":[102,174],"quick":[103],"progression.":[104],"also":[106,168],"monitored":[107],"dynamic":[109,189],"change":[110],"serum":[112],"neuron-specific":[113],"enolase":[114],"(NSE)":[115],"pro-gastrin":[117],"releasing":[118],"peptide":[119],"(Pro-GRP).":[120],"Results:":[121],"Adenocarcinoma":[122],"could":[123,140,183],"transform":[124],"into":[125],"TKI.":[131],"Tumor":[132],"cells":[133],"heterogeneity,":[135],"so":[136],"be":[141,184],"co-existed.":[142],"fluctuation":[144],"NSE":[147,182],"consistent":[149],"response":[152,179],"progression":[157],"tumor.":[160],"Conclusion:":[161],"Regimens":[162],"primary":[165],"available":[169],"SCLC,":[173,210],"duration":[176],"short.":[181],"an":[185],"effective":[186],"biomarker":[187],"monitoring":[190],"efficacy":[193],"in":[194],"transformation.":[196],"Keywords:":[197],"inhibitor,":[204],"-TKI,":[206],"cancer,":[209],"pathological":[211],"resistance":[213]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-12-26T00:00:00"}
